Eae10 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae10 (Experimental allergic encephalomyelitis QTL 10) Rattus norvegicus

Symbol: Eae10
Name: Experimental allergic encephalomyelitis QTL 10
RGD ID: 61413
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time   (CMO:0001402)    
LOD Score: 3.5
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,622,685 - 18,274,498RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01419,191,664 - 19,909,740RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01419,098,434 - 19,816,468RGDRnor5.0
RGSC_v3.41419,142,085 - 19,800,225RGDRGSC3.4
RGSC_v3.11419,142,085 - 19,800,225RGD
Cross Type: F2
Strains Crossed: DA E3 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
paresis  (QTM)
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
DA  (IEA)
E3  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
Related QTLs

Related QTL Description Reference
Pia6 maps to same region RGD:61031


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2085Albalbumin141760739717622814Rat
1310750Adamts3ADAM metallopeptidase with thrombospondin type 1, motif 3141823112818437771Rat
1562348Ankrd17ankyrin repeat domain 17141772323917861841Rat
1559547Cox18cytochrome c oxidase assembly factor COX18141786458117877483Rat
1597130Rpl8-ps4ribosomal protein L8, pseudogene 4141769362617694361Rat
41281688LOC120096803small nucleolar RNA SNORA17141816018618160317Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10135D14Wox11135141762256217622685Ratregion
33551D14Mit6191141827449818274691Ratregion
41998D14Arb4246141762249617622741Ratregion
42390D14Rat143119141821258418212709Ratregion
41690D14Rat102200141817462718174822Ratregion
45163D14Got25175141797429517974470Ratregion
45164D14Got26138141815274618152886Ratregion
738059D14Hmgc3144141773143117731575Ratregion
1633391D14Got130171141797433417974505Ratregion
5039006RH127459183141786069517860878Ratregion
5059482BI291183150141780692017807070Ratregion
5047872RH132577182141787728617877468Ratregion
5087526PMC275467P2208141762278117622989Ratregion
5085228AI598408157141775846017758617Ratregion
5507587Alb1128141762198717622819Ratregion
5502361RH124614257141786153317861790Ratregion
5503412G34499109141784556517845674Ratregion
5504734PMC86057P4438141762292017623358Ratregion
Position Markers

Flank 1: (D14Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21418,274,498 - 18,274,691 (+)MAPPER
Rnor_6.01419,909,740 - 19,909,932NCBI
Rnor_5.01419,816,468 - 19,816,660UniSTS
RGSC_v3.41419,800,225 - 19,800,418RGD
RGSC_v3.41419,800,226 - 19,800,418UniSTS
RGSC_v3.11419,800,225 - 19,800,418RGD
Celera1417,640,308 - 17,640,500UniSTS
Cytogenetic Map14p22UniSTS
Flank 2: (D14Wox11)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21417,622,562 - 17,622,685 (+)MAPPER
Rnor_6.01419,191,542 - 19,191,664NCBI
Rnor_5.01419,098,312 - 19,098,434UniSTS
Rnor_5.01419,098,311 - 19,098,434NCBI
Rnor_5.01419,098,310 - 19,098,434NCBI
RGSC_v3.41419,141,962 - 19,142,085RGD
RGSC_v3.41419,141,963 - 19,142,085UniSTS
RGSC_v3.11419,141,962 - 19,142,085RGD
Celera1416,987,724 - 16,987,846UniSTS
RH 3.4 Map14215.6UniSTS
RH 3.4 Map14215.6RGD
Cytogenetic Map14p22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
61413Eae10Experimental allergic encephalomyelitis QTL 103.5nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)141762268518274498Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Eae10

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details QTL is also significant for duration of disease (LOD = 2.5), both scores only in females 61031