Gpm6a (glycoprotein m6a) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Gpm6a (glycoprotein m6a) Rattus norvegicus
Analyze
Symbol: Gpm6a
Name: glycoprotein m6a
RGD ID: 631368
Description: Enables calcium channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: M6a; neuronal membrane glycoprotein M6-a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,374,385 - 43,706,461 (-)NCBIGRCr8
mRatBN7.21636,641,282 - 36,973,377 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1642,008,018 - 42,338,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01645,368,826 - 45,698,861 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01640,750,344 - 41,066,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01639,367,697 - 39,719,292 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01639,144,853 - 39,493,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41639,670,748 - 39,783,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11639,670,823 - 39,783,459 (-)NCBI
Celera1634,795,943 - 34,908,788 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (EXP)
terbufos  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Alfonso J, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17196-201. Epub 2005 Nov 14.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis. Formoso K, etal., Mol Cell Neurosci. 2016 Dec;77:95-104. doi: 10.1016/j.mcn.2016.10.005. Epub 2016 Oct 26.
4. Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. Fuchsova B, etal., J Biol Chem. 2009 Nov 13;284(46):32075-88. doi: 10.1074/jbc.M109.012377. Epub 2009 Sep 8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation. Mukobata S, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):722-8.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Immunoelectron microscopic localization of the M6a antigen in rat brain. Roussel G, etal., J Neurocytol. 1998 Sep;27(9):695-703. doi: 10.1023/a:1006924400768.
12. Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts. Scorticati C, etal., J Neurochem. 2011 Nov;119(3):521-31. doi: 10.1111/j.1471-4159.2011.07252.x. Epub 2011 Apr 13.
13. Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. Wu DF, etal., J Biol Chem. 2007 Jul 27;282(30):22239-47. Epub 2007 Jun 4.
Additional References at PubMed
PMID:12477932   PMID:18241840   PMID:18776950   PMID:19056867   PMID:19180239   PMID:19298174   PMID:20074218   PMID:21714103   PMID:22871113   PMID:23012479   PMID:23959066   PMID:24769233  
PMID:25940868   PMID:26809475   PMID:36943192   PMID:37189342  


Genomics

Comparative Map Data
Gpm6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,374,385 - 43,706,461 (-)NCBIGRCr8
mRatBN7.21636,641,282 - 36,973,377 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1642,008,018 - 42,338,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01645,368,826 - 45,698,861 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01640,750,344 - 41,066,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01639,367,697 - 39,719,292 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01639,144,853 - 39,493,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41639,670,748 - 39,783,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11639,670,823 - 39,783,459 (-)NCBI
Celera1634,795,943 - 34,908,788 (-)NCBICelera
Cytogenetic Map16p11NCBI
GPM6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384175,632,937 - 176,002,691 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4175,632,934 - 176,002,664 (-)EnsemblGRCh38hg38GRCh38
GRCh374176,554,088 - 176,923,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364176,791,082 - 177,160,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 344176,929,237 - 177,298,797NCBI
Celera4173,882,262 - 174,251,819 (-)NCBICelera
Cytogenetic Map4q34.2NCBI
HuRef4172,304,394 - 172,674,410 (-)NCBIHuRef
CHM1_14176,530,612 - 176,900,675 (-)NCBICHM1_1
T2T-CHM13v2.04178,971,366 - 179,341,143 (-)NCBIT2T-CHM13v2.0
Gpm6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39855,232,469 - 55,513,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl855,407,878 - 55,513,906 (+)EnsemblGRCm39 Ensembl
GRCm38854,779,434 - 55,060,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,954,843 - 55,060,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37856,040,081 - 56,146,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36856,453,541 - 56,559,569 (+)NCBIMGSCv36mm8
Celera857,650,307 - 57,756,272 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.33NCBI
Gpm6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540331,861,945 - 31,997,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540331,704,540 - 31,997,382 (+)NCBIChiLan1.0ChiLan1.0
GPM6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23173,359,853 - 173,727,990 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14173,740,237 - 174,109,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04167,826,285 - 168,194,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14180,059,938 - 180,428,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4180,059,938 - 180,428,459 (-)Ensemblpanpan1.1panPan2
GPM6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11653,697,830 - 53,846,773 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1653,698,043 - 53,845,259 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1649,017,267 - 49,350,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01655,829,048 - 56,161,090 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,829,183 - 56,163,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,724,013 - 54,054,937 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01654,320,566 - 54,651,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01654,556,465 - 54,887,736 (+)NCBIUU_Cfam_GSD_1.0
Gpm6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494325,924,766 - 26,232,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365166,338,819 - 6,481,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365166,339,058 - 6,647,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPM6A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1538,259,244 - 38,305,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11538,258,496 - 38,555,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21543,980,735 - 44,241,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPM6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17121,715,329 - 122,082,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7121,714,770 - 121,894,739 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037101,794,371 - 102,161,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpm6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247696,762,743 - 6,904,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247696,763,158 - 7,082,764 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpm6a
1085 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:562
Count of miRNA genes:278
Interacting mature miRNAs:354
Transcripts:ENSRNOT00000014312
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8
Medium 2 16 16 7 16 66 18 16 10
Low 2 41 41 25 12 25 8 8 17 23 1 8
Below cutoff 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014312   ⟹   ENSRNOP00000014312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,754,160 (-)Ensembl
Rnor_6.0 Ensembl1639,367,697 - 39,476,025 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092968   ⟹   ENSRNOP00000075966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,776 - 36,754,519 (-)Ensembl
Rnor_6.0 Ensembl1639,368,185 - 39,476,384 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092971   ⟹   ENSRNOP00000075962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)Ensembl
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100181   ⟹   ENSRNOP00000095052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,666,617 (-)Ensembl
RefSeq Acc Id: NM_001394533   ⟹   NP_001381462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,706,461 (-)NCBI
mRatBN7.21636,641,282 - 36,973,377 (-)NCBI
RefSeq Acc Id: NM_001394534   ⟹   NP_001381463
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,487,812 (-)NCBI
mRatBN7.21636,641,282 - 36,754,710 (-)NCBI
RefSeq Acc Id: NM_178105   ⟹   NP_835206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,487,812 (-)NCBI
mRatBN7.21636,641,282 - 36,754,710 (-)NCBI
Rnor_6.01639,367,697 - 39,476,025 (-)NCBI
Rnor_5.01639,144,853 - 39,493,517 (-)NCBI
RGSC_v3.41639,670,748 - 39,783,384 (-)RGD
Celera1634,795,943 - 34,908,788 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094504   ⟹   XP_038950432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,602,384 (-)NCBI
mRatBN7.21636,641,282 - 36,869,402 (-)NCBI
RefSeq Acc Id: XM_063275414   ⟹   XP_063131484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,706,427 (-)NCBI
RefSeq Acc Id: XM_063275415   ⟹   XP_063131485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,401,416 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_835206   ⟸   NM_178105
- Peptide Label: isoform 1
- UniProtKB: Q812E9 (UniProtKB/Swiss-Prot),   A0A8I6APM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075962   ⟸   ENSRNOT00000092971
RefSeq Acc Id: ENSRNOP00000075966   ⟸   ENSRNOT00000092968
RefSeq Acc Id: ENSRNOP00000014312   ⟸   ENSRNOT00000014312
RefSeq Acc Id: XP_038950432   ⟸   XM_039094504
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GWN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095052   ⟸   ENSRNOT00000100181
RefSeq Acc Id: NP_001381462   ⟸   NM_001394533
- Peptide Label: isoform 2
- UniProtKB: A6JPG6 (UniProtKB/TrEMBL),   A0A8I6APM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381463   ⟸   NM_001394534
- Peptide Label: isoform 3
- UniProtKB: A0A1B0GWN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131484   ⟸   XM_063275414
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131485   ⟸   XM_063275415
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GWN8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q812E9-F1-model_v2 AlphaFold Q812E9 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700091
Promoter ID:EPDNEW_R10604
Type:initiation region
Name:Gpm6a_1
Description:glycoprotein m6a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01639,719,143 - 39,719,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631368 AgrOrtholog
BioCyc Gene G2FUF-11476 BioCyc
Ensembl Genes ENSRNOG00000010731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007814 UniProtKB/Swiss-Prot
  ENSRNOG00060007153 UniProtKB/Swiss-Prot
  ENSRNOG00065014802 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014312 ENTREZGENE
  ENSRNOT00000014312.8 UniProtKB/Swiss-Prot
  ENSRNOT00000092968 ENTREZGENE
  ENSRNOT00000092968.2 UniProtKB/TrEMBL
  ENSRNOT00000092971 ENTREZGENE
  ENSRNOT00000092971.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100181.1 UniProtKB/TrEMBL
  ENSRNOT00055013096 UniProtKB/Swiss-Prot
  ENSRNOT00060011789 UniProtKB/Swiss-Prot
  ENSRNOT00065024489 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313006 IMAGE-MGC_LOAD
InterPro Myelin_PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myelin_PLP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306439 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105292 IMAGE-MGC_LOAD
NCBI Gene 306439 ENTREZGENE
PANTHER NEURONAL MEMBRANE GLYCOPROTEIN M6-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myelin_PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpm6a PhenoGen
PRINTS MYELINPLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYELIN_PLP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYELIN_PLP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010731 RatGTEx
  ENSRNOG00055007814 RatGTEx
  ENSRNOG00060007153 RatGTEx
  ENSRNOG00065014802 RatGTEx
SMART PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GWN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APM4 ENTREZGENE, UniProtKB/TrEMBL
  A6JPG6 ENTREZGENE, UniProtKB/TrEMBL
  GPM6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Gpm6a  glycoprotein m6a      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation gated selectively by phosphorylation with PKC in the downstream of NGF signaling pathway 708586