Impdh2 (inosine monophosphate dehydrogenase 2)

Gene: Impdh2 (inosine monophosphate dehydrogenase 2) Rattus norvegicus

Analyze

Symbol:

Impdh2

Name:

inosine monophosphate dehydrogenase 2

RGD ID:

735092

Description:

Enables IMP dehydrogenase activity and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2); PARTICIPATES IN mycophenolic acid pharmacokinetics pathway; de novo purine biosynthetic pathway; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2; MGC72938

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IMPDH2 (inosine monophosphate dehydrogenase 2)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Impdh2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Impdh2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IMPDH2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IMPDH2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Impdh2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IMPDH2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IMPDH2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Impdh2 (inosine monophosphate dehydrogenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPL28 (ribosomal protein L28)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	IMPDH2 (inosine monophosphate dehydrogenase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Impdh2 (inosine monophosphate dehydrogenase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	impdh2 (IMP (inosine 5'-monophosphate) dehydrogenase 2)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T22D1.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ras	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	impdh2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,135,204 - 118,139,892 (+)	NCBI		GRCr8
mRatBN7.2	8	109,256,705 - 109,261,365 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,256,728 - 109,261,359 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,874,980 - 114,879,615 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,074,314 - 113,078,949 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,916,954 - 110,921,589 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,346,983 - 117,351,619 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,347,029 - 117,351,610 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,691,495 - 116,696,122 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,607,025 - 113,611,613 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,626,482 - 113,631,068 (+)	NCBI
Celera	8	108,552,537 - 108,557,125 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

Animal Disease Models (ISO)

dystonia (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,7-dihydropurine-6-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-fluorouracil (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

aminoglutethimide (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

azathioprine (ISO)

Berberrubine (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenthion (ISO)

flusilazole (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

guanosine (EXP)

hexaconazole (ISO)

IMP (ISO)

ivermectin (ISO)

Maleic hydrazide (ISO)

mercaptopurine (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

miconazole (ISO)

microcystin RR (ISO)

Mizoribine (EXP)

mycophenolic acid (EXP)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nimesulide (EXP)

oridonin (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

PhIP (EXP)

pirinixic acid (ISO)

propiconazole (ISO)

purine-6-thiol (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

senecionine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

Soman (EXP)

sunitinib (ISO)

Tanshinone I (ISO)

thioacetamide (EXP)

tioguanine (ISO)

topotecan (EXP)

triadimefon (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

Triptolide (ISO)

triptonide (ISO)

tungsten (ISO)

ursodeoxycholic acid (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' XMP biosynthetic process (IEA,ISO)

cellular response to interleukin-4 (IEA,ISO)

circadian rhythm (IEA,ISO,ISS)

GMP biosynthetic process (IEA,ISO)

GTP biosynthetic process (IBA,IEA,ISO,ISS)

lymphocyte proliferation (IEA,ISO)

purine nucleotide biosynthetic process (ISO)

retina development in camera-type eye (IEP)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO,ISS)

nucleus (IEA,ISO)

Molecular Function

identical protein binding (IPI)

IMP dehydrogenase activity (IBA,IDA,IEA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

de novo purine biosynthetic pathway (TAS)

mycophenolic acid pharmacokinetics pathway (ISO)

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.	Gu JJ, etal., Mol Cell Biol 2003 Sep;23(18):6702-12.
3.	Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.	Gunter JH, etal., Int J Biochem Cell Biol. 2008;40(9):1716-28. Epub 2008 Jan 18.
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase.	Yamada Y, etal., Biochemistry. 1988 Mar 22;27(6):2193-6.

Additional References at PubMed

PMID:7763314	PMID:9798653	PMID:14766016	PMID:19946888	PMID:20458337	PMID:21525035	PMID:28985504

Genomics

Comparative Map Data

Impdh2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,135,204 - 118,139,892 (+)	NCBI		GRCr8
mRatBN7.2	8	109,256,705 - 109,261,365 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,256,728 - 109,261,359 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,874,980 - 114,879,615 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,074,314 - 113,078,949 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,916,954 - 110,921,589 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,346,983 - 117,351,619 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,347,029 - 117,351,610 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,691,495 - 116,696,122 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,607,025 - 113,611,613 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,626,482 - 113,631,068 (+)	NCBI
Celera	8	108,552,537 - 108,557,125 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

IMPDH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,024,325 - 49,029,398 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,024,325 - 49,029,447 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	49,061,758 - 49,066,831 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,036,762 - 49,041,879 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	49,036,766 - 49,041,826	NCBI
Celera	3	49,018,480 - 49,023,597 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,119,623 - 49,124,740 (-)	NCBI		HuRef
CHM1_1	3	49,014,319 - 49,019,436 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,052,365 - 49,057,438 (-)	NCBI		T2T-CHM13v2.0

Impdh2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,437,635 - 108,442,776 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,437,485 - 108,442,783 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	108,560,436 - 108,565,577 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,560,286 - 108,565,584 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,462,832 - 108,467,904 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,418,604 - 108,423,676 (+)	NCBI		MGSCv36	mm8
Celera	9	108,171,703 - 108,176,814 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.5	NCBI

Impdh2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,045,833 - 1,051,978 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,047,138 - 1,051,980 (-)	NCBI	ChiLan1.0	ChiLan1.0

IMPDH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,002,115 - 49,008,297 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,007,028 - 49,013,216 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	48,948,965 - 48,954,276 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,030,291 - 50,035,676 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,030,303 - 50,035,676 (-)	Ensembl	panpan1.1		panPan2

IMPDH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,136,106 - 40,140,983 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,136,154 - 40,140,972 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	40,054,292 - 40,059,168 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	40,493,283 - 40,498,161 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	40,493,262 - 40,498,161 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,859,889 - 39,864,764 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,263,666 - 40,268,542 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	40,543,176 - 40,548,052 (+)	NCBI		UU_Cfam_GSD_1.0

Impdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	63,988,280 - 63,993,092 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	745,511 - 753,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	748,777 - 753,582 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IMPDH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,658,650 - 31,663,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	31,658,642 - 31,663,660 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	34,901,646 - 34,906,719 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IMPDH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,424,646 - 10,429,917 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	10,421,996 - 10,429,662 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	156,652,325 - 156,657,621 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Impdh2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,071,141 - 3,075,882 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	3,071,132 - 3,075,870 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Impdh2
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	41
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000047717
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

RH134444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,260,746 - 109,261,127 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,351,013 - 117,351,393	NCBI	Rnor6.0
Rnor_5.0	8	116,695,516 - 116,695,896	UniSTS	Rnor5.0
RGSC_v3.4	8	113,611,009 - 113,611,389	UniSTS	RGSC3.4
Celera	8	108,556,521 - 108,556,901	UniSTS
Cytogenetic Map	8	q32	UniSTS

AI171562

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,261,412 - 109,261,574 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,351,679 - 117,351,840	NCBI	Rnor6.0
Rnor_5.0	8	116,696,182 - 116,696,343	UniSTS	Rnor5.0
RGSC_v3.4	8	113,611,675 - 113,611,836	UniSTS	RGSC3.4
Celera	8	108,557,187 - 108,557,348	UniSTS
RH 3.4 Map	8	1116.8	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC060585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000047717 ⟹ ENSRNOP00000040635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,256,728 - 109,261,359 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,347,029 - 117,351,610 (+)	Ensembl

RefSeq Acc Id:

NM_199099 ⟹ NP_954530

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,135,257 - 118,139,892 (+)	NCBI
mRatBN7.2	8	109,256,728 - 109,261,363 (+)	NCBI
Rnor_6.0	8	117,347,029 - 117,351,617 (+)	NCBI
Rnor_5.0	8	116,691,495 - 116,696,122 (+)	NCBI
RGSC_v3.4	8	113,607,025 - 113,611,613 (+)	RGD
Celera	8	108,552,537 - 108,557,125 (+)	RGD

Sequence:

show sequence

GGGCTCTGCGGCGCGGTCCTCTGAGGCACGCGTCCGTGTTCCTCGTTGGTCATGGCGGACTACC
TGATTAGCGGAGGCACTTCTTACGTGCCAGACGACGGGCTCACCGCACAGCAGCTCTTCAACTG
CGGGGACGGCCTGACCTACAATGACTTTCTCATTCTTCCTGGATATATCGACTTCACTGCGGAC
CAGGTGGACTTGACCTCTGCTCTAACCAAGAAGATTACTCTGAAGACCCCCTTGGTTTCCTCAC
CTATGGACACTGTCACGGAGGCTGGAATGGCCATCGCAATGGCGCTTACAGGAGGCATTGGCTT
CATCCACCACAACTGCACACCTGAATTCCAGGCCAATGAAGTTCGGAAAGTGAAGAAATATGAA
CAGGGATTCATCACTGACCCTGTGGTCCTTAGCCCCAAGGATCGTGTGCGCGATGTTTTTGAGG
CCAAAGCCAGGCATGGCTTCTGTGGTATCCCCATCACAGATACCGGCCGGATGGGGAGTCGATT
GGTGGGCATCATCTCCTCGAGGGACATTGACTTCCTCAAGGAGGAAGAGCATGATCGCTTCTTG
GAAGAGATCATGACTAAGAGAGAAGATTTAGTGGTAGCCCCTGCCGGCGTCACTCTAAAAGAAG
CAAATGAAATTCTGCAGCGCAGTAAAAAGGGAAAGTTGCCCATTGTGAATGAGAGTGATGAGCT
GGTAGCCATCATCGCCCGGACAGACCTCAAGAAGAATCGTGACTACCCACTGGCTTCCAAAGAT
ACCAAAAAGCAACTACTGTGTGGGGCAGCCATTGGCACCCATGAGGATGACAAGTATCGGCTGG
ACTTACTGGCCCTTGCTGGTGTGGATGTGGTAGTTTTGGACTCTTCCCAGGGAAACTCCATTTT
CCAAATCAATATGATCAAGTACATCAAGGAAAAATACCCCAATCTCCAGGTCATCGGAGGCAAT
GTAGTCACTGCTGCTCAAGCCAAGAACCTCATCGACGCAGGTGTGGACGCTCTGCGAGTCGGCA
TGGGAAGTGGTTCCATCTGCATCACCCAGGAAGTGTTGGCCAGTGGGCGACCCCAAGCAACAGC
AGTATACAAGGTCTCTGAGTATGCCCGTCGCTTCGGTGTCCCTGTTATTGCTGATGGAGGAATC
CAGAATGTGGGTCATATTGCCAAAGCTTTGGCTCTTGGGGCCTCTACAGTCATGATGGGCTCCC
TCTTGGCTGCCACCACTGAGGCCCCTGGTGAGTACTTCTTCTCCGATGGGATCCGGCTGAAGAA
GTATCGTGGTATGGGCTCTCTTGATGCCATGGACAAACACCTCAGCAGCCAGAACCGATATTTC
AGTGAAGCTGACAAGATCAAAGTGGCCCAAGGAGTTTCAGGGGCAGTGCAGGACAAAGGGTCTA
TCCACAAGTTTGTCCCTTATTTGATTGCTGGCATCCAGCATTCCTGTCAGGACATTGGTGCCAA
GAGCTTAACCCAAGTCAGAGCCATGATGTACTCGGGGGAACTTAAATTTGAGAAGAGAACGTCC
TCAGCTCAGGTGGAAGGTGGCGTTCACGGCCTCCATTCGTATGAGAAACGGCTCTTCTGAAAAC
AGATCCAGTATATGCCTTGAATTTTTCAATAAAAGTTTGAAAAAACGAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243751 ⟹ XP_006243813

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,135,204 - 118,139,882 (+)	NCBI
mRatBN7.2	8	109,256,705 - 109,261,365 (+)	NCBI
Rnor_6.0	8	117,346,983 - 117,351,619 (+)	NCBI
Rnor_5.0	8	116,691,495 - 116,696,122 (+)	NCBI

Sequence:

show sequence

TGTGACGGAGTAGTCTAGTTTATATTGGCGCGGTCCAGAAGGCAGAGGCCTCTGCGGCGCGGTC
CTCTGAGGCACGCGTCCGTGTTCCTCGTTGGTCATGGCGGACTACCTGATTAGCGGAGGCACTT
CTTACGTGCCAGACGACGGGCTCACCGCACAGCAGCTCTTCAACTGCGGGGACGGCCTGACCTA
CAATGACTTTCTCATTCTTCCTGGATATATCGACTTCACTGCGGACCAGGTGGACTTGACCTCT
GCTCTAACCAAGAAGATTACTCTGAAGACCCCCTTGGTTTCCTCACCTATGGACACTGTCACGG
AGGCTGGAATGGCCATCGCAATGGCGCTTACAGGAGGCATTGGCTTCATCCACCACAACTGCAC
ACCTGAATTCCAGGCCAATGAAGTTCGGAAAGTGAAGAAATATGAACAGGGATTCATCACTGAC
CCTGTGGTCCTTAGCCCCAAGGATCGTGTGCGCGATGTTTTTGAGGCCAAAGCCAGGCATGGCT
TCTGTGGTATCCCCATCACAGATACCGGCCGGATGGGGAGTCGATTGGTGGGCATCATCTCCTC
GAGGGACATTGACTTCCTCAAGGAGGAAGAGCATGATCGCTTCTTGGAAGAGATCATGACTAAG
AGAGAAGATTTAGTGGTAGCCCCTGCCGGCGTCACTCTAAAAGAAGCAAATGAAATTCTGCAGC
GCAGTAAAAAGGGAAAGTTGCCCATTGTGAATGAGAGTGATGAGCTGGTAGCCATCATCGCCCG
GACAGACCTCAAGAAGAATCGTGACTACCCACTGGCTTCCAAAGATACCAAAAAGCAACTACTG
TGTGGGGCAGCCATTGGCACCCATGAGGATGACAAGTATCGGCTGGACTTACTGGCCCTTGCTG
GTGTGGATGTGGTAGTTTTGGACTCTTCCCAGGGAAACTCCATTTTCCAAATCAATATGATCAA
GTACATCAAGGAAAAATACCCCAATCTCCAGGTCATCGGAGGCAATGTAGTCACTGCTGCTCAA
GCCAAGAACCTCATCGACGCAGGTGTGGACGCTCTGCGAGTCGGCATGGGAAGTGGTTCCATCT
GCATCACCCAGGAAGCGGCTCCCAAGATCCCACCAGACATAAAGTCCCACAGCCCCAAATGCCC
TTCTACTGTCTCGGGCTGCTATATGTTGGCCTGTGGGCGACCCCAAGCAACAGCAGTATACAAG
GTCTCTGAGTATGCCCGTCGCTTCGGTGTCCCTGTTATTGCTGATGGAGGAATCCAGAATGTGG
GTCATATTGCCAAAGCTTTGGCTCTTGGGGCCTCTACAGTCATGATGGGCTCCCTCTTGGCTGC
CACCACTGAGGCCCCTGGTGAGTACTTCTTCTCCGATGGGATCCGGCTGAAGAAGTATCGTGGT
ATGGGCTCTCTTGATGCCATGGACAAACACCTCAGCAGCCAGAACCGATATTTCAGTGAAGCTG
ACAAGATCAAAGTGGCCCAAGGAGTTTCAGGGGCAGTGCAGGACAAAGGGTCTATCCACAAGTT
TGTCCCTTATTTGATTGCTGGCATCCAGCATTCCTGTCAGGACATTGGTGCCAAGAGCTTAACC
CAAGTCAGAGCCATGATGTACTCGGGGGAACTTAAATTTGAGAAGAGAACGTCCTCAGCTCAGG
TGGAAGGTGGCGTTCACGGCCTCCATTCGTATGAGAAACGGCTCTTCTGAAAACAGATCCAGTA
TATGCCTTGAATTTTTCAATAAAAGTTTGAAAAAACAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_954530	(Get FASTA)	NCBI Sequence Viewer
	XP_006243813	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60585	(Get FASTA)	NCBI Sequence Viewer
	E9PU28	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000040635
	ENSRNOP00000040635.3

RefSeq Acc Id:

NP_954530 ⟸ NM_199099

- UniProtKB:

E9PU28 (UniProtKB/Swiss-Prot), Q6P9U9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTP
LVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVR
DVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGV
TLKEANEILQRSKKGKLPIVNESDELVAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDD
KYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDA
LRVGMGSGSICITQEVLASGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTV
MMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQ
DKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHGLHSYEKR
LF

hide sequence

RefSeq Acc Id:	XP_006243813 ⟸ XM_006243751
- Peptide Label:	isoform X1
- UniProtKB:	Q6P9U9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTP LVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVR DVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGV TLKEANEILQRSKKGKLPIVNESDELVAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDD KYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDA LRVGMGSGSICITQEAAPKIPPDIKSHSPKCPSTVSGCYMLACGRPQATAVYKVSEYARRFGVP VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHL SSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGEL KFEKRTSSAQVEGGVHGLHSYEKRLF hide sequence

RefSeq Acc Id:

ENSRNOP00000040635 ⟸ ENSRNOT00000047717

Protein Domains

CBS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PU28-F1-model_v2	AlphaFold	E9PU28	1-514	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696308

Promoter ID:

EPDNEW_R6832

Type:

initiation region

Name:

Impdh2_1

Description:

inosine monophosphate dehydrogenase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	117,347,032 - 117,347,092	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735092	AgrOrtholog
BioCyc Gene	G2FUF-29135	BioCyc
BioCyc Pathway	PWY-5695 [inosine 5'-phosphate degradation]	BioCyc
	PWY-7221 [guanosine ribonucleotides de novo biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-5695	BioCyc
	PWY-7221	BioCyc
Ensembl Genes	ENSRNOG00000031965	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000047717	ENTREZGENE
	ENSRNOT00000047717.5	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6891123	IMAGE-MGC_LOAD
InterPro	Aldolase_TIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CBS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH/GMP_Rdtase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH_GMPRt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:301005	UniProtKB/TrEMBL
MGC_CLONE	MGC:72938	IMAGE-MGC_LOAD
NCBI Gene	301005	ENTREZGENE
PANTHER	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11911	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	IMPDH2	RGD
PhenoGen	Impdh2	PhenoGen
PIRSF	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH_GMP_RED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031965	RatGTEx
SMART	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Inosine monophosphate dehydrogenase (IMPDH)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QJV6_RAT	UniProtKB/TrEMBL
	E9PU28	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6P9U9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-29	Impdh2	inosine monophosphate dehydrogenase 2	Impdh2	IMP (inosine 5'-monophosphate) dehydrogenase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Impdh2	IMP (inosine 5'-monophosphate) dehydrogenase 2	Impdh2	IMP (inosine monophosphate) dehydrogenase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-06	Impdh2	IMP (inosine monophosphate) dehydrogenase 2	Impdh2	inosine 5'-phosphate dehydrogenase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Impdh2	inosine 5'-phosphate dehydrogenase 2	Impdh2	inosine 5-monophosphate dehydrogenase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Impdh2	inosine 5-monophosphate dehydrogenase 2		IMP (inosine monophosphate) dehydrogenase 2	Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways