Fzd3 (frizzled class receptor 3) - Rat Genome Database

Name: Fzd3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fzd3 (frizzled class receptor 3) Rattus norvegicus

Analyze

Symbol:

Fzd3

Name:

frizzled class receptor 3

RGD ID:

628814

Description:

Predicted to enable PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in response to electrical stimulus and response to xenobiotic stimulus. Predicted to be located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Predicted to be active in plasma membrane. Predicted to colocalize with presynaptic active zone. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, the planar cell polarity pathway; basal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

frizzled 3; frizzled family receptor 3; frizzled homolog 3; frizzled homolog 3 (Drosophila); frizzled-3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD3 (frizzled class receptor 3)	RGD	RGD
Mus musculus (house mouse):	Fzd3 (frizzled class receptor 3)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Fzd3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FZD3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd3 (frizzled class receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FZD3 (frizzled class receptor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fzd3 (frizzled class receptor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd3a (frizzled class receptor 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	fzd3b (frizzled class receptor 3b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mom-5	Alliance	DIOPT (Hieranoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fzd3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	43,596,962 - 43,664,047 (-)	NCBI		GRCr8
mRatBN7.2	15	39,421,366 - 39,488,369 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	39,421,355 - 39,488,369 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	41,285,253 - 41,352,327 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	42,435,950 - 42,503,032 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	40,881,715 - 40,948,712 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	48,601,259 - 48,670,257 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	48,601,266 - 48,670,257 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	52,344,559 - 52,411,769 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	15	39,096,287 - 39,163,152 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Agenesis of Corpus Callosum (ISO)

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

benign familial infantile seizures 6 (ISO)

cerebellar hypoplasia (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

schizophrenia (ISO)

Williams-Beuren syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

adenosine (ISO)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

Aroclor 1254 (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

chlorpyrifos (EXP,ISO)

clofibrate (ISO)

clorgyline (ISO)

copper(II) sulfate (ISO)

cordycepin (ISO)

cyclosporin A (ISO)

diazinon (EXP)

diclofenac (ISO)

dieldrin (EXP)

dorsomorphin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

lithium chloride (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

miconazole (ISO)

N-nitrosodiethylamine (ISO)

nickel sulfate (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

retinyl acetate (ISO)

rotenone (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IBA,ISO)

cell proliferation in midbrain (ISO)

commissural neuron axon guidance (ISO)

dopaminergic neuron axon guidance (ISO)

establishment of planar polarity (ISO)

hair follicle development (ISO)

inner ear morphogenesis (ISO)

midbrain development (ISO)

motor neuron migration (ISO)

negative regulation of execution phase of apoptosis (ISO)

negative regulation of mitotic cell cycle, embryonic (ISO)

neural tube closure (ISO)

non-canonical Wnt signaling pathway (IBA)

positive regulation of neuroblast proliferation (ISO)

post-anal tail morphogenesis (ISO)

response to electrical stimulus (IEP)

response to xenobiotic stimulus (IEP)

serotonergic neuron axon guidance (ISO)

sympathetic ganglion development (ISO)

Wnt signaling pathway, planar cell polarity pathway (ISO)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (ISO)

axon (ISO)

cytoplasm (ISO)

dendrite (ISO)

filopodium tip (ISO)

glutamatergic synapse (ISO)

lateral plasma membrane (ISO)

neuronal cell body (ISO)

plasma membrane (IBA,ISO)

presynaptic active zone (ISO)

presynaptic active zone membrane (ISO)

Molecular Function

PDZ domain binding (ISO)

protein binding (ISO)

Wnt receptor activity (IBA,ISO)

Wnt-protein binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, the planar cell polarity pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.	Hashimoto R, etal., J Neural Transm. 2005 Feb;112(2):303-7.
4.	Planar cell polarity signaling in vertebrates.	Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
5.	The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.	Katsu T, etal., Neurosci Lett. 2003 Dec 15;353(1):53-6.
6.	Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21.	Kirikoshi H, etal., Biochem Biophys Res Commun 2000 Apr 29;271(1):8-14.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
14.	A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.	Wang YK, etal., Hum Mol Genet. 1997 Mar;6(3):465-72.
15.	Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.	Wright M, etal., Biochem Biophys Res Commun 1999 Sep 24;263(2):384-8.
16.	Identification and expression of frizzled-3 protein in rat frontal cortex after antidepressant and electroconvulsive treatment.	Yamada M, etal., J Pharmacol Sci. 2005 Nov;99(3):239-46. Epub 2005 Oct 27.
17.	Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.	Zhang Y, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129(1):16-9.

Additional References at PubMed

PMID:11407985	PMID:12399112	PMID:14671310	PMID:15035989	PMID:16495441	PMID:16687519	PMID:18256285	PMID:18986540	PMID:19038973	PMID:19300477	PMID:19388021	PMID:19842188
PMID:19966784	PMID:20016102	PMID:20473291	PMID:20631168	PMID:20802536	PMID:21106844	PMID:21325504	PMID:21746835	PMID:24305805	PMID:31145996

Genomics

Comparative Map Data

Fzd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	43,596,962 - 43,664,047 (-)	NCBI		GRCr8
mRatBN7.2	15	39,421,366 - 39,488,369 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	39,421,355 - 39,488,369 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	41,285,253 - 41,352,327 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	42,435,950 - 42,503,032 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	40,881,715 - 40,948,712 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	48,601,259 - 48,670,257 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	48,601,266 - 48,670,257 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	52,344,559 - 52,411,769 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	15	39,096,287 - 39,163,152 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

FZD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	28,494,212 - 28,574,258 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	28,494,205 - 28,574,267 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	28,351,729 - 28,431,775 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	28,407,692 - 28,477,901 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	28,407,691 - 28,477,878	NCBI
Celera	8	27,311,635 - 27,381,797 (+)	NCBI		Celera
Cytogenetic Map	8	p21.1	NCBI
HuRef	8	26,896,974 - 26,976,914 (+)	NCBI		HuRef
CHM1_1	8	28,553,619 - 28,633,637 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	28,772,375 - 28,852,426 (+)	NCBI		T2T-CHM13v2.0

Fzd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	65,429,890 - 65,499,912 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	65,429,898 - 65,499,912 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	65,192,441 - 65,262,463 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	65,192,449 - 65,262,463 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	65,811,278 - 65,881,300 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	64,156,509 - 64,214,778 (-)	NCBI		MGSCv36	mm8
Celera	14	62,949,327 - 63,019,543 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.09	NCBI

Fzd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	50,899,523 - 50,959,071 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	50,899,658 - 50,959,077 (+)	NCBI	ChiLan1.0	ChiLan1.0

FZD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	47,032,683 - 47,115,786 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	22,745,829 - 22,828,705 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	27,773,699 - 27,853,980 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	24,973,644 - 25,053,388 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	24,973,644 - 25,042,115 (+)	Ensembl	panpan1.1		panPan2

FZD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	28,969,126 - 29,075,763 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	28,952,477 - 29,075,851 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	29,618,932 - 29,725,782 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	29,127,606 - 29,234,347 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	29,107,555 - 29,234,327 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	29,087,452 - 29,194,695 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	28,971,836 - 29,078,759 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	29,137,221 - 29,244,439 (-)	NCBI		UU_Cfam_GSD_1.0

Fzd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	7,234,538 - 7,310,652 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	1,275,470 - 1,333,540 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	1,275,500 - 1,334,878 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	12,281,155 - 12,390,530 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	12,281,127 - 12,394,768 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	13,436,031 - 13,538,954 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FZD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	26,598,544 - 26,668,983 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	26,598,610 - 26,667,543 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	15,464,757 - 15,538,321 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	23,147,452 - 23,230,879 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	23,147,512 - 23,240,711 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fzd3
285 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	171
Count of miRNA genes:	128
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000071464
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat

Markers in Region

RH130377

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,421,577 - 39,421,773 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	48,601,471 - 48,601,666	NCBI	Rnor6.0
Rnor_5.0	15	52,344,771 - 52,344,966	UniSTS	Rnor5.0
Celera	15	39,096,499 - 39,096,694	UniSTS

BE115404

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,450,848 - 39,451,007 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	48,632,980 - 48,633,136	NCBI	Rnor6.0
Rnor_5.0	15	52,374,405 - 52,374,561	UniSTS	Rnor5.0
Celera	15	39,125,696 - 39,125,854	UniSTS
RH 3.4 Map	15	294.6	UniSTS

Fzd3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,464,758 - 39,464,918 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	48,646,320 - 48,646,479	NCBI	Rnor6.0
Rnor_5.0	15	52,387,832 - 52,387,991	UniSTS	Rnor5.0
Celera	15	39,139,589 - 39,139,748	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		4	2	2		2			74	20	24	5
Low	3	37	38	22	17	22	8	8		15	17	6	8
Below cutoff		2	17	17	2	17		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF323956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF481947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000071464 ⟹ ENSRNOP00000067360

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	39,421,369 - 39,488,369 (-)	Ensembl
Rnor_6.0 Ensembl	15	48,601,266 - 48,670,257 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109699 ⟹ ENSRNOP00000083631

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	39,421,355 - 39,488,369 (-)	Ensembl

RefSeq Acc Id:

NM_153474 ⟹ NP_703204

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	43,596,962 - 43,663,960 (-)	NCBI
mRatBN7.2	15	39,421,366 - 39,488,369 (-)	NCBI
Rnor_6.0	15	48,601,259 - 48,670,257 (-)	NCBI
Rnor_5.0	15	52,344,559 - 52,411,769 (-)	NCBI
Celera	15	39,096,287 - 39,163,152 (-)	RGD

Sequence:

show sequence

CCGCCTGCGGGGCCAGCGGTGCTACCCGGGAGAGCCCGGAGGCCGGCGGTGAGATATTTCAACA
AGAAAGAAATCACTCTCCTAAGATGGAATCTGTGATTTGGGAATGTGGTTGATCAACTTGATAT
GCTGGCCAGATGTGCCCATGTAATAAAATGAAAAGAAGATACAAGATGATGTCATTTTCCCGTA
TTGTGAAACCAAAAACAAATGCCCTTTGTGAGACCAGGTTAACAGTCCTTTGATAGTACAGGGA
GTTTTTAGCAGATATAGAAGAGGATACTTTCAAGCTGAGACCTGCTGGCATATACTGATCTAAA
GCACATCTTGAGTAGATCTGACCATCCGAGGCTCATTTTGATCCAGGAAGAATGGCTGTGAGCT
GGATTGTCTTTTATCTTTGGCTCTTGACTGTGTTTCTGGGGCAGATAGGTGGGCACAGTTTGTT
TTCTTGTGAACCTATAACCTTGAGGATGTGCCAAGATTTGCCTTACAATACTACCTTCATGCCT
AATCTTCTGAACCATTATGACCAGCAGACAGCAGCTTTAGCAATGGAGCCATTCCACCCTATGG
TGAACCTGGATTGTTCTCGGGATTTTCGGCCATTTCTTTGTGCACTCTATGCCCCTATTTGTAT
GGAATATGGACGTGTCACACTCCCCTGCCGTAGGCTGTGTCAGCGTGCCTATAGTGAGTGCTCA
AAGCTCATGGAGATGTTTGGTGTCCCCTGGCCTGAAGATATGGAGTGCAGTAGGTTTCCAGATT
GTGATGAGCCATATCCCCGACTTGTGGATTTGAATTTAGTTGGAGATCCAACTGAAGGAGCCCC
AGTGGCAGTACAGAGGGATTATGGTTTTTGGTGTCCCCGAGAGTTGAAAATTGATCCTGACCTT
GGCTATTCCTTTCTGCACGTGCGAGATTGTTCACCACCATGTCCCAATATGTACTTCAGGAGAG
AAGAACTGTCATTTGCTCGCTATTTCATAGGCCTGATTTCAATCATTTGCCTCTCTGCCACATT
GGTTACTTTTTTAACCTTTCTGATTGACGTCACAAGATTCCGTTACCCTGAAAGACCTATCATA
TTTTATGCAGTCTGCTACATGATGGTGTCATTAATTTTCTTCATTGGGTTTTTGCTTGAGGACC
GAGTAGCCTGCAATGCATCTAGCCCTGCACAGTATAAGGCTTCCACAGTGACACAAGGATCTCA
CAATAAGGCCTGTACCATGCTCTTCATGGTACTCTATTTTTTCACTATGGCTGGCAGTGTATGG
TGGGTAATTCTTACCATCACATGGTTTTTAGCAGCTGTGCCAAAGTGGGGCAGTGAAGCTATTG
AGAAAAAAGCATTGCTGTTTCATGCCAGTGCCTGGGGCATCCCCGGAACTCTAACTATCATCCT
TTTAGCGATGAATAAAATTGAAGGTGACAATATTAGTGGCGTGTGCTTTGTCGGCCTCTACGAC
GTAGATGCATTAAGATATTTTGTTCTTGCTCCCCTCTGCCTGTATGTGGTAGTTGGGGTTTCTC
TCCTCTTAGCCGGCATTATATCCCTAAACAGAGTTCGGATTGAGATCCCATTAGAAAAGGAAAA
CCAAGATAAGTTAGTGAAGTTCATGATCCGGATCGGTGTTTTCAGCATTCTCTACCTTGTCCCA
CTCTTGGTTGTAATTGGATGTTACTTTTATGAGCAAGCTTACCGCGGCATCTGGGAAACAACAT
GGATACAGGAACGCTGCAGAGAATATCACATTCCGTGTCCGTACCAGGTTACTCAGATGAGTCG
TCCAGACCTGATTCTCTTTCTGATGAAGTATCTCATGGCTCTCATAGTTGGGATTCCCTCTATT
TTTTGGGTTGGAAGCAAAAAAACATGCTTTGAATGGGCCAGCTTTTTCCATGGGCGTAAGAAAA
AAGAGACAGTGAATGAGAGCCGGCAGGTGCTCCAGGAACCTGACTTTGCTCAGTCACTCCTGAG
GGACCCAAATACTCCAATTATAAGAAAATCAAGAGGAACTTCCACTCAAGGGACATCCACACAT
GCTTCTTCAACTCAGCTGGCCATGGTGGATGATCAAAGAAGCAAAGCAGGGAGTGTCCACAGCA
AAGTGAGCAGCTACCATGGCAGCCTCCACAGGTCACGTGATGGCAGGTACACTCCCTGCAGTTA
CCGAGGGATGGAGGAGAGACTACCTCACGGCAGCATGTCACGGCTGACAGATCACTCCAGGCAC
AGTAGTTCTCATCGGCTCAATGAGCAGTCCCGACACAGCAGCATCCGAGACCTCAGCAACAACC
CCATGACTCACATTACACATGGCACCAGCATGAACCGTGTTATTGAAGAGGATGGAACCAGTGC
TTAGTCTTGTCTAAGGTGAAATGTGTGCTGTGGAAAAGCAGGTGTTAGTCTTGGCCTTCGCATG
GCTGGCTGCTGTTACTTGCTGTCACTCTGCTTTCTCGGGCAGAGTGTGCCCACTGGGAAAGTAG
ATCTTTGCTCTTTGTGTCACATCAACCTTGGGATATGAACACATCCAAAACACTAGGAATCATG
TCATCACAAAAGTAATTCTTTTAGGCTGTGGAGAGATGACTGTCTGGTAAGCATTTTTATAAAT
CCGCTTATTTTATATCTAGAAAAATCCTCTATGTGTGGTGACTGCTTTGTAGTGAATTTTCATA
TAATATGAACTAAGTTGTGAAATGACATTCTGGTAGCTCTGTTAATAAAACAAAGTTTCAGAAT
TAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063274036 ⟹ XP_063130106

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	43,605,095 - 43,664,047 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_703204	(Get FASTA)	NCBI Sequence Viewer
	XP_063130106	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN14442	(Get FASTA)	NCBI Sequence Viewer
	AAN51982	(Get FASTA)	NCBI Sequence Viewer
	EDL85351	(Get FASTA)	NCBI Sequence Viewer
	EDL85352	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067360
	ENSRNOP00000067360.2
	ENSRNOP00000083631.1

RefSeq Acc Id:	NP_703204 ⟸ NM_153474
- Peptide Label:	precursor
- UniProtKB:	Q8CJC4 (UniProtKB/TrEMBL), A0A8I5ZWZ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVSWIVFYLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEP FHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECS RFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNM YFRREELSFARYFIGLISIICLSATLVTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF LLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWG SEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVV VGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGI WETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFH GRKKKETVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAG SVHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRD LSNNPMTHITHGTSMNRVIEEDGTSA hide sequence

RefSeq Acc Id:

ENSRNOP00000067360 ⟸ ENSRNOT00000071464

RefSeq Acc Id:

ENSRNOP00000083631 ⟸ ENSRNOT00000109699

RefSeq Acc Id:	XP_063130106 ⟸ XM_063274036
- Peptide Label:	isoform X1

Protein Domains

FZ G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RCN5-F1-model_v2	AlphaFold	M0RCN5	1-666	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628814	AgrOrtholog
BioCyc Gene	G2FUF-13362	BioCyc
Ensembl Genes	ENSRNOG00000047211	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000071464	ENTREZGENE
	ENSRNOT00000071464.2	UniProtKB/TrEMBL
	ENSRNOT00000109699.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Frizzled	UniProtKB/TrEMBL
	Frizzled/SFRP	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	FZ3_CRD	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
KEGG Report	rno:266715	UniProtKB/TrEMBL
NCBI Gene	266715	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/TrEMBL
	PTHR11309:SF22	UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PhenoGen	Fzd3	PhenoGen
PRINTS	FRIZZLED	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000047211	RatGTEx
SMART	FRI	UniProtKB/TrEMBL
	Frizzled	UniProtKB/TrEMBL
Superfamily-SCOP	Frizzled_Cys-rich	UniProtKB/TrEMBL
UniProt	A0A8I5ZWZ3	ENTREZGENE, UniProtKB/TrEMBL
	A6K6J1_RAT	UniProtKB/TrEMBL
	M0RCN5_RAT	UniProtKB/TrEMBL
	Q8CJC4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Fzd3	frizzled class receptor 3	Fzd3	frizzled family receptor 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Fzd3	frizzled family receptor 3	Fzd3	frizzled homolog 3 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Fzd3	frizzled homolog 3 (Drosophila)			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Fzd3	frizzled homolog 3 (Drosophila)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)