Socs1 (suppressor of cytokine signaling 1) - Rat Genome Database

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Gene: Socs1 (suppressor of cytokine signaling 1) Rattus norvegicus
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Symbol: Socs1
Name: suppressor of cytokine signaling 1
RGD ID: 69272
Description: Predicted to enable insulin-like growth factor receptor binding activity; kinase regulator activity; and protein kinase binding activity. Involved in several processes, including cellular response to thyrotropin-releasing hormone; negative regulation of hepatic stellate cell proliferation; and positive regulation of fibroblast apoptotic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Biomarker of liver disease (multiple); myocardial infarction; obesity; rheumatic heart disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1); PARTICIPATES IN insulin signaling pathway; interleukin-12 signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cish1; cytokine inducible SH2-containing protein 1; Socs-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,389,574 - 5,391,265 (+)NCBIGRCr8
mRatBN7.2104,882,651 - 4,884,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,882,560 - 4,884,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,579,226 - 9,580,917 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,100,342 - 9,102,033 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,738,623 - 4,740,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,956,795 - 4,958,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,782,936 - 3,783,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,819,971 - 4,820,609 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,819,970 - 4,820,609 (+)NCBI
Celera103,904,246 - 3,905,811 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
alcoholic hepatitis  (IEP)
allergic contact dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Breast Neoplasms  (ISO)
Charcot-Marie-Tooth disease type 1C  (ISO)
colitis  (ISO)
colon cancer  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IDA)
diffuse large B-cell lymphoma  (ISO)
ductal carcinoma in situ  (ISO)
Dysbiosis  (ISO)
Endotoxemia  (ISO)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Autoinflammatory Syndrome, with or without Immunodeficiency  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IEP,ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypertriglyceridemia  (ISO)
Immuno-Hemolytic Anemia  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
invasive ductal carcinoma  (ISO)
Landau-Kleffner syndrome  (ISO)
laryngeal carcinoma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
MHC class II deficiency  (ISO)
myocardial infarction  (IEP)
Neuralgia  (IEP)
obesity  (IEP)
ovarian carcinoma  (ISO)
prostate cancer  (ISO)
Reperfusion Injury  (ISO)
rheumatic heart disease  (IEP)
Sepsis  (IEP)
steatotic liver disease  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia due to platelet alloimmunization  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IEP)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antigen  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lomustine  (ISO)
manganese(II) chloride  (EXP)
muramyl dipeptide  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phosphane  (EXP)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (ISO)
pyridaben  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulpiride  (EXP)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to lipopolysaccharide  (IEP)
cellular response to organic cyclic compound  (IDA)
cellular response to thyrotropin-releasing hormone  (IEP)
cellular response to type II interferon  (IEP)
cellular response to vascular endothelial growth factor stimulus  (IEP)
cytokine-mediated signaling pathway  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
intracellular signal transduction  (IEA)
macrophage differentiation  (IEA,ISO)
negative regulation of CD8-positive, alpha-beta T cell differentiation  (IEA,ISO,ISS)
negative regulation of hepatic stellate cell proliferation  (IMP)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA,IEA)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IEA,ISO,ISS)
positive regulation of fibroblast apoptotic process  (IMP)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
protein ubiquitination  (IEA)
regulation of cytokine production  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to cytokine  (IEP)
response to erythropoietin  (IEP)
response to estradiol  (IEP)
response to lipopolysaccharide  (IEP)
response to peptide hormone  (IEP)
response to progesterone  (IEP)
response to xenobiotic stimulus  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lack of prognostic significance of SOCS-1 expression in colorectal adenocarcinomas. Ayyildiz T, etal., Asian Pac J Cancer Prev. 2014;15(19):8469-74. doi: 10.7314/apjcp.2014.15.19.8469.
2. Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Bagnyukova TV, etal., Cell Cycle. 2008 Oct;7(20):3202-10. doi: 10.4161/cc.7.20.6816. Epub 2008 Oct 18.
3. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Carper MJ, etal., Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. Epub 2008 Jan 2.
4. Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease. Chen A, etal., Int J Mol Med. 2020 Feb;45(2):429-440. doi: 10.3892/ijmm.2019.4420. Epub 2019 Dec 6.
5. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Chen CY, etal., Genes Chromosomes Cancer. 2003 Jul;37(3):300-5. doi: 10.1002/gcc.10222.
6. VEGF-C attenuates ischemia reperfusion injury of liver graft in rats. Cheng MX, etal., Transpl Immunol. 2019 Jun;54:59-64. doi: 10.1016/j.trim.2019.02.004. Epub 2019 Feb 13.
7. Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction. Chong MM, etal., J Immunol. 2004 May 1;172(9):5714-21. doi: 10.4049/jimmunol.172.9.5714.
8. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer. Deng Y, etal., Life Sci. 2021 Aug 1;278:119491. doi: 10.1016/j.lfs.2021.119491. Epub 2021 Apr 13.
9. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Friedrich MG, etal., Eur J Cancer. 2005 Nov;41(17):2769-78. Epub 2005 Oct 19.
10. [DNA methylation on urinalysis and as a prognostic marker in urothelial cancer of the bladder]. Friedrich MG, etal., Urologe A. 2007 Jul;46(7):761-8.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice. Gendo Y, etal., Inflamm Intest Dis. 2019 Feb;3(3):145-154. doi: 10.1159/000495462. Epub 2019 Jan 10.
13. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Hanada T, etal., Immunity. 2003 Sep;19(3):437-50. doi: 10.1016/s1074-7613(03)00240-1.
14. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. Hanada T, etal., J Exp Med. 2006 Jun 12;203(6):1391-7. doi: 10.1084/jem.20060436. Epub 2006 May 22.
15. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Hashimoto M, etal., Cancer Sci. 2009 Apr;100(4):730-6. doi: 10.1111/j.1349-7006.2009.01098.x.
16. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
17. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
18. Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. Hussain S, etal., J Recept Signal Transduct Res. 2011 Apr;31(2):147-56. doi: 10.3109/10799893.2011.553836.
19. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Jiang S, etal., Cancer Res. 2010 Apr 15;70(8):3119-27. doi: 10.1158/0008-5472.CAN-09-4250. Epub 2010 Mar 30.
20. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
21. Promoter methylation and expression of SOCS-1 affect clinical outcome and epithelial-mesenchymal transition in colorectal cancer. Kang XC, etal., Biomed Pharmacother. 2016 May;80:23-29. doi: 10.1016/j.biopha.2016.02.011. Epub 2016 Mar 14.
22. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
23. LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer. Li F, etal., Cancer Biother Radiopharm. 2020 Feb;35(1):72-76. doi: 10.1089/cbr.2019.2898. Epub 2020 Jan 7.
24. microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis via the MAPK Signaling Pathway Through Targeting SOCS1. Liu D, etal., Front Pharmacol. 2020 Apr 7;11:270. doi: 10.3389/fphar.2020.00270. eCollection 2020.
25. Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma. Liu L, etal., Gene Ther. 2013 Jan;20(1):84-92. doi: 10.1038/gt.2012.4. Epub 2012 Feb 9.
26. Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6. Liu SZ, etal., Dig Dis Sci. 2017 Jan;62(1):105-114. doi: 10.1007/s10620-016-4277-0. Epub 2016 Aug 18.
27. Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. Liu Y, etal., J Immunol. 2008 May 1;180(9):6270-8.
28. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
29. Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. Mafanda EK, etal., Cytokine. 2019 Dec;124:154501. doi: 10.1016/j.cyto.2018.07.032. Epub 2018 Aug 8.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling. Miki T, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):68-75. Epub 2005 Dec 23.
32. Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma. Miyoshi H, etal., J Gastroenterol. 2004 Jun;39(6):563-9. doi: 10.1007/s00535-003-1343-0.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
35. Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. Okochi O, etal., Clin Cancer Res. 2003 Nov 1;9(14):5295-8.
36. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
37. Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Park ES, etal., Mol Endocrinol. 2000 Mar;14(3):440-8. doi: 10.1210/mend.14.3.0433.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
41. GOA pipeline RGD automated data pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Comprehensive gene review and curation RGD comprehensive gene curation
44. Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats. Sakuda S, etal., J Hepatol. 2002 Mar;36(3):378-84.
45. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma. Starska K, etal., Folia Histochem Cytobiol. 2009 Jan;47(3):401-10. doi: 10.2478/v10042-009-0075-2.
46. Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Steyn FJ, etal., Endocrinology. 2008 Jun;149(6):3206-14. Epub 2008 Mar 6.
47. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Sugase T, etal., Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.
48. Long noncoding RNA CASC2 suppresses esophageal squamous cell carcinoma progression by increasing SOCS1 expression. Sun K and Zhang G, Cell Biosci. 2019 Nov 9;9:90. doi: 10.1186/s13578-019-0353-4. eCollection 2019.
49. Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Sutherland KD, etal., Oncogene. 2004 Oct 7;23(46):7726-33.
50. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Suzuki M, etal., Cancer Lett. 2006 Oct 28;242(2):222-30. Epub 2006 Feb 3.
51. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
52. Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta. Toba H, etal., Eur J Pharmacol. 2012 Sep 15;691(1-3):190-7. doi: 10.1016/j.ejphar.2012.07.018. Epub 2012 Jul 14.
53. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
54. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
55. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
56. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
57. Effect of SOCS1 on diabetic renal injury through regulating TLR signaling pathway. Wu XY, etal., Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):8068-8074. doi: 10.26355/eurrev_201909_19023.
58. Inhibition of MicroRNA-221 Alleviates Neuropathic Pain Through Targeting Suppressor of Cytokine Signaling 1. Xia L, etal., J Mol Neurosci. 2016 Jul;59(3):411-20. doi: 10.1007/s12031-016-0748-1. Epub 2016 Apr 8.
59. The inhibitory effect of Gualou Guizhi Decoction on post-ischemic neuroinflammation via miR-155 in MCAO rats. Yang J, etal., Ann Palliat Med. 2021 Feb;10(2):1370-1379. doi: 10.21037/apm-20-518. Epub 2020 Oct 16.
60. Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection. Yu CR, etal., Inflammation. 2015 Apr;38(2):555-65. doi: 10.1007/s10753-014-9962-6.
61. Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1. Zhang M, etal., J Immunol. 2011 Aug 15;187(4):1674-83. doi: 10.4049/jimmunol.1001937. Epub 2011 Jul 8.
Additional References at PubMed
PMID:8720108   PMID:9202126   PMID:9202127   PMID:9727029   PMID:9889194   PMID:10679190   PMID:11342531   PMID:11371356   PMID:11606785   PMID:11854514   PMID:14522994   PMID:16127460  
PMID:16956890   PMID:19080716   PMID:19100470   PMID:19135225   PMID:19176113   PMID:19344732   PMID:20185635   PMID:20519071   PMID:20519645   PMID:20548288   PMID:20832564   PMID:21364493  
PMID:21606371   PMID:22302831   PMID:22387553   PMID:22875468   PMID:23222907   PMID:24091940   PMID:24376119   PMID:24660535   PMID:24880459   PMID:25019494   PMID:25488154   PMID:25847945  
PMID:26617805   PMID:28036111   PMID:28331994   PMID:28842621   PMID:29854745   PMID:30972748   PMID:32587662   PMID:35124149   PMID:36222378   PMID:37219532  


Genomics

Comparative Map Data
Socs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,389,574 - 5,391,265 (+)NCBIGRCr8
mRatBN7.2104,882,651 - 4,884,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,882,560 - 4,884,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,579,226 - 9,580,917 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,100,342 - 9,102,033 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,738,623 - 4,740,314 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,956,795 - 4,958,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,782,936 - 3,783,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,819,971 - 4,820,609 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,819,970 - 4,820,609 (+)NCBI
Celera103,904,246 - 3,905,811 (+)NCBICelera
Cytogenetic Map10q11NCBI
SOCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,254,417 - 11,256,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,254,417 - 11,256,204 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,348,274 - 11,350,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,255,775 - 11,257,540 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,255,774 - 11,257,540NCBI
Celera1611,517,679 - 11,519,444 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,266,017 - 11,267,782 (-)NCBIHuRef
CHM1_11611,348,201 - 11,349,966 (-)NCBICHM1_1
T2T-CHM13v2.01611,290,646 - 11,292,433 (-)NCBIT2T-CHM13v2.0
Socs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,601,672 - 10,603,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,600,104 - 10,603,400 (-)EnsemblGRCm39 Ensembl
GRCm381610,783,808 - 10,785,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,783,901 - 10,785,629 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,697,386 - 10,699,114 (-)NCBIMGSCv36mm8
Celera1611,411,246 - 11,412,974 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.81NCBI
Socs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,321,337 - 7,323,109 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,321,337 - 7,323,109 (+)NCBIChiLan1.0ChiLan1.0
SOCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,801,785 - 11,806,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,578,424 - 15,580,662 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,196,432 - 10,198,205 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SOCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,511,003 - 31,511,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,509,268 - 31,511,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,893,176 - 32,894,903 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,692,882 - 31,694,609 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1631,506,103 - 31,507,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,380,389 - 31,382,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,804,768 - 31,806,494 (+)NCBIUU_Cfam_GSD_1.0
Socs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,469,049 - 111,470,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365309,312,965 - 9,316,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365309,312,965 - 9,315,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,881,225 - 31,884,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,879,143 - 31,883,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,670,021 - 32,674,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,731,866 - 10,733,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,732,350 - 10,732,991 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,430,111 - 19,432,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,444,877 - 8,446,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Socs1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:111
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000003458
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1034063205387112Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat

Markers in Region
U88325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,884,050 - 4,884,151 (+)MAPPERmRatBN7.2
Rnor_6.0104,958,181 - 4,958,281NCBIRnor6.0
Rnor_5.0103,783,702 - 3,783,802UniSTSRnor5.0
RGSC_v3.4104,820,737 - 4,820,837UniSTSRGSC3.4
Celera103,905,520 - 3,905,620UniSTS
Cytogenetic Map10q11UniSTS
RH143234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,883,872 - 4,884,157 (+)MAPPERmRatBN7.2
Rnor_6.0104,958,003 - 4,958,287NCBIRnor6.0
Rnor_5.0103,783,524 - 3,783,808UniSTSRnor5.0
RGSC_v3.4104,820,559 - 4,820,843UniSTSRGSC3.4
Celera103,905,342 - 3,905,626UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 7 9 13
Low 2 43 30 21 10 21 6 9 74 35 28 11 6
Below cutoff 20 20 20 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003458   ⟹   ENSRNOP00000003458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl104,882,560 - 4,884,383 (+)Ensembl
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)Ensembl
RefSeq Acc Id: NM_145879   ⟹   NP_665886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,389,574 - 5,391,265 (+)NCBI
mRatBN7.2104,882,651 - 4,884,342 (+)NCBI
Rnor_6.0104,956,795 - 4,958,472 (+)NCBI
Rnor_5.0103,782,936 - 3,783,574 (+)NCBI
RGSC_v3.4104,819,971 - 4,820,609 (+)RGD
Celera103,904,246 - 3,905,811 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_665886 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB64204 (Get FASTA)   NCBI Sequence Viewer  
  EDL96211 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003458
  ENSRNOP00000003458.1
GenBank Protein Q9QX78 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_665886   ⟸   NM_145879
- UniProtKB: Q9QX78 (UniProtKB/Swiss-Prot),   G3V6B4 (UniProtKB/TrEMBL),   A6K4I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003458   ⟸   ENSRNOT00000003458
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX78-F1-model_v2 AlphaFold Q9QX78 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69272 AgrOrtholog
BioCyc Gene G2FUF-26140 BioCyc
Ensembl Genes ENSRNOG00000002568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003458 ENTREZGENE
  ENSRNOT00000003458.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS1_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252971 UniProtKB/TrEMBL
NCBI Gene 252971 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10155:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Socs1 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002568 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217532
UniProt A6K4I9 ENTREZGENE, UniProtKB/TrEMBL
  G3V6B4 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX78 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-22 Socs1  suppressor of cytokine signaling 1  Cish1  cytokine inducible SH2-containing protein 1  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-06-10 Cish1  cytokine inducible SH2-containing protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of a family of negative regulators of cytokine signalling 634751