RGD Reference Report - MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1. - Rat Genome Database

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MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1.

Authors: Hu, YK  Wang, X  Li, L  Du, YH  Ye, HT  Li, CY 
Citation: Hu YK, etal., Neurosci Bull. 2013 Dec;29(6):745-51. doi: 10.1007/s12264-013-1348-5. Epub 2013 Jun 5.
RGD ID: 10045852
Pubmed: PMID:23740209   (View Abstract at PubMed)
PMCID: PMC5561832   (View Article at PubMed Central)
DOI: DOI:10.1007/s12264-013-1348-5   (Journal Full-text)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. Many microRNAs (miRs) participate in regulating amyloid beta (Abeta) formation and the metabolism of tau protein in the process of AD, and some are up-regulated in AD patients or transgenic models of AD. However, the role of miR-98 in AD remains unclear. Here, we showed that the expression of miR-98 was negatively correlated with the insulin-like growth factor 1 (IGF-1) protein level in APP/PS1 mice. MiR-98 target sites in IGF-1 were confirmed by luciferase assay in HEK293 cells. Overexpression of miR-98 in N2a/APP cells down-regulated the IGF-1 protein level and promoted Abeta production, whereas inhibition of miR-98 in N2a/APP cells up-regulated the IGF-1 protein level and suppressed Abeta production. Furthermore, overexpression of miR-98 in N2a/WT cells increased the phosphorylation of tau, whereas inhibition of miR-98 reduced it. These results suggest that miR-98 increases Abeta formation and tau phosphorylation by inhibiting the translation of IGF-1, which might provide a therapeutic strategy for AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  ISOIgf1 (Mus musculus)10045852; 10045852protein:decreased expression:hippocampus:RGD 
Alzheimer's disease  IEP 10045852protein:decreased expression:hippocampus:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information