Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein and Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA
[bisphenol A co-treated with Tamoxifen] results in increased expression of PPARGC1B mRNA and bisphenol A affects the reaction [Tamoxifen affects the expression of PPARGC1B mRNA]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein and Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1B mRNA] and Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1B protein]
[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1B mRNA
Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis.