RGD Reference Report - Translation drives mRNA quality control. - Rat Genome Database

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Translation drives mRNA quality control.

Authors: Shoemaker, CJ  Green, R 
Citation: Shoemaker CJ and Green R, Nat Struct Mol Biol. 2012 Jun 5;19(6):594-601. doi: 10.1038/nsmb.2301.
RGD ID: 10044227
Pubmed: PMID:22664987   (View Abstract at PubMed)
PMCID: PMC4299859   (View Article at PubMed Central)
DOI: DOI:10.1038/nsmb.2301   (Journal Full-text)

There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion of these pathways often focuses on mRNA fate, there is growing consensus that there are other important outcomes of these processes that must be simultaneously considered. Here, we seek to highlight similarities between NMD, NGD and NSD and their probable origins on the ribosome during translation.


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