Orc4 (origin recognition complex, subunit 4)

Gene: Orc4 (origin recognition complex, subunit 4) Rattus norvegicus

Analyze

Symbol:

Orc4

Name:

origin recognition complex, subunit 4

RGD ID:

735212

Description:

Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Predicted to be involved in DNA replication initiation; polar body extrusion after meiotic divisions; and protein polymerization. Predicted to act upstream of or within DNA replication. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Predicted to be active in cytoplasm. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC72574; Orc4l; Orc4l2; origin recognition complex subunit 4; origin recognition complex, subunit 4-like; origin recognition complex, subunit 4-like (S. cerevisiae); origin recognition complex, subunit 4-like (yeast); origin recognition complex, subunit 4-like 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ORC4 (origin recognition complex subunit 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Orc4 (origin recognition complex, subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Orc4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ORC4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ORC4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Orc4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ORC4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ORC4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Orc4 (origin recognition complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ORC4 (origin recognition complex subunit 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Orc4 (origin recognition complex, subunit 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	orc4 (origin recognition complex, subunit 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ORC4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Orc4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	orc4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	53,700,046 - 53,743,293 (-)	NCBI		GRCr8
mRatBN7.2	3	33,290,844 - 33,334,022 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	33,294,355 - 33,333,824 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	36,677,728 - 36,716,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	45,262,461 - 45,301,116 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	43,084,856 - 43,123,482 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	33,034,913 - 33,075,833 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	33,037,034 - 33,075,685 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	38,201,914 - 38,240,600 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	29,813,264 - 29,851,852 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	31,495,196 - 31,533,857 (-)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 1 (ISO)

genetic disease (ISO)

Meier-Gorlin syndrome (ISO)

Meier-Gorlin syndrome 2 (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4-nitrophenol (ISO)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

allethrin (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

calcitriol (ISO)

cobalt dichloride (EXP,ISO)

crocidolite asbestos (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

D-glucose (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

disodium selenite (ISO)

ethanol (ISO)

fenvalerate (EXP)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gallic acid (ISO)

glafenine (EXP)

glucose (ISO)

gold atom (ISO)

gold(0) (ISO)

inulin (ISO)

ivermectin (ISO)

ketamine (EXP)

lead(0) (ISO)

methotrexate (ISO)

methylparaben (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

pyrethrins (EXP)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

sulindac (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA replication (ISO)

DNA replication initiation (IBA,IEA,ISO,ISS)

polar body extrusion after meiotic divisions (IEA,ISO)

protein polymerization (IEA,ISO)

Cellular Component

chromosome, telomeric region (IEA,ISO)

cytoplasm (ISO)

cytosol (IEA,ISO)

nuclear origin of replication recognition complex (IBA,IEA,ISO,ISS)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO,ISS)

origin recognition complex (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

DNA replication origin binding (IBA,IEA,ISO,ISS)

nucleotide binding (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex.	Springer J, etal., Chromosoma 1999 Aug;108(4):243-9.
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8915587	PMID:9353276	PMID:17716973	PMID:19135898	PMID:20932478	PMID:21383955	PMID:24270157

Genomics

Comparative Map Data

Orc4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	53,700,046 - 53,743,293 (-)	NCBI		GRCr8
mRatBN7.2	3	33,290,844 - 33,334,022 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	33,294,355 - 33,333,824 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	36,677,728 - 36,716,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	45,262,461 - 45,301,116 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	43,084,856 - 43,123,482 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	33,034,913 - 33,075,833 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	33,037,034 - 33,075,685 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	38,201,914 - 38,240,600 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	29,813,264 - 29,851,852 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	31,495,196 - 31,533,857 (-)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

ORC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	147,930,396 - 148,021,551 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	147,930,396 - 148,021,604 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	148,687,965 - 148,779,120 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	148,408,202 - 148,495,606 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	148,525,463 - 148,612,868	NCBI
Celera	2	142,405,877 - 142,493,295 (-)	NCBI		Celera
Cytogenetic Map	2	q23.1	NCBI
HuRef	2	140,685,335 - 140,777,468 (-)	NCBI		HuRef
CHM1_1	2	148,693,611 - 148,784,819 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	148,380,848 - 148,472,005 (-)	NCBI		T2T-CHM13v2.0

Orc4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	48,792,836 - 48,840,287 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	48,792,836 - 48,840,289 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	48,902,824 - 48,952,902 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	48,902,824 - 48,950,277 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	48,758,274 - 48,804,787 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	48,724,861 - 48,771,243 (-)	NCBI		MGSCv36	mm8
Celera	2	50,575,226 - 50,621,420 (-)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	28.42	NCBI

Orc4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	13,932,495 - 14,006,806 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	13,933,896 - 14,006,808 (-)	NCBI	ChiLan1.0	ChiLan1.0

ORC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	26,909,798 - 26,997,388 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	26,924,800 - 27,012,354 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	11,841,808 - 11,931,620 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	152,291,976 - 152,379,639 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	152,292,822 - 152,379,487 (-)	Ensembl	panpan1.1		panPan2

ORC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	49,728,812 - 49,815,599 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	49,728,344 - 49,815,604 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	49,852,526 - 49,939,229 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	51,201,322 - 51,288,103 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	51,193,458 - 51,288,099 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	49,847,294 - 49,933,994 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	49,981,280 - 50,068,020 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	51,378,650 - 51,465,414 (-)	NCBI		UU_Cfam_GSD_1.0

Orc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	112,424,304 - 112,486,767 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	29,131,789 - 29,194,863 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	29,131,892 - 29,193,258 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	4,096,647 - 4,171,398 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	4,096,539 - 4,176,332 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	3,748,071 - 3,824,433 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORC4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	33,314,020 - 33,401,770 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	33,314,271 - 33,355,588 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	166,136,574 - 166,225,926 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Orc4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624866	622,859 - 716,787 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624866	626,556 - 716,725 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Orc4
208 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	20
Count of miRNA genes:	18
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000006937
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	17374703	35528639	Rat
731172	Bp151	Blood pressure QTL 151		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	18311454	47233430	Rat
12879849	Bw180	Body weight QTL 180		0.037	body mass (VT:0001259)	body weight (CMO:0000012)	3	18311454	47233430	Rat
12879850	Cm91	Cardiac mass QTL 91		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	18311454	47233430	Rat
12879851	Cm92	Cardiac mass QTL 92		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	18311454	47233430	Rat
12879852	Cm93	Cardiac mass QTL 93		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	18311454	47233430	Rat
12879853	Am5	Aortic mass QTL 5		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	18311454	47233430	Rat
12879854	Kidm63	Kidney mass QTL 63		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	18311454	47233430	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
1298073	Cm13	Cardiac mass QTL 13	2.5		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	25013911	38192233	Rat
631832	Sach1	Saccharin preference QTL 1	2.7	0.02	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	3	27494621	44188411	Rat
2313049	Bss72	Bone structure and strength QTL 72	2.6	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	3	27494621	50302886	Rat
2313076	Bss74	Bone structure and strength QTL 74	2	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	3	27494621	50302886	Rat
2313079	Bss73	Bone structure and strength QTL 73	1.5		tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	3	27494621	50302886	Rat
2313093	Bmd77	Bone mineral density QTL 77	2.2	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	3	27494621	50302886	Rat
2313101	Bmd76	Bone mineral density QTL 76	3.6	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	3	27494621	50302886	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	48	32	19	32	8	8	74	34	41	11	8
Low		7	9	9		9		3		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC060516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X94507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000006937 ⟹ ENSRNOP00000006937

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	33,294,392 - 33,333,055 (-)	Ensembl
Rnor_6.0 Ensembl	3	33,037,034 - 33,075,685 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099552 ⟹ ENSRNOP00000085949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	33,294,367 - 33,333,045 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103065 ⟹ ENSRNOP00000077265

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	33,294,365 - 33,333,824 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109006 ⟹ ENSRNOP00000083931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	33,294,583 - 33,333,055 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109819 ⟹ ENSRNOP00000077188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	33,294,355 - 33,319,460 (-)	Ensembl

RefSeq Acc Id:

NM_199092 ⟹ NP_954523

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,703,611 - 53,742,264 (-)	NCBI
mRatBN7.2	3	33,294,351 - 33,333,005 (-)	NCBI
Rnor_6.0	3	33,037,032 - 33,075,685 (-)	NCBI
Rnor_5.0	3	38,201,914 - 38,240,600 (-)	NCBI
RGSC_v3.4	3	29,813,264 - 29,851,852 (-)	RGD
Celera	3	31,495,196 - 31,533,857 (-)	RGD

