Abo3 (histo-blood group ABO system transferase 3) - Rat Genome Database

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Gene: Abo3 (histo-blood group ABO system transferase 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abo3
Name: histo-blood group ABO system transferase 3
RGD ID: 628609
Description: Enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in defense response to bacterium. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase); INTERACTS WITH 17beta-estradiol; fenvalerate; testosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a transferase; Abo; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); ABO blood group (transferase B, alpha 1-3-galactosyltransferase); ABO blood group-like 1; Abol1; alpha 1-3-N-acetylgalactosaminyltransferase-like 1; B blood group galactosyltransferase; b transferase; blood group A glycosyltransferase 1; cis-AB transferase 1; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Gbgt1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase 1; histo-blood group B transferase; N-acetylgalactosaminyltransferase A blood group-like enzyme; NAGAT 1; transferase B, alpha 1-3-galactosyltransferase)
RGD Orthologs
Alliance Genes
More Info homologs ...
Is Marker For: Strains:   W-Tg(CAG-ABO*A)32Jmsk   W-Tg(CAG-ABO*B)13Jmsk   W-Tg(CAG-ABO*B)2Jmsk  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,141,941 - 30,159,129 (+)NCBIGRCr8
mRatBN7.239,743,861 - 9,761,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,646,515 - 9,761,043 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,109,880 - 5,127,376 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,118,956 - 5,126,901 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,462,400 - 10,479,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,253,147 - 5,269,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera34,553,035 - 4,569,671 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens. Cailleau-Thomas A, etal., Eur J Biochem 2002 Aug;269(16):4040-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat encodes the paralogous gene equivalent of the human histo-blood group ABO gene. Association with antigen expression by overexpression of human ABO transferase. Iwamoto S, etal., J Biol Chem 2002 Nov 29;277(48):46463-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection. Olson FJ, etal., J Biol Chem 2002 Apr 26;277(17):15044-52.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12799344  


Genomics

Variants

.
Variants in Abo3
2234 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:80
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000006553, ENSRNOT00000074271
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat


Related Rat Strains
The following Strains have been annotated to Abo3
W-Tg(CAG-ABO*A)32Jmsk     W-Tg(CAG-ABO*B)13Jmsk     W-Tg(CAG-ABO*B)2Jmsk    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system renal system reproductive system respiratory system
High
Medium 2
Low 4 4 4 3
Below cutoff 11 10 2 10 19 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006553   ⟹   ENSRNOP00000006553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,743,869 - 9,761,043 (+)Ensembl
Rnor_6.0 Ensembl35,118,956 - 5,126,901 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074271   ⟹   ENSRNOP00000065701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,687,102 - 9,761,043 (+)Ensembl
Rnor_6.0 Ensembl35,118,962 - 5,126,901 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108913   ⟹   ENSRNOP00000077013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,752,800 - 9,761,043 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113251   ⟹   ENSRNOP00000087139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,752,315 - 9,761,043 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116703   ⟹   ENSRNOP00000084937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,646,515 - 9,761,043 (+)Ensembl
RefSeq Acc Id: NM_023094   ⟹   NP_075582
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,141,941 - 30,159,129 (+)NCBI
mRatBN7.239,743,861 - 9,761,049 (+)NCBI
Rnor_6.035,109,880 - 5,126,901 (+)NCBI
Rnor_5.0310,462,400 - 10,479,896 (+)NCBI
RGSC_v3.435,253,147 - 5,269,783 (+)RGD
Celera34,553,035 - 4,569,671 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_075582   ⟸   NM_023094
- UniProtKB: Q8R4Y3 (UniProtKB/Swiss-Prot),   Q8R005 (UniProtKB/Swiss-Prot),   Q8CFC6 (UniProtKB/Swiss-Prot),   Q8CFC5 (UniProtKB/Swiss-Prot),   Q8R552 (UniProtKB/Swiss-Prot),   Q9ET32 (UniProtKB/Swiss-Prot),   A0A0H2UI32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006553   ⟸   ENSRNOT00000006553
RefSeq Acc Id: ENSRNOP00000065701   ⟸   ENSRNOT00000074271
RefSeq Acc Id: ENSRNOP00000087139   ⟸   ENSRNOT00000113251
RefSeq Acc Id: ENSRNOP00000077013   ⟸   ENSRNOT00000108913
RefSeq Acc Id: ENSRNOP00000084937   ⟸   ENSRNOT00000116703

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ET32-F1-model_v2 AlphaFold Q9ET32 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628609 AgrOrtholog
BioCyc Gene G2FUF-50340 BioCyc
Ensembl Genes ENSRNOG00000039906 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006553 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000006553.8 UniProtKB/Swiss-Prot
  ENSRNOT00000074271 UniProtKB/TrEMBL
  ENSRNOT00000074271.4 UniProtKB/Swiss-Prot
  ENSRNOT00000108913.1 UniProtKB/TrEMBL
  ENSRNOT00000113251.1 UniProtKB/TrEMBL
  ENSRNOT00000116703.1 UniProtKB/TrEMBL
InterPro Glyco_trans_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65270 UniProtKB/Swiss-Prot
NCBI Gene 65270 ENTREZGENE
PANTHER HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10462 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abo3 PhenoGen
RatGTEx ENSRNOG00000039906 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHD6_RAT UniProtKB/TrEMBL
  A0A0H2UI32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5T8_RAT UniProtKB/TrEMBL
  A0A8I6A083_RAT UniProtKB/TrEMBL
  A0A8I6AFZ9_RAT UniProtKB/TrEMBL
  BGAT1_RAT UniProtKB/Swiss-Prot
  Q8CFC5 ENTREZGENE
  Q8CFC6 ENTREZGENE
  Q8R005 ENTREZGENE
  Q8R4Y3 ENTREZGENE
  Q8R552 ENTREZGENE
  Q9ET32 ENTREZGENE
UniProt Secondary Q8CFC5 UniProtKB/Swiss-Prot
  Q8CFC6 UniProtKB/Swiss-Prot
  Q8R005 UniProtKB/Swiss-Prot
  Q8R4Y3 UniProtKB/Swiss-Prot
  Q8R552 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-17 Abol1  alpha 1-3-N-acetylgalactosaminyltransferase-like 1  Gbgt1l  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1-like  Name and Symbol changed 629549 APPROVED
2015-12-17 Gbgt1l  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1-like  Gbgt1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1  Name and Symbol changed 629549 APPROVED
2015-12-17 Abo3  histo-blood group ABO system transferase 3  Abol1  alpha 1-3-N-acetylgalactosaminyltransferase-like 1  Name and Symbol changed 629549 APPROVED
2013-12-11 Gbgt1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1  Abol1  ABO blood group-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-04-21 Abol1  ABO blood group-like 1  Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a short N-terminal intracytoplasmic domain, a transmembrane domain followed by a stem region and a catalytic domain 625720
gene_expression A antigen expressesd in tongue, oesophagus, large intestine, pancreas, parotid gland, submaxillary gland stomach, seminal vesicle, parathyroid gland, and thymus 625720
gene_function showed histo-blood group A-transferase activity 631948
gene_homology amino acid sequence is 70, 71 and 77% identity with the human, pig and mouse sequences, respectively 625720
gene_mapping mapped to rat chromosome 3 (q11-q12), a region homologous to human 9q34 625720
gene_process demonstrated a small UDP-Gal:Fucalpha1,2GalalphaGal transferase (B transferase) activity 625720
gene_regulation induced during infection with the parasite Nipponstrongylus brasiliensis