Rcan2 (regulator of calcineurin 2) - Rat Genome Database

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Gene: Rcan2 (regulator of calcineurin 2) Rattus norvegicus
Analyze
Symbol: Rcan2
Name: regulator of calcineurin 2
RGD ID: 69198
Description: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in calcium-mediated signaling. Predicted to act upstream of or within several processes, including calcineurin-NFAT signaling cascade; locomotion involved in locomotory behavior; and short-term memory. Predicted to be active in cytoplasm and nucleus. Orthologous to human RCAN2 (regulator of calcineurin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcineurin inhibitory protein ZAKI-4; calcipressin-2; Dcip2; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene1-like 1; Dscr1l1; MGC93057; Zaki-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,456,861 - 24,674,234 (-)NCBIGRCr8
mRatBN7.2916,959,478 - 17,174,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,959,480 - 17,174,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,543,367 - 25,758,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,617,888 - 30,832,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,907,100 - 29,122,117 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,518,568 - 19,749,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,518,558 - 19,749,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,397,065 - 18,626,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,623,121 - 12,853,302 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,620,444 - 12,850,624 (-)NCBI
Celera914,685,543 - 14,899,643 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
iron dichloride  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism. Siddiq A, etal., Endocrinology 2001 May;142(5):1752-9.
7. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Wang Y, etal., Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H533-9.
Additional References at PubMed
PMID:12477932   PMID:16648267   PMID:23117660  


Genomics

Comparative Map Data
Rcan2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,456,861 - 24,674,234 (-)NCBIGRCr8
mRatBN7.2916,959,478 - 17,174,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,959,480 - 17,174,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,543,367 - 25,758,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,617,888 - 30,832,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,907,100 - 29,122,117 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,518,568 - 19,749,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,518,558 - 19,749,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,397,065 - 18,626,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,623,121 - 12,853,302 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,620,444 - 12,850,624 (-)NCBI
Celera914,685,543 - 14,899,643 (-)NCBICelera
Cytogenetic Map9q13NCBI
RCAN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,220,736 - 46,491,970 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,220,736 - 46,491,972 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,188,473 - 46,459,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,296,428 - 46,401,490 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,296,433 - 46,401,364NCBI
Celera647,741,020 - 47,846,061 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef645,911,564 - 46,182,793 (-)NCBIHuRef
CHM1_1646,191,709 - 46,463,038 (-)NCBICHM1_1
T2T-CHM13v2.0646,055,860 - 46,329,613 (-)NCBIT2T-CHM13v2.0
Rcan2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,112,243 - 44,350,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,112,242 - 44,350,407 (+)EnsemblGRCm39 Ensembl
GRCm381743,801,352 - 44,039,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,801,351 - 44,039,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv371743,938,800 - 44,176,465 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,264,906 - 43,502,571 (+)NCBIMGSCv36mm8
Celera1747,226,766 - 47,458,244 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.77NCBI
Rcan2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,243,143 - 11,405,795 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,243,195 - 11,406,488 (-)NCBIChiLan1.0ChiLan1.0
RCAN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2560,713,940 - 60,987,123 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1656,580,011 - 56,853,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,801,389 - 46,074,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,074,850 - 47,347,556 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,074,850 - 47,312,149 (-)Ensemblpanpan1.1panPan2
RCAN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,427,095 - 14,647,327 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,428,406 - 14,687,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,458,631 - 14,718,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,927,188 - 15,187,200 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,927,180 - 15,187,355 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,442,961 - 14,703,496 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,531,756 - 14,791,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,628,322 - 14,888,571 (-)NCBIUU_Cfam_GSD_1.0
Rcan2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,849,314 - 50,090,256 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,915,701 - 14,110,891 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647613,869,797 - 14,110,892 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RCAN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,980,527 - 41,282,835 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,979,814 - 41,282,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2747,364,244 - 47,451,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RCAN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,775,137 - 26,034,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,939,629 - 26,034,448 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,223,466 - 46,511,471 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rcan2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,086,096 - 14,250,567 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,086,947 - 14,250,473 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rcan2
1757 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1408
Count of miRNA genes:323
Interacting mature miRNAs:433
Transcripts:ENSRNOT00000013956, ENSRNOT00000029593
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat

Markers in Region
D9Rat36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,961,398 - 16,961,545 (+)MAPPERmRatBN7.2
Rnor_6.0919,520,489 - 19,520,635NCBIRnor6.0
Rnor_5.0918,398,986 - 18,399,132UniSTSRnor5.0
RGSC_v3.4912,625,042 - 12,625,188UniSTSRGSC3.4
RGSC_v3.4912,625,041 - 12,625,186RGDRGSC3.4
RGSC_v3.1912,622,363 - 12,622,508RGD
Celera914,687,464 - 14,687,610UniSTS
RH 2.0 Map991.1RGD
SHRSP x BN Map914.0098RGD
FHH x ACI Map911.26RGD
Cytogenetic Map9q12UniSTS
D9Rat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,044,075 - 17,044,281 (+)MAPPERmRatBN7.2
Rnor_6.0919,613,434 - 19,613,639NCBIRnor6.0
Rnor_5.0918,492,020 - 18,492,225UniSTSRnor5.0
RGSC_v3.4912,718,425 - 12,718,630UniSTSRGSC3.4
RGSC_v3.4912,718,424 - 12,718,629RGDRGSC3.4
RGSC_v3.1912,715,743 - 12,716,211RGD
Celera914,770,349 - 14,770,554UniSTS
RH 2.0 Map9111.5RGD
SHRSP x BN Map914.0098RGD
FHH x ACI Map911.19RGD
Cytogenetic Map9q12UniSTS
D9Rat78  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,007,152 - 17,007,395 (+)MAPPERmRatBN7.2
Rnor_6.0919,566,867 - 19,567,109NCBIRnor6.0
Rnor_5.0918,445,364 - 18,445,606UniSTSRnor5.0
RGSC_v3.4912,671,423 - 12,671,665UniSTSRGSC3.4
RGSC_v3.4912,671,417 - 12,671,665RGDRGSC3.4
RGSC_v3.1912,668,745 - 12,668,987RGD
Celera914,733,567 - 14,733,815UniSTS
RH 3.4 Map9102.1RGD
RH 3.4 Map9102.1UniSTS
RH 2.0 Map989.9RGD
SHRSP x BN Map915.0998RGD
FHH x ACI Map911.19RGD
Cytogenetic Map9q12UniSTS
D9Rat193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,111,709 - 17,111,930 (+)MAPPERmRatBN7.2
Rnor_6.0919,686,780 - 19,687,000NCBIRnor6.0
Rnor_5.0918,564,617 - 18,564,837UniSTSRnor5.0
RGSC_v3.4912,789,442 - 12,789,663RGDRGSC3.4
RGSC_v3.4912,789,443 - 12,789,663UniSTSRGSC3.4
RGSC_v3.1912,786,764 - 12,786,985RGD
Celera914,838,072 - 14,838,292UniSTS
FHH x ACI Map911.19UniSTS
FHH x ACI Map911.19RGD
Cytogenetic Map9q12UniSTS
D9Got19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,092,452 - 17,092,701 (+)MAPPERmRatBN7.2
mRatBN7.22192,261,793 - 192,263,017 (+)MAPPERmRatBN7.2
Rnor_6.02207,246,641 - 207,247,864NCBIRnor6.0
Rnor_6.0919,667,346 - 19,667,592NCBIRnor6.0
Rnor_5.0918,545,183 - 18,545,429UniSTSRnor5.0
Rnor_5.02226,666,272 - 226,667,495UniSTSRnor5.0
RGSC_v3.4912,770,190 - 12,770,436UniSTSRGSC3.4
RGSC_v3.42200,022,638 - 200,023,861UniSTSRGSC3.4
RGSC_v3.4912,770,189 - 12,770,436RGDRGSC3.4
RGSC_v3.1912,767,512 - 12,767,758RGD
Celera914,818,832 - 14,819,078UniSTS
Celera2184,728,678 - 184,729,901UniSTS
RH 3.4 Map9118.29RGD
RH 3.4 Map9118.29UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map9q12UniSTS
D9Got24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,119,986 - 17,120,201 (+)MAPPERmRatBN7.2
Rnor_6.0919,695,057 - 19,695,271NCBIRnor6.0
Rnor_5.0918,572,894 - 18,573,108UniSTSRnor5.0
RGSC_v3.4912,797,719 - 12,797,934RGDRGSC3.4
RGSC_v3.4912,797,720 - 12,797,934UniSTSRGSC3.4
RGSC_v3.1912,795,041 - 12,795,256RGD
Celera914,846,353 - 14,846,567UniSTS
Cytogenetic Map9q12UniSTS
Dscr1l1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,961,773 - 16,962,003 (+)MAPPERmRatBN7.2
Rnor_6.0919,520,864 - 19,521,093NCBIRnor6.0
Rnor_5.0918,399,361 - 18,399,590UniSTSRnor5.0
RGSC_v3.4912,625,417 - 12,625,646UniSTSRGSC3.4
Celera914,687,839 - 14,688,068UniSTS
Cytogenetic Map9q12UniSTS
BF401166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,029,190 - 17,029,284 (+)MAPPERmRatBN7.2
Rnor_6.0919,598,539 - 19,598,632NCBIRnor6.0
Rnor_6.0919,587,946 - 19,588,039NCBIRnor6.0
Rnor_5.0918,477,036 - 18,477,129UniSTSRnor5.0
Rnor_5.0918,466,443 - 18,466,536UniSTSRnor5.0
RGSC_v3.4912,692,945 - 12,693,038UniSTSRGSC3.4
Celera914,755,610 - 14,755,703UniSTS
RH 3.4 Map9102.0UniSTS
Cytogenetic Map9q12UniSTS
RH133146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,959,533 - 16,959,743 (+)MAPPERmRatBN7.2
Rnor_6.0919,518,624 - 19,518,833NCBIRnor6.0
Rnor_5.0918,397,121 - 18,397,330UniSTSRnor5.0
RGSC_v3.4912,623,177 - 12,623,386UniSTSRGSC3.4
Celera914,685,599 - 14,685,808UniSTS
Cytogenetic Map9q12UniSTS
BF398967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,164,041 - 17,164,156 (+)MAPPERmRatBN7.2
Rnor_6.0919,738,844 - 19,738,958NCBIRnor6.0
Rnor_5.0918,616,305 - 18,616,419UniSTSRnor5.0
RGSC_v3.4912,842,533 - 12,842,647UniSTSRGSC3.4
Celera914,890,469 - 14,890,583UniSTS
RH 3.4 Map9107.0UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 8 11 68 29 8 8
Low 3 43 27 19 27 6 6 33 11
Below cutoff 14 14 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013956   ⟹   ENSRNOP00000013954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,959,480 - 17,174,856 (-)Ensembl
Rnor_6.0 Ensembl919,518,570 - 19,749,145 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000029593   ⟹   ENSRNOP00000029489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,961,715 - 17,043,907 (-)Ensembl
Rnor_6.0 Ensembl919,518,558 - 19,613,360 (-)Ensembl
RefSeq Acc Id: NM_175578   ⟹   NP_783168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,456,861 - 24,672,189 (-)NCBI
mRatBN7.2916,959,478 - 17,174,823 (-)NCBI
Rnor_6.0919,518,568 - 19,749,145 (-)NCBI
Rnor_5.0918,397,065 - 18,626,606 (-)NCBI
RGSC_v3.4912,623,121 - 12,853,302 (-)RGD
Celera914,685,543 - 14,899,643 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244593   ⟹   XP_006244655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,456,861 - 24,541,679 (-)NCBI
mRatBN7.2916,959,478 - 17,044,063 (-)NCBI
Rnor_6.0919,518,568 - 19,613,468 (-)NCBI
Rnor_5.0918,397,065 - 18,626,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266599   ⟹   XP_063122669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,456,861 - 24,674,234 (-)NCBI
RefSeq Acc Id: XM_063266600   ⟹   XP_063122670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,456,861 - 24,671,871 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_783168   ⟸   NM_175578
- UniProtKB: A0A0G2JSK3 (UniProtKB/TrEMBL),   A6JJ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244655   ⟸   XM_006244593
- Peptide Label: isoform X2
- UniProtKB: Q8CH26 (UniProtKB/Swiss-Prot),   Q8CH27 (UniProtKB/Swiss-Prot),   A6JJ25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029489   ⟸   ENSRNOT00000029593
RefSeq Acc Id: ENSRNOP00000013954   ⟸   ENSRNOT00000013956
RefSeq Acc Id: XP_063122669   ⟸   XM_063266599
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122670   ⟸   XM_063266600
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CH27-F1-model_v2 AlphaFold Q8CH27 1-197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696559
Promoter ID:EPDNEW_R7076
Type:multiple initiation site
Name:Rcan2_2
Description:regulator of calcineurin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7077  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,613,357 - 19,613,417EPDNEW
RGD ID:13696553
Promoter ID:EPDNEW_R7077
Type:multiple initiation site
Name:Rcan2_1
Description:regulator of calcineurin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7076  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,749,175 - 19,749,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69198 AgrOrtholog
BioCyc Gene G2FUF-28122 BioCyc
Ensembl Genes ENSRNOG00000010350 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019911 UniProtKB/Swiss-Prot
  ENSRNOG00060021049 UniProtKB/Swiss-Prot
  ENSRNOG00065024820 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013956 ENTREZGENE
  ENSRNOT00000013956.6 UniProtKB/TrEMBL
  ENSRNOT00000029593.5 UniProtKB/Swiss-Prot
  ENSRNOT00055033999 UniProtKB/Swiss-Prot
  ENSRNOT00060036451 UniProtKB/Swiss-Prot
  ENSRNOT00065042619 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193921 IMAGE-MGC_LOAD
InterPro Calcipressin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCAN2_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140666 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93057 IMAGE-MGC_LOAD
NCBI Gene 140666 ENTREZGENE
PANTHER PTHR10300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10300:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calcipressin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rcan2 PhenoGen
RatGTEx ENSRNOG00000010350 RatGTEx
  ENSRNOG00055019911 RatGTEx
  ENSRNOG00060021049 RatGTEx
  ENSRNOG00065024820 RatGTEx
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSK3 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ23 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ25 ENTREZGENE, UniProtKB/TrEMBL
  Q8CH26 ENTREZGENE
  Q8CH27 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CH26 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Rcan2  regulator of calcineurin 2  Dscr1l1  Down syndrome critical region gene 1-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dscr1l1  Down syndrome critical region gene 1-like 1    Down syndrome critical region gene1-like 1  Name updated 1299863 APPROVED
2002-06-10 Dscr1l1  down syndrome critical region gene1-like 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency may result in abnormal brain development by hypothyroidism 68685
gene_expression detected in both cerebral cortex and cerebellum in early embryonic days, unchanged by age or thyroid status 68685
gene_expression expressed in cardiac myocytes 625605
gene_function functions as a calcineurin inhibitor 68685
gene_process may have a role in brain development and function by modulating calcineurin function 68685
gene_process calcineurin inhibitor 625605
gene_regulation mechanical strain induces the mRNA 625605