Bhlhe40 (basic helix-loop-helix family, member e40) - Rat Genome Database

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Gene: Bhlhe40 (basic helix-loop-helix family, member e40) Rattus norvegicus
Analyze
Symbol: Bhlhe40
Name: basic helix-loop-helix family, member e40
RGD ID: 68439
Description: Predicted to enable several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein dimerization activity. Involved in several processes, including circadian rhythm; negative regulation of transcription by RNA polymerase II; and regulation of neuronal synaptic plasticity. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human BHLHE40 (basic helix-loop-helix family member e40); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basic helix-loop-helix domain containing, class B2; Bhlhb2; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; Dec1; enhancer-of split and hairy-related protein 2; enhancer-of-split and hairy-related protein 2; SHARP-2; Sharp2; stimulated by retinoic acid 14; Stra13; Stra14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,174,450 - 143,180,150 (+)NCBIGRCr8
mRatBN7.24141,618,453 - 141,624,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,040,502 - 147,046,182 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,821,233 - 142,826,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,465,221 - 141,470,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Celera4130,269,971 - 130,275,671 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
ferric oxide  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
Heptachlor epoxide  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
PX-866  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear body  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
10. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells. Yamada K, etal., Biol Reprod 2004 Jan;70(1):76-82. Epub 2003 Sep 3.
Additional References at PubMed
PMID:12297495   PMID:12624110   PMID:12796501   PMID:14672706   PMID:14725860   PMID:15038852   PMID:15147242   PMID:15193144   PMID:15560782   PMID:15733865   PMID:17487425   PMID:18411297  
PMID:18602890   PMID:19029909   PMID:19786558   PMID:20205554   PMID:21430201   PMID:26590300   PMID:26820676   PMID:27792527   PMID:28797635   PMID:29952285   PMID:30012868   PMID:35659652  
PMID:36881362  


Genomics

Comparative Map Data
Bhlhe40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,174,450 - 143,180,150 (+)NCBIGRCr8
mRatBN7.24141,618,453 - 141,624,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,040,502 - 147,046,182 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,821,233 - 142,826,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,465,221 - 141,470,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,703,619 - 140,709,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04205,170,129 - 205,175,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,139,486 - 144,145,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14144,384,326 - 144,390,027 (+)NCBI
Celera4130,269,971 - 130,275,671 (+)NCBICelera
Cytogenetic Map4q41NCBI
BHLHE40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3834,979,437 - 4,985,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl34,979,437 - 4,985,323 (+)EnsemblGRCh38hg38GRCh38
GRCh3735,021,122 - 5,027,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,996,208 - 5,001,861 (+)NCBINCBI36Build 36hg18NCBI36
Build 3434,996,207 - 5,001,861NCBI
Celera34,959,047 - 4,964,811 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef34,954,421 - 4,960,188 (+)NCBIHuRef
CHM1_134,971,113 - 4,976,884 (+)NCBICHM1_1
T2T-CHM13v2.034,970,406 - 4,979,102 (+)NCBIT2T-CHM13v2.0
Bhlhe40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,637,590 - 108,643,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,637,590 - 108,643,886 (+)EnsemblGRCm39 Ensembl
GRCm386108,660,629 - 108,666,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,660,629 - 108,666,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,610,623 - 108,616,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,626,406 - 108,632,702 (+)NCBIMGSCv36mm8
Celera6110,461,756 - 110,468,060 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.85NCBI
Bhlhe40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,463,018 - 8,468,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,463,337 - 8,468,877 (-)NCBIChiLan1.0ChiLan1.0
BHLHE40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v224,985,872 - 4,991,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan134,990,663 - 4,996,646 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v034,927,487 - 4,933,215 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,028,217 - 5,033,968 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,028,515 - 5,032,470 (+)Ensemblpanpan1.1panPan2
BHLHE40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,641,872 - 12,647,519 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,642,702 - 12,647,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,616,237 - 12,621,884 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02012,685,779 - 12,691,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,685,620 - 12,691,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,390,474 - 12,396,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,731,885 - 12,737,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,718,100 - 12,723,747 (-)NCBIUU_Cfam_GSD_1.0
Bhlhe40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,360,673 - 11,365,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365774,315,977 - 4,322,032 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365774,316,099 - 4,321,193 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHLHE40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,526,116 - 61,533,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,526,121 - 61,533,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,830,821 - 67,836,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BHLHE40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,049,673 - 41,055,365 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,049,712 - 41,055,360 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,612,281 - 125,617,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,413,365 - 15,420,123 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477315,413,400 - 15,418,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhlhe40
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:88
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000009563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat

Markers in Region
D4Wox44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,623,426 - 141,623,565 (+)MAPPERmRatBN7.2
Rnor_6.04140,708,592 - 140,708,730NCBIRnor6.0
Rnor_5.04205,175,102 - 205,175,240UniSTSRnor5.0
RGSC_v3.44144,144,459 - 144,144,597UniSTSRGSC3.4
Celera4130,274,944 - 130,275,082UniSTS
Cytogenetic Map4q41UniSTS
RH139327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,621,578 - 141,621,825 (+)MAPPERmRatBN7.2
Rnor_6.04140,706,744 - 140,706,990NCBIRnor6.0
Rnor_5.04205,173,254 - 205,173,500UniSTSRnor5.0
RGSC_v3.44144,142,611 - 144,142,857UniSTSRGSC3.4
Celera4130,273,096 - 130,273,342UniSTS
RH 3.4 Map8866.1UniSTS
Cytogenetic Map4q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 41 28 16 28 8 11 31 33 21 11 8
Low 10 16 13 3 13 43 2 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009563   ⟹   ENSRNOP00000009564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4141,618,476 - 141,624,774 (+)Ensembl
Rnor_6.0 Ensembl4140,703,619 - 140,709,319 (+)Ensembl
RefSeq Acc Id: NM_053328   ⟹   NP_445780
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84143,174,450 - 143,180,150 (+)NCBI
mRatBN7.24141,618,453 - 141,624,154 (+)NCBI
Rnor_6.04140,703,619 - 140,709,319 (+)NCBI
Rnor_5.04205,170,129 - 205,175,829 (+)NCBI
RGSC_v3.44144,139,486 - 144,145,186 (+)RGD
Celera4130,269,971 - 130,275,671 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445780 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63587 (Get FASTA)   NCBI Sequence Viewer  
  BAD01588 (Get FASTA)   NCBI Sequence Viewer  
  EDL91480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009564
  ENSRNOP00000009564.1
GenBank Protein O35780 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_445780   ⟸   NM_053328
- UniProtKB: O35780 (UniProtKB/Swiss-Prot),   F7FCF3 (UniProtKB/TrEMBL),   Q76JQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009564   ⟸   ENSRNOT00000009563
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35780-F1-model_v2 AlphaFold O35780 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693283
Promoter ID:EPDNEW_R3808
Type:initiation region
Name:Bhlhe40_1
Description:basic helix-loop-helix family, member e40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04140,703,686 - 140,703,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68439 AgrOrtholog
BioCyc Gene G2FUF-43448 BioCyc
Ensembl Genes ENSRNOG00000007152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009563 ENTREZGENE
  ENSRNOT00000009563.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Bhlhe40 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bhlhe40 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007152 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233060
UniProt BHE40_RAT UniProtKB/Swiss-Prot
  F7FCF3 ENTREZGENE, UniProtKB/TrEMBL
  O35780 ENTREZGENE
  Q76JQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-19 Bhlhe40  basic helix-loop-helix family, member e40  Bhlhb2  basic helix-loop-helix domain containing, class B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bhlhb2  basic helix-loop-helix domain containing, class B2       Name updated 70584 APPROVED
2002-02-27 Bhlhb2  basic helix-loop-helix domain containing, class B2      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the suprachiasmic nucleus of the hypothalamus (SCN) in a circadian fashion 625726
gene_expression expression in neurons of the cerebral cortex is induced by kainic acid 68312
gene_process expression may be associated with neuronal stimulation 728119
gene_product member of a family of neuronal bHLH proteins 728119