Ahcy (adenosylhomocysteinase) - Rat Genome Database

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Gene: Ahcy (adenosylhomocysteinase) Rattus norvegicus
Analyze
Symbol: Ahcy
Name: adenosylhomocysteinase
RGD ID: 69260
Description: Enables NAD binding activity; adenosylhomocysteinase activity; and identical protein binding activity. Involved in several processes, including S-adenosylhomocysteine catabolic process; chronic inflammatory response to antigenic stimulus; and circadian sleep/wake cycle. Predicted to be located in endoplasmic reticulum; melanosome; and nucleus. Predicted to be active in cytosol. Used to study hyperhomocysteinemia and pyridoxine deficiency anemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase); PARTICIPATES IN methionine cycle/metabolic pathway; choline metabolic pathway; glycine N-methyltransferase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adoHcyase; S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ahcy-ps4  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,029,338 - 164,044,562 (-)NCBIGRCr8
mRatBN7.23143,569,134 - 143,584,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,569,094 - 143,584,393 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,436,772 - 147,451,996 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,054,058 - 156,069,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,793,593 - 153,808,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,587,833 - 150,603,057 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,587,833 - 150,603,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,957,240 - 156,972,464 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,544,834 - 145,560,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,450,455 - 145,465,680 (-)NCBI
Celera3142,299,485 - 142,314,709 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (ISO)
D-penicillamine  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
glafenine  (EXP)
glycine betaine  (EXP,ISO)
homocysteine  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (EXP,ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO,TAS)
endoplasmic reticulum  (IEA)
melanosome  (IEA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Baric I, etal., Proc Natl Acad Sci U S A 2004 Mar 23;101(12):4234-9. Epub 2004 Mar 15.
2. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
3. Regional and subcellular distribution of S-adenosylhomocysteine hydrolase in the adult rat brain. Broch OJ and Ueland PM, J Neurochem. 1980 Aug;35(2):484-8.
4. Day-night variations of adenosine and its metabolizing enzymes in the brain cortex of the rat--possible physiological significance for the energetic homeostasis and the sleep-wake cycle. Chagoya de Sanchez V, etal., Brain Res. 1993 May 28;612(1-2):115-21.
5. Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function. Chen YF, etal., Circulation. 2002 Sep 3;106(10):1275-81.
6. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Isolation, cloning and characterization of a low-molecular-mass purine nucleoside- and nucleotide-binding protein. Gilmour J, etal., Biochem J. 1997 Sep 1;326 ( Pt 2):471-7.
9. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Rat liver S-adenosylhomocysteinase. Spectrophotometric study of coenzyme binding. Gomi T, etal., Biochim Biophys Acta. 1989 Feb 2;994(2):172-9.
12. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. Huang Y, etal., J Biol Chem 2002 Mar 1;277(9):7477-82.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. Kobayashi S, etal., J Neurochem. 2000 Feb;74(2):621-32.
15. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues. Nguyen TT, etal., J Nutr Sci Vitaminol (Tokyo). 2001 Jun;47(3):188-94.
19. Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from rat liver as derived from the cDNA sequence. Ogawa H, etal., Proc Natl Acad Sci U S A 1987 Feb;84(3):719-23.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. Ovechkin AV, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L905-11. Epub 2006 Jun 30.
22. Localization of S-adenosylhomocysteine hydrolase and adenosine deaminase immunoreactivities in rat brain. Patel BT and Tudball N, Brain Res. 1986 Apr 9;370(2):250-64.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis. Saso Y, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):106-12.
29. Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190. Takata Y, etal., J Biol Chem. 2002 Jun 21;277(25):22670-6. doi: 10.1074/jbc.M201116200. Epub 2002 Apr 1.
30. Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. Tyagi N, etal., J Mol Neurosci. 2012 May;47(1):128-38. doi: 10.1007/s12031-011-9695-z. Epub 2012 Jan 3.
Additional References at PubMed
PMID:3759971   PMID:7744082   PMID:8419320   PMID:10387078   PMID:10913437   PMID:12023972   PMID:12477932   PMID:17310100   PMID:19056867   PMID:19805518   PMID:20458337   PMID:22871113  
PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Ahcy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,029,338 - 164,044,562 (-)NCBIGRCr8
mRatBN7.23143,569,134 - 143,584,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,569,094 - 143,584,393 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,436,772 - 147,451,996 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,054,058 - 156,069,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,793,593 - 153,808,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,587,833 - 150,603,057 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,587,833 - 150,603,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,957,240 - 156,972,464 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,544,834 - 145,560,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,450,455 - 145,465,680 (-)NCBI
Celera3142,299,485 - 142,314,709 (-)NCBICelera
Cytogenetic Map3q41NCBI
AHCY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,231,981 - 34,311,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,280,268 - 34,311,802 (-)EnsemblGRCh38hg38GRCh38
GRCh372032,868,074 - 32,899,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,331,737 - 32,354,784 (-)NCBINCBI36Build 36hg18NCBI36
Build 342032,331,736 - 32,354,784NCBI
Celera2029,617,551 - 29,649,079 (-)NCBICelera
Cytogenetic Map20q11.22ENTREZGENE
HuRef2029,649,874 - 29,681,357 (-)NCBIHuRef
CHM1_12032,769,165 - 32,800,706 (-)NCBICHM1_1
T2T-CHM13v2.02035,953,425 - 36,034,942 (-)NCBIT2T-CHM13v2.0
Ahcy
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,901,230 - 154,916,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,901,230 - 154,916,417 (-)EnsemblGRCm39 Ensembl
GRCm382155,059,310 - 155,074,497 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,059,310 - 155,074,497 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,885,046 - 154,900,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,750,751 - 154,765,867 (-)NCBIMGSCv36mm8
Celera2160,986,232 - 161,001,420 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.94NCBI
Ahcy
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,992,295 - 27,013,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,992,295 - 27,013,100 (+)NCBIChiLan1.0ChiLan1.0
AHCY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,981,145 - 40,031,255 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,980,593 - 40,024,358 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,603,701 - 30,626,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,738,007 - 31,760,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,738,007 - 31,760,803 (-)Ensemblpanpan1.1panPan2
AHCY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,410,553 - 23,423,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,411,140 - 23,419,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,058,324 - 23,071,803 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,101,284 - 24,114,771 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,100,998 - 24,114,735 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,389,987 - 23,403,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,484,066 - 23,497,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,923,430 - 23,937,131 (-)NCBIUU_Cfam_GSD_1.0
Ahcy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,415,357 - 172,434,758 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,314,705 - 6,334,439 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,314,797 - 6,333,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHCY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,726,084 - 37,744,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,726,084 - 37,744,378 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,693,955 - 42,706,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17q21NCBI
AHCY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,579,254 - 38,601,218 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl238,579,024 - 38,601,208 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,256,407 - 88,278,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahcy
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,053,280 - 5,072,679 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,053,336 - 5,071,902 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ahcy
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:79
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000024310
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
RH141077  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 5 8 74 35 41 11 5
Low 8 3 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024310   ⟹   ENSRNOP00000024310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,569,094 - 143,584,393 (-)Ensembl
Rnor_6.0 Ensembl3150,587,833 - 150,603,082 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114905   ⟹   ENSRNOP00000079171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,569,094 - 143,578,409 (-)Ensembl
RefSeq Acc Id: NM_017201   ⟹   NP_058897
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,029,338 - 164,044,562 (-)NCBI
mRatBN7.23143,569,134 - 143,584,359 (-)NCBI
Rnor_6.03150,587,833 - 150,603,057 (-)NCBI
Rnor_5.03156,957,240 - 156,972,464 (-)NCBI
RGSC_v3.43145,544,834 - 145,560,058 (-)RGD
Celera3142,299,485 - 142,314,709 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058897   ⟸   NM_017201
- UniProtKB: P10760 (UniProtKB/Swiss-Prot),   A6KI17 (UniProtKB/TrEMBL),   A0A8I5ZM95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024310   ⟸   ENSRNOT00000024310
RefSeq Acc Id: ENSRNOP00000079171   ⟸   ENSRNOT00000114905
Protein Domains
S-adenosyl-L-homocysteine hydrolase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10760-F1-model_v2 AlphaFold P10760 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692579
Promoter ID:EPDNEW_R3104
Type:multiple initiation site
Name:Ahcy_1
Description:adenosylhomocysteinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03150,603,095 - 150,603,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69260 AgrOrtholog
BioCyc Gene G2FUF-47153 BioCyc
BioCyc Pathway METHIONINE-DEG1-PWY [L-methionine degradation I (to L-homocysteine)] BioCyc
  PWY-5041 [S-adenosyl-L-methionine salvage II] BioCyc
BioCyc Pathway Image METHIONINE-DEG1-PWY BioCyc
  PWY-5041 BioCyc
Ensembl Genes ENSRNOG00000017777 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005580 UniProtKB/Swiss-Prot
  ENSRNOG00055024122 UniProtKB/Swiss-Prot
  ENSRNOG00060007906 UniProtKB/Swiss-Prot
  ENSRNOG00060026924 UniProtKB/Swiss-Prot
  ENSRNOG00065010890 UniProtKB/Swiss-Prot
  ENSRNOG00065027869 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024310 ENTREZGENE
  ENSRNOT00000024310.4 UniProtKB/Swiss-Prot
  ENSRNOT00000114905.1 UniProtKB/TrEMBL
  ENSRNOT00055008970 UniProtKB/Swiss-Prot
  ENSRNOT00055041423 UniProtKB/Swiss-Prot
  ENSRNOT00060013030 UniProtKB/Swiss-Prot
  ENSRNOT00060046660 UniProtKB/Swiss-Prot
  ENSRNOT00065017660 UniProtKB/Swiss-Prot
  ENSRNOT00065048058 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599994 IMAGE-MGC_LOAD
InterPro Adenosylhomocyst_ase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosylhomocysteinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ado_hCys_hydrolase_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-Ado-L-homoCys_hydrolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72509 IMAGE-MGC_LOAD
NCBI Gene 29443 ENTREZGENE
PANTHER ADENOSYLHOMOCYSTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AdoHcyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AHCY RGD
PhenoGen Ahcy PhenoGen
PIRSF Ad_hcy_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADOHCYASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADOHCYASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017777 RatGTEx
  ENSRNOG00055005580 RatGTEx
  ENSRNOG00055024122 RatGTEx
  ENSRNOG00060007906 RatGTEx
  ENSRNOG00060026924 RatGTEx
  ENSRNOG00065010890 RatGTEx
  ENSRNOG00065027869 RatGTEx
SMART AdoHcyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZM95 ENTREZGENE, UniProtKB/TrEMBL
  A6KI15_RAT UniProtKB/TrEMBL
  A6KI17 ENTREZGENE, UniProtKB/TrEMBL
  P10760 ENTREZGENE
  Q6P743_RAT UniProtKB/TrEMBL
  SAHH_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-09-17 Ahcy  adenosylhomocysteinase  Ahcy  S-adenosylhomocysteine hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ahcy  S-adenosylhomocysteine hydrolase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function a competitive inhibitor of s-adenosyl-l-methionine-dependent methyl transferase reactions 724707
gene_process may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine 724707