Lim2 (lens intrinsic membrane protein 2) - Rat Genome Database

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Gene: Lim2 (lens intrinsic membrane protein 2) Rattus norvegicus
Analyze
Symbol: Lim2
Name: lens intrinsic membrane protein 2
RGD ID: 621482
Description: Predicted to be a structural constituent of eye lens. Predicted to act upstream of or within lens development in camera-type eye. Located in vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to human LIM2 (lens intrinsic membrane protein 2); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2 (19 kDa); lens intrinsic membrane protein 2, 19kDa; MP17; MP18; Mp19; MP20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Celera188,114,711 - 88,120,877 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. Church RL and Wang JH, Curr Eye Res 1993 Dec;12(12):1057-65.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. Gonen T, etal., BMC Cell Biol. 2001;2:17. Epub 2001 Aug 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Pras E, etal., Am J Hum Genet. 2002 May;70(5):1363-7. Epub 2002 Mar 26.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:2584203   PMID:6510713   PMID:6877261   PMID:7088001   PMID:7679355   PMID:8812411   PMID:9238094  


Genomics

Comparative Map Data
Lim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Celera188,114,711 - 88,120,877 (+)NCBICelera
Cytogenetic Map1q22NCBI
LIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,379,909 - 51,387,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,379,909 - 51,387,974 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,883,163 - 51,891,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,574,976 - 56,583,009 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,574,975 - 56,583,009NCBI
Celera1948,934,200 - 48,942,254 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,215,130 - 48,223,189 (-)NCBIHuRef
CHM1_11951,885,115 - 51,893,162 (-)NCBICHM1_1
T2T-CHM13v2.01954,468,540 - 54,476,605 (-)NCBIT2T-CHM13v2.0
Lim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,079,523 - 43,085,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,079,512 - 43,085,420 (+)EnsemblGRCm39 Ensembl
GRCm38743,430,099 - 43,435,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,430,088 - 43,435,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv37750,685,471 - 50,691,361 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,298,021 - 43,303,911 (+)NCBIMGSCv36mm8
Celera738,896,762 - 38,902,653 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
Lim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,019,244 - 1,024,375 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555581,019,709 - 1,024,375 (+)NCBIChiLan1.0ChiLan1.0
LIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,417,235 - 57,425,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,338,718 - 59,346,839 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,315,028 - 48,323,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,200,260 - 57,208,358 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,200,260 - 57,208,354 (-)Ensemblpanpan1.1panPan2
LIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,593,457 - 105,599,788 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,593,224 - 105,599,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,166,165 - 105,172,438 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,103,001 - 106,109,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,102,710 - 106,109,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,774,650 - 105,780,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,415,503 - 105,421,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,211,043 - 106,217,316 (+)NCBIUU_Cfam_GSD_1.0
Lim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934923,074,318 - 23,076,287 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493737846,650 - 48,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,481,686 - 58,489,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1658,482,690 - 58,489,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,700,855 - 51,707,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,298,667 - 44,306,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,298,958 - 44,306,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,347,860 - 24,355,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,493,670 - 3,497,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,493,670 - 3,497,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lim2
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000023858
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat

Markers in Region
BG373005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,841,346 - 93,841,570 (-)MAPPERmRatBN7.2
Rnor_6.0198,497,276 - 98,497,499NCBIRnor6.0
Rnor_5.0199,574,081 - 99,574,304UniSTSRnor5.0
RGSC_v3.4193,809,566 - 93,809,789UniSTSRGSC3.4
Celera188,118,460 - 88,118,683UniSTS
Cytogenetic Map1q22UniSTS
RH127383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,836,890 - 93,837,093 (-)MAPPERmRatBN7.2
Rnor_6.0198,501,753 - 98,501,955NCBIRnor6.0
Rnor_5.0199,578,558 - 99,578,760UniSTSRnor5.0
RGSC_v3.4193,805,110 - 93,805,312UniSTSRGSC3.4
Celera188,114,004 - 88,114,206UniSTS
Cytogenetic Map1q22UniSTS
GDB:373986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,838,340 - 93,838,493 (-)MAPPERmRatBN7.2
Rnor_6.0198,500,353 - 98,500,505NCBIRnor6.0
Rnor_5.0199,577,158 - 99,577,310UniSTSRnor5.0
RGSC_v3.4193,806,560 - 93,806,712UniSTSRGSC3.4
Celera188,115,454 - 88,115,606UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 31 4 15 15 2
Below cutoff 2 6 10 1 11 1 1 1 44 17 16 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023858   ⟹   ENSRNOP00000023858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)Ensembl
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)Ensembl
RefSeq Acc Id: NM_053771   ⟹   NP_446223
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81102,974,188 - 102,980,358 (+)NCBI
mRatBN7.2193,837,597 - 93,843,769 (+)NCBI
Rnor_6.0198,495,082 - 98,501,248 (-)NCBI
Rnor_5.0199,571,887 - 99,578,053 (-)NCBI
RGSC_v3.4193,805,817 - 93,811,981 (+)RGD
Celera188,114,711 - 88,120,877 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_446223   ⟸   NM_053771
- UniProtKB: P54825 (UniProtKB/Swiss-Prot),   A6JAH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023858   ⟸   ENSRNOT00000023858

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54825-F1-model_v2 AlphaFold P54825 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621482 AgrOrtholog
BioCyc Gene G2FUF-59852 BioCyc
Ensembl Genes ENSRNOG00000017681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055005638 UniProtKB/Swiss-Prot
  ENSRNOG00060010800 UniProtKB/Swiss-Prot
  ENSRNOG00065028462 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023858 ENTREZGENE
  ENSRNOT00000023858.3 UniProtKB/Swiss-Prot
  ENSRNOT00055009069 UniProtKB/Swiss-Prot
  ENSRNOT00060018296 UniProtKB/Swiss-Prot
  ENSRNOT00065049031 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LMIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114903 ENTREZGENE
PANTHER EPITHELIAL MEMBRANE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LENS FIBER MEMBRANE INTRINSIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lim2 PhenoGen
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LENSMEMPROT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PMP22_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017681 RatGTEx
  ENSRNOG00055005638 RatGTEx
  ENSRNOG00060010800 RatGTEx
  ENSRNOG00065028462 RatGTEx
UniProt A6JAH5 ENTREZGENE, UniProtKB/TrEMBL
  LMIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lim2  lens intrinsic membrane protein 2    lens intrinsic membrane protein 2, 19kDa  Name updated 1299863 APPROVED
2004-09-10 Lim2  lens intrinsic membrane protein 2, 19kDa    lens intrinsic membrane protein 2 (19 kDa)  Name updated 1299863 APPROVED
2002-08-07 Lim2  lens intrinsic membrane protein 2 (19 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane 727321
gene_physical_interaction interacts with galectin-3 possibly through a lectin site 727321
gene_product member of the tetraspanin superfamily 727321