Sequence:

show sequence

CTTGGCTGCCGCAGGTGAAACAGAGCTGGGAAGGCGGTGAACAATCCTGGGTCCTTACAGTCGG
CGGAGGCTGCCCGATTTAGGCAGGCTTTATTGAGAGAGATTTGAGTTAGTCAAGATGAGCAATC
GTAAAAGCAAGAATAACATACATGCAGAGTGTCTTTCCCAGGTACAAAGAATTTTACGTGAAAG
GTTTTGTCATCATACTCCTCATAGCAACCTATTTGGAGTGCAAGTACAATACAAGCATTTAATT
GAGCTACTCAAAAGAACTGCTATCTATGGAGAAAGTAATTCTTTACTCATTGTTGGACCACGAG
GATCAGGAAAGACCACGTTATTAAATCATGCCTTGAAAGAGCTCATGCAAATAGGAGACATGAG
TGAAAATGTGTTACAAGTTCACTTAAATGGACTGCTACAGACAAATGATAAAATTGCTCTGAAA
GAGATCACAAGACAATTAAATCTAGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTG
AAAACCTTTCGTTTCTTCTGGAAGCTTTGCAGAAAGGTAACCGGACTAGCAGTTGCCCAGTGAT
CTTCATACTGGATGAATTTGATCTTTTTGCTCATCAGAAAAACCAAACACTCCTTTATAATCTT
TTTGACATTTCTCAATCTGCACAGACACCAATAGCAGTTATTGGCCTTACATGTAGACTGGATA
TTTTGGAACTCTTAGAAAAGAGAGTGAAGTCACGATTTTCTCACCGGCAGATACATTTAATGAA
TTCATTTGATTTTCCGCAATATTTGAAAATATTTAAAGAACAATTATCTCTACCTGCAGAATTC
CCAGATAAGATTTTTGCTGAGAAATGGAATGAGAATGCTCATTGTCTCTCCGAAGATTCAACTG
TGCTTGAAGTTCTACAGAAGCATTTCAATGTCAACAAAAACTTGCAATCATTACATATGCTATT
GATGCTTGCTTTAAATCGAGTAACCGTGACACACCCATTTATGACCTCAGCAGATCTGATGGAG
GCGCAGCACTTGTGTAGCTTGGATGCCAAAGCGAGTATTGTACATGGTCTGTCAGTCTTGGAAA
TCTGTCTTATAATAGCAATGAAACATTTAAATGACATATATGAAGAGGAGCCCTTTAATTTTCA
AATGGTGTATAATGAATTTCAGAAATTCATTCAAAGAAAGGCCCATTCTGTTTATAACTTTGAG
AAACCTGTGGTCATGAAGGCATTTGAGCACTTACAACAATTGGAATTAATAAAACCCATGGAAA
GAACCTCAGTCAATTCTCAGAGAGAATACCAGCTAGTCAAACTACTTTTGGATAATACTCAGAT
TATGAATGCCCTACAGAAATACTCCAACTGCCCTACAGATGTCAGGCAGTGGGCAACATCCTCG
CTCAGCTGGCTGTGAAGATTTTAAGTACATTTCTGTGAAGACCTAAAACTAGTGTTCTTTAATA
AGATACGCTACTACATTACTTTGTTTATAAATATTGTTTATGGGAAACCTGCACTTAGTATCTT
GACTATGTTTTGAATATTGACTGTGCATGGACAGTTTCATTAATTTAAATTACACCATACAAGT
AACAATTCAAAATAATAAAATGTGCTTATTTTACGGGTGATCCATAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008761705 ⟹ XP_008759927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,311 (-)	NCBI
mRatBN7.2	3	33,292,232 - 33,333,041 (-)	NCBI
Rnor_6.0	3	33,035,204 - 33,075,832 (-)	NCBI

