Pgrmc1 (progesterone receptor membrane component 1)

Gene: Pgrmc1 (progesterone receptor membrane component 1) Rattus norvegicus

Analyze

Symbol:

Pgrmc1

Name:

progesterone receptor membrane component 1

RGD ID:

70890

Description:

Predicted to enable heme binding activity and protein homodimerization activity. Involved in several processes, including learning or memory; modification of synaptic structure; and negative regulation of synapse organization. Located in neuron projection; neuronal cell body; and synapse. Orthologous to human PGRMC1 (progesterone receptor membrane component 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

25-Dx; 25Dx; acidic 25 kDa protein; membrane-associated progesterone receptor component 1; membrane-bound progesterone receptor; MPR; VEMA; ventral midline antigen

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	120,698,610 - 120,706,805 (+)	NCBI		GRCr8
mRatBN7.2	X	115,832,865 - 115,841,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	115,832,884 - 115,888,682 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	117,934,866 - 117,943,066 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,504,010 - 121,512,210 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,050,166 - 119,058,365 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,205,869 - 123,213,880 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,205,869 - 123,213,882 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,352,144 - 123,360,155 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	8,265,543 - 8,273,667 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	8,271,098 - 8,279,223 (-)	NCBI
Celera	X	115,065,055 - 115,073,267 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

autistic disorder (ISO)

cataract (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

metabolic dysfunction-associated steatotic liver disease (ISS)

primary ovarian insufficiency 16 (ISO)

Prostatic Neoplasms (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

afimoxifene (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

captan (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

cetrorelix (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clofibrate (EXP)

clozapine (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

desogestrel (ISO)

diethyl maleate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

enzyme inhibitor (ISO)

felbamate (EXP)

fipronil (EXP)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gefitinib (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

menadione (ISO)

nefazodone (EXP)

nimesulide (EXP)

omeprazole (EXP)

oxaliplatin (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP)

phenytoin (EXP)

picoxystrobin (ISO)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

procymidone (EXP)

progesterone (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (EXP)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

testosterone (EXP)

testosterone enanthate (ISO)

thapsigargin (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

valproic acid (ISO)

venlafaxine hydrochloride (EXP)

vincaleukoblastine (ISO)

vinclozolin (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

associative learning (IGI)

axon guidance (IEP)

heme biosynthetic process (ISO,ISS)

memory (IGI)

modification of synaptic structure (IGI)

negative regulation of synapse organization (IGI)

positive regulation of lipoprotein transport (ISO,ISS)

positive regulation of protein localization to plasma membrane (ISO)

Cellular Component

cell body (IDA)

endomembrane system (IBA)

endoplasmic reticulum (IBA)

endoplasmic reticulum membrane (IEA)

extracellular region (IEA)

membrane (IBA)

mitochondrial outer membrane (IEA,ISO,ISS)

neuron projection (IDA)

neuronal cell body (IDA)

postsynaptic density (TAS)

smooth endoplasmic reticulum membrane (IEA)

synapse (IDA)

Molecular Function

heme binding (ISO,ISS)

metal ion binding (IEA)

protein binding (ISO)

protein homodimerization activity (ISO,ISS)

steroid binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.	Izzo NJ, etal., PLoS One. 2014 Nov 12;9(11):e111898. doi: 10.1371/journal.pone.0111898. eCollection 2014.
4.	Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.	Izzo NJ, etal., PLoS One. 2014 Nov 12;9(11):e111899. doi: 10.1371/journal.pone.0111899. eCollection 2014.
5.	Gene Data Set	MGD Curation, June 12, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS.	Runko E, etal., Mol Cell Neurosci 1999 Dec;14(6):428-43.
9.	Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.	Selmin O, etal., Carcinogenesis 1996 Dec;17(12):2609-15.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11087948	PMID:15033482	PMID:15207350	PMID:15489334	PMID:15570619	PMID:15934950	PMID:16279947	PMID:16641100	PMID:17991724	PMID:19946888	PMID:20144686	PMID:20977928
PMID:21148105	PMID:21730960	PMID:22147012	PMID:22719051	PMID:22778217	PMID:23211561	PMID:23242527	PMID:23376485	PMID:23653459	PMID:25002582	PMID:25253729	PMID:26335282
PMID:26988023	PMID:27599036	PMID:31748741	PMID:34645803	PMID:34970218

Genomics

Comparative Map Data

Pgrmc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	120,698,610 - 120,706,805 (+)	NCBI		GRCr8
mRatBN7.2	X	115,832,865 - 115,841,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	115,832,884 - 115,888,682 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	117,934,866 - 117,943,066 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,504,010 - 121,512,210 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,050,166 - 119,058,365 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,205,869 - 123,213,880 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,205,869 - 123,213,882 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,352,144 - 123,360,155 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	8,265,543 - 8,273,667 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	8,271,098 - 8,279,223 (-)	NCBI
Celera	X	115,065,055 - 115,073,267 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

PGRMC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	119,236,285 - 119,244,466 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	119,236,245 - 119,244,466 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	118,370,248 - 118,378,429 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	118,254,291 - 118,262,457 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	118,152,144 - 118,160,310	NCBI
Celera	X	118,824,941 - 118,833,159 (+)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	107,864,078 - 107,872,271 (+)	NCBI		HuRef
CHM1_1	X	118,281,446 - 118,289,662 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	117,614,039 - 117,622,220 (+)	NCBI		T2T-CHM13v2.0

Pgrmc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	35,861,846 - 35,869,732 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	35,861,859 - 35,869,732 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	36,598,193 - 36,606,079 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	36,598,206 - 36,606,079 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	34,138,220 - 34,146,074 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	33,029,670 - 33,037,524 (+)	NCBI		MGSCv36	mm8
Celera	X	23,322,277 - 23,330,131 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	21.0	NCBI

Pgrmc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	698,734 - 706,946 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	698,895 - 706,586 (-)	NCBI	ChiLan1.0	ChiLan1.0

PGRMC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	118,631,349 - 118,639,583 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	118,634,953 - 118,643,187 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	108,282,958 - 108,291,187 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	118,711,495 - 118,719,714 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	118,711,495 - 118,719,714 (+)	Ensembl	panpan1.1		panPan2

PGRMC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	91,329,243 - 91,337,951 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	91,329,243 - 91,337,951 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	77,405,200 - 77,413,908 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	93,069,899 - 93,078,605 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	93,069,840 - 93,078,601 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	90,522,743 - 90,531,448 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	92,281,492 - 92,290,197 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	92,010,000 - 92,018,705 (+)	NCBI		UU_Cfam_GSD_1.0

Pgrmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	90,353,427 - 90,361,506 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	10,625,889 - 10,634,136 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	10,625,989 - 10,634,058 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGRMC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	97,735,244 - 97,743,423 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	97,735,402 - 97,743,424 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	113,925,761 - 113,933,800 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGRMC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	31,998,876 - 32,007,022 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pgrmc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624895	3,264,798 - 3,273,529 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624895	3,265,326 - 3,273,531 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pgrmc1
28 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	311
Count of miRNA genes:	188
Interacting mature miRNAs:	235
Transcripts:	ENSRNOT00000017101
Prediction methods:	Miranda, Pita, Pita,Targetscan, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	112934952	138400867	Rat
5685004	Bss104	Bone structure and strength QTL 104	3.9		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	X	113805422	126975220	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

RH139267

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	30,511,961 - 30,512,089 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	34,204,203 - 34,204,330	NCBI	Rnor6.0
Rnor_5.0	19	45,084,621 - 45,084,748	UniSTS	Rnor5.0
RGSC_v3.4	19	32,324,466 - 32,324,593	UniSTS	RGSC3.4
Celera	19	29,992,287 - 29,992,414	UniSTS
RH 3.4 Map	19	234.8	UniSTS
Cytogenetic Map	19	q11	UniSTS
Cytogenetic Map	X	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	4	4	74	35	41	11	4
Low							4	7					4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF163321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ005837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U63315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000017101 ⟹ ENSRNOP00000017101

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	115,832,884 - 115,888,682 (+)	Ensembl
Rnor_6.0 Ensembl	X	123,205,869 - 123,213,882 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079231 ⟹ ENSRNOP00000071066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	123,205,891 - 123,212,727 (+)	Ensembl

RefSeq Acc Id:

NM_021766 ⟹ NP_068534

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	120,698,610 - 120,706,805 (+)	NCBI
mRatBN7.2	X	115,832,865 - 115,841,060 (+)	NCBI
Rnor_6.0	X	123,205,869 - 123,213,880 (+)	NCBI
Rnor_5.0	X	123,352,144 - 123,360,155 (+)	NCBI
RGSC_v3.4	X	8,265,543 - 8,273,667 (-)	RGD
Celera	X	115,065,055 - 115,073,267 (+)	RGD

Sequence:

show sequence

GCAAAATTAATTTATTGGCCACTGTTCGCTTAGAGGGCGGAGGAAGCCGACTGTTTCGGTCTCT
GCATAACAGGCCCAAACCTTTGCTCCAGAGATCATGGCTGCCGAGGATGTGGTGGCGACTGGCG
CCGACCCCAGCGAGCTGGAGGGCGGCGGGCTGCTTCAAGAGATTTTCACGTCGCCTCTCAACCT
GCTGCTCCTTGGCCTCTGCATCTTCCTGCTCTACAAGATCGTTCGCGGGGACCAGCCCGGTGCC
AGTGGGGACAACGACGACGACGAGCCGCCCCCGCTGCCTCGCCTCAAGCCGCGTGACTTCACCC
CTGCCGAACTAAGGCGATACGATGGAGTCCAGGACCCGCGCATTCTTATGGCCATCAACGGCAA
GGTGTTCGACGTGACCAAAGGCCGCAAGTTCTATGGGCCGGAGGGACCATACGGGGTCTTTGCT
GGAAGAGATGCATCCAGGGGCCTTGCCACATTTTGCCTGGACAAAGAAGCACTGAAGGATGAGT
ATGATGACCTTTCTGACCTCACTCCTGCCCAGCAGGAGACCCTGAATGACTGGGACTCTCAGTT
CAGTTCACCTTCAAGTACCATCACGTGGGGAAAACTGCTTGAAGGAGCGGAGGAGCCGATTGTG
TACTCGGATGATGAAGAACAAAAGATGAGGCTGCTCGGAAGAGTGACTGAAGCAGTCAGTGGAG
CATATCTATTTTTGTATTTTGCAAAATCATTTGTAACATTCCAGTCTGTCTTTACAACATGGTG
ATTTCAATATTTAGAGAAGTTTTGAACTTGTAAGTTTTTTAAGTAACATCACTAGTGACACCGA
TAAAATCAACTCGTCTTAGAATGCATGATGTGTTTGTACGTCACAAATCCAGAAAGTGAACTTT
AGTTCTCTAGATCCAAATGGTAAAGCTGTTTCTCTTCTATCTGTAGTTAAAACTGAATTACAAT
TTTATTTTCCTGAGAGGGAAAACTTGGGTTATTTCCACAAACTGGCCTTTTTTCAAGTGCACAC
ACACACAGTGGCCCCAAATGGTCAATGTACTAAGAATGAAGAGAGAAGGTCTTAGCCATGCTAT
AGTCTGAAAACAAGCCCATTTTACCCAACAGACTTAACTGCATGATTTTTGTTTTATCTACCTC
TAAAGCAAAACTGCAGTGTTCCAAAGTCTGTGGTATTGATTCAAAACAGAAGTCCAGTAACAAA
ATGAAAACTCAATAATGGGTTTAGTTGGGGCAAACACATTGCCTGTGTTCATGGACTGATTTAT
CATCCCTGTCCCCACGTGGACACTCCCACACACAGTAACTCTCACACACCTGGTAATTGGCAGT
TGGAACTACAACAGAAATCTGAAAATTCAAGGTAGAACTTTGCAAAAGAAAAATCTGTTGCTTG
TAGCAGGGCAATGGTTATGTGGTTATTGGCCAAATGTAAAATTTGAGAGCAATATACAGGACAG
GAACAGGTGTGCGCTTTTCAAAAGCTTCCACTGACATCTCTGAAGAATGAGAAAACACTACATG
GCACTAGCTGGGTGATTTTGAAAGGAAAATACATTCCTAAGGTAACAGTTAATCCTCTGTTGTT
ACAAAACTCGTAGTCGCTTCAAAAATAGTAGTCAGGTGTCTAGGTCTTGGATAATACTCTTGGT
TAATACTAAACCTAGCTTAAGTAGACTCTGCAGTTGTATACATTTGTTAAAAGTATTATCTGAA
CAACTAGTGAGGTTTCAGACTCTTGTAATTGTAGTTAAATAGTCATTGTATTTTCTTGTGAGCT
GTGTTTAATGGTTTTACCTCAAATCAGAAAAAAATGAAGTGCTTGGGTCAGTTAATAAAACGGT
TTTGCCCAGTAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_068534	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB07125	(Get FASTA)	NCBI Sequence Viewer
	AAF17359	(Get FASTA)	NCBI Sequence Viewer
	AAH62073	(Get FASTA)	NCBI Sequence Viewer
	CAA06732	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017101
	ENSRNOP00000017101.6
	ENSRNOP00055035572
	ENSRNOP00060026949
	ENSRNOP00065012396
GenBank Protein	P70580	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_068534 ⟸ NM_021766
- UniProtKB:	P70580 (UniProtKB/Swiss-Prot), O70606 (UniProtKB/Swiss-Prot), Q549C4 (UniProtKB/Swiss-Prot), A6JMF3 (UniProtKB/TrEMBL), A0A0H2UHK2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPP LPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATF CLDKEALKDEYDDLSDLTPAQQETLNDWDSQFSSPSSTITWGKLLEGAEEPIVYSDDEEQKMRL LGRVTEAVSGAYLFLYFAKSFVTFQSVFTTW hide sequence

RefSeq Acc Id:

ENSRNOP00000071066 ⟸ ENSRNOT00000079231

RefSeq Acc Id:

ENSRNOP00000017101 ⟸ ENSRNOT00000017101

Protein Domains

Cytochrome b5 heme-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70580-F1-model_v2	AlphaFold	P70580	1-195	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701981

Promoter ID:

EPDNEW_R12504

Type:

multiple initiation site

Name:

Pgrmc1_1

Description:

progesterone receptor membrane component 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	123,205,872 - 123,205,932	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70890	AgrOrtholog
BioCyc Gene	G2FUF-1318	BioCyc
Ensembl Genes	ENSRNOG00000012786	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055025275	UniProtKB/Swiss-Prot
	ENSRNOG00060019057	UniProtKB/Swiss-Prot
	ENSRNOG00065010138	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017101	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000017101.7	UniProtKB/Swiss-Prot
	ENSRNOT00055043581	UniProtKB/Swiss-Prot
	ENSRNOT00060032952	UniProtKB/Swiss-Prot
	ENSRNOT00065016336	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.120.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599449	IMAGE-MGC_LOAD
InterPro	Cyt_B5-like_heme/steroid-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291948	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72462	IMAGE-MGC_LOAD
NCBI Gene	291948	ENTREZGENE
PANTHER	MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pgrmc1	PhenoGen
RatGTEx	ENSRNOG00000012786	RatGTEx
	ENSRNOG00055025275	RatGTEx
	ENSRNOG00060019057	RatGTEx
	ENSRNOG00065010138	RatGTEx
SMART	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55856	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UHK2	ENTREZGENE, UniProtKB/TrEMBL
	A6JMF3	ENTREZGENE, UniProtKB/TrEMBL
	O70606	ENTREZGENE
	P70580	ENTREZGENE, UniProtKB/Swiss-Prot
	Q549C4	ENTREZGENE
UniProt Secondary	O70606	UniProtKB/Swiss-Prot
	Q549C4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Pgrmc1	progesterone receptor membrane component 1			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_drugs	mRNA expression is induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)	70623

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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