Adamts5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5) - Rat Genome Database

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Gene: Adamts5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5) Rattus norvegicus
Analyze
Symbol: Adamts5
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 5
RGD ID: 735196
Description: Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including heart development; myoblast fusion; and negative regulation of cold-induced thermogenesis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Used to study osteoarthritis. Biomarker of degenerative disc disease; mucopolysaccharidosis VI; and osteoarthritis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,486,945 - 38,533,516 (-)NCBIGRCr8
mRatBN7.21125,000,627 - 25,047,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1125,000,637 - 25,047,205 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,692,495 - 33,740,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,392,761 - 26,440,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,581,643 - 25,629,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,411,174 - 25,456,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,410,975 - 25,456,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,035,108 - 29,080,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,503,380 - 25,548,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,503,379 - 25,548,845 (-)NCBI
Celera1124,802,423 - 24,847,800 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-mannosamine  (ISO)
all-trans-retinoic acid  (ISO)
Ammothamnine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
dapagliflozin  (EXP)
DDT  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
GW 4064  (ISO)
inulin  (ISO)
L-proline betaine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-2-Phenylcyclopropanecarboxylic acid  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Global analyses of gene expression in early experimental osteoarthritis. Appleton CT, etal., Arthritis Rheum. 2007 Jun;56(6):1854-68.
2. Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling. Bauters D, etal., Mol Metab. 2017 May 10;6(7):715-724. doi: 10.1016/j.molmet.2017.05.004. eCollection 2017 Jul.
3. Early cartilage degeneration in a rat experimental model of developmental dysplasia of the hip. Bo N, etal., Connect Tissue Res. 2012;53(6):513-20. doi: 10.3109/03008207.2012.700346. Epub 2012 Jul 20.
4. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Carames B, etal., Ann Rheum Dis. 2012 Apr;71(4):575-81. doi: 10.1136/annrheumdis-2011-200557. Epub 2011 Nov 14.
5. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Chiusaroli R, etal., Osteoarthritis Cartilage. 2013 Nov;21(11):1807-10. doi: 10.1016/j.joca.2013.08.015. Epub 2013 Aug 15.
6. Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis. Chu X, etal., Int J Mol Med. 2013 May;31(5):1222-8. doi: 10.3892/ijmm.2013.1318. Epub 2013 Mar 26.
7. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. Funck-Brentano T, etal., PLoS One. 2012;7(3):e33543. doi: 10.1371/journal.pone.0033543. Epub 2012 Mar 14.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case-control study. Gu J, etal., Rheumatol Int. 2013 Nov;33(11):2893-7. doi: 10.1007/s00296-012-2506-1. Epub 2012 Sep 9.
10. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). Lai A, etal., J Orthop Res. 2013 Apr;31(4):621-31. doi: 10.1002/jor.22281. Epub 2012 Nov 28.
11. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Liang QQ, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.
12. Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis. Liu YD, etal., Osteoarthritis Cartilage. 2014 Feb;22(2):302-12. doi: 10.1016/j.joca.2013.11.014. Epub 2013 Dec 5.
13. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. Malfait AM, etal., J Biol Chem 2002 Jun 21;277(25):22201-8. Epub 2002 Apr 15.
14. Expression of ADAMTS-5 in deformed human temporomandibular joint discs. Matsumoto T, etal., Histol Histopathol. 2008 Dec;23(12):1485-93.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. Rodriguez-Lopez J, etal., Arthritis Rheum. 2008 Feb;58(2):435-41. doi: 10.1002/art.23201.
21. Deletion of the transforming growth factor beta receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Shen J, etal., Arthritis Rheum. 2013 Dec;65(12):3107-19. doi: 10.1002/art.38122.
22. Expression of versican and ADAMTS during rat tooth eruption. Sone S, etal., J Mol Histol. 2005 May;36(4):281-8.
23. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. Yamanishi Y, etal., J Immunol. 2002 Feb 1;168(3):1405-12.
24. Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, etal., Arthritis Res Ther. 2012 Mar 6;14(2):R51. doi: 10.1186/ar3764.
Additional References at PubMed
PMID:12477932   PMID:16583222   PMID:20632367   PMID:21055467   PMID:23684986   PMID:23845380   PMID:24006456   PMID:24126801   PMID:24220035   PMID:28980719  