Sequence:

show sequence

TTAACACCCCCAGCTGCCTCCTCCCTCCTTAGGGAAAGTGGAGGGACGGAAGTAGGCGTGGACC
GAGGCAAAAGGAGGTCACGTGTTGGGGCGGGGCGGGGCCGCAGGCCGGCCGAGCACGGTGCATG
CTGGGAGTTGCTGTGTGTTCTTGGCTGCCGCAGGTGAAACAGAGCTGGGAAGGCGGTGAACAAT
CCTGGGTCCTTACAGTCGGCGGAGGCTGCCCGATTTAGGCAGGCTTTATTGAGAGAGGGCTGAC
CACTTGGCACTGGATGACCATTTAGTATCCTGAGGAAGACTCCTGTCTTAGCGTTACTGTTGCT
GTGAGAGAAATTTTGTGGGGCACTGGATTATGACACCAGACAGAAGATCTGGATTTGAGTTAGT
CAAGATGAGCAATCGTAAAAGCAAGAATAACATACATGCAGAGTGTCTTTCCCAGGTACAAAGA
ATTTTACGTGAAAGGTTTTGTCATCATACTCCTCATAGCAACCTATTTGGAGTGCAAGTACAAT
ACAAGCATTTAATTGAGCTACTCAAAAGAACTGCTATCTATGGAGAAAGTAATTCTTTACTCAT
TGTTGGACCACGAGGATCAGGAAAGACCACGTTATTAAATCATGCCTTGAAAGAGCTCATGCAA
ATAGGAGACATGAGTGAAAATGTGTTACAAGTTCACTTAAATGGACTGCTACAGACAAATGATA
AAATTGCTCTGAAAGAGATCACAAGACAATTAAATCTAGAAAATGTAGTTGGAGATAAAGTTTT
TGGAAGCTTTGCTGAAAACCTTTCGTTTCTTCTGGAAGCTTTGCAGAAAGGTAACCGGACTAGC
AGTTGCCCAGTGATCTTCATACTGGATGAATTTGATCTTTTTGCTCATCAGAAAAACCAAACAC
TCCTTTATAATCTTTTTGACATTTCTCAATCTGCACAGACACCAATAGCAGTTATTGGCCTTAC
ATGTAGACTGGATATTTTGGAACTCTTAGAAAAGAGAGTGAAGTCACGATTTTCTCACCGGCAG
ATACATTTAATGAATTCATTTGATTTTCCGCAATATTTGAAAATATTTAAAGAACAATTATCTC
TACCTGCAGAATTCCCAGATAAGATTTTTGCTGAGAAATGGAATGAGAATGCTCATTGTCTCTC
CGAAGATTCAACTGTGCTTGAAGTTCTACAGAAGCATTTCAATGTCAACAAAAACTTGCAATCA
TTACATATGCTATTGATGCTTGCTTTAAATCGAGTAACCGTGACACACCCATTTATGACCTCAG
CAGATCTGATGGAGGCGCAGCACTTGTGTAGCTTGGATGCCAAAGCGAGTATTGTACATGGTCT
GTCAGTCTTGGAAATCTGTCTTATAATAGCAATGAAACATTTAAATGACATATATGAAGAGGAG
CCCTTTAATTTTCAAATGGTGTATAATGAATTTCAGAAATTCATTCAAAGAAAGGCCCATTCTG
TTTATAACTTTGAGAAACCTGTGGTCATGAAGGCATTTGAGCACTTACAACAATTGGAATTAAT
AAAACCCATGGAAAGAACCTCAGTCAATTCTCAGAGAGAATACCAGCTAGTCAAACTACTTTTG
GATAATACTCAGATTATGAATGCCCTACAGAAATACTCCAACTGCCCTACAGATGTCAGGCAGT
GGGCAACATCCTCGCTCAGCTGGCTGTGAAGATTTTAAGTACATTTCTGTGAAGACCTAAAACT
AGTGTTCTTTAATAAGATACGCTACTACATTACTTTGTTTATAAATATTGTTTATGGGAAACCT
GCACTTAGTATCTTGACTATGTTTTGAATATTGACTGTGCATGGACAGTTTCATTAATTTAAAT
TACACCATACAAGTAACAATTCAAAATAATAAAATGTGCTTATTTTACGGGTGATCCATAAGAT
GACTTGATACTCTTGTGAAATGTATGTGGTCCATTGGAAAGGTTCATTTCAACTCAGCATTTAC
AGATCTTAATGCTAAGCAGTGAGGAGAGAAATAGGAACAGGAATGACATGAGGAATATTCCGGC
TAGATTAGGAGCCTGTGGAGAGTGGGGTTGGTTTGGTTTTCTGAGTTGGTTTCTATAGGATCCT
GCCATTTTGGATCCTGTACAGATCCCCATGGCTGAAGAGCTCGTGTGGAAAGAGTCCAAACAAT
TCAGCATTTTCTTCTGTGCACATTTCACCACAACTGGAGGAGTTTTTGTTTAATATACATTCTG
GGTATACTTTAGTTCAAAAGGGATCAAAATTGCCATCTAACAGGTATCTTAAAGGATTCCTGGT
AACTACTTCCACAAATAAGTATTCATTCCACAGTGTGAGCTGTTGGCTTTGAATTCTCTGAGAA
CAAGGAATGTTGGTCAGAGTTCACTTCCTAAATACATAGACATAGAACTAACAGGTTGAAATAG
AATATAATCTCAGTGAGTTACTTTGTTGAAGAATATTTGATTGAATATTTAGTTACAGTAAGAT
TTTATAAAATAGAGATCCCTTCTACTTGCAACTTGTAAAGTTTCTGCAGAATTAAATGCTATTT
TATTTATAGATTAGGAAACTCTCACCAGTGTCTGAGTCCAGGATCACAGTATGGGAATGACAGG
TGTGACCTTGAATGCAGCTTCGGTTGACTGACATTAAAGCCAATGTTGTTAAAAACTAAAGCTT
AGCAACAACGTTTTACTATTTTTATAGGATACTGTAAGAAATAATTTGACTTTTAAGAAATCTT
AAATATAAATTTCCTCTGCATTAATGTAGTACCTCATAGTTAAAACCTACTTTCTTCATACACA
GCCTTTTCCTTTCTTACAATAAAACATGTTTAGCTTTCTATGCTTTTTTTAATCATGATAAAAA
TGAAGCCATAGTAACTATCAAGGTCATAGAAGTATAGACGTAGATGCCCAATTTTTAAACTACT
TTCACCTTATAAGTTGTTCAAACTTCATTATTAGAGAATTCTAAAATGAGAAAAATTAGATTCT
TAAAAAACCTAAGAATGTTCAAGGTGGAAGTGTCCGTCTATAACATACAATTTCACAACTTAAG
AGTAGAAGCAAGAAAGGTAAATACTTTTAGGAGGTTCCAAACTAGTCTTGAGTTATCCCAACAA
GAGCGGAGGGGGAGGAATGATTGTGAACAGAAAGTCTGACTGGACTTTCTCTGCAGTGAAGAGA
ATTTAGAGTCTCTGCTCAAGACGCCCCCTGGCCAAGAGACGTTAAAACAGACAGAAAAGACTTT
GCATGTTTCCCTTCTACCGTGTGGCCTACTGAAACTTGGGTCTTGTTTAAAAGGCATCTGATTT
TATGCAGACACATGTCGGAAAAGTTAGACTCTCTTGTTCAGACTTCCATATGGTAATGTCTTGT
AATGTAAGGACATAGTATCCACTGACCCAGAGAGTTAGACATCGCAGACTGCACAATGGGAAAC
CGCGTTTCTGTACCAGTGAAACAGTCTGATCAGACTACAGTGGGAGGAAAATTCCCTAATTCAC
AAACTTCCCTGATTTTTTTTACCCTCTGTAAGAACATAAATACACAGCTAAAGAAAAACTGCAT
GTGCAAATAATACCATATTCATTTTTTATTTAACATGGGGATGGAATGGGGATAGCATACATTT
TATTTGTACAATATTTAACAATCACTTATTCAAGGTGGGATTTTATGGGGATTTTTTTCATTTT
TAGCTTTCTGTTAAATACTTGCAGAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039104460 ⟹ XP_038960388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,311 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,041 (-)	NCBI

RefSeq Acc Id:

XM_039104461 ⟹ XP_038960389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,320 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,041 (-)	NCBI

RefSeq Acc Id:

XM_039104463 ⟹ XP_038960391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,322 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,041 (-)	NCBI

RefSeq Acc Id:

XM_039104464 ⟹ XP_038960392

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,117 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,858 (-)	NCBI

RefSeq Acc Id:

XM_039104465 ⟹ XP_038960393

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,117 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,858 (-)	NCBI

RefSeq Acc Id:

XM_039104466 ⟹ XP_038960394

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,735,172 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,325,923 (-)	NCBI

RefSeq Acc Id:

XM_039104469 ⟹ XP_038960397

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,117 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,858 (-)	NCBI

RefSeq Acc Id:

XM_039104470 ⟹ XP_038960398

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,293 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,334,022 (-)	NCBI

RefSeq Acc Id:

XM_039104471 ⟹ XP_038960399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,103 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,847 (-)	NCBI

RefSeq Acc Id:

XM_039104472 ⟹ XP_038960400

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,128 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,332,897 (-)	NCBI

RefSeq Acc Id:

XM_039104473 ⟹ XP_038960401

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,735,203 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,325,944 (-)	NCBI

RefSeq Acc Id:

XM_039104474 ⟹ XP_038960402

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,117 (-)	NCBI
mRatBN7.2	3	33,290,844 - 33,333,858 (-)	NCBI

RefSeq Acc Id:

XM_063283239 ⟹ XP_063139309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,278 (-)	NCBI

RefSeq Acc Id:

XM_063283240 ⟹ XP_063139310

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,101 (-)	NCBI

RefSeq Acc Id:

XM_063283242 ⟹ XP_063139312

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,311 (-)	NCBI

RefSeq Acc Id:

XM_063283243 ⟹ XP_063139313

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,742,322 (-)	NCBI

RefSeq Acc Id:

XM_063283244 ⟹ XP_063139314

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,101 (-)	NCBI

RefSeq Acc Id:

XM_063283246 ⟹ XP_063139316

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	53,700,046 - 53,743,103 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_954523	(Get FASTA)	NCBI Sequence Viewer
	XP_008759927	(Get FASTA)	NCBI Sequence Viewer
	XP_038960388	(Get FASTA)	NCBI Sequence Viewer
	XP_038960389	(Get FASTA)	NCBI Sequence Viewer
	XP_038960391	(Get FASTA)	NCBI Sequence Viewer
	XP_038960392	(Get FASTA)	NCBI Sequence Viewer
	XP_038960393	(Get FASTA)	NCBI Sequence Viewer
	XP_038960394	(Get FASTA)	NCBI Sequence Viewer
	XP_038960397	(Get FASTA)	NCBI Sequence Viewer
	XP_038960398	(Get FASTA)	NCBI Sequence Viewer
	XP_038960399	(Get FASTA)	NCBI Sequence Viewer
	XP_038960400	(Get FASTA)	NCBI Sequence Viewer
	XP_038960401	(Get FASTA)	NCBI Sequence Viewer
	XP_038960402	(Get FASTA)	NCBI Sequence Viewer
	XP_063139309	(Get FASTA)	NCBI Sequence Viewer
	XP_063139310	(Get FASTA)	NCBI Sequence Viewer
	XP_063139312	(Get FASTA)	NCBI Sequence Viewer
	XP_063139313	(Get FASTA)	NCBI Sequence Viewer
	XP_063139314	(Get FASTA)	NCBI Sequence Viewer
	XP_063139316	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60516	(Get FASTA)	NCBI Sequence Viewer
	EDM00467	(Get FASTA)	NCBI Sequence Viewer
	EDM00468	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006937
	ENSRNOP00000006937.4
	ENSRNOP00000077188.1
	ENSRNOP00000077265
	ENSRNOP00000077265.1
	ENSRNOP00000083931.1
	ENSRNOP00000085949.1
	ENSRNOP00055001892
	ENSRNOP00060046208
	ENSRNOP00065009734
GenBank Protein	Q6P9Z8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_954523 ⟸ NM_199092

- UniProtKB:

Q6P9Z8 (UniProtKB/Swiss-Prot), A6JEZ2 (UniProtKB/TrEMBL), A0A8L2Q2Z8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSNRKSKNNIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKRTAIYGESNSLLIV
GPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFG
SFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIGLTC
RLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKIFAEKWNENAHCLSE
DSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLS
VLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIK
PMERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL

hide sequence

RefSeq Acc Id:	XP_008759927 ⟸ XM_008761705
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5Y5K9 (UniProtKB/TrEMBL), A0A8L2Q2Z8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTPDRRSGFELVKMSNRKSKNNIHAECLSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKR TAIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQ LNLENVVGDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQ SAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFDFPQYLKIFKEQLSLPAEFPDKIF AEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLC SLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKAHSVYNFEKPVVM KAFEHLQQLELIKPMERTSVNSQREYQLVKLLLDNTQIMNALQKYSNCPTDVRQWATSSLSWL hide sequence

RefSeq Acc Id:

