GLUCO127_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GLUCO127_H (Glucose level QTL 127 (human)) Homo sapiens

Symbol: GLUCO127_H
Name: Glucose level QTL 127 (human)
RGD ID: 2314995
Trait: Glucose level
LOD Score: 2.7
P Value: Not Available
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376153,709,285 - 171,115,067RGD_MAPPER_PIPELINEGRCh37
Build 366153,629,300 - 170,899,992RGDNCBI36
Cross Type: Not Available
Population Stats: San Antonio Family Diabetes Study



Candidate Gene Status
IGF2R is a candidate Gene for GLUCO127_H
ACAT2 is a candidate Gene for GLUCO127_H

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Duggirala R, etal., Am J Hum Genet. 2001 May;68(5):1149-64. Epub 2001 Mar 29.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Peak: (D6S264)
Human AssemblyChrPosition (strand)Source
GRCh376166,709,199 - 166,709,370UniSTS
GRCh376166,709,250 - 166,709,371UniSTS
Build 366166,629,240 - 166,629,361RGD
Celera6167,448,614 - 167,448,725RGD
Celera6167,448,563 - 167,448,724UniSTS
HuRef6164,180,198 - 164,180,305UniSTS
HuRef6164,180,147 - 164,180,304UniSTS
Marshfield Genetic Map6179.07RGD
Genethon Genetic Map6179.1UniSTS
Stanford-G3 RH Map66515.0UniSTS
GeneMap99-GB4 RH Map6638.5UniSTS
GeneMap99-G3 RH Map66818.0UniSTS


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general Bivariate analysis as well as independent analyses suggest pleiotropic effects on obesity and lipid related measures 2314906
qtl_map chromosome 6q25.2-26, 210 cm 2314906
qtl_population San Antonio Family Diabetes Study 2314906
qtl_population_details 27 extended Mexican American families ascertained on type 2 diabetic probands, about 310 nondiabetic individuals (WHO criteria, 1985), not receiving diabetes drugs, average age about 39 years, average BMI of 29.4 kg/M2 2314906
qtl_statistics_details Software used:SOLAR, variance components methods, natural log of insulin sensitivity (HOMA%S) trait, and covariates used were age and sex 2314906