Pde8b (phosphodiesterase 8B) - Rat Genome Database

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Gene: Pde8b (phosphodiesterase 8B) Rattus norvegicus
Analyze
Symbol: Pde8b
Name: phosphodiesterase 8B
RGD ID: 735041
Description: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-specific cyclic nucleotide phosphodiesterase PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; RNPDE8B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,009,841 - 28,244,050 (-)NCBIGRCr8
mRatBN7.2226,275,117 - 26,479,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,312,032 - 33,416,252 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,412,277 - 31,516,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,230,581 - 26,334,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0224,718,548 - 24,955,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,719,976 - 24,923,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,877,817 - 44,112,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,352,725 - 25,469,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,273,093 - 25,389,578 (-)NCBI
Celera222,346,017 - 22,449,253 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Dov A, etal., Endocrinology. 2008 Feb;149(2):741-8. Epub 2007 Nov 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi T, etal., Gene 2003 Nov 13;319:21-31.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, etal., Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Epub 2008 Jul 26.
Additional References at PubMed
PMID:9784418   PMID:21187369   PMID:22925203  


Genomics

Comparative Map Data
Pde8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,009,841 - 28,244,050 (-)NCBIGRCr8
mRatBN7.2226,275,117 - 26,479,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,312,032 - 33,416,252 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,412,277 - 31,516,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,230,581 - 26,334,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0224,718,548 - 24,955,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,719,976 - 24,923,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,877,817 - 44,112,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,352,725 - 25,469,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,273,093 - 25,389,578 (-)NCBI
Celera222,346,017 - 22,449,253 (-)NCBICelera
Cytogenetic Map2q12NCBI
PDE8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38577,086,715 - 77,428,256 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl577,086,732 - 77,427,124 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl577,210,449 - 77,428,256 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,476,129 - 76,724,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,542,462 - 76,758,999 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,542,461 - 76,758,982NCBI
Celera572,400,947 - 72,618,614 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,713,174 - 71,930,868 (+)NCBIHuRef
CHM1_1575,940,448 - 76,157,815 (+)NCBICHM1_1
T2T-CHM13v2.0577,568,346 - 77,910,865 (+)NCBIT2T-CHM13v2.0
Pde8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,160,962 - 95,386,904 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,160,962 - 95,386,844 (-)EnsemblGRCm39 Ensembl
GRCm381395,024,105 - 95,250,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,024,454 - 95,250,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv371395,794,060 - 96,020,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,125,209 - 96,356,676 (-)NCBIMGSCv36mm8
Celera1398,642,301 - 98,869,729 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.22NCBI
Pde8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,512,151 - 23,635,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542523,512,865 - 23,614,326 (-)NCBIChiLan1.0ChiLan1.0
PDE8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2437,864,204 - 38,117,980 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,024,360 - 36,271,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0537,874,089 - 38,121,322 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,401,194 - 38,617,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,402,790 - 38,617,743 (-)Ensemblpanpan1.1panPan2
PDE8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,289,867 - 29,432,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,291,549 - 29,432,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,529,732 - 30,795,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,211,247 - 29,477,045 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,212,086 - 29,476,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,145,547 - 29,411,320 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,126,263 - 29,366,339 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,457,265 - 29,761,295 (-)NCBIUU_Cfam_GSD_1.0
Pde8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,408,778 - 185,646,290 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365495,212,834 - 5,448,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365495,212,693 - 5,450,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,949,174 - 86,323,795 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1286,007,190 - 86,323,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,703,295 - 87,929,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,425,722 - 71,668,747 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,456,017 - 71,668,437 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,170,235 - 20,506,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,695,480 - 1,936,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,695,362 - 1,936,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde8b
1334 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000044087
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
D2Got3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,377,311 - 26,377,507 (+)MAPPERmRatBN7.2
Rnor_6.0224,820,372 - 24,820,567NCBIRnor6.0
Rnor_5.0243,980,033 - 43,980,228UniSTSRnor5.0
RGSC_v3.4225,465,211 - 25,465,407RGDRGSC3.4
RGSC_v3.4225,465,212 - 25,465,407UniSTSRGSC3.4
RGSC_v3.1225,385,581 - 25,385,776RGD
Celera222,445,256 - 22,445,451UniSTS
RH 3.4 Map213.3UniSTS
RH 3.4 Map213.3RGD
RH 2.0 Map277.9RGD
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 35 4 10
Low 3 18 22 19 2 19 8 9 39 35 37 1 8
Below cutoff 13 29 22 17 22 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044087   ⟹   ENSRNOP00000050643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)Ensembl
Rnor_6.0 Ensembl224,719,976 - 24,923,128 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094022   ⟹   ENSRNOP00000097636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,480,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098984   ⟹   ENSRNOP00000083813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,479,725 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103381   ⟹   ENSRNOP00000093552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,480,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112845   ⟹   ENSRNOP00000082132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,480,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115022   ⟹   ENSRNOP00000089849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116408   ⟹   ENSRNOP00000093463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,480,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116670   ⟹   ENSRNOP00000081508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,276,635 - 26,364,444 (-)Ensembl
RefSeq Acc Id: NM_199268   ⟹   NP_954889
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,011,359 - 28,116,051 (-)NCBI
mRatBN7.2226,276,635 - 26,381,307 (-)NCBI
Rnor_6.0224,720,066 - 24,824,369 (-)NCBI
Rnor_5.0243,877,817 - 44,112,405 (-)NCBI
RGSC_v3.4225,352,725 - 25,469,209 (-)RGD
Celera222,346,017 - 22,449,253 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231811   ⟹   XP_006231873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,762 (-)NCBI
mRatBN7.2226,275,117 - 26,479,725 (-)NCBI
Rnor_6.0224,718,548 - 24,923,730 (-)NCBI
Rnor_5.0243,877,817 - 44,112,405 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760670   ⟹   XP_008758892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,839 (-)NCBI
mRatBN7.2226,275,117 - 26,479,725 (-)NCBI
Rnor_6.0224,718,548 - 24,923,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590816   ⟹   XP_017446305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,761 (-)NCBI
mRatBN7.2226,276,635 - 26,479,725 (-)NCBI
Rnor_6.0224,718,548 - 24,923,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590817   ⟹   XP_017446306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,763 (-)NCBI
mRatBN7.2226,275,117 - 26,479,725 (-)NCBI
Rnor_6.0224,718,548 - 24,923,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102163   ⟹   XP_038958091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,762 (-)NCBI
mRatBN7.2226,275,117 - 26,479,725 (-)NCBI
RefSeq Acc Id: XM_039102164   ⟹   XP_038958092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,099,010 (-)NCBI
mRatBN7.2226,276,743 - 26,364,266 (-)NCBI
RefSeq Acc Id: XM_063281701   ⟹   XP_063137771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,214,763 (-)NCBI
RefSeq Acc Id: XM_063281702   ⟹   XP_063137772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,009,841 - 28,244,050 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_954889   ⟸   NM_199268
- UniProtKB: Q76KC5 (UniProtKB/TrEMBL),   F7ES56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231873   ⟸   XM_006231811
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AJW4 (UniProtKB/TrEMBL),   A0A8I6AKA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758892   ⟸   XM_008760670
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTX5 (UniProtKB/TrEMBL),   A0A8I6GB63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446305   ⟸   XM_017590816
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GB63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446306   ⟸   XM_017590817
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AKA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050643   ⟸   ENSRNOT00000044087
RefSeq Acc Id: XP_038958091   ⟸   XM_039102163
- Peptide Label: isoform X6
- UniProtKB: A6I4Y1 (UniProtKB/TrEMBL),   A0A8I6AKA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958092   ⟸   XM_039102164
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZT43 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081508   ⟸   ENSRNOT00000116670
RefSeq Acc Id: ENSRNOP00000093463   ⟸   ENSRNOT00000116408
RefSeq Acc Id: ENSRNOP00000089849   ⟸   ENSRNOT00000115022
RefSeq Acc Id: ENSRNOP00000093552   ⟸   ENSRNOT00000103381
RefSeq Acc Id: ENSRNOP00000083813   ⟸   ENSRNOT00000098984
RefSeq Acc Id: ENSRNOP00000097636   ⟸   ENSRNOT00000094022
RefSeq Acc Id: ENSRNOP00000082132   ⟸   ENSRNOT00000112845
RefSeq Acc Id: XP_063137772   ⟸   XM_063281702
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063137771   ⟸   XM_063281701
- Peptide Label: isoform X4
Protein Domains
3'5'-cyclic nucleotide phosphodiesterase PDE8   PAS   PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76KC5-F1-model_v2 AlphaFold Q76KC5 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735041 AgrOrtholog
BioCyc Gene G2FUF-54822 BioCyc
Ensembl Genes ENSRNOG00000010280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044087 ENTREZGENE
  ENSRNOT00000044087.4 UniProtKB/TrEMBL
  ENSRNOT00000094022.1 UniProtKB/TrEMBL
  ENSRNOT00000098984.1 UniProtKB/TrEMBL
  ENSRNOT00000103381.1 UniProtKB/TrEMBL
  ENSRNOT00000112845.1 UniProtKB/TrEMBL
  ENSRNOT00000115022.1 UniProtKB/TrEMBL
  ENSRNOT00000116408.1 UniProtKB/TrEMBL
  ENSRNOT00000116670.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro Metal-dep_PHydrolase_HD_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_PDE8 UniProtKB/TrEMBL
KEGG Report rno:309962 UniProtKB/TrEMBL
NCBI Gene 309962 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
  HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8B UniProtKB/TrEMBL
Pfam PAS_9 UniProtKB/TrEMBL
  PDE8 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PhenoGen Pde8b PhenoGen
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PAS UniProtKB/TrEMBL
  PDEASE_I UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010280 RatGTEx
SMART HDc UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A8I5ZT43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJW4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKA5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALV2_RAT UniProtKB/TrEMBL
  A0A8I6AT14_RAT UniProtKB/TrEMBL
  A0A8I6GB63 ENTREZGENE, UniProtKB/TrEMBL
  A6I4Y0_RAT UniProtKB/TrEMBL
  A6I4Y1 ENTREZGENE, UniProtKB/TrEMBL
  A6I4Y2_RAT UniProtKB/TrEMBL
  A6I4Y3_RAT UniProtKB/TrEMBL
  F7ES56 ENTREZGENE, UniProtKB/TrEMBL
  Q76KC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Pde8b  phosphodiesterase 8B  RNPDE8B  cAMP-specific cyclic nucleotide phosphodiesterase PDE8  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein includes REC, PAS and catalytic PDE domains 1302744
gene_expression by northern blot, expression was found to be highest in brain with lower expression in heart, lung, liver, kidney and testis and with very low expression in thymus 1302744
gene_expression expression was high in every area of brain tested with the exception of cerebellum 1302744
gene_homology REC, PAS and PDE domains in the rat protein are 98-100% identical to the corresponding domains in the mouse and human PDE8B proteins 1302744
gene_protein protein consists of 760 amino acids and appears to be N-terminally truncated with respect to the rat Rnpde8a protein 1302744