ENSRNOP00000006937 ⟸ ENSRNOT00000006937

RefSeq Acc Id:	XP_038960398 ⟸ XM_039104470
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960397 ⟸ XM_039104469
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960402 ⟸ XM_039104474
- Peptide Label:	isoform X6
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960393 ⟸ XM_039104465
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960392 ⟸ XM_039104464
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960399 ⟸ XM_039104471
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960391 ⟸ XM_039104463
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960389 ⟸ XM_039104461
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960388 ⟸ XM_039104460
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960400 ⟸ XM_039104472
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960401 ⟸ XM_039104473
- Peptide Label:	isoform X6
- UniProtKB:	A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960394 ⟸ XM_039104466
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A4W8 (UniProtKB/TrEMBL), A0A8L2Q2Z8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000083931 ⟸ ENSRNOT00000109006

RefSeq Acc Id:

ENSRNOP00000077188 ⟸ ENSRNOT00000109819

RefSeq Acc Id:

ENSRNOP00000077265 ⟸ ENSRNOT00000103065

RefSeq Acc Id:

ENSRNOP00000085949 ⟸ ENSRNOT00000099552

RefSeq Acc Id:	XP_063139309 ⟸ XM_063283239
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063139316 ⟸ XM_063283246
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063139314 ⟸ XM_063283244
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063139310 ⟸ XM_063283240
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063139313 ⟸ XM_063283243
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063139312 ⟸ XM_063283242
- Peptide Label:	isoform X4

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P9Z8-F1-model_v2	AlphaFold	Q6P9Z8	1-434	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692068

Promoter ID:

EPDNEW_R2593

Type:

multiple initiation site

Name:

Orc4_1

Description:

origin recognition complex, subunit 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	33,075,692 - 33,075,752	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735212	AgrOrtholog
BioCyc Gene	G2FUF-49787	BioCyc
Ensembl Genes	ENSRNOG00000005021	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055001565	UniProtKB/Swiss-Prot
	ENSRNOG00060032221	UniProtKB/Swiss-Prot
	ENSRNOG00065008296	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006937	ENTREZGENE
	ENSRNOT00000006937.6	UniProtKB/TrEMBL
	ENSRNOT00000099552.1	UniProtKB/TrEMBL
	ENSRNOT00000103065.1	UniProtKB/TrEMBL
	ENSRNOT00000109006.1	UniProtKB/TrEMBL
	ENSRNOT00000109819.1	UniProtKB/TrEMBL
	ENSRNOT00055002515	UniProtKB/Swiss-Prot
	ENSRNOT00060055865	UniProtKB/Swiss-Prot
	ENSRNOT00065013163	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5598062	IMAGE-MGC_LOAD
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AAA_16	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_dom	UniProtKB/TrEMBL
	ORC4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ORC4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:295596	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72574	IMAGE-MGC_LOAD
NCBI Gene	295596	ENTREZGENE
PANTHER	ORIGIN RECOGNITION COMPLEX SUBUNIT 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12087	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AAA_16	UniProtKB/TrEMBL
	ATPase_2	UniProtKB/TrEMBL
	ORC4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Orc4	PhenoGen
PIRSF	ORC4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005021	RatGTEx
	ENSRNOG00055001565	RatGTEx
	ENSRNOG00060032221	RatGTEx
	ENSRNOG00065008296	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5Y5K9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y9D5_RAT	UniProtKB/TrEMBL
	A0A8I5ZY14_RAT	UniProtKB/TrEMBL
	A0A8I6A4W8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q2Z8	ENTREZGENE, UniProtKB/TrEMBL
	A6JEZ2	ENTREZGENE, UniProtKB/TrEMBL
	ORC4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-02	Orc4	origin recognition complex, subunit 4	Orc4l2	origin recognition complex, subunit 4-like 2	Data merged from RGD:619987	737654	APPROVED
2011-08-02	Orc4	origin recognition complex, subunit 4	Orc4l	origin recognition complex, subunit 4-like (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Orc4l	origin recognition complex, subunit 4-like (yeast)	Orc4l	origin recognition complex, subunit 4-like (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Orc4l	origin recognition complex, subunit 4-like (S. cerevisiae)		origin recognition complex, subunit 4-like (yeast)	Name updated	1299863	APPROVED
2002-08-07	Orc4	origin recognition complex, subunit 4			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the postsynaptic density	633356

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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