Adam32 (ADAM metallopeptidase domain 32) - Rat Genome Database

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Gene: Adam32 (ADAM metallopeptidase domain 32) Rattus norvegicus
Analyze
Symbol: Adam32
Name: ADAM metallopeptidase domain 32
RGD ID: 735114
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; male gonad development; and proteolysis. Predicted to be active in plasma membrane. Orthologous to human ADAM32 (ADAM metallopeptidase domain 32); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 32; a disintegrin and metalloprotease domain 32; disintegrin and metalloproteinase domain-containing protein 32; LOC361170; metalloprotease/disintegrin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,805,023 - 73,914,787 (+)NCBIGRCr8
mRatBN7.21667,102,384 - 67,212,163 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,102,320 - 67,212,161 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,379,605 - 72,489,322 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,785,283 - 75,894,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,033,344 - 71,138,574 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,889,035 - 71,999,151 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,889,235 - 71,999,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,538,126 - 71,647,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,527,593 - 71,620,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,550,906 - 71,641,753 (+)NCBI
Celera1665,006,303 - 65,114,461 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adam32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,805,023 - 73,914,787 (+)NCBIGRCr8
mRatBN7.21667,102,384 - 67,212,163 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,102,320 - 67,212,161 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,379,605 - 72,489,322 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,785,283 - 75,894,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,033,344 - 71,138,574 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,889,035 - 71,999,151 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,889,235 - 71,999,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,538,126 - 71,647,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,527,593 - 71,620,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,550,906 - 71,641,753 (+)NCBI
Celera1665,006,303 - 65,114,461 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
ADAM32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,107,529 - 39,284,917 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,106,990 - 39,284,917 (+)EnsemblGRCh38hg38GRCh38
GRCh37838,965,048 - 39,142,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,084,207 - 39,261,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 34839,084,324 - 39,261,592NCBI
Celera837,916,690 - 38,094,247 (+)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,498,153 - 37,675,475 (+)NCBIHuRef
CHM1_1839,167,105 - 39,344,434 (+)NCBICHM1_1
T2T-CHM13v2.0839,384,664 - 39,562,013 (+)NCBIT2T-CHM13v2.0
Adam32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,326,159 - 25,438,933 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,326,156 - 25,438,820 (-)EnsemblGRCm39 Ensembl
GRCm38824,836,143 - 24,948,918 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,836,140 - 24,948,804 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,946,615 - 26,059,276 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,301,689 - 26,414,332 (-)NCBIMGSCv36mm8
Celera826,309,930 - 26,416,097 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map813.65NCBI
Adam32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555363,352,117 - 3,482,742 (-)NCBIChiLan1.0ChiLan1.0
ADAM32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2757,668,071 - 57,853,420 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1833,385,615 - 33,570,711 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0838,408,648 - 38,592,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1835,583,724 - 35,766,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl835,583,724 - 35,766,318 (+)Ensemblpanpan1.1panPan2
ADAM32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11626,228,380 - 26,410,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1626,228,415 - 26,410,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,750,011 - 26,932,252 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01628,058,373 - 28,241,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,058,376 - 28,382,944 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11626,353,463 - 26,535,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,930,158 - 27,112,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,968,171 - 27,150,845 (-)NCBIUU_Cfam_GSD_1.0
Adam32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494348,946,408 - 49,069,462 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367102,403,994 - 2,511,771 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100525542
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,388,412 - 47,520,413 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,388,085 - 47,521,808 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,464,572 - 54,592,633 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215661
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,132,409 - 37,284,974 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,133,791 - 37,283,751 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660524,689,417 - 4,847,205 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247803,895,153 - 4,041,791 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam32
1494 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000038266
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 5 5 2 2 7 7 2 2
Below cutoff 2 26 21 10 14 10 6 7 47 17 24 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038266   ⟹   ENSRNOP00000031189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,102,320 - 67,212,161 (+)Ensembl
Rnor_6.0 Ensembl1671,889,235 - 71,999,148 (+)Ensembl
RefSeq Acc Id: NM_001170582   ⟹   NP_001164053
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,805,072 - 73,914,787 (+)NCBI
mRatBN7.21667,102,435 - 67,212,163 (+)NCBI
Rnor_6.01671,889,444 - 71,999,150 (+)NCBI
Rnor_5.01671,538,126 - 71,647,772 (+)NCBI
Celera1665,006,303 - 65,114,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094670   ⟹   XP_038950598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,805,023 - 73,914,787 (+)NCBI
mRatBN7.21667,102,384 - 67,212,163 (+)NCBI
RefSeq Acc Id: XR_001841542
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,805,023 - 73,891,958 (+)NCBI
mRatBN7.21667,102,384 - 67,189,337 (+)NCBI
Rnor_6.01671,889,035 - 71,976,323 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001164053 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC18729 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031189
  ENSRNOP00000031189.6
Reference Protein Sequences
RefSeq Acc Id: NP_001164053   ⟸   NM_001170582
- Peptide Label: precursor
- UniProtKB: D3ZEP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031189   ⟸   ENSRNOT00000038266
RefSeq Acc Id: XP_038950598   ⟸   XM_039094670
- Peptide Label: isoform X1
- UniProtKB: D3ZEP8 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEP8-F1-model_v2 AlphaFold D3ZEP8 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735114 AgrOrtholog
BioCyc Gene G2FUF-10950 BioCyc
Ensembl Genes ENSRNOG00000025728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038266 ENTREZGENE
  ENSRNOT00000038266.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:361170 UniProtKB/TrEMBL
NCBI Gene 361170 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam32 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025728 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt D3ZEP8 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPJ2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam32  ADAM metallopeptidase domain 32  Adam32  a disintegrin and metallopeptidase domain 32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Adam32  a disintegrin and metallopeptidase domain 32  Adam32  a disintegrin and metalloprotease domain 32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Adam32  a disintegrin and metalloprotease domain 32  LOC361170  metalloprotease/disintegrin  Symbol and Name updated 1299863 APPROVED