RGD Reference Report - Structures and connections of enkephalin- and gamma-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study. - Rat Genome Database

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Structures and connections of enkephalin- and gamma-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study.

Authors: Huang, W  Chen, JX  Li, YM  Lu, YC  Wu, XJ 
Citation: Huang W, etal., Neurol Sci. 2011 Feb;32(1):53-8. doi: 10.1007/s10072-010-0387-1. Epub 2010 Aug 5.
RGD ID: 10003148
Pubmed: PMID:20686827   (View Abstract at PubMed)
DOI: DOI:10.1007/s10072-010-0387-1   (Journal Full-text)

GABA and enkephalin (ENK) are principle inhibitory transmitters in the rostral portion of the nucleus tractus solitarius (rNTS) for regulating the gustatory information. Although the existence of GABA- and ENK-immunoreactive (ir) profiles in the rNTS has been demonstrated, there are no morphological data revealing the connections between them. In the present study, using immunofluorescent and electron microscopic methods, we examined their relationship in the rNTS of rat. Results showed the following: (1) dense ENK-ir fibers and terminals and GABA-ir cell bodies, fibers, and terminals were observed in the rNTS; (2) ENK-ir terminals mainly make symmetric synapses with GABA-ir and immunonegative somas and dendrites; (3) co-existence of ENK/GABA-ir axon terminals and convergence of ENK- and GABA-ir terminals on one immunonegative soma or dendrite can also be observed. These results suggest that ENK should inhibit directly or excite indirectly (by blocking the inhibition of the GABAergic neurons) the gustatory neurons in the rNTS.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon terminus  IDA 10003148 RGD 
cell body fiber  IDA 10003148 RGD 
dendrite  IDA 10003148 RGD 
symmetric synapse  IDA 10003148 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Penk  (proenkephalin)


Additional Information