Cox4i2 (cytochrome c oxidase subunit 4i2) - Rat Genome Database

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Gene: Cox4i2 (cytochrome c oxidase subunit 4i2) Rattus norvegicus
Analyze
Symbol: Cox4i2
Name: cytochrome c oxidase subunit 4i2
RGD ID: 69422
Description: Predicted to enable cytochrome-c oxidase activity. Involved in cellular response to hypoxia. Predicted to be located in mitochondrial membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX IV-2; Cox4b; CoxIV-2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial; cytochrome c oxidase subunit IV; cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit IV isoform 2 (lung); cytochrome c oxidase subunit IV isoform 2 precursor; cytochrome c oxidase subunit IVb; cytochrome c oxidase, subunit 4b; cytochrome c oxidase, subunit IVb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,686,193 - 161,699,605 (+)NCBIGRCr8
mRatBN7.23141,228,443 - 141,239,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,228,443 - 141,239,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,133,387 - 145,144,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,717,214 - 153,728,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,456,966 - 151,467,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,234,546 - 148,245,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,234,193 - 148,245,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,637,397 - 154,648,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,103,348 - 143,114,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,008,969 - 143,019,858 (+)NCBI
Celera3139,977,862 - 139,988,751 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Aras S, etal., Nucleic Acids Res. 2013 Feb 1;41(4):2255-66. doi: 10.1093/nar/gks1454. Epub 2013 Jan 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mammalian subunit IV isoforms of cytochrome c oxidase. Huttemann M, etal., Gene 2001 Apr 4;267(1):111-23.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect? Prior LJ, etal., Int J Obes (Lond). 2008 Aug 26.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. Shteyer E, etal., Am J Hum Genet. 2009 Mar;84(3):412-7. doi: 10.1016/j.ajhg.2009.02.006. Epub 2009 Mar 5.
16. Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes. Singh S, etal., Glia. 2009 Nov 1;57(14):1480-91. doi: 10.1002/glia.20864.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11980919   PMID:14651853   PMID:17923681   PMID:18614015   PMID:21641552   PMID:29991768  


Genomics

Comparative Map Data
Cox4i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,686,193 - 161,699,605 (+)NCBIGRCr8
mRatBN7.23141,228,443 - 141,239,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,228,443 - 141,239,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,133,387 - 145,144,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,717,214 - 153,728,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,456,966 - 151,467,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,234,546 - 148,245,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,234,193 - 148,245,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,637,397 - 154,648,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,103,348 - 143,114,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,008,969 - 143,019,858 (+)NCBI
Celera3139,977,862 - 139,988,751 (+)NCBICelera
Cytogenetic Map3q41NCBI
COX4I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,637,912 - 31,645,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,637,912 - 31,645,006 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,225,715 - 30,232,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,689,352 - 29,696,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,689,351 - 29,696,461NCBI
Celera2026,982,036 - 26,989,145 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,014,417 - 27,021,500 (+)NCBIHuRef
CHM1_12030,129,576 - 30,136,686 (+)NCBICHM1_1
T2T-CHM13v2.02033,362,179 - 33,369,276 (+)NCBIT2T-CHM13v2.0
Cox4i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,596,093 - 152,606,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,596,093 - 152,606,957 (+)EnsemblGRCm39 Ensembl
GRCm382152,753,916 - 152,765,039 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,754,173 - 152,765,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,579,909 - 152,590,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,445,614 - 152,456,478 (+)NCBIMGSCv36mm8
Celera2158,570,176 - 158,581,023 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
LOC102018506
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,320,720 - 29,329,127 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,320,720 - 29,329,082 (-)NCBIChiLan1.0ChiLan1.0
LOC100980404
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,324,893 - 37,338,299 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,318,011 - 37,331,411 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,927,883 - 27,935,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,060,321 - 29,067,448 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,061,447 - 29,067,440 (+)Ensemblpanpan1.1panPan2
COX4I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,122,033 - 21,128,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,120,213 - 21,128,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,769,248 - 20,775,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,808,912 - 21,815,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,809,986 - 21,815,167 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,086,709 - 21,092,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,191,943 - 21,198,224 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,622,189 - 21,628,661 (+)NCBIUU_Cfam_GSD_1.0
LOC101956526
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,200,494 - 170,207,563 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648518,631,826 - 18,637,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX4I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,341,889 - 35,346,090 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COX4I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,031,595 - 36,041,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,032,458 - 36,041,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,877,032 - 90,886,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714003
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741850,551 - 861,313 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741852,104 - 863,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox4i2
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:70
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000010418
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 29 2 2 2 8 29 11
Low 2 14 43 27 19 27 8 11 74 27 12 8
Below cutoff 12 12 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010418   ⟹   ENSRNOP00000010418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,228,443 - 141,239,331 (+)Ensembl
Rnor_6.0 Ensembl3148,234,193 - 148,245,416 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118018   ⟹   ENSRNOP00000082539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,228,884 - 141,239,331 (+)Ensembl
RefSeq Acc Id: NM_053472   ⟹   NP_445924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,688,714 - 161,699,602 (+)NCBI
mRatBN7.23141,228,443 - 141,239,331 (+)NCBI
Rnor_6.03148,234,546 - 148,245,418 (+)NCBI
Rnor_5.03154,637,397 - 154,648,541 (+)NCBI
RGSC_v3.43143,103,348 - 143,114,236 (+)RGD
Celera3139,977,862 - 139,988,751 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235280   ⟹   XP_006235342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,689,025 - 161,699,605 (+)NCBI
mRatBN7.23141,228,754 - 141,239,337 (+)NCBI
Rnor_6.03148,234,857 - 148,245,424 (+)NCBI
Rnor_5.03154,637,397 - 154,648,541 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592079   ⟹   XP_017447568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,689,201 - 161,699,605 (+)NCBI
mRatBN7.23141,228,908 - 141,239,337 (+)NCBI
Rnor_6.03148,235,011 - 148,245,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105994   ⟹   XP_038961922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,689,304 - 161,699,605 (+)NCBI
mRatBN7.23141,228,915 - 141,239,337 (+)NCBI
RefSeq Acc Id: XM_063284730   ⟹   XP_063140800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,689,023 - 161,699,605 (+)NCBI
RefSeq Acc Id: XM_063284731   ⟹   XP_063140801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,686,193 - 161,699,605 (+)NCBI
RefSeq Acc Id: XM_063284732   ⟹   XP_063140802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,691,385 - 161,699,605 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445924   ⟸   NM_053472
- Peptide Label: isoform 2 precursor
- UniProtKB: Q91Y94 (UniProtKB/Swiss-Prot),   A6KHQ9 (UniProtKB/TrEMBL),   A0A8L2UI91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235342   ⟸   XM_006235280
- Peptide Label: isoform X2
- UniProtKB: Q91Y94 (UniProtKB/Swiss-Prot),   A6KHQ9 (UniProtKB/TrEMBL),   A0A8L2UI91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447568   ⟸   XM_017592079
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVG3 (UniProtKB/TrEMBL),   A6KHQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010418   ⟸   ENSRNOT00000010418
RefSeq Acc Id: XP_038961922   ⟸   XM_039105994
- Peptide Label: isoform X2
- UniProtKB: Q91Y94 (UniProtKB/Swiss-Prot),   A6KHQ9 (UniProtKB/TrEMBL),   A0A8L2UI91 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082539   ⟸   ENSRNOT00000118018
RefSeq Acc Id: XP_063140801   ⟸   XM_063284731
- Peptide Label: isoform X2
- UniProtKB: Q91Y94 (UniProtKB/Swiss-Prot),   A6KHQ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140800   ⟸   XM_063284730
- Peptide Label: isoform X2
- UniProtKB: Q91Y94 (UniProtKB/Swiss-Prot),   A6KHQ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140802   ⟸   XM_063284732
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91Y94-F1-model_v2 AlphaFold Q91Y94 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692550
Promoter ID:EPDNEW_R3074
Type:initiation region
Name:Cox4i2_1
Description:cytochrome c oxidase subunit 4i2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,234,516 - 148,234,576EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69422 AgrOrtholog
BioCyc Gene G2FUF-47249 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000007827 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010418 ENTREZGENE
  ENSRNOT00000010418.6 UniProtKB/TrEMBL
  ENSRNOT00000118018.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.442.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_su4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84683 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10707 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cox4i2 PhenoGen
PRINTS CYTCOXIDASE4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007827 RatGTEx
Superfamily-SCOP SSF81406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205515
UniProt A0A8I5ZVG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UI91 ENTREZGENE, UniProtKB/TrEMBL
  A6KHQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KHQ9 ENTREZGENE, UniProtKB/TrEMBL
  COX42_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox4i2  cytochrome c oxidase subunit 4i2  Cox4i2  cytochrome c oxidase subunit IV isoform 2 (lung)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Cox4i2  cytochrome c oxidase subunit IV isoform 2 (lung)  Cox4i2  cytochrome c oxidase subunit IV isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cox4i2  cytochrome c oxidase subunit IV isoform 2  Cox4b  cytochrome c oxidase, subunit 4b  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cox4b  cytochrome c oxidase, subunit 4b      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is abundant in lung and found at low levels in heart, brain and spleen 68709
gene_function cytochrome c oxidase subunit, which catalyzes the transfer of electrons from cytochrome c to dioxygen 68709
gene_process functions in the terminal respiration chain 68709