Kcnb2 (potassium voltage-gated channel subfamily B member 2) - Rat Genome Database

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Gene: Kcnb2 (potassium voltage-gated channel subfamily B member 2) Rattus norvegicus
Analyze
Symbol: Kcnb2 (Ensembl: AC125757.1)
Name: potassium voltage-gated channel subfamily B member 2
RGD ID: 621349
Description: Enables delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Involved in potassium ion transmembrane transport and protein localization to plasma membrane. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDRK; Kv2.2; potassium channel, voltage gated Shab-related subfamily B, member 2; potassium voltage gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Vetf3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr858,340,085 - 8,811,184 (-)NCBIGRCr8
mRatBN7.253,567,012 - 4,028,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl53,569,685 - 4,028,599 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx55,686,237 - 6,146,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.057,325,121 - 7,785,453 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.057,023,712 - 7,485,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,975,934 - 3,430,837 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.052,965,248 - 3,418,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.452,683,952 - 3,154,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.152,683,951 - 3,154,908 (-)NCBI
Celera53,165,386 - 3,621,344 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily. Hwang PM, etal., J Neurosci. 1993 Apr;13(4):1569-76.
4. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Hwang PM, etal., Neuron 1992 Mar;8(3):473-81.
5. Formation of heteromeric Kv2 channels in mammalian brain neurons. Kihira Y, etal., J Biol Chem. 2010 May 14;285(20):15048-55. doi: 10.1074/jbc.M109.074260. Epub 2010 Mar 4.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, etal., J Biol Chem 1997 Sep 26;272(39):24371-9.
Additional References at PubMed
PMID:17379638   PMID:20853508   PMID:23788641   PMID:24252178   PMID:26538660   PMID:29941597   PMID:30091655  


Genomics

Comparative Map Data
Kcnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr858,340,085 - 8,811,184 (-)NCBIGRCr8
mRatBN7.253,567