Genomics

Comparative Map Data
Adamts5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,486,945 - 38,533,516 (-)NCBIGRCr8
mRatBN7.21125,000,627 - 25,047,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1125,000,637 - 25,047,205 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,692,495 - 33,740,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,392,761 - 26,440,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,581,643 - 25,629,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,411,174 - 25,456,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,410,975 - 25,456,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,035,108 - 29,080,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,503,380 - 25,548,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,503,379 - 25,548,845 (-)NCBI
Celera1124,802,423 - 24,847,800 (-)NCBICelera
Cytogenetic Map11q11NCBI
ADAMTS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382126,917,922 - 26,967,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2126,917,922 - 26,967,088 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,290,241 - 28,339,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,212,112 - 27,260,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,215,656 - 27,260,703NCBI
Celera2113,473,563 - 13,522,743 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2113,695,092 - 13,744,202 (-)NCBIHuRef
CHM1_12127,852,147 - 27,901,362 (-)NCBICHM1_1
T2T-CHM13v2.02125,276,336 - 25,326,235 (-)NCBIT2T-CHM13v2.0
Adamts5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391685,655,045 - 85,698,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1685,653,061 - 85,698,716 (-)EnsemblGRCm39 Ensembl
GRCm381685,858,157 - 85,901,125 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1685,856,173 - 85,901,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv371685,858,402 - 85,901,370 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361685,751,613 - 85,789,480 (-)NCBIMGSCv36mm8
Celera1686,076,565 - 86,106,690 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1648.34NCBI
Adamts5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540726,603,479 - 26,643,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540726,597,165 - 26,643,972 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22223,102,173 - 23,151,603 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12117,964,851 - 18,015,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02113,352,222 - 13,402,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12126,738,671 - 26,788,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,744,807 - 26,788,736 (-)Ensemblpanpan1.1panPan2
ADAMTS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13122,242,901 - 22,289,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3122,248,092 - 22,289,802 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3122,237,302 - 22,284,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03122,341,143 - 22,388,689 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3122,342,725 - 22,388,670 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13122,313,499 - 22,361,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03122,319,121 - 22,366,648 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03122,794,062 - 22,841,615 (-)NCBIUU_Cfam_GSD_1.0
Adamts5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497122,777,168 - 22,824,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936640858,322 - 898,182 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936640857,565 - 899,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13190,361,744 - 190,413,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113190,353,019 - 190,413,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213200,401,972 - 200,451,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,252,922 - 65,359,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,254,285 - 65,299,800 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660717,902,441 - 7,947,424 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474514,896,340 - 14,935,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474514,890,111 - 14,934,972 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts5
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:205
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000002185
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 3 10 2 2 16 23 4 2
Low 3 38 39 26 9 26 6 9 74 19 18 7 6
Below cutoff 15 15 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085444   ⟹   ENSRNOP00000068781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1125,000,637 - 25,047,205 (-)Ensembl
Rnor_6.0 Ensembl1125,410,975 - 25,456,836 (-)Ensembl
RefSeq Acc Id: NM_198761   ⟹   NP_942056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,486,945 - 38,533,516 (-)NCBI
mRatBN7.21125,000,627 - 25,047,205 (-)NCBI
Rnor_6.01125,411,174 - 25,456,639 (-)NCBI
Rnor_5.01129,035,108 - 29,080,570 (-)NCBI
RGSC_v3.41125,503,380 - 25,548,851 (-)RGD
Celera1124,802,423 - 24,847,800 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_942056 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ88212 (Get FASTA)   NCBI Sequence Viewer  
  EDM10632 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068781
  ENSRNOP00000068781.1
Reference Protein Sequences
RefSeq Acc Id: NP_942056   ⟸   NM_198761
- Peptide Label: precursor
- UniProtKB: G3V673 (UniProtKB/TrEMBL),   A6JL67 (UniProtKB/TrEMBL),   Q6TY19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068781   ⟸   ENSRNOT00000085444
Protein Domains
Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V673-F1-model_v2 AlphaFold G3V673 1-927 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735196 AgrOrtholog
BioCyc Gene G2FUF-22074 BioCyc
Ensembl Genes ENSRNOG00000057794 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085444 ENTREZGENE
  ENSRNOT00000085444.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS5 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:304135 UniProtKB/TrEMBL
NCBI Gene 304135 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts5 PhenoGen
PRINTS ADAMTS5 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057794 RatGTEx
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt A6JL67 ENTREZGENE, UniProtKB/TrEMBL
  G3V673 ENTREZGENE, UniProtKB/TrEMBL
  Q6TY19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts5  ADAM metallopeptidase with thrombospondin type 1 motif, 5  Adamts5  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adamts5  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)  Name updated 1299863 APPROVED
2004-09-10 Adamts5  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)      Symbol and Name status set to approved 1299863 APPROVED