Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Rattus norvegicus
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Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
Description: ENCODES a protein that exhibits activating transcription factor binding; calcium-dependent protein binding; calmodulin binding; INVOLVED IN negative regulation of ATF6-mediated unfolded protein response; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH post-traumatic stress disorder; Seizures; Stress Disorders, Post-Traumatic; FOUND IN proteasome complex; endoplasmic reticulum (ortholog); integral component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Wolfram syndrome 1; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
Orthologs:
Homo sapiens (human) : WFS1 (wolframin ER transmembrane glycoprotein)  HGNC
Mus musculus (house mouse) : Wfs1 (wolframin ER transmembrane glycoprotein)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Wfs1 (wolframin ER transmembrane glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : WFS1 (wolframin ER transmembrane glycoprotein)
Canis lupus familiaris (dog) : WFS1 (wolframin ER transmembrane glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfs1 (wolframin ER transmembrane glycoprotein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Celera1472,756,725 - 72,781,236 (+)NCBI
Cytogenetic Map14q21NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Wfs1
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 68954
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2017-08-08
Status: ACTIVE