Ltbp2 (latent transforming growth factor beta binding protein 2) - Rat Genome Database

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Gene: Ltbp2 (latent transforming growth factor beta binding protein 2) Rattus norvegicus
Analyze
Symbol: Ltbp2
Name: latent transforming growth factor beta binding protein 2
RGD ID: 68380
Description: Predicted to enable microfibril binding activity. Involved in response to alkaloid. Predicted to be located in extracellular region. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and megalocornea. Orthologous to human LTBP2 (latent transforming growth factor beta binding protein 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: latent-transforming growth factor beta-binding protein 2; LTBP-2 like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,161,029 - 110,261,586 (-)NCBIGRCr8
mRatBN7.26104,429,947 - 104,530,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,599,632 - 104,696,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,898,799 - 104,995,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,268,141 - 104,364,559 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,500,114 - 108,596,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,500,112 - 108,596,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,955,322 - 117,049,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,826,446 - 108,924,746 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,829,901 - 108,928,202 (-)NCBI
Celera6102,254,815 - 102,349,980 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
graphite  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
microcystin-LR  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Null mutations in LTBP2 cause primary congenital glaucoma. Ali M, etal., Am J Hum Genet. 2009 May;84(5):664-71. doi: 10.1016/j.ajhg.2009.03.017. Epub 2009 Apr 9.
2. The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea. Breidthardt T, etal., Clin Sci (Lond). 2012 Nov;123(9):557-66. doi: 10.1042/CS20120058.
3. Gene expression signals involved in ischemic injury, extracellular matrix composition and fibrosis defined by global mRNA profiling of the human left ventricular myocardium. Gabrielsen A, etal., J Mol Cell Cardiol. 2007 Apr;42(4):870-83. doi: 10.1016/j.yjmcc.2006.12.016. Epub 2007 Jan 8.
4. Analyzing gene expression profiles with preliminary validations in cardiac hypertrophy induced by pressure overload. Gao J, etal., Can J Physiol Pharmacol. 2018 Aug;96(8):701-709. doi: 10.1139/cjpp-2017-0585. Epub 2018 Mar 6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells. Gong W, etal., Gastroenterology 1998 Feb;114(2):352-63.
8. LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix. Haji-Seyed-Javadi R, etal., Hum Mutat. 2012 Aug;33(8):1182-7. doi: 10.1002/humu.22105. Epub 2012 May 29.
9. Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils. Inoue T, etal., Hum Mol Genet. 2014 Nov 1;23(21):5672-82. doi: 10.1093/hmg/ddu283. Epub 2014 Jun 6.
10. Congenital megalocornea with zonular weakness and childhood lens-related secondary glaucoma - a distinct phenotype caused by recessive LTBP2 mutations. Khan AO, etal., Mol Vis. 2011;17:2570-9. Epub 2011 Oct 4.
11. TGF-beta1-dependent differential expression of a rat homolog for latent TGF-beta binding protein in astrocytes and C6 glioma cells. Krohn K Glia 1999 Feb 15;25(4):332-42.
12. A homozygous mutation in LTBP2 causes isolated microspherophakia. Kumar A, etal., Hum Genet. 2010 Oct;128(4):365-71. doi: 10.1007/s00439-010-0858-8. Epub 2010 Jul 9.
13. Loss of function mutations in the gene encoding latent transforming growth factor beta binding protein 2, LTBP2, cause primary congenital glaucoma. Narooie-Nejad M, etal., Hum Mol Genet. 2009 Oct 15;18(20):3969-77. doi: 10.1093/hmg/ddp338. Epub 2009 Aug 4.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Pang XF, etal., Acta Physiol (Oxf). 2020 Mar;228(3):e13377. doi: 10.1111/apha.13377. Epub 2019 Nov 6.
17. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Park S, etal., Circulation. 2018 Sep 18;138(12):1224-1235. doi: 10.1161/CIRCULATIONAHA.118.035420.
18. Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. Park S, etal., JACC Basic Transl Sci. 2020 Apr 15;5(5):432-443. doi: 10.1016/j.jacbts.2020.01.016. eCollection 2020 May.
19. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Potus F, etal., Int J Mol Sci. 2018 Sep 12;19(9):2730. doi: 10.3390/ijms19092730.
20. Novel mutations in LTBP2 identified in familial cases of primary congenital glaucoma. Rauf B, etal., Mol Vis. 2020 Feb 24;26:14-25. eCollection 2020.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Shi Y, etal., Matrix Biol. 2021 Jan;95:15-31. doi: 10.1016/j.matbio.2020.10.002. Epub 2020 Oct 9.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction. Wang HB, etal., Int J Mol Med. 2019 Oct;44(4):1447-1461. doi: 10.3892/ijmm.2019.4291. Epub 2019 Jul 30.
27. Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma. Yang Y, etal., Genet Test Mol Biomarkers. 2017 Apr;21(4):252-258. doi: 10.1089/gtmb.2016.0203. Epub 2017 Feb 27.
Additional References at PubMed
PMID:10743502   PMID:11104663   PMID:15326124   PMID:20551380   PMID:21362503   PMID:21700711   PMID:23376485   PMID:23533145   PMID:24006456   PMID:27068509   PMID:27559042  


Genomics

Comparative Map Data
Ltbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,161,029 - 110,261,586 (-)NCBIGRCr8
mRatBN7.26104,429,947 - 104,530,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,599,632 - 104,696,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,898,799 - 104,995,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,268,141 - 104,364,559 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,500,114 - 108,596,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,500,112 - 108,596,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,955,322 - 117,049,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,826,446 - 108,924,746 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,829,901 - 108,928,202 (-)NCBI
Celera6102,254,815 - 102,349,980 (-)NCBICelera
Cytogenetic Map6q31NCBI
LTBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,498,183 - 74,612,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,498,183 - 74,612,378 (-)EnsemblGRCh38hg38GRCh38
GRCh371474,964,886 - 75,078,940 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,034,639 - 74,148,787 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,034,639 - 74,148,787NCBI
Celera1455,003,271 - 55,117,403 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,133,330 - 55,247,309 (-)NCBIHuRef
CHM1_11474,904,422 - 75,018,171 (-)NCBICHM1_1
T2T-CHM13v2.01468,707,154 - 68,821,330 (-)NCBIT2T-CHM13v2.0
Ltbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,829,986 - 84,923,581 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,829,986 - 84,923,306 (-)EnsemblGRCm39 Ensembl
GRCm381284,783,212 - 84,876,558 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,783,212 - 84,876,532 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,124,162 - 86,217,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,672,960 - 85,766,280 (-)NCBIMGSCv36mm8
Celera1286,239,349 - 86,332,994 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.39NCBI
Ltbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523932,347 - 1,003,256 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523919,220 - 1,005,747 (+)NCBIChiLan1.0ChiLan1.0
LTBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,581,989 - 75,695,595 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,798,495 - 74,911,671 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,051,325 - 55,164,613 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,899,154 - 74,012,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,901,851 - 74,011,914 (-)Ensemblpanpan1.1panPan2
LTBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,657,618 - 47,758,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,659,363 - 47,760,938 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,340,607 - 47,442,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,883,641 - 47,985,169 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,884,344 - 47,985,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,554,781 - 47,656,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,576,054 - 47,677,565 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,974,056 - 48,075,556 (-)NCBIUU_Cfam_GSD_1.0
Ltbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,277,917 - 28,386,253 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,685,334 - 3,791,063 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,682,044 - 3,790,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,745,396 - 97,852,502 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,744,974 - 97,852,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,589,203 - 103,694,470 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,707,348 - 51,823,449 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,708,479 - 51,823,347 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,940,753 - 40,055,605 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,059,213 - 27,159,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,058,531 - 27,162,229 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltbp2
449 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:195
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000031331
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat

Markers in Region
D6Got159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,501,212 - 104,501,342 (+)MAPPERmRatBN7.2
Rnor_6.06108,571,459 - 108,571,588NCBIRnor6.0
Rnor_5.06116,982,029 - 116,982,158UniSTSRnor5.0
RGSC_v3.46108,899,758 - 108,899,888RGDRGSC3.4
RGSC_v3.46108,899,759 - 108,899,888UniSTSRGSC3.4
RGSC_v3.16108,903,215 - 108,903,344RGD
Celera6102,325,132 - 102,325,261UniSTS
RH 3.4 Map6774.2UniSTS
RH 3.4 Map6774.2RGD
RH 2.0 Map6979.8RGD
Cytogenetic Map6q31UniSTS
D6Got324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,477,174 - 104,477,264 (+)MAPPERmRatBN7.2
Rnor_6.06108,547,383 - 108,547,472NCBIRnor6.0
Rnor_5.06117,005,741 - 117,005,830UniSTSRnor5.0
Celera6102,301,874 - 102,301,963UniSTS
Cytogenetic Map6q31UniSTS
RH134026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,430,015 - 104,430,220 (+)MAPPERmRatBN7.2
Rnor_6.06108,500,183 - 108,500,387NCBIRnor6.0
Rnor_5.06117,049,033 - 117,049,237UniSTSRnor5.0
RGSC_v3.46108,826,508 - 108,826,712UniSTSRGSC3.4
Celera6102,254,884 - 102,255,088UniSTS
RH 3.4 Map6781.0UniSTS
Cytogenetic Map6q31UniSTS
RH139165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,459,214 - 104,459,344 (+)MAPPERmRatBN7.2
Rnor_6.06108,529,381 - 108,529,510NCBIRnor6.0
Rnor_5.06117,023,190 - 117,023,319UniSTSRnor5.0
RGSC_v3.46108,856,295 - 108,856,424UniSTSRGSC3.4
Celera6102,283,983 - 102,284,112UniSTS
RH 3.4 Map6742.4UniSTS
Cytogenetic Map6q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 2 13 11
Low 2 27 33 17 17 17 7 7 23 35 22 7
Below cutoff 1 24 24 24 1 4 43 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031331   ⟹   ENSRNOP00000038437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)Ensembl
Rnor_6.0 Ensembl6108,500,114 - 108,596,446 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077458   ⟹   ENSRNOP00000075533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)Ensembl
Rnor_6.0 Ensembl6108,500,119 - 108,596,446 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082792   ⟹   ENSRNOP00000071831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)Ensembl
Rnor_6.0 Ensembl6108,500,112 - 108,596,569 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113831   ⟹   ENSRNOP00000088184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,429,947 - 104,526,208 (-)Ensembl
RefSeq Acc Id: NM_021586   ⟹   NP_067597
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,029 - 110,257,298 (-)NCBI
mRatBN7.26104,429,947 - 104,526,208 (-)NCBI
Rnor_6.06108,500,114 - 108,596,446 (-)NCBI
Rnor_5.06116,955,322 - 117,049,306 (+)NCBI
RGSC_v3.46108,826,446 - 108,924,746 (-)RGD
Celera6102,254,815 - 102,349,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240350   ⟹   XP_006240412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,034 - 110,261,586 (-)NCBI
mRatBN7.26104,429,947 - 104,530,498 (-)NCBI
Rnor_6.06108,500,119 - 108,596,653 (-)NCBI
Rnor_5.06116,955,322 - 117,049,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112808   ⟹   XP_038968736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,034 - 110,258,428 (-)NCBI
mRatBN7.26104,429,947 - 104,527,374 (-)NCBI
RefSeq Acc Id: XM_039112809   ⟹   XP_038968737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,034 - 110,258,429 (-)NCBI
mRatBN7.26104,429,947 - 104,527,375 (-)NCBI
RefSeq Acc Id: XM_063262382   ⟹   XP_063118452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,034 - 110,258,426 (-)NCBI
RefSeq Acc Id: XM_063262384   ⟹   XP_063118454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,161,034 - 110,258,427 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067597   ⟸   NM_021586
- UniProtKB: A6JDY9 (UniProtKB/TrEMBL),   F1M7L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240412   ⟸   XM_006240350
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1G5 (UniProtKB/TrEMBL),   A6JDZ0 (UniProtKB/TrEMBL),   A0A8I6A5Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038437   ⟸   ENSRNOT00000031331
RefSeq Acc Id: ENSRNOP00000071831   ⟸   ENSRNOT00000082792
RefSeq Acc Id: ENSRNOP00000075533   ⟸   ENSRNOT00000077458
RefSeq Acc Id: XP_038968737   ⟸   XM_039112809
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5Z7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968736   ⟸   XM_039112808
- Peptide Label: isoform X2
- UniProtKB: A6JDY9 (UniProtKB/TrEMBL),   F1M7L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088184   ⟸   ENSRNOT00000113831
RefSeq Acc Id: XP_063118454   ⟸   XM_063262384
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063118452   ⟸   XM_063262382
- Peptide Label: isoform X4
Protein Domains
EGF-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35806-F1-model_v2 AlphaFold O35806 1-1764 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694744
Promoter ID:EPDNEW_R5256
Type:initiation region
Name:Ltbp2_1
Description:latent transforming growth factor beta binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06108,596,555 - 108,596,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68380 AgrOrtholog
BioCyc Gene G2FUF-36806 BioCyc
Ensembl Genes ENSRNOG00000012094 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031331 ENTREZGENE
  ENSRNOT00000031331.5 UniProtKB/TrEMBL
  ENSRNOT00000077458.2 UniProtKB/TrEMBL
  ENSRNOT00000082792.2 UniProtKB/TrEMBL
  ENSRNOT00000113831.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59106 UniProtKB/Swiss-Prot
NCBI Gene 59106 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  VACUOLAR-SORTING RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ltbp2 PhenoGen
PIRSF Fibrillin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012094 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57581 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206937
UniProt A0A0G2K1G5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAU7_RAT UniProtKB/TrEMBL
  A0A8I6A5Z7 ENTREZGENE, UniProtKB/TrEMBL
  A6JDY9 ENTREZGENE, UniProtKB/TrEMBL
  A6JDZ0 ENTREZGENE, UniProtKB/TrEMBL
  F1M7L7 ENTREZGENE, UniProtKB/TrEMBL
  LTBP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ltbp2  latent transforming growth factor beta binding protein 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference