Rapgef3 (Rap guanine nucleotide exchange factor 3) - Rat Genome Database

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Gene: Rapgef3 (Rap guanine nucleotide exchange factor 3) Rattus norvegicus
Analyze
Symbol: Rapgef3
Name: Rap guanine nucleotide exchange factor 3
RGD ID: 621869
Description: Enables cAMP binding activity and transmembrane transporter binding activity. Involved in several processes, including cellular response to L-dopa; nervous system development; and positive regulation of nitrogen compound metabolic process. Located in several cellular components, including basolateral part of cell; brush border membrane; and distal axon. Colocalizes with cortical actin cytoskeleton and plasma membrane. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3); PARTICIPATES IN adenosine signaling pathway; long term potentiation; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); Epac; epac 1; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; MGC124613; Rap guanine nucleotide exchange factor (GEF) 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,754,883 - 130,777,303 (-)NCBIGRCr8
mRatBN7.27128,875,772 - 128,898,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,875,773 - 128,898,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,672,963 - 130,694,833 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,898,495 - 132,920,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,810,963 - 132,832,833 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,232,263 - 139,254,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,232,251 - 139,254,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,423,916 - 139,445,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,452,945 - 136,474,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,529,382 - 136,551,096 (-)NCBI
Celera7125,367,430 - 125,389,118 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
artery development  (IEP)
associative learning  (IEA,ISO)
cellular response to cAMP  (IEA,ISO,ISS)
cellular response to L-dopa  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
dorsal root ganglion development  (IEP)
establishment of endothelial barrier  (IEA,ISO,ISS)
intracellular signal transduction  (ISO)
liver regeneration  (IEP)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of syncytium formation by plasma membrane fusion  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of calcium ion transmembrane transport  (IMP)
positive regulation of cell size  (IMP)
positive regulation of GTP binding  (IMP)
positive regulation of potassium:proton exchanging ATPase activity  (IMP)
positive regulation of protein export from nucleus  (IEA,ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of stress fiber assembly  (IEA,ISO,ISS)
positive regulation of syncytium formation by plasma membrane fusion  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
Rap protein signal transduction  (IEA,ISO,ISS)
Ras protein signal transduction  (IBA,IEA)
regulation of actin cytoskeleton organization  (IMP,ISO,ISS)
regulation of angiogenesis  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
response to nicotine  (IEP)
small GTPase-mediated signal transduction  (IEA)
spinal cord development  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting. Borland G, etal., Mol Pharmacol. 2006 Jan;69(1):374-84. Epub 2005 Oct 21.
2. Expression of the cAMP Binding Protein EPAC1 in Thyroid Tumors and Growth Regulation of Thyroid Cells and Thyroid Carcinoma Cells by EPAC Proteins. Broecker-Preuss M, etal., Horm Metab Res. 2015 Mar;47(3):200-8. doi: 10.1055/s-0034-1390484. Epub 2014 Nov 5.
3. Association study of the Epac gene and tobacco smoking and nicotine dependence. Chen X, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):116-9.
4. Treatment with alpha-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts. Colombo G, etal., Brain Behav Immun. 2008 Aug;22(6):817-23. doi: 10.1016/j.bbi.2007.11.009. Epub 2008 Jan 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation. Hochbaum D, etal., J Biol Chem. 2011 Jan 7;286(1):859-66. doi: 10.1074/jbc.M110.163816. Epub 2010 Nov 3.
8. Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Joshi R, etal., Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63. doi: 10.1016/j.mce.2014.06.012. Epub 2014 Jun 25.
9. A family of cAMP-binding proteins that directly activate Rap1. Kawasaki H, etal., Science 1998 Dec 18;282(5397):2275-9.
10. Region-specific transcriptional response to chronic nicotine in rat brain. Konu O, etal., Brain Res. 2001 Aug 3;909(1-2):194-203.
11. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. Kwak HJ, etal., Cell Signal. 2008 May;20(5):803-14. doi: 10.1016/j.cellsig.2007.12.011. Epub 2007 Dec 28.
12. Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I. Laroche-Joubert N, etal., J Biol Chem 2002 May 24;277(21):18598-604.
13. Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Laurent AC, etal., Cardiovasc Res. 2015 Jan 1;105(1):55-64. doi: 10.1093/cvr/cvu242. Epub 2014 Nov 19.
14. Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration. Li JW, etal., J Genet. 2011 Dec;90(3):435-42.
15. Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2. Li Y, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F525-33. Epub 2008 May 21.
16. Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. Magiera MM, etal., Biochem J. 2004 Sep 15;382(Pt 3):803-10.
17. Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Metrich M, etal., Circ Res. 2008 Apr 25;102(8):959-65. doi: 10.1161/CIRCRESAHA.107.164947. Epub 2008 Mar 6.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Miller CL, etal., Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20.
20. Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not fibrosis. Monceau V, etal., Radiother Oncol. 2014 Apr;111(1):63-71. doi: 10.1016/j.radonc.2014.01.025. Epub 2014 Apr 7.
21. Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration. Murray AJ and Shewan DA, Mol Cell Neurosci. 2008 Aug;38(4):578-88. doi: 10.1016/j.mcn.2008.05.006. Epub 2008 May 20.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. EPAC expression and function in cardiac fibroblasts and myofibroblasts. Olmedo I, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):414-22. doi: 10.1016/j.taap.2013.06.022. Epub 2013 Jul 8.
24. Multiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellular signal-regulated kinase signaling pathways. Park KH, etal., J Neurosci Res. 2014 Dec;92(12):1746-56. doi: 10.1002/jnr.23450. Epub 2014 Jul 12.
25. Epac enhances excitation-transcription coupling in cardiac myocytes. Pereira L, etal., J Mol Cell Cardiol. 2012 Jan;52(1):283-91. doi: 10.1016/j.yjmcc.2011.10.016. Epub 2011 Oct 29.
26. Interplay among cGMP, cAMP, and Ca2+ in living olfactory sensory neurons in vitro and in vivo. Pietrobon M, etal., J Neurosci. 2011 Jun 8;31(23):8395-405. doi: 10.1523/JNEUROSCI.6722-10.2011.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. Purves GI, etal., J Physiol. 2009 Jul 15;587(Pt 14):3639-50. doi: 10.1113/jphysiol.2009.173534.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes. Ruiz-Hurtado G, etal., J Mol Cell Cardiol. 2012 Nov;53(5):617-25. doi: 10.1016/j.yjmcc.2012.08.004. Epub 2012 Aug 19.
34. Evidence for the involvement of cAMP-GEF (Epac) pathway in amylase release from the rat parotid gland. Shimomura H, etal., Arch Biochem Biophys. 2004 Nov 1;431(1):124-8.
35. Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina. Whitaker CM and Cooper NG, Neuroscience. 2009 Oct 31.
36. Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration. Yokoyama U, etal., Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1547-55. doi: 10.1152/ajpheart.01317.2007. Epub 2008 Aug 8.
37. Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. Yokoyama U, etal., J Biol Chem. 2008 Oct 17;283(42):28702-9. Epub 2008 Aug 11.
Additional References at PubMed
PMID:12477932   PMID:14622088   PMID:14712229   PMID:15133061   PMID:15334074   PMID:15545605   PMID:16076873   PMID:16123333   PMID:16207818   PMID:16684923   PMID:17234888   PMID:17702820  
PMID:17725712   PMID:17895835   PMID:18021770   PMID:18063584   PMID:18178724   PMID:18202100   PMID:18434542   PMID:18550542   PMID:18685024   PMID:19056867   PMID:19244230   PMID:19279233  
PMID:19592485   PMID:19661162   PMID:19666481   PMID:20007468   PMID:20585956   PMID:20640531   PMID:21393242   PMID:21454546   PMID:21840392   PMID:22076955   PMID:23080165   PMID:23376036  
PMID:23867755   PMID:24349260   PMID:24469067   PMID:24586073   PMID:24733293   PMID:25593293   PMID:25719403   PMID:26219954   PMID:26269639   PMID:26462734   PMID:26466753   PMID:26553454  
PMID:26854595   PMID:27142830   PMID:27385722   PMID:27789473   PMID:27984207   PMID:27995459   PMID:28039940   PMID:28216156   PMID:29037982   PMID:30225708   PMID:30551377   PMID:35702948  
PMID:36768322   PMID:37753572  


Genomics

Comparative Map Data
Rapgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,754,883 - 130,777,303 (-)NCBIGRCr8
mRatBN7.27128,875,772 - 128,898,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,875,773 - 128,898,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,672,963 - 130,694,833 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,898,495 - 132,920,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,810,963 - 132,832,833 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,232,263 - 139,254,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,232,251 - 139,254,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,423,916 - 139,445,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,452,945 - 136,474,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,529,382 - 136,551,096 (-)NCBI
Celera7125,367,430 - 125,389,118 (-)NCBICelera
Cytogenetic Map7q36NCBI
RAPGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,734,363 - 47,758,880 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,734,363 - 47,771,040 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,128,146 - 48,152,663 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,417,293 - 46,438,952 (-)NCBINCBI36Build 36hg18NCBI36
Build 341246,417,293 - 46,438,822NCBI
Celera1246,925,923 - 46,950,362 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,159,564 - 45,184,005 (-)NCBIHuRef
CHM1_11248,094,358 - 48,118,798 (-)NCBICHM1_1
T2T-CHM13v2.01247,695,675 - 47,720,196 (-)NCBIT2T-CHM13v2.0
Rapgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,637,886 - 97,666,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,642,651 - 97,665,853 (-)EnsemblGRCm39 Ensembl
GRCm381597,744,770 - 97,768,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,744,770 - 97,767,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,575,201 - 97,598,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361597,572,987 - 97,595,706 (-)NCBIMGSCv36mm8
Celera1599,871,753 - 99,894,632 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1553.74NCBI
Rapgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,655,056 - 6,674,311 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,655,056 - 6,674,311 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21046,409,026 - 46,433,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11246,405,818 - 46,430,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01240,974,756 - 40,999,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,836,354 - 41,873,252 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,848,785 - 41,873,252 (+)Ensemblpanpan1.1panPan2
RAPGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,993,452 - 7,030,372 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,993,452 - 7,017,316 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,291,724 - 39,314,353 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,060,331 - 7,082,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,060,331 - 7,082,947 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,997,147 - 7,019,732 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,032,603 - 7,055,256 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,580,125 - 39,602,733 (-)NCBIUU_Cfam_GSD_1.0
LOC101973720
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,505,399 - 67,557,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365125,608,659 - 5,627,513 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365125,636,758 - 5,659,300 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365125,636,197 - 5,659,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,101,299 - 78,134,105 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,101,286 - 78,134,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAPGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11143,954,517 - 43,979,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1143,957,425 - 43,978,047 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,402,390 - 202,425,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,496,856 - 4,519,911 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248164,496,848 - 4,519,782 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rapgef3
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:77
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000067767
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 20 8 6 42 35 27 11
Low 2 23 49 41 13 41 8 11 32 14 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078644   ⟹   ENSRNOP00000072633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,875,773 - 128,897,672 (-)Ensembl
Rnor_6.0 Ensembl7139,232,251 - 139,254,149 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083182   ⟹   ENSRNOP00000069952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,875,773 - 128,897,898 (-)Ensembl
Rnor_6.0 Ensembl7139,232,830 - 139,254,551 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096691   ⟹   ENSRNOP00000076511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,875,773 - 128,898,521 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098812   ⟹   ENSRNOP00000077363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,875,773 - 128,898,521 (-)Ensembl
RefSeq Acc Id: NM_021690   ⟹   NP_067722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,754,946 - 130,776,816 (-)NCBI
mRatBN7.27128,875,848 - 128,897,719 (-)NCBI
Rnor_6.07139,232,326 - 139,254,196 (-)NCBI
Rnor_5.07139,423,916 - 139,445,945 (-)NCBI
RGSC_v3.47136,452,945 - 136,474,659 (-)RGD
Celera7125,367,430 - 125,389,118 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079828   ⟹   XP_038935756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,754,883 - 130,776,839 (-)NCBI
mRatBN7.27128,875,772 - 128,897,757 (-)NCBI
RefSeq Acc Id: XM_039079829   ⟹   XP_038935757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,754,883 - 130,777,303 (-)NCBI
mRatBN7.27128,875,785 - 128,898,203 (-)NCBI
RefSeq Acc Id: XM_039079830   ⟹   XP_038935758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,754,883 - 130,775,620 (-)NCBI
mRatBN7.27128,875,772 - 128,896,526 (-)NCBI
RefSeq Acc Id: XM_063264182   ⟹   XP_063120252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,754,883 - 130,777,303 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067722   ⟸   NM_021690
- UniProtKB: Q3B7C8 (UniProtKB/TrEMBL),   A0A0G2K3G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069952   ⟸   ENSRNOT00000083182
RefSeq Acc Id: ENSRNOP00000072633   ⟸   ENSRNOT00000078644
RefSeq Acc Id: XP_038935756   ⟸   XM_039079828
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y034 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935758   ⟸   XM_039079830
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K3G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935757   ⟸   XM_039079829
- Peptide Label: isoform X2
- UniProtKB: Q9Z1C8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000077363   ⟸   ENSRNOT00000098812
RefSeq Acc Id: ENSRNOP00000076511   ⟸   ENSRNOT00000096691
RefSeq Acc Id: XP_063120252   ⟸   XM_063264182
- Peptide Label: isoform X3
Protein Domains
Cyclic nucleotide-binding   DEP   N-terminal Ras-GEF   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1C8-F1-model_v2 AlphaFold Q9Z1C8 1-926 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621869 AgrOrtholog
BioCyc Gene G2FUF-32185 BioCyc
Ensembl Genes ENSRNOG00000059961 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078644.2 UniProtKB/TrEMBL
  ENSRNOT00000083182.2 UniProtKB/TrEMBL
  ENSRNOT00000096691 ENTREZGENE
  ENSRNOT00000096691.1 UniProtKB/TrEMBL
  ENSRNOT00000098812.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.8.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936411 IMAGE-MGC_LOAD
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59326 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124613 IMAGE-MGC_LOAD
NCBI Gene 59326 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rapgef3 PhenoGen
PRINTS CAMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059961 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWN8_RAT UniProtKB/TrEMBL
  A0A0G2K3G8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y034 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YCC0_RAT UniProtKB/TrEMBL
  A6KC40_RAT UniProtKB/TrEMBL
  Q3B7C8 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1C8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef3  Rap guanine nucleotide exchange factor 3  Rapgef3  Rap guanine nucleotide exchange factor (GEF) 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rapgef3  Rap guanine nucleotide exchange factor (GEF) 3    cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)  Name updated 1299863 APPROVED
2004-09-10 Rapgef3  cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)  Epac    Symbol and Name updated 1299863 APPROVED
2002-08-07 Epac  cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in the neonatal brain including the septum and thalamus 632397
gene_process activates Ras and Ras-like small G-proteins 632397
gene_protein protein has binding sites for calcium, diacylglyserol and Rap-specific GEF 632397