RGD Reference Report - Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. - Rat Genome Database

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Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women.

Authors: Garnero, P  Sornay-Rendu, E  Delmas, PD 
Citation: Garnero P, etal., Lancet. 2000 Mar 11;355(9207):898-9.
RGD ID: 10045863
Pubmed: PMID:10752709   (View Abstract at PubMed)

The link between serum insulin-like growth factor 1 (IGF-1) and postmenopausal osteoporosis remains controversial. In this study of healthy postmenopausal women, decreased serum concentrations of IGF-1 were strongly associated with an increased risk of osteoporotic fractures independently of bone-mineral density.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Osteoporotic Fractures susceptibilityIEP 10045863protein:decreased expression:serumRGD 
Osteoporotic Fractures susceptibilityISOIGF1 (Homo sapiens)10045863; 10045863protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information