RGD Reference Report - Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. - Rat Genome Database

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Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.

Authors: Jiang, S  Hu, N  Zhou, J  Zhang, J  Gao, R  Hu, J  Guan, H 
Citation: Jiang S, etal., Age (Dordr). 2013 Dec;35(6):2435-44. doi: 10.1007/s11357-013-9512-4. Epub 2013 Jan 20.
RGD ID: 10042984
Pubmed: PMID:23334603   (View Abstract at PubMed)
PMCID: PMC3824989   (View Article at PubMed Central)
DOI: DOI:10.1007/s11357-013-9512-4   (Journal Full-text)

Werner syndrome is caused by mutations in the DNA repair Werner helicase (WRN) gene and characterized by accelerated aging including cataracts. Age-related cataract (ARC) cases (N = 504) and controls (N = 244) were recruited from a population-based study to evaluate the association of single-nucleotide polymorphisms (SNPs) of WRN and another DNA repair gene (human 8-oxoguanine DNA N-glycosylase 1) with ARC. Among the five SNPs tested, only WRN rs1346044 was found to be significantly associated between cases and controls before multiple-testing adjustment. The minor C allele of rs1346044 was associated with ARC with an odds ratio (OR) of 0.66, suggesting a protective role of the C allele for developing ARC. The stratification analysis on the subtypes of ARC showed that rs1346044 was significantly associated with cortical cataract, but not with nuclear, posterior subcapsular, and mixed types after multiple-testing adjustment (OR = 0.51, p< 0.01). The genetic model analysis showed that the results fit the dominant model (OR = 0.44, p < 0.001). The comet assay used to assess the extent of DNA damage in peripheral lymphocytes of ARC cases found that the DNA damage in lymphocytes from patients with CC genotype was significantly less than that in patients with TT genotype. We concluded that the C allele of rs1346044, a non-synonymous SNP resulting in the conversion of Cys to Arg at amino acid position 1367 of WRN, alters susceptibility to ARC, especially the cortical type of the disease, in the Han Chinese. The underlying mechanism of its protective role might be related to the improved DNA repair function.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
senile cataract susceptibilityIAGP 10042984DNA:missense mutation:cds:p.C1367R (rs1346044) (human)RGD 
senile cataract  ISOWRN (Homo sapiens)10042984DNA:missense mutation:cds:p.C1367R (rs1346044) (human)RGD 
senile cataract susceptibilityISOWRN (Homo sapiens)10042984DNA:missense mutation:cds:p.C1367R (rs1346044) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Age-related cataract susceptibilityIAGP 10042984DNA:missense mutation:cds:p.C1367R (rs1346044)RGD 
Reduced visual acuity susceptibilityIAGP 10042984DNA:missense mutation:cds:p.C1367R (rs1346044)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Wrn  (WRN RecQ like helicase)

Genes (Mus musculus)
Wrn  (Werner syndrome RecQ like helicase)

Genes (Homo sapiens)
WRN  (WRN RecQ like helicase)


Additional Information