Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Lung Neoplasms | | ISO | CLTB (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:27935865 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Lung Neoplasms | | ISO | CLTB (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:27935865 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. | Kirchhausen T, etal., Science 1987 Apr 17;236(4799):320-4. |
4. | Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. | Maycox PR, etal., J Cell Biol. 1992 Sep;118(6):1379-88. |
5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
8. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
9. | A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. | Rapoport I, etal., Mol Biol Cell. 2008 Jan;19(1):405-13. Epub 2007 Oct 31. |
10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
11. | Synaptic vesicle endocytosis. | Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645. |
12. | Possible involvement of clathrin in neuritogenesis induced by a protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12 cells. | Saito Y, etal., J Biochem. 1992 Oct;112(4):448-55. |
PMID:9188501 | PMID:16025302 | PMID:20427320 | PMID:25427558 | PMID:28259758 | PMID:29476059 | PMID:35352799 |
Cltb (Rattus norvegicus - Norway rat) |
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CLTB (Homo sapiens - human) |
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Cltb (Mus musculus - house mouse) |
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Cltb (Chinchilla lanigera - long-tailed chinchilla) |
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CLTB (Pan paniscus - bonobo/pygmy chimpanzee) |
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CLTB (Canis lupus familiaris - dog) |
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Cltb (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CLTB (Sus scrofa - pig) |
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CLTB (Chlorocebus sabaeus - green monkey) |
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Cltb (Heterocephalus glaber - naked mole-rat) |
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Variants in Cltb
55 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
BE110258 |
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BE105422 |
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CLTB_4592 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 39 | 11 | 8 |
Low | 2 | ||||||||||||
Below cutoff |
RefSeq Transcripts | NM_053835 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006253595 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | CH474032 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
FQ213176 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ213983 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ229322 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000017 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L01561 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L01562 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M15883 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M19262 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000023651 ⟹ ENSRNOP00000023651 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000115689 ⟹ ENSRNOP00000085439 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_053835 ⟹ NP_446287 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006253595 ⟹ XP_006253657 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_446287 | (Get FASTA) | NCBI Sequence Viewer |
XP_006253657 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA40890 | (Get FASTA) | NCBI Sequence Viewer |
AAA40891 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94040 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94041 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94042 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94043 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94044 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000023651 | ||
ENSRNOP00000023651.2 | |||
ENSRNOP00000085439 | |||
ENSRNOP00000085439.1 | |||
ENSRNOP00055019991 | |||
ENSRNOP00060024922 | |||
ENSRNOP00065012476 | |||
GenBank Protein | P08082 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_446287 ⟸ NM_053835 |
- UniProtKB: | P08082 (UniProtKB/Swiss-Prot), A6KAY2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006253657 ⟸ XM_006253595 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6KAY3 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000023651 ⟸ ENSRNOT00000023651 |
RefSeq Acc Id: | ENSRNOP00000085439 ⟸ ENSRNOT00000115689 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P08082-F1-model_v2 | AlphaFold | P08082 | 1-229 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13700321 | ||||||||
Promoter ID: | EPDNEW_R10844 | ||||||||
Type: | initiation region | ||||||||
Name: | Cltb_1 | ||||||||
Description: | clathrin, light chain B | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621353 | AgrOrtholog |
BioCyc Gene | G2FUF-10176 | BioCyc |
Ensembl Genes | ENSRNOG00000017506 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOG00055014227 | UniProtKB/Swiss-Prot | |
ENSRNOG00060017933 | UniProtKB/Swiss-Prot | |
ENSRNOG00065010189 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000023651 | ENTREZGENE |
ENSRNOT00000023651.7 | UniProtKB/Swiss-Prot | |
ENSRNOT00000115689.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00055024467 | UniProtKB/Swiss-Prot | |
ENSRNOT00060030776 | UniProtKB/Swiss-Prot | |
ENSRNOT00065016426 | UniProtKB/Swiss-Prot | |
InterPro | Clathrin_L-chain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
KEGG Report | rno:116561 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 116561 | ENTREZGENE |
PANTHER | CLATHRIN LIGHT CHAIN | UniProtKB/TrEMBL |
CLATHRIN LIGHT CHAIN B | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PTHR10639 | UniProtKB/Swiss-Prot | |
Pfam | Clathrin_lg_ch | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Cltb | PhenoGen |
PROSITE | CLATHRIN_LIGHT_CHN_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CLATHRIN_LIGHT_CHN_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000017506 | RatGTEx |
ENSRNOG00055014227 | RatGTEx | |
ENSRNOG00060017933 | RatGTEx | |
ENSRNOG00065010189 | RatGTEx | |
UniProt | A6KAY1_RAT | UniProtKB/TrEMBL |
A6KAY2 | ENTREZGENE, UniProtKB/TrEMBL | |
A6KAY3 | ENTREZGENE, UniProtKB/TrEMBL | |
A6KAY4_RAT | UniProtKB/TrEMBL | |
A6KAY5_RAT | UniProtKB/TrEMBL | |
CLCB_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2011-08-01 | Cltb | clathrin, light chain B | Cltb | clathrin, light chain (Lcb) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-09-09 | Cltb | clathrin, light chain (Lcb) | Cltb | clathrin, light polypeptide (Lcb) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-09-10 | Cltb | clathrin, light polypeptide (Lcb) | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Cltb | clathrin, light polypeptide (Lcb) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_expression | alternatively spliced isoform Lcb2 is expressed specifically in brain neurons, while isoform Lcb3 is expressed in other tissues | 728399 |
gene_transcript | Lcb2 and Lcb3 are alternatively spliced isoforms | 728399 |