Obp2b (odorant binding protein 2B) - Rat Genome Database

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Gene: Obp2b (odorant binding protein 2B) Rattus norvegicus
Analyze
Symbol: Obp2b
Name: odorant binding protein 2B
RGD ID: 708374
Description: Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. Orthologous to human OBP2B (odorant binding protein 2B); INTERACTS WITH alachlor; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Obp2a; Obp2aa; odorant binding protein 2A; odorant-binding protein; odorant-binding protein 2a; Ry2g12
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,960,375 - 28,983,394 (+)NCBIGRCr8
mRatBN7.238,582,074 - 8,585,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,582,074 - 8,585,258 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxPNT010000191.130,986 - 34,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.031,243,692 - 1,246,879 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,468,471 - 18,471,658 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,969,692 - 3,002,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,970,090 - 3,211,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.038,528,160 - 8,543,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.032,951,129 - 2,954,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,934,278 - 3,937,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of putative odorant-binding and odorant-metabolizing proteins. Dear TN, etal., Biochemistry 1991 Oct 29;30(43):10376-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Obp2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,960,375 - 28,983,394 (+)NCBIGRCr8
mRatBN7.238,582,074 - 8,585,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,582,074 - 8,585,258 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxPNT010000191.130,986 - 34,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.031,243,692 - 1,246,879 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,468,471 - 18,471,658 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,969,692 - 3,002,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,970,090 - 3,211,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.038,528,160 - 8,543,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.032,951,129 - 2,954,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,934,278 - 3,937,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map3p13NCBI
OBP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,205,279 - 133,223,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,205,277 - 133,209,250 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,080,666 - 136,084,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,070,487 - 135,074,449 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,110,219 - 133,114,182NCBI
Celera9106,622,026 - 106,625,988 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,573,630 - 105,577,592 (-)NCBIHuRef
CHM1_19136,230,489 - 136,234,451 (-)NCBICHM1_1
T2T-CHM13v2.09145,418,863 - 145,436,839 (-)NCBIT2T-CHM13v2.0
Obp2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,604,120 - 25,630,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,627,021 - 25,630,109 (+)EnsemblGRCm39 Ensembl
GRCm38225,714,109 - 25,740,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,737,009 - 25,740,097 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,592,529 - 25,595,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,558,946 - 25,561,623 (+)NCBIMGSCv36mm8
Celera225,463,235 - 25,466,323 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.91NCBI
OBP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,145,062 - 6,190,646 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,147,397 - 6,189,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,291,500 - 104,331,592 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,939,328 - 132,943,153 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,939,353 - 132,943,117 (-)Ensemblpanpan1.1panPan2
OBP2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,932,868 - 4,935,739 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607910,723,572 - 10,726,322 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Obp2b
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:94
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000037403
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system reproductive system
High
Medium
Low 3
Below cutoff 1 1 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000064437   ⟹   ENSRNOP00000062290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,000,477 - 3,002,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071907   ⟹   ENSRNOP00000067672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,582,074 - 8,585,258 (+)Ensembl
Rnor_6.0 Ensembl32,970,090 - 3,211,910 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080402   ⟹   ENSRNOP00000074582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,167,744 - 3,211,910 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083774   ⟹   ENSRNOP00000070923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,167,792 - 3,180,682 (+)Ensembl
RefSeq Acc Id: NM_173148   ⟹   NP_775171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,186 - 28,983,370 (+)NCBI
mRatBN7.238,582,074 - 8,585,258 (+)NCBI
Rnor_6.032,970,090 - 3,002,956 (+)NCBI
Rnor_5.038,528,160 - 8,543,525 (+)NCBI
RGSC_v3.433,934,278 - 3,937,462 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283182   ⟹   XP_063139252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283183   ⟹   XP_063139253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283184   ⟹   XP_063139254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283185   ⟹   XP_063139255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283186   ⟹   XP_063139256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283187   ⟹   XP_063139257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,979,252 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283188   ⟹   XP_063139258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,979,252 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283189   ⟹   XP_063139259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,979,252 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283190   ⟹   XP_063139260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,979,252 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283191   ⟹   XP_063139261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,385 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283192   ⟹   XP_063139262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,385 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283193   ⟹   XP_063139263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,386 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283194   ⟹   XP_063139264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,446 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283195   ⟹   XP_063139265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,375 - 28,983,394 (+)NCBI
RefSeq Acc Id: XM_063283196   ⟹   XP_063139266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,960,375 - 28,983,394 (+)NCBI
RefSeq Acc Id: XR_010064573
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,980,338 - 28,983,394 (+)NCBI
RefSeq Acc Id: XR_010064574
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,979,252 - 28,983,394 (+)NCBI
RefSeq Acc Id: NP_775171   ⟸   NM_173148
- Peptide Label: precursor
- UniProtKB: M0RDH1 (UniProtKB/TrEMBL),   A6MGQ9 (UniProtKB/TrEMBL),   Q63613 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074582   ⟸   ENSRNOT00000080402
RefSeq Acc Id: ENSRNOP00000070923   ⟸   ENSRNOT00000083774
RefSeq Acc Id: ENSRNOP00000067672   ⟸   ENSRNOT00000071907
RefSeq Acc Id: ENSRNOP00000062290   ⟸   ENSRNOT00000064437
RefSeq Acc Id: XP_063139265   ⟸   XM_063283195
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139266   ⟸   XM_063283196
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139262   ⟸   XM_063283192
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139261   ⟸   XM_063283191
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139263   ⟸   XM_063283193
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139264   ⟸   XM_063283194
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139260   ⟸   XM_063283190
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139259   ⟸   XM_063283189
- Peptide Label: isoform X3
- UniProtKB: A6MGQ9 (UniProtKB/TrEMBL),   M0RDH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139258   ⟸   XM_063283188
- Peptide Label: isoform X3
- UniProtKB: A6MGQ9 (UniProtKB/TrEMBL),   M0RDH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139257   ⟸   XM_063283187
- Peptide Label: isoform X3
- UniProtKB: A6MGQ9 (UniProtKB/TrEMBL),   M0RDH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139256   ⟸   XM_063283186
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139255   ⟸   XM_063283185
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139254   ⟸   XM_063283184
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139252   ⟸   XM_063283182
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139253   ⟸   XM_063283183
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ62-F1-model_v2 AlphaFold A0A0G2JZ62 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708374 AgrOrtholog
BioCyc Gene G2FUF-50416 BioCyc
Ensembl Genes ENSRNOG00000048417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071907 ENTREZGENE
  ENSRNOT00000071907.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  vonEbner_gland UniProtKB/TrEMBL
KEGG Report rno:286933 UniProtKB/TrEMBL
NCBI Gene 286933 ENTREZGENE
PANTHER ODORANT-BINDING PROTEIN 2A-RELATED UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Obp2b PhenoGen
PRINTS VNEBNERGLAND UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048417 RatGTEx
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt A6MGQ9 ENTREZGENE, UniProtKB/TrEMBL
  M0RDH1 ENTREZGENE, UniProtKB/TrEMBL
  Q63613 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Obp2aa  odorant binding protein 2B  Obp2a  odorant binding protein 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Obp2b  odorant binding protein 2B  Obp2aa  odorant binding protein 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Obp2b  odorant binding protein 2B  Ry2g12  odorant-binding protein  Symbol and Name updated 1299863 APPROVED