Abcc5 (ATP binding cassette subfamily C member 5) - Rat Genome Database

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Gene: Abcc5 (ATP binding cassette subfamily C member 5) Rattus norvegicus
Analyze
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
RGD ID: 70913
Description: Predicted to enable several functions, including ABC-type xenobiotic transporter activity; glutathione transmembrane transporter activity; and heme transmembrane transporter activity. Involved in response to insulin and response to lipopolysaccharide. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5); PARTICIPATES IN multidrug resistance-associated protein mediated transport pathway; azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abcc5a; ATP-binding cassette sub-family C (CFTR/MRP) member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; MGC156604; Mrp5; multidrug resistance-associated protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,975,579 - 94,071,659 (+)NCBIGRCr8
mRatBN7.21180,473,809 - 80,567,257 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,473,872 - 80,567,253 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,196,026 - 89,290,231 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,849,454 - 81,943,659 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,910,512 - 81,004,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,395,982 - 84,490,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,460,314 - 87,554,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,714,334 - 82,809,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,771,922 - 82,866,943 (+)NCBI
Celera1179,313,876 - 79,407,221 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',7'-bis-(2-carboxyethyl)carboxyfluorescein  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-fluorouridine  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
allyl alcohol  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
captan  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
dUMP  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethoxyquin  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
MK 571  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
oltipraz  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picene  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
probenecid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
sodium dichromate  (ISO)
soybean oil  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
xanthohumol  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats. Dazert P, etal., Neuroscience. 2006 Nov 3;142(4):1071-9. Epub 2006 Sep 25.
2. Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS. Donner MG, etal., Biol Chem. 2004 Mar-Apr;385(3-4):331-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. Jedlitschky G, etal., J Biol Chem 2000 Sep 29;275(39):30069-74.
6. Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. Konig J, etal., Int J Cancer. 2005 Jun 20;115(3):359-67.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
13. Modulation of gene expression profiles by hyperosmolarity and insulin. Schafer C, etal., Cell Physiol Biochem. 2007;20(5):369-86.
Additional References at PubMed
PMID:10840050   PMID:12477932   PMID:14715514   PMID:15297306   PMID:16614078   PMID:22015764   PMID:26244301  


Genomics

Comparative Map Data
Abcc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,975,579 - 94,071,659 (+)NCBIGRCr8
mRatBN7.21180,473,809 - 80,567,257 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,473,872 - 80,567,253 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,196,026 - 89,290,231 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,849,454 - 81,943,659 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,910,512 - 81,004,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,395,982 - 84,490,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,460,314 - 87,554,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,714,334 - 82,809,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,771,922 - 82,866,943 (+)NCBI
Celera1179,313,876 - 79,407,221 (+)NCBICelera
Cytogenetic Map11q23NCBI
ABCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,919,934 - 184,017,884 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,919,934 - 184,017,939 (-)EnsemblGRCh38hg38GRCh38
GRCh373183,637,722 - 183,735,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,120,416 - 185,218,421 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,120,427 - 185,218,377NCBI
Celera3182,081,049 - 182,178,505 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,047,368 - 181,143,321 (-)NCBIHuRef
CHM1_13183,602,021 - 183,699,858 (-)NCBICHM1_1
T2T-CHM13v2.03186,729,643 - 186,827,475 (-)NCBIT2T-CHM13v2.0
Abcc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,150,053 - 20,245,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,150,053 - 20,245,144 (-)EnsemblGRCm39 Ensembl
GRCm381620,331,303 - 20,426,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,331,303 - 20,426,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,331,376 - 20,426,467 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,244,846 - 20,339,937 (-)NCBIMGSCv36mm8
Celera1620,894,801 - 20,990,015 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.41NCBI
Abcc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,447,920 - 23,522,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,447,920 - 23,522,732 (+)NCBIChiLan1.0ChiLan1.0
ABCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,792,224 - 181,891,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,796,940 - 181,895,418 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,956,139 - 181,054,112 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,122,590 - 189,219,492 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,122,590 - 189,219,492 (-)Ensemblpanpan1.1panPan2
ABCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,856,624 - 16,947,844 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,856,633 - 16,946,422 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,943,958 - 21,030,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,763,912 - 16,854,022 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,763,907 - 16,855,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,802,194 - 16,888,327 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,797,769 - 16,884,117 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,027,936 - 17,114,432 (-)NCBIUU_Cfam_GSD_1.0
Abcc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,746,167 - 119,824,457 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,837,993 - 5,916,274 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,838,044 - 5,916,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13121,869,600 - 121,926,071 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113121,868,614 - 121,957,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,309,020 - 131,358,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,409,921 - 5,505,334 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,409,861 - 5,505,315 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,190,772 - 14,287,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,534,329 - 72,623,263 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,529,299 - 72,621,108 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc5
332 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1191
Count of miRNA genes:345
Interacting mature miRNAs:466
Transcripts:ENSRNOT00000002316, ENSRNOT00000048306
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
RH143810  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,506,031 - 80,506,296 (+)MAPPERmRatBN7.2
Rnor_6.01184,428,176 - 84,428,440NCBIRnor6.0
Rnor_5.01187,493,015 - 87,493,279UniSTSRnor5.0
RGSC_v3.41182,746,829 - 82,747,093UniSTSRGSC3.4
Celera1179,346,070 - 79,346,334UniSTS
RH 3.4 Map11657.9UniSTS
Cytogenetic Map11q23UniSTS
AI555746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,566,968 - 80,567,171 (+)MAPPERmRatBN7.2
Rnor_6.01184,489,927 - 84,490,129NCBIRnor6.0
Rnor_5.01187,554,233 - 87,554,435UniSTSRnor5.0
RGSC_v3.41182,809,070 - 82,809,272UniSTSRGSC3.4
Celera1179,406,937 - 79,407,139UniSTS
RH 3.4 Map11658.0UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 34 18 19 18 6 9 74 30 35 11 6
Low 10 23 23 23 2 2 5 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002316   ⟹   ENSRNOP00000002316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,473,872 - 80,567,253 (+)Ensembl
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048306   ⟹   ENSRNOP00000039986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,473,940 - 80,507,940 (+)Ensembl
Rnor_6.0 Ensembl1184,399,417 - 84,428,650 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091595   ⟹   ENSRNOP00000073913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1184,399,417 - 84,488,920 (+)Ensembl
RefSeq Acc Id: NM_053924   ⟹   NP_446376
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,978,285 - 94,071,655 (+)NCBI
mRatBN7.21180,473,872 - 80,567,253 (+)NCBI
Rnor_6.01184,396,033 - 84,490,211 (+)NCBI
Rnor_5.01187,460,314 - 87,554,521 (+)NCBI
RGSC_v3.41182,714,334 - 82,809,354 (+)RGD
Celera1179,313,876 - 79,407,221 (+)RGD
Sequence:
RefSeq Acc Id: XM_017597849   ⟹   XP_017453338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,017,571 - 94,071,659 (+)NCBI
mRatBN7.21180,513,176 - 80,567,257 (+)NCBI
Rnor_6.01184,435,424 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087904   ⟹   XP_038943832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,071,659 (+)NCBI
mRatBN7.21180,474,037 - 80,567,257 (+)NCBI
RefSeq Acc Id: XM_039087905   ⟹   XP_038943833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,020,532 (+)NCBI
mRatBN7.21180,473,811 - 80,516,101 (+)NCBI
RefSeq Acc Id: XM_039087907   ⟹   XP_038943835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,012,349 (+)NCBI
mRatBN7.21180,473,809 - 80,507,941 (+)NCBI
RefSeq Acc Id: XM_039087908   ⟹   XP_038943836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,013,227 (+)NCBI
mRatBN7.21180,473,811 - 80,508,815 (+)NCBI
RefSeq Acc Id: XM_063270243   ⟹   XP_063126313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,017,076 - 94,071,659 (+)NCBI
RefSeq Acc Id: XM_063270244   ⟹   XP_063126314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,012,349 (+)NCBI
RefSeq Acc Id: XR_010055931
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,020,532 (+)NCBI
RefSeq Acc Id: XR_010055932
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,975,579 - 94,020,532 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446376   ⟸   NM_053924
- UniProtKB: A0A0G2K6R4 (UniProtKB/Swiss-Prot),   Q9QYM0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453338   ⟸   XM_017597849
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000039986   ⟸   ENSRNOT00000048306
RefSeq Acc Id: ENSRNOP00000002316   ⟸   ENSRNOT00000002316
RefSeq Acc Id: ENSRNOP00000073913   ⟸   ENSRNOT00000091595
RefSeq Acc Id: XP_038943835   ⟸   XM_039087907
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943833   ⟸   XM_039087905
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943836   ⟸   XM_039087908
- Peptide Label: isoform X5
- UniProtKB: A1A5M8 (UniProtKB/TrEMBL),   F7EV50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943832   ⟸   XM_039087904
- Peptide Label: isoform X1
- UniProtKB: Q9QYM0 (UniProtKB/Swiss-Prot),   A0A0G2K6R4 (UniProtKB/Swiss-Prot),   G3V676 (UniProtKB/TrEMBL),   A6JSB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126314   ⟸   XM_063270244
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063126313   ⟸   XM_063270243
- Peptide Label: isoform X2
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYM0-F1-model_v2 AlphaFold Q9QYM0 1-1436 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698284
Promoter ID:EPDNEW_R8808
Type:initiation region
Name:Abcc5_1
Description:ATP binding cassette subfamily C member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,396,076 - 84,396,136EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70913 AgrOrtholog
BioCyc Gene G2FUF-20720 BioCyc
Ensembl Genes ENSRNOG00000029178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002316 ENTREZGENE
  ENSRNOT00000002316.8 UniProtKB/TrEMBL
  ENSRNOT00000048306.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116721 UniProtKB/Swiss-Prot
NCBI Gene 116721 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24223:SF196 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC5 RGD
PhenoGen Abcc5 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029178 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6R4 ENTREZGENE
  A1A5M8 ENTREZGENE, UniProtKB/TrEMBL
  A6JSB4 ENTREZGENE, UniProtKB/TrEMBL
  F7EV50 ENTREZGENE
  G3V676 ENTREZGENE, UniProtKB/TrEMBL
  MRP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K6R4 UniProtKB/Swiss-Prot
  F7EV50 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcc5  ATP binding cassette subfamily C member 5  Abcc5  ATP-binding cassette, subfamily C (CFTR/MRP), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc5  ATP-binding cassette, subfamily C (CFTR/MRP), member 5  Abcc5  ATP-binding cassette, sub-family C (CFTR/MRP), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Abcc5  ATP-binding cassette, sub-family C (CFTR/MRP), member 5  Abcc5a  ATP-binding cassette, sub-family C (CFTR/MRP), member 5a  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-07-09 Abcc5a  ATP-binding cassette, sub-family C (CFTR/MRP), member 5a      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference