Magi2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) - Rat Genome Database

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Gene: Magi2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) Rattus norvegicus
Analyze
Symbol: Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
RGD ID: 621855
Description: Enables kinesin binding activity. A structural constituent of postsynaptic density. Involved in several processes, including nerve growth factor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of synaptic membrane adhesion. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and slit diaphragm. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin receptor interacting protein 1; Acvrinp1; Acvrip1; AIP-1; atrophin-1-interacting protein 1; MAGI-2; membrane-associated guanylate kinase inverted 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; synaptic-scaffolding molecule
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8415,278,518 - 16,762,427 (-)NCBIGRCr8
mRatBN7.2414,386,389 - 15,870,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,386,399 - 15,870,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,521,700 - 20,999,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0415,323,728 - 16,811,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,707,338 - 15,197,475 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,995,241 - 12,472,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,995,234 - 11,610,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,987,831 - 12,456,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,909,448 - 11,441,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1410,054,955 - 11,441,302 (-)NCBI
Celera49,948,183 - 11,419,535 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
CGP 52608  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
furan  (EXP)
hexane  (EXP)
L-ascorbic acid  (ISO)
linuron  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Babayeva S, etal., Am J Physiol Renal Physiol. 2011 Feb;300(2):F549-60. doi: 10.1152/ajprenal.00566.2009. Epub 2010 Jun 9.
2. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. Bender J, etal., PLoS One. 2015 Sep 9;10(9):e0136768. doi: 10.1371/journal.pone.0136768. eCollection 2015.
3. S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. Danielson E, etal., J Neurosci. 2012 May 16;32(20):6967-80. doi: 10.1523/JNEUROSCI.0025-12.2012.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Synaptic scaffolding molecule interacts with axin. Hirabayashi S, etal., J Neurochem 2004 Jul;90(2):332-9.
6. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. Hirao K, etal., J Biol Chem 1998 Aug 14;273(33):21105-10.
7. Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein. Hirao K, etal., J Biol Chem 2000 Jan 28;275(4):2966-72.
8. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
9. MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. Hu Y, etal., Arch Biochem Biophys. 2007 Nov 1;467(1):1-9. Epub 2007 Aug 22.
10. Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Ide N, etal., Biochem Biophys Res Commun. 1999 Mar 24;256(3):456-61.
11. CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. Kawata A, etal., J Biochem. 2006 May;139(5):931-9.
12. Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. Kitano J, etal., J Biol Chem 2003 Apr 25;278(17):14762-8. Epub 2003 Feb 13.
13. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36.
14. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Lehtonen S, etal., Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9814-9. Epub 2005 Jul 1.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. Mok H, etal., J Neurosci. 2002 Jul 1;22(13):5253-8.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Interaction of synaptic scaffolding molecule and Beta -catenin. Nishimura W, etal., J Neurosci 2002 Feb 1;22(3):757-65.
19. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Ohtsuka T, etal., Biochem Biophys Res Commun. 1999 Nov;265(1):38-44.
20. Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs. Rehbein M, etal., J Neurochem 2002 Sep;82(5):1039-46.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Identification and characterization of a PDZ protein that interacts with activin type II receptors. Shoji H, etal., J Biol Chem. 2000 Feb 25;275(8):5485-92.
24. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. Sugi T, etal., EMBO J. 2007 Apr 18;26(8):2192-205. Epub 2007 Mar 29.
25. Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons. Sumita K, etal., J Neurochem. 2007 Jan;100(1):154-66. doi: 10.1111/j.1471-4159.2006.04170.x. Epub 2006 Oct 24.
26. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
27. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. Valiente M, etal., J Biol Chem. 2005 Aug 12;280(32):28936-43. Epub 2005 Jun 10.
28. The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. Woo J, etal., J Cell Biol. 2013 Jun 10;201(6):929-44. doi: 10.1083/jcb.201209132.
29. MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. Yao I, etal., J Biol Chem 1999 Apr 23;274(17):11889-96.
30. PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. Yap CC, etal., Biochem Biophys Res Commun 2003 Feb 21;301(4):1122-8.
Additional References at PubMed
PMID:10760291   PMID:11526121   PMID:14596909   PMID:15458844   PMID:16648306   PMID:16870733   PMID:20534458   PMID:22128856   PMID:22871113  


Genomics

Comparative Map Data
Magi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8415,278,518 - 16,762,427 (-)NCBIGRCr8
mRatBN7.2414,386,389 - 15,870,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,386,399 - 15,870,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,521,700 - 20,999,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0415,323,728 - 16,811,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,707,338 - 15,197,475 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,995,241 - 12,472,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,995,234 - 11,610,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,987,831 - 12,456,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,909,448 - 11,441,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1410,054,955 - 11,441,302 (-)NCBI
Celera49,948,183 - 11,419,535 (-)NCBICelera
Cytogenetic Map4q11NCBI
MAGI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38778,017,055 - 79,453,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl778,017,055 - 79,453,667 (-)EnsemblGRCh38hg38GRCh38
GRCh37777,646,372 - 79,082,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36777,484,310 - 78,920,826 (-)NCBINCBI36Build 36hg18NCBI36
Build 34777,291,048 - 78,727,541NCBI
Celera772,346,978 - 73,783,869 (-)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef772,249,405 - 73,685,020 (-)NCBIHuRef
CHM1_1777,576,560 - 79,013,089 (-)NCBICHM1_1
T2T-CHM13v2.0779,268,893 - 80,705,470 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2776,978,436 - 78,414,480 (-)NCBI
Magi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39519,431,787 - 20,909,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl519,432,034 - 20,909,790 (+)EnsemblGRCm39 Ensembl
GRCm38519,219,387 - 20,704,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl519,227,036 - 20,704,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv37518,732,864 - 20,210,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36518,738,799 - 20,216,616 (+)NCBIMGSCv36mm8
Celera516,180,595 - 17,665,978 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.6NCBI
Magi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554106,400,242 - 7,294,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554106,739,115 - 7,295,027 (+)NCBIChiLan1.0ChiLan1.0
MAGI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2695,878,453 - 97,322,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17144,143,091 - 145,586,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0769,943,704 - 71,395,176 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1783,759,307 - 84,511,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl783,758,512 - 84,760,872 (-)Ensemblpanpan1.1panPan2
MAGI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11817,973,058 - 19,098,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1817,918,928 - 18,930,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1817,565,936 - 18,971,443 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01818,307,564 - 19,031,590 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1818,283,692 - 19,747,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11818,054,185 - 19,371,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01817,997,659 - 18,302,395 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01818,251,940 - 19,581,985 (-)NCBIUU_Cfam_GSD_1.0
Magi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511860,250,078 - 60,938,785 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647921,373,746 - 21,920,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647921,373,917 - 22,062,498 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAGI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9100,847,013 - 102,170,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19100,846,693 - 102,171,199 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29112,312,166 - 112,574,012 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAGI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12169,460,345 - 70,916,684 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604233,007,517 - 34,474,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Magi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473927,134,993 - 28,430,686 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473927,132,533 - 28,430,765 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Magi2
9484 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:107
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000066643
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat

Markers in Region
D4Rat6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,770,630 - 14,770,800 (+)MAPPERmRatBN7.2
Rnor_6.0411,381,746 - 11,381,915NCBIRnor6.0
Rnor_5.0411,368,225 - 11,368,394UniSTSRnor5.0
RGSC_v3.4410,298,231 - 10,298,400UniSTSRGSC3.4
RGSC_v3.4410,298,194 - 10,298,520RGDRGSC3.4
RGSC_v3.1410,298,194 - 10,298,520RGD
Celera410,327,416 - 10,327,585UniSTS
RH 3.4 Map455.7RGD
RH 3.4 Map455.7UniSTS
RH 2.0 Map481.2RGD
SHRSP x BN Map45.5999RGD
Cytogenetic Map4q11UniSTS
D4Got18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,886,312 - 14,886,475 (+)MAPPERmRatBN7.2
Rnor_6.0411,495,960 - 11,496,122NCBIRnor6.0
Rnor_5.0411,481,773 - 11,481,935UniSTSRnor5.0
RGSC_v3.4410,418,029 - 10,418,192RGDRGSC3.4
RGSC_v3.4410,418,030 - 10,418,192UniSTSRGSC3.4
RGSC_v3.1410,418,030 - 10,418,192RGD
Celera410,441,826 - 10,441,988UniSTS
RH 3.4 Map456.8UniSTS
RH 3.4 Map456.8RGD
RH 2.0 Map483.5RGD
Cytogenetic Map4q11UniSTS
D4Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2415,583,060 - 15,583,255 (+)MAPPERmRatBN7.2
Rnor_6.0412,186,517 - 12,186,711NCBIRnor6.0
Rnor_5.0412,171,476 - 12,171,670UniSTSRnor5.0
RGSC_v3.4411,143,530 - 11,143,725RGDRGSC3.4
RGSC_v3.4411,143,531 - 11,143,725UniSTSRGSC3.4
RGSC_v3.1411,143,530 - 11,143,725RGD
Celera411,132,622 - 11,132,816UniSTS
RH 3.4 Map461.2UniSTS
RH 3.4 Map461.2RGD
RH 2.0 Map4101.0RGD
Cytogenetic Map4q11UniSTS
D4Uwm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,808,285 - 14,808,493 (+)MAPPERmRatBN7.2
Rnor_6.0411,419,429 - 11,419,636NCBIRnor6.0
Rnor_5.0411,405,721 - 11,405,928UniSTSRnor5.0
RGSC_v3.4410,336,506 - 10,336,713UniSTSRGSC3.4
Celera410,364,840 - 10,365,047UniSTS
Cytogenetic Map4q11UniSTS
BF388517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2415,298,656 - 15,298,791 (+)MAPPERmRatBN7.2
Rnor_6.0411,905,884 - 11,906,018NCBIRnor6.0
Rnor_5.0411,889,656 - 11,889,790UniSTSRnor5.0
RGSC_v3.4410,849,959 - 10,850,093UniSTSRGSC3.4
Celera410,846,344 - 10,846,478UniSTS
RH 3.4 Map4510.5UniSTS
Cytogenetic Map4q11UniSTS
RH141994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2415,483,019 - 15,483,223 (+)MAPPERmRatBN7.2
Rnor_6.0412,088,254 - 12,088,457NCBIRnor6.0
Rnor_5.0412,073,213 - 12,073,416UniSTSRnor5.0
RGSC_v3.4411,041,195 - 11,041,398UniSTSRGSC3.4
Celera411,031,414 - 11,031,617UniSTS
RH 3.4 Map461.3UniSTS
Cytogenetic Map4q11UniSTS
BE106713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,429,794 - 14,429,946 (+)MAPPERmRatBN7.2
Rnor_6.0411,044,930 - 11,045,081NCBIRnor6.0
Rnor_5.0411,032,438 - 11,032,589UniSTSRnor5.0
RGSC_v3.449,950,497 - 9,950,648UniSTSRGSC3.4
Celera49,989,547 - 9,989,698UniSTS
RH 3.4 Map454.5UniSTS
Cytogenetic Map4q11UniSTS
BI301779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,929,662 - 14,929,889 (+)MAPPERmRatBN7.2
Rnor_6.0411,538,966 - 11,539,192NCBIRnor6.0
Rnor_5.0411,524,161 - 11,524,387UniSTSRnor5.0
RGSC_v3.4410,473,309 - 10,473,535UniSTSRGSC3.4
Celera410,485,158 - 10,485,384UniSTS
RH 3.4 Map457.0UniSTS
Cytogenetic Map4q11UniSTS
BF399248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2415,702,894 - 15,703,041 (+)MAPPERmRatBN7.2
Rnor_6.0412,305,500 - 12,305,646NCBIRnor6.0
Rnor_5.0412,290,340 - 12,290,486UniSTSRnor5.0
Celera411,252,454 - 11,252,600UniSTS
RH 3.4 Map460.8UniSTS
Cytogenetic Map4q11UniSTS
AU046470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,533,648 - 14,533,793 (+)MAPPERmRatBN7.2
Rnor_6.0411,148,190 - 11,148,334NCBIRnor6.0
Rnor_5.0411,135,100 - 11,135,244UniSTSRnor5.0
RGSC_v3.4410,056,962 - 10,057,107UniSTSRGSC3.4
Celera410,094,121 - 10,094,261UniSTS
Cytogenetic Map4q11UniSTS
AU049234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,657,394 - 14,657,933 (+)MAPPERmRatBN7.2
mRatBN7.2414,657,715 - 14,657,933 (+)MAPPERmRatBN7.2
Rnor_6.0411,270,518 - 11,271,107NCBIRnor6.0
Rnor_6.0411,270,888 - 11,271,107NCBIRnor6.0
Rnor_5.0411,257,798 - 11,258,017UniSTSRnor5.0
Rnor_5.0411,257,428 - 11,258,017UniSTSRnor5.0
RGSC_v3.4410,181,964 - 10,182,183UniSTSRGSC3.4
Celera410,219,001 - 10,219,220UniSTS
Cytogenetic Map4q11UniSTS
AU049610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,470,612 - 14,470,791 (+)MAPPERmRatBN7.2
Rnor_6.0411,085,573 - 11,085,751NCBIRnor6.0
Rnor_5.0411,072,435 - 11,072,613UniSTSRnor5.0
RGSC_v3.449,992,756 - 9,992,934UniSTSRGSC3.4
Celera410,030,355 - 10,030,533UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 7
Low 7 9 11 6 6 10 35 31 11 6
Below cutoff 3 36 27 20 8 20 2 4 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF034863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066643   ⟹   ENSRNOP00000059912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,388,323 - 15,155,328 (-)Ensembl
Rnor_6.0 Ensembl410,995,234 - 11,610,518 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078799   ⟹   ENSRNOP00000070380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,428,358 - 15,001,949 (-)Ensembl
Rnor_6.0 Ensembl411,044,326 - 11,497,531 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094238   ⟹   ENSRNOP00000090186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,386,399 - 15,870,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095227   ⟹   ENSRNOP00000095318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,388,315 - 15,870,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115899   ⟹   ENSRNOP00000091952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,386,399 - 15,870,240 (-)Ensembl
RefSeq Acc Id: NM_053621   ⟹   NP_446073
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,518 - 16,762,135 (-)NCBI
mRatBN7.2414,386,389 - 15,870,036 (-)NCBI
Rnor_6.0410,995,241 - 12,472,423 (-)NCBI
Rnor_5.0410,987,831 - 12,456,502 (-)NCBI
RGSC_v3.449,909,448 - 11,441,301 (-)RGD
Celera49,948,183 - 11,419,535 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285352   ⟹   XP_063141422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285353   ⟹   XP_063141423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285354   ⟹   XP_063141424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285355   ⟹   XP_063141425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285356   ⟹   XP_063141426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285357   ⟹   XP_063141427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285358   ⟹   XP_063141428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285359   ⟹   XP_063141429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285360   ⟹   XP_063141430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285361   ⟹   XP_063141431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,811,276 (-)NCBI
RefSeq Acc Id: XM_063285362   ⟹   XP_063141432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,281,075 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285363   ⟹   XP_063141433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,321,277 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285364   ⟹   XP_063141434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,281,075 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285365   ⟹   XP_063141435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,281,138 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285366   ⟹   XP_063141436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,281,075 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285367   ⟹   XP_063141437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285368   ⟹   XP_063141438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,374,430 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285369   ⟹   XP_063141439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,321,277 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285370   ⟹   XP_063141440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,427 (-)NCBI
RefSeq Acc Id: XM_063285371   ⟹   XP_063141441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,321,277 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285372   ⟹   XP_063141442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,782,742 (-)NCBI
RefSeq Acc Id: XM_063285373   ⟹   XP_063141443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,047,087 (-)NCBI
RefSeq Acc Id: XM_063285374   ⟹   XP_063141444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285375   ⟹   XP_063141445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,741,580 (-)NCBI
RefSeq Acc Id: XM_063285376   ⟹   XP_063141446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,440,065 (-)NCBI
RefSeq Acc Id: XM_063285377   ⟹   XP_063141447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,460,311 (-)NCBI
RefSeq Acc Id: XM_063285378   ⟹   XP_063141448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,440,065 (-)NCBI
RefSeq Acc Id: XM_063285379   ⟹   XP_063141449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,432,091 - 16,762,409 (-)NCBI
RefSeq Acc Id: XM_063285380   ⟹   XP_063141450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,440,065 (-)NCBI
RefSeq Acc Id: XM_063285381   ⟹   XP_063141451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,440,065 (-)NCBI
RefSeq Acc Id: XM_063285382   ⟹   XP_063141452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8415,278,541 - 15,440,065 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446073 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141422 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141423 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141424 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141425 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141426 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141427 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141428 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141429 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141430 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141431 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141432 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141433 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141435 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141436 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141437 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141438 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141439 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141440 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141441 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141442 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141443 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141444 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141445 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141446 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141447 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141448 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141449 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141450 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141451 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141452 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC31124 (Get FASTA)   NCBI Sequence Viewer  
  AAD31015 (Get FASTA)   NCBI Sequence Viewer  
  EDL99441 (Get FASTA)   NCBI Sequence Viewer  
  EDL99442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059912.4
  ENSRNOP00000070380.2
  ENSRNOP00000090186.1
  ENSRNOP00000091952.1
  ENSRNOP00000095318
  ENSRNOP00000095318.1
GenBank Protein O88382 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446073   ⟸   NM_053621
- UniProtKB: Q9R271 (UniProtKB/Swiss-Prot),   O88382 (UniProtKB/Swiss-Prot),   A0A8I6AQ06 (UniProtKB/TrEMBL),   A6K5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059912   ⟸   ENSRNOT00000066643
RefSeq Acc Id: ENSRNOP00000070380   ⟸   ENSRNOT00000078799
RefSeq Acc Id: ENSRNOP00000095318   ⟸   ENSRNOT00000095227
RefSeq Acc Id: ENSRNOP00000091952   ⟸   ENSRNOT00000115899
RefSeq Acc Id: ENSRNOP00000090186   ⟸   ENSRNOT00000094238
RefSeq Acc Id: XP_063141440   ⟸   XM_063285370
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063141444   ⟸   XM_063285374
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063141437   ⟸   XM_063285367
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063141425   ⟸   XM_063285355
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141428   ⟸   XM_063285358
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063141423   ⟸   XM_063285353
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141429   ⟸   XM_063285359
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AD37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141424   ⟸   XM_063285354
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063141430   ⟸   XM_063285360
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063141427   ⟸   XM_063285357
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AH48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141426   ⟸   XM_063285356
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141422   ⟸   XM_063285352
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063141443   ⟸   XM_063285373
- Peptide Label: isoform X22
RefSeq Acc Id: XP_063141431   ⟸   XM_063285361
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063141442   ⟸   XM_063285372
- Peptide Label: isoform X21
RefSeq Acc Id: XP_063141445   ⟸   XM_063285375
- Peptide Label: isoform X24
RefSeq Acc Id: XP_063141447   ⟸   XM_063285377
- Peptide Label: isoform X26
RefSeq Acc Id: XP_063141451   ⟸   XM_063285381
- Peptide Label: isoform X30
RefSeq Acc Id: XP_063141448   ⟸   XM_063285378
- Peptide Label: isoform X27
RefSeq Acc Id: XP_063141452   ⟸   XM_063285382
- Peptide Label: isoform X31
RefSeq Acc Id: XP_063141450   ⟸   XM_063285380
- Peptide Label: isoform X29
RefSeq Acc Id: XP_063141446   ⟸   XM_063285376
- Peptide Label: isoform X25
RefSeq Acc Id: XP_063141436   ⟸   XM_063285366
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063141434   ⟸   XM_063285364
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063141432   ⟸   XM_063285362
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063141435   ⟸   XM_063285365
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063141439   ⟸   XM_063285369
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063141441   ⟸   XM_063285371
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063141433   ⟸   XM_063285363
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063141438   ⟸   XM_063285368
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063141449   ⟸   XM_063285379
- Peptide Label: isoform X28
Protein Domains
Guanylate kinase-like   PDZ   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88382-F1-model_v2 AlphaFold O88382 1-1277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621855 AgrOrtholog
BioCyc Gene G2FUF-45949 BioCyc
Ensembl Genes ENSRNOG00000013962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066643.4 UniProtKB/TrEMBL
  ENSRNOT00000078799.2 UniProtKB/TrEMBL
  ENSRNOT00000094238.1 UniProtKB/TrEMBL
  ENSRNOT00000095227 ENTREZGENE
  ENSRNOT00000095227.1 UniProtKB/TrEMBL
  ENSRNOT00000115899.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113970 UniProtKB/Swiss-Prot
NCBI Gene 113970 ENTREZGENE
PANTHER MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10316:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAGI_u1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Magi2 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013962 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXR9_RAT UniProtKB/TrEMBL
  A0A8I6AD37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQ06 ENTREZGENE, UniProtKB/TrEMBL
  A6K5D2 ENTREZGENE, UniProtKB/TrEMBL
  A6K5D3_RAT UniProtKB/TrEMBL
  D3ZY03_RAT UniProtKB/TrEMBL
  MAGI2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R271 ENTREZGENE
UniProt Secondary D3ZRR9 UniProtKB/TrEMBL
  Q9R271 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Magi2  membrane associated guanylate kinase, WW and PDZ domain containing 2  Acvrinp1  activin receptor interacting protein 1  Symbol and Name updated 1299863 APPROVED
2005-01-20 Acvrinp1  activin receptor interacting protein 1  Acvrip1    Symbol updated 1299863 APPROVED
2002-08-07 Acvrip1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains six PDZ, two WW, and one guanylate kinase (GK) domains 632272
gene_function interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin 1304344
gene_physical_interaction interacts with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins 632272
gene_physical_interaction interacts with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins 632273