Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | hepatocellular carcinoma | | ISO | CELSR3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28284560 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | hepatocellular carcinoma | | ISO | CELSR3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28284560 | |
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# | Reference Title | Reference Citation |
1. | The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. | Formstone CJ and Little PF, Mech Dev 2001 Nov;109(1):91-4. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
4. | Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. | Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34. |
5. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
6. | GOA pipeline | RGD automated data pipeline |
7. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. | Wiberg C, etal., J Biol Chem 2003 Sep 26;278(39):37698-704. |
PMID:15778712 | PMID:17618280 | PMID:20473291 | PMID:20631168 | PMID:21106844 | PMID:24305805 |
Celsr3 (Rattus norvegicus - Norway rat) |
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CELSR3 (Homo sapiens - human) |
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Celsr3 (Mus musculus - house mouse) |
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Celsr3 (Chinchilla lanigera - long-tailed chinchilla) |
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CELSR3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CELSR3 (Canis lupus familiaris - dog) |
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Celsr3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CELSR3 (Sus scrofa - pig) |
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CELSR3 (Chlorocebus sabaeus - green monkey) |
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Celsr3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Celsr3
135 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
BF386320 |
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BF406162 |
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Celsr3 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 64 | ||||||||||||
Low | 2 | 10 | 2 | 2 | 10 | 25 | |||||||
Below cutoff | 3 | 38 | 20 | 17 | 8 | 17 | 8 | 8 | 13 | 16 | 10 | 8 |
RefSeq Transcripts | NM_031320 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006243860 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006243861 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039082204 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039082205 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063266218 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005487934 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005487935 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_010054036 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB011528 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC096455 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473954 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000008 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000084220 ⟹ ENSRNOP00000068821 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000112823 ⟹ ENSRNOP00000079747 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000118398 ⟹ ENSRNOP00000085264 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_031320 ⟹ NP_112610 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006243860 ⟹ XP_006243922 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006243861 ⟹ XP_006243923 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039082204 ⟹ XP_038938132 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039082205 ⟹ XP_038938133 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063266218 ⟹ XP_063122288 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_005487934 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XR_005487935 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XR_010054036 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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Protein RefSeqs | NP_112610 | (Get FASTA) | NCBI Sequence Viewer |
XP_006243922 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006243923 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038938132 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038938133 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063122288 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | BAA32459 | (Get FASTA) | NCBI Sequence Viewer |
EDL77136 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000068821 | ||
ENSRNOP00000068821.2 | |||
ENSRNOP00000079747 | |||
ENSRNOP00000079747.1 | |||
ENSRNOP00000085264 | |||
ENSRNOP00000085264.1 | |||
ENSRNOP00055009347 | |||
ENSRNOP00060023340 | |||
ENSRNOP00065007851 | |||
GenBank Protein | O88278 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_112610 ⟸ NM_031320 |
- Peptide Label: | precursor |
- UniProtKB: | O88278 (UniProtKB/Swiss-Prot), A0A8L2R1D5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006243922 ⟸ XM_006243860 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8L2R1D5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006243923 ⟸ XM_006243861 |
- Peptide Label: | isoform X5 |
- UniProtKB: | A6I391 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000068821 ⟸ ENSRNOT00000084220 |
RefSeq Acc Id: | XP_038938132 ⟸ XM_039082204 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A8L2R1D5 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038938133 ⟸ XM_039082205 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A8L2R1D5 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000085264 ⟸ ENSRNOT00000118398 |
RefSeq Acc Id: | ENSRNOP00000079747 ⟸ ENSRNOT00000112823 |
RefSeq Acc Id: | XP_063122288 ⟸ XM_063266218 |
- Peptide Label: | isoform X4 |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:621787 | AgrOrtholog |
BioCyc Gene | G2FUF-29112 | BioCyc |
Ensembl Genes | ENSRNOG00000053889 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ENSRNOG00055007121 | UniProtKB/Swiss-Prot | |
ENSRNOG00060016910 | UniProtKB/Swiss-Prot | |
ENSRNOG00065006816 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000084220.2 | UniProtKB/TrEMBL |
ENSRNOT00000112823 | ENTREZGENE | |
ENSRNOT00000112823.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00000118398.1 | UniProtKB/TrEMBL | |
ENSRNOT00055011835 | UniProtKB/Swiss-Prot | |
ENSRNOT00060028987 | UniProtKB/Swiss-Prot | |
ENSRNOT00065010630 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 2.60.120.200 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
2.60.220.50 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
4.10.1240.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Cadherins | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Laminin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Rhodopsin 7-helix transmembrane proteins | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | Cadherin-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cadherin-like_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Cadherin_CS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ConA-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF-like_Ca-bd_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GAIN_dom_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GAIN_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_2-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_2_extracell_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_2_extracellular_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_2_secretin-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_2_secretin-like_CS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Laminin_EGF | UniProtKB/Swiss-Prot | |
Laminin_G | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LE_dom | UniProtKB/TrEMBL | |
KEGG Report | rno:83466 | UniProtKB/Swiss-Prot |
NCBI Gene | 83466 | ENTREZGENE |
PANTHER | CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
FAT ATYPICAL CADHERIN-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | 7tm_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cadherin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
HRM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Laminin_EGF | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Laminin_G_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Celsr3 | PhenoGen |
PRINTS | CADHERIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
GPCRSECRETIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | ASX_HYDROXYL | UniProtKB/Swiss-Prot |
CADHERIN_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CADHERIN_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_LAM_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_LAM_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
G_PROTEIN_RECEP_F2_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
G_PROTEIN_RECEP_F2_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
G_PROTEIN_RECEP_F2_4 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LAM_G_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000053889 | RatGTEx |
ENSRNOG00055007121 | RatGTEx | |
ENSRNOG00060016910 | RatGTEx | |
ENSRNOG00065006816 | RatGTEx | |
SMART | EGF | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EGF_CA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EGF_Lam | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
HormR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LamG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00112 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | EGF/Laminin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF111418 | UniProtKB/Swiss-Prot | |
SSF49313 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF49899 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I6A2Y0_RAT | UniProtKB/TrEMBL |
A0A8L2R1D5 | ENTREZGENE, UniProtKB/TrEMBL | |
A6I391 | ENTREZGENE, UniProtKB/TrEMBL | |
CELR3_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2013-02-27 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-25 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-01-20 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Celsr3 | cadherin EGF LAG seven-pass G-type receptor 3 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_domains | contains multiple EGF-like motifs | 68762 |