Fxyd1 (FXYD domain-containing ion transport regulator 1) - Rat Genome Database

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Gene: Fxyd1 (FXYD domain-containing ion transport regulator 1) Rattus norvegicus
Analyze
Symbol: Fxyd1
Name: FXYD domain-containing ion transport regulator 1
RGD ID: 69306
Description: Enables ATPase binding activity and myosin binding activity. Involved in positive regulation of transport; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Biomarker of congestive heart failure. Orthologous to human FXYD1 (FXYD domain containing ion transport regulator 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phospholemman; Plm; sodium/potassium-transporting ATPase subunit FXYD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,414,556 - 95,418,645 (-)NCBIGRCr8
mRatBN7.2186,287,163 - 86,291,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,287,165 - 86,291,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,707,554 - 91,711,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,173,699 - 100,177,749 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,465,832 - 93,469,879 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,484,197 - 89,488,279 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,639,290 - 90,643,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,095,551 - 86,098,079 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,173,662 - 86,176,167 (-)NCBI
Celera180,656,116 - 80,660,202 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
kainic acid  (ISO)
lead(0)  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pioglitazone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of an endogenous inhibitor of the cardiac Na+/Ca2+ exchanger, phospholemman. Ahlers BA, etal., J Biol Chem. 2005 May 20;280(20):19875-82. Epub 2005 Mar 17.
2. Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. Chen LS, etal., Genomics 1997 May 1;41(3):435-43.
3. Overexpression of the Na+/K+ ATPase alpha2 but not alpha1 isoform attenuates pathological cardiac hypertrophy and remodeling. Correll RN, etal., Circ Res. 2014 Jan 17;114(2):249-56. doi: 10.1161/CIRCRESAHA.114.302293. Epub 2013 Nov 11.
4. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. Feschenko MS, etal., J Neurosci. 2003 Mar 15;23(6):2161-9.
5. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. Fuller W, etal., FASEB J. 2004 Jan;18(1):197-9. Epub 2003 Nov 3.
6. FXYD1, a modulator of Na,K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability. Garcia-Rudaz C, etal., J Neuroendocrinol. 2009 Feb;21(2):108-22. doi: 10.1111/j.1365-2826.2008.01812.x.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman. Hafver TL, etal., J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Effects of phospholemman downregulation on contractility and [Ca(2+)]i transients in adult rat cardiac myocytes. Mirza MA, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1322-30. Epub 2003 Dec 18.
12. Reduction of phospholemman expression decreases osmosensitive taurine efflux in astrocytes. Moran J, etal., Biochim Biophys Acta. 2001 Apr 23;1538(2-3):313-20.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Expression of phospholemman and its association with Na+-K+-ATPase in skeletal muscle: effects of aging and exercise training. Reis J, etal., J Appl Physiol (1985). 2005 Oct;99(4):1508-15. Epub 2005 Jun 16.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes. Song J, etal., Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H576-83.
18. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ and Rael E, Genomics 2000 Aug 15;68(1):41-56.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus. Wetzel RK and Sweadner KJ, Am J Physiol Renal Physiol. 2003 Jul;285(1):F121-9. Epub 2003 Mar 25.
21. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle. Wypijewski KJ, etal., J Biol Chem. 2013 May 10;288(19):13808-20. doi: 10.1074/jbc.M113.460956. Epub 2013 Mar 26.
Additional References at PubMed
PMID:1710217   PMID:9486665   PMID:12169672   PMID:12606048   PMID:15563542   PMID:15653756   PMID:16373350   PMID:16921169   PMID:17095720   PMID:19339511   PMID:21325644   PMID:21454534  
PMID:21849407   PMID:21868384   PMID:22442718  


Genomics

Comparative Map Data
Fxyd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,414,556 - 95,418,645 (-)NCBIGRCr8
mRatBN7.2186,287,163 - 86,291,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,287,165 - 86,291,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,707,554 - 91,711,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,173,699 - 100,177,749 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,465,832 - 93,469,879 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,484,197 - 89,488,279 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,639,290 - 90,643,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,095,551 - 86,098,079 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,173,662 - 86,176,167 (-)NCBI
Celera180,656,116 - 80,660,202 (-)NCBICelera
Cytogenetic Map1q21NCBI
FXYD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,137,188 - 35,143,109 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,138,824 - 35,143,109 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,629,728 - 35,634,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,321,572 - 40,325,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,321,571 - 40,325,793NCBI
Celera1932,343,168 - 32,347,389 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,137,604 - 32,141,943 (+)NCBIHuRef
CHM1_11935,631,706 - 35,635,892 (+)NCBICHM1_1
T2T-CHM13v2.01937,681,906 - 37,687,737 (+)NCBIT2T-CHM13v2.0
Fxyd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,751,103 - 30,758,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,751,103 - 30,756,624 (-)EnsemblGRCm39 Ensembl
GRCm38731,051,678 - 31,055,873 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl731,051,678 - 31,057,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,836,697 - 31,840,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,760,440 - 30,764,415 (-)NCBIMGSCv36mm8
Celera725,619,198 - 25,623,176 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.29NCBI
Fxyd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,457,985 - 4,460,528 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,456,909 - 4,460,895 (+)NCBIChiLan1.0ChiLan1.0
FXYD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,151,080 - 41,155,360 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,134,412 - 43,138,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,080,180 - 32,089,141 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,821,536 - 40,827,352 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,824,448 - 40,827,039 (+)Ensemblpanpan1.1panPan2
FXYD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,436,239 - 117,440,619 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,430,865 - 117,439,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,836,898 - 116,841,243 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01118,033,833 - 118,038,215 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,033,833 - 118,037,313 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,596,446 - 117,600,789 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,221,771 - 117,226,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,278,254 - 118,282,589 (-)NCBIUU_Cfam_GSD_1.0
Fxyd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,526,623 - 10,528,799 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,117,816 - 1,118,860 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,117,083 - 1,121,059 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXYD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,071,852 - 30,076,012 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,073,136 - 30,075,699 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,845,205 - 7,849,364 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxyd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,368,519 - 8,371,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,368,519 - 8,372,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fxyd1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000028624
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 39 27 16 27 8 11 38 28 36 11 8
Low 18 14 3 14 34 7 5
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB712570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM109156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028624   ⟹   ENSRNOP00000028624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,287,166 - 86,291,202 (-)Ensembl
Rnor_6.0 Ensembl189,484,199 - 89,488,223 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102674   ⟹   ENSRNOP00000083421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,287,167 - 86,291,278 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107868   ⟹   ENSRNOP00000080325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,287,167 - 86,290,329 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109818   ⟹   ENSRNOP00000079164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,287,165 - 86,291,249 (-)Ensembl
RefSeq Acc Id: NM_031648   ⟹   NP_113836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,580 (-)NCBI
mRatBN7.2186,287,165 - 86,291,191 (-)NCBI
Rnor_6.0189,484,199 - 89,488,223 (-)NCBI
Rnor_5.0190,639,290 - 90,643,385 (-)NCBI
RGSC_v3.4186,095,551 - 86,098,079 (-)RGD
Celera180,656,116 - 80,660,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228839   ⟹   XP_006228901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,767 (-)NCBI
mRatBN7.2186,287,163 - 86,290,374 (-)NCBI
Rnor_6.0189,484,197 - 89,487,404 (-)NCBI
Rnor_5.0190,639,290 - 90,643,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589629   ⟹   XP_017445118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,619 (-)NCBI
mRatBN7.2186,287,163 - 86,291,129 (-)NCBI
Rnor_6.0189,484,197 - 89,488,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589630   ⟹   XP_017445119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,753 (-)NCBI
mRatBN7.2186,287,163 - 86,290,345 (-)NCBI
Rnor_6.0189,484,197 - 89,487,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589631   ⟹   XP_017445120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,638 (-)NCBI
mRatBN7.2186,287,163 - 86,291,243 (-)NCBI
Rnor_6.0189,484,197 - 89,488,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088778   ⟹   XP_038944706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,638 (-)NCBI
mRatBN7.2186,287,163 - 86,291,478 (-)NCBI
RefSeq Acc Id: XM_039088782   ⟹   XP_038944710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,645 (-)NCBI
mRatBN7.2186,287,163 - 86,291,129 (-)NCBI
RefSeq Acc Id: XM_063272174   ⟹   XP_063128244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,628 (-)NCBI
RefSeq Acc Id: XM_063272182   ⟹   XP_063128252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,417,735 (-)NCBI
RefSeq Acc Id: XM_063272185   ⟹   XP_063128255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,617 (-)NCBI
RefSeq Acc Id: XM_063272192   ⟹   XP_063128262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,414,556 - 95,418,641 (-)NCBI
Protein Sequences
Protein RefSeqs NP_113836 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228901 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445118 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445119 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445120 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944706 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944710 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128244 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128252 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128255 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128262 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53169 (Get FASTA)   NCBI Sequence Viewer  
  EDM07670 (Get FASTA)   NCBI Sequence Viewer  
  EDM07671 (Get FASTA)   NCBI Sequence Viewer  
  EDM07672 (Get FASTA)   NCBI Sequence Viewer  
  EDM07673 (Get FASTA)   NCBI Sequence Viewer  
  EDM07674 (Get FASTA)   NCBI Sequence Viewer  
  EDM07675 (Get FASTA)   NCBI Sequence Viewer  
  EDM07676 (Get FASTA)   NCBI Sequence Viewer  
  EDM07677 (Get FASTA)   NCBI Sequence Viewer  
  EDM07678 (Get FASTA)   NCBI Sequence Viewer  
  EDM07679 (Get FASTA)   NCBI Sequence Viewer  
  EDM07680 (Get FASTA)   NCBI Sequence Viewer  
  EDM07681 (Get FASTA)   NCBI Sequence Viewer  
  EDM07682 (Get FASTA)   NCBI Sequence Viewer  
  EDM07683 (Get FASTA)   NCBI Sequence Viewer  
  EDM07684 (Get FASTA)   NCBI Sequence Viewer  
  EDM07685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028624
  ENSRNOP00000028624.2
  ENSRNOP00000079164
  ENSRNOP00000079164.1
  ENSRNOP00000080325.1
  ENSRNOP00000083421.1
GenBank Protein O08589 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_113836   ⟸   NM_031648
- Peptide Label: precursor
- UniProtKB: A0A0H2UHS8 (UniProtKB/TrEMBL),   A6JA55 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228901   ⟸   XM_006228839
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445120   ⟸   XM_017589631
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445118   ⟸   XM_017589629
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G4X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445119   ⟸   XM_017589630
- Peptide Label: isoform X3
- UniProtKB: A6JA56 (UniProtKB/TrEMBL),   A0A8I5ZW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028624   ⟸   ENSRNOT00000028624
RefSeq Acc Id: XP_038944706   ⟸   XM_039088778
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944710   ⟸   XM_039088782
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000083421   ⟸   ENSRNOT00000102674
RefSeq Acc Id: ENSRNOP00000079164   ⟸   ENSRNOT00000109818
RefSeq Acc Id: ENSRNOP00000080325   ⟸   ENSRNOT00000107868
RefSeq Acc Id: XP_063128262   ⟸   XM_063272192
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128244   ⟸   XM_063272174
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G4X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128255   ⟸   XM_063272185
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128252   ⟸   XM_063272182
- Peptide Label: isoform X5
- UniProtKB: O08589 (UniProtKB/Swiss-Prot),   A6JA62 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08589-F1-model_v2 AlphaFold O08589 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689942
Promoter ID:EPDNEW_R467
Type:initiation region
Name:Fxyd1_1
Description:FXYD domain-containing ion transport regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,488,234 - 89,488,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69306 AgrOrtholog
BioCyc Gene G2FUF-60049 BioCyc
Ensembl Genes ENSRNOG00000021079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028624 ENTREZGENE
  ENSRNOT00000028624.5 UniProtKB/TrEMBL
  ENSRNOT00000102674.1 UniProtKB/TrEMBL
  ENSRNOT00000107868.1 UniProtKB/TrEMBL
  ENSRNOT00000109818.1 UniProtKB/TrEMBL
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FXYD_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion-transport_regulator_FXYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58971 UniProtKB/TrEMBL
NCBI Gene 58971 ENTREZGENE
PANTHER PHOSPHOLEMMAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP1G1_PLM_MAT8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fxyd1 PhenoGen
PROSITE FXYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021079 RatGTEx
TIGR TC229427
UniProt A0A0H2UHS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPC3_RAT UniProtKB/TrEMBL
  A0A8I5ZW12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G4X1 ENTREZGENE, UniProtKB/TrEMBL
  A6JA49_RAT UniProtKB/TrEMBL
  A6JA50_RAT UniProtKB/TrEMBL
  A6JA51_RAT UniProtKB/TrEMBL
  A6JA52_RAT UniProtKB/TrEMBL
  A6JA53_RAT UniProtKB/TrEMBL
  A6JA55 ENTREZGENE, UniProtKB/TrEMBL
  A6JA56 ENTREZGENE, UniProtKB/TrEMBL
  A6JA59_RAT UniProtKB/TrEMBL
  A6JA62 ENTREZGENE, UniProtKB/TrEMBL
  A6JA64_RAT UniProtKB/TrEMBL
  O08589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fxyd1  FXYD domain-containing ion transport regulator 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains FXYD (prolinephenylalanineXtyrosineaspartate) motif 632671
gene_function a major substrate for protein kinases A and C in heart and skeletal muscle 625647
gene_mutations_overexpression a major substrate for protein kinases A and C in heart and skeletal muscle  
gene_product member of the FXYD gene family of small ion transport regulators 625647
gene_protein 72 amino -acid 625647