Scin (scinderin) - Rat Genome Database

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Pathways
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Gene: Scin (scinderin) Rattus norvegicus
Analyze
Symbol: Scin
Name: scinderin
RGD ID: 735034
Description: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Part of protein-containing complex. Orthologous to human SCIN (scinderin); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adseverin; Scind
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8662,836,641 - 62,915,287 (-)NCBIGRCr8
mRatBN7.2657,109,500 - 57,188,123 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl657,109,403 - 57,188,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx657,380,003 - 57,480,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0657,694,940 - 57,795,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0657,179,603 - 57,270,868 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0659,975,375 - 60,055,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl659,976,003 - 60,054,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0669,564,441 - 69,641,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4659,237,930 - 59,357,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1659,241,055 - 59,360,127 (-)NCBI
Celera656,160,567 - 56,251,246 (-)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
irinotecan  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor. Svensson C, etal., Biochem Biophys Res Commun 2002 Mar 15;291(5):1194-200.
Additional References at PubMed
PMID:11568009   PMID:19056867   PMID:19666531   PMID:22114352   PMID:23376485   PMID:28823945  


Genomics

Comparative Map Data
Scin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8662,836,641 - 62,915,287 (-)NCBIGRCr8
mRatBN7.2657,109,500 - 57,188,123 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl657,109,403 - 57,188,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx657,380,003 - 57,480,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0657,694,940 - 57,795,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0657,179,603 - 57,270,868 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0659,975,375 - 60,055,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl659,976,003 - 60,054,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0669,564,441 - 69,641,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4659,237,930 - 59,357,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1659,241,055 - 59,360,127 (-)NCBI
Celera656,160,567 - 56,251,246 (-)NCBICelera
Cytogenetic Map6q21NCBI
SCIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38712,570,720 - 12,660,182 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl712,570,577 - 12,660,182 (+)EnsemblGRCh38hg38GRCh38
GRCh37712,610,346 - 12,699,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36712,595,673 - 12,659,752 (+)NCBINCBI36Build 36hg18NCBI36
Build 34712,402,387 - 12,466,467NCBI
Celera712,587,891 - 12,670,905 (+)NCBICelera
Cytogenetic Map7p21.3NCBI
HuRef712,488,818 - 12,571,812 (+)NCBIHuRef
CHM1_1712,610,380 - 12,693,312 (+)NCBICHM1_1
T2T-CHM13v2.0712,701,807 - 12,791,257 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2712,661,354 - 12,744,363 (+)NCBI
Scin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391240,109,768 - 40,184,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1240,109,768 - 40,184,227 (-)EnsemblGRCm39 Ensembl
GRCm381240,059,769 - 40,134,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1240,059,769 - 40,134,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv371240,786,356 - 40,860,815 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361240,570,192 - 40,644,606 (-)NCBIMGSCv36mm8
Celera1241,488,078 - 41,562,781 (-)NCBICelera
Cytogenetic Map12B1NCBI
cM Map1218.06NCBI
Scin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541016,285,217 - 16,358,280 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541016,286,131 - 16,358,286 (+)NCBIChiLan1.0ChiLan1.0
SCIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2617,441,949 - 17,526,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1765,766,665 - 65,851,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0713,269,361 - 13,351,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1712,613,996 - 12,696,244 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl712,613,996 - 12,696,244 (+)Ensemblpanpan1.1panPan2
SCIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11427,429,476 - 27,477,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1427,412,351 - 27,477,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1426,912,136 - 26,989,694 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01427,226,368 - 27,303,850 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1427,226,395 - 27,306,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11427,396,521 - 27,473,978 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01427,127,055 - 27,204,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01427,495,113 - 27,521,348 (+)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.01427,385,153 - 27,462,823 (+)NCBIUU_Cfam_GSD_1.0
Scin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511871,891,966 - 71,969,069 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936795418,436 - 495,936 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936795418,874 - 495,990 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl982,103,087 - 82,185,283 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1982,103,271 - 82,185,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2990,266,490 - 90,348,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12145,453,034 - 45,537,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2145,452,659 - 45,537,323 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604258,931,149 - 59,016,257 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473917,304,486 - 17,384,050 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473917,303,805 - 17,384,105 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scin
521 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000005988
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 35 4 3
Low 10 22 7 17 7 2 2 11 31 8 2
Below cutoff 17 33 32 32 6 8 35 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005988   ⟹   ENSRNOP00000005988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl657,109,403 - 57,188,242 (-)Ensembl
Rnor_6.0 Ensembl659,976,003 - 60,054,279 (-)Ensembl
RefSeq Acc Id: NM_198748   ⟹   NP_942043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8662,836,641 - 62,915,287 (-)NCBI
mRatBN7.2657,109,500 - 57,188,123 (-)NCBI
Rnor_6.0659,976,003 - 60,054,279 (-)NCBI
Rnor_5.0669,564,441 - 69,641,704 (-)NCBI
RGSC_v3.4659,237,930 - 59,357,001 (-)RGD
Celera656,160,567 - 56,251,246 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_942043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP85593 (Get FASTA)   NCBI Sequence Viewer  
  EDM03335 (Get FASTA)   NCBI Sequence Viewer  
  EDM03336 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005988
  ENSRNOP00000005988.4
Reference Protein Sequences
RefSeq Acc Id: NP_942043   ⟸   NM_198748
- UniProtKB: E9PU64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005988   ⟸   ENSRNOT00000005988
Protein Domains
Gelsolin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU64-F1-model_v2 AlphaFold E9PU64 1-715 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694570
Promoter ID:EPDNEW_R5095
Type:single initiation site
Name:Scin_1
Description:scinderin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0660,054,343 - 60,054,403EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735034 AgrOrtholog
BioCyc Gene G2FUF-37745 BioCyc
Ensembl Genes ENSRNOG00000004498 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005988 ENTREZGENE
  ENSRNOT00000005988.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom UniProtKB/TrEMBL
  Gelsolin UniProtKB/TrEMBL
  Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Gelsolin_dom UniProtKB/TrEMBL
KEGG Report rno:298975 UniProtKB/TrEMBL
NCBI Gene 298975 ENTREZGENE
PANTHER Gelsolin UniProtKB/TrEMBL
  PTHR11977:SF78 UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/TrEMBL
PhenoGen Scin PhenoGen
PRINTS GELSOLIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004498 RatGTEx
SMART GEL UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/TrEMBL
  SSF82754 UniProtKB/TrEMBL
UniProt A6HBD0_RAT UniProtKB/TrEMBL
  A6HBD1_RAT UniProtKB/TrEMBL
  E9PU64 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQ08_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Scin  scinderin      Symbol and Name status set to approved 1299863 APPROVED