Wnt7a (Wnt family member 7A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Wnt7a (Wnt family member 7A) Rattus norvegicus
Analyze
Symbol: Wnt7a
Name: Wnt family member 7A
RGD ID: 69079
Description: Enables frizzled binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of JNK cascade; and response to estradiol. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in Schaffer collateral - CA1 synapse; extracellular space; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family, member 7A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,420,276 - 125,466,149 (-)NCBIGRCr8
mRatBN7.24123,863,108 - 123,908,981 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,329,923 - 129,375,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,104,358 - 125,150,304 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,728,903 - 123,774,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,994,425 - 123,040,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,505,391 - 187,551,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,541,281 - 125,586,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,786,638 - 125,787,010 (-)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
asarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (EXP)
dipentyl phthalate  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
methylseleninic acid  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
ozone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrvinium  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
testosterone  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
XAV939  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
asymmetric protein localization involved in cell fate determination  (ISO)
canonical Wnt signaling pathway  (IBA,IMP,ISO)
cartilage condensation  (ISO)
cartilage development  (ISO)
cell fate commitment  (IBA)
cell proliferation in forebrain  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system vasculogenesis  (ISO)
cerebellar granule cell differentiation  (ISO)
chondrocyte differentiation  (ISO)
dendritic spine morphogenesis  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic axis specification  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
establishment of blood-brain barrier  (ISO)
establishment of cell polarity  (ISO)
forelimb morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
limb development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of neurogenesis  (ISO)
neuron differentiation  (IBA)
neurotransmitter secretion  (ISO)
non-canonical Wnt signaling pathway  (ISO)
oviduct development  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epithelial cell proliferation involved in wound healing  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of excitatory synapse assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (IBA,IMP)
positive regulation of protein metabolic process  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of axon diameter  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of postsynapse organization  (ISO)
regulation of presynapse assembly  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
reproductive structure development  (ISO)
response to estradiol  (IEP)
response to estrogen  (ISO)
secondary palate development  (ISO)
skeletal muscle satellite cell activation  (ISO)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (ISO)
skeletal system morphogenesis  (ISO)
skin morphogenesis  (ISO)
somatic stem cell division  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell development  (ISO)
synapse assembly  (ISO)
synapse organization  (ISO)
uterus development  (ISO)
uterus morphogenesis  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole A, etal., J Biol Chem 2003 Sep 26;278(39):37024-31.
2. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama S, etal., Toxicol Sci. 2006 Jun;91(2):419-30. Epub 2006 Mar 21.
6. Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. Li S, etal., J Clin Endocrinol Metab. 2001 Jan;86(1):454-7.
7. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Lyu J and Joo CK, Cornea. 2006 Dec;25(10 Suppl 1):S24-8.
8. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Maekawa M, etal., Genes Cells. 2005 Oct;10(10):1001-14.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
17. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
18. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
19. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
20. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
Additional References at PubMed
PMID:7885472   PMID:8167409   PMID:9362463   PMID:9405095   PMID:12399112   PMID:12843296   PMID:12937339   PMID:14695376   PMID:15040835   PMID:15070830   PMID:15073149   PMID:15242796  
PMID:15756457   PMID:15802269   PMID:15880584   PMID:16805831   PMID:16818724   PMID:16826533   PMID:17202865   PMID:17507554   PMID:17988238   PMID:18096705   PMID:18413325   PMID:18986540  
PMID:19023080   PMID:19129494   PMID:19497282   PMID:20530549   PMID:21670302   PMID:24502851   PMID:26400647   PMID:28733458   PMID:31852613   PMID:32949181  


Genomics

Comparative Map Data
Wnt7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,420,276 - 125,466,149 (-)NCBIGRCr8
mRatBN7.24123,863,108 - 123,908,981 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,329,923 - 129,375,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,104,358 - 125,150,304 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,728,903 - 123,774,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,994,425 - 123,040,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,505,391 - 187,551,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,541,281 - 125,586,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,786,638 - 125,787,010 (-)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBICelera
Cytogenetic Map4q34NCBI
WNT7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38313,816,258 - 13,880,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl313,816,258 - 13,880,071 (-)EnsemblGRCh38hg38GRCh38
GRCh37313,857,755 - 13,921,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36313,835,083 - 13,896,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 34313,835,082 - 13,896,619NCBI
Celera313,798,391 - 13,859,925 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef313,793,735 - 13,855,835 (-)NCBIHuRef
CHM1_1313,810,090 - 13,871,973 (-)NCBICHM1_1
T2T-CHM13v2.0313,816,895 - 13,880,668 (-)NCBIT2T-CHM13v2.0
Wnt7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,340,963 - 91,388,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,340,963 - 91,388,345 (-)EnsemblGRCm39 Ensembl
GRCm38691,363,981 - 91,411,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,363,981 - 91,411,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,313,977 - 91,361,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36691,329,487 - 91,376,873 (-)NCBIMGSCv36mm8
Celera693,257,779 - 93,305,821 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.45NCBI
Wnt7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542912,647,993 - 12,694,895 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542912,647,993 - 12,693,998 (+)NCBIChiLan1.0ChiLan1.0
WNT7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,792,607 - 13,856,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1313,797,369 - 13,861,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0313,733,487 - 13,797,189 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,075,359 - 14,138,386 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,077,839 - 14,138,386 (-)Ensemblpanpan1.1panPan2
WNT7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,072,010 - 4,139,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,073,929 - 4,139,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,112,838 - 4,179,523 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,096,079 - 4,162,950 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,096,088 - 4,163,110 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1203,815,330 - 3,882,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,137,783 - 4,204,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,102,223 - 4,168,959 (-)NCBIUU_Cfam_GSD_1.0
Wnt7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494219,620,674 - 19,645,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493689845,115 - 70,326 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493689845,903 - 70,313 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,538,894 - 70,602,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,538,802 - 70,602,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,997,741 - 78,061,325 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12249,805,415 - 49,863,115 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2249,805,463 - 49,862,830 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041116,634,304 - 116,694,158 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479612,431,959 - 12,472,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479612,431,310 - 12,472,303 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt7a
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:175
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000070832
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat

Markers in Region
RH132187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,863,233 - 123,864,186 (+)MAPPERmRatBN7.2
Rnor_6.04122,994,551 - 122,995,503NCBIRnor6.0
Rnor_5.04187,550,526 - 187,551,478UniSTSRnor5.0
RGSC_v3.44125,540,371 - 125,541,323UniSTSRGSC3.4
Celera4112,782,393 - 112,783,345UniSTS
RH 3.4 Map4735.73UniSTS
Cytogenetic Map4q34UniSTS
BE106651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,864,606 - 123,864,766 (+)MAPPERmRatBN7.2
Rnor_6.04122,995,924 - 122,996,083NCBIRnor6.0
Rnor_5.04187,549,946 - 187,550,105UniSTSRnor5.0
RGSC_v3.44125,541,744 - 125,541,903UniSTSRGSC3.4
Celera4112,783,766 - 112,783,925UniSTS
RH 3.4 Map4736.63UniSTS
Cytogenetic Map4q34UniSTS
Wnt7a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,863,936 - 123,864,483 (+)MAPPERmRatBN7.2
Rnor_6.04122,995,254 - 122,995,800NCBIRnor6.0
Rnor_5.04187,550,229 - 187,550,775UniSTSRnor5.0
RGSC_v3.44125,541,074 - 125,541,620UniSTSRGSC3.4
Celera4112,783,096 - 112,783,642UniSTS
Cytogenetic Map4q34UniSTS
UNH1042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,870,702 - 123,871,013 (+)MAPPERmRatBN7.2
Rnor_6.04123,002,020 - 123,002,330NCBIRnor6.0
Rnor_5.04187,543,698 - 187,544,009NCBIRnor5.0
RGSC_v3.44125,547,840 - 125,548,150UniSTSRGSC3.4
Celera4112,789,809 - 112,790,119UniSTS
Cytogenetic Map4q34UniSTS
Wnt7a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,865,107 - 123,865,314 (+)MAPPERmRatBN7.2
Rnor_6.04122,996,425 - 122,996,631NCBIRnor6.0
Rnor_5.04187,549,398 - 187,549,604UniSTSRnor5.0
RGSC_v3.44125,542,245 - 125,542,451UniSTSRGSC3.4
Celera4112,784,267 - 112,784,473UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 60 8 7
Low 9 14 1 22 4
Below cutoff 11 20 14 8 14 4 4 20 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070832   ⟹   ENSRNOP00000066101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)Ensembl
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)Ensembl
RefSeq Acc Id: NM_001100473   ⟹   NP_001093943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,276 - 125,466,149 (-)NCBI
mRatBN7.24123,863,108 - 123,908,981 (-)NCBI
Rnor_6.04122,994,425 - 123,040,609 (-)NCBI
Rnor_5.04187,505,391 - 187,551,604 (+)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106916   ⟹   XP_038962844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,289 - 125,464,337 (-)NCBI
mRatBN7.24123,863,114 - 123,907,174 (-)NCBI
RefSeq Acc Id: XM_039106917   ⟹   XP_038962845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,289 - 125,464,343 (-)NCBI
mRatBN7.24123,863,114 - 123,907,177 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001093943   ⟸   NM_001100473
- Peptide Label: precursor
- UniProtKB: M0R9D3 (UniProtKB/TrEMBL),   A6IB96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066101   ⟸   ENSRNOT00000070832
RefSeq Acc Id: XP_038962845   ⟸   XM_039106917
- Peptide Label: isoform X2
- UniProtKB: A6IB97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962844   ⟸   XM_039106916
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9D3-F1-model_v2 AlphaFold M0R9D3 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69079 AgrOrtholog
BioCyc Gene G2FUF-43724 BioCyc
Ensembl Genes ENSRNOG00000048782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070832 ENTREZGENE
  ENSRNOT00000070832.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report rno:114850 UniProtKB/TrEMBL
NCBI Gene 114850 ENTREZGENE
PANTHER PROTEIN WNT-7A UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt7a PhenoGen
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048782 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A6IB96 ENTREZGENE, UniProtKB/TrEMBL
  A6IB97 ENTREZGENE, UniProtKB/TrEMBL
  M0R9D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt7a  Wnt family member 7A  Wnt7a  wingless-type MMTV integration site family, member 7A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt7a  wingless-type MMTV integration site family, member 7A  Wnt7a  wingless-related MMTV integration site 7A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Wnt7a  wingless-type MMTV integration site 7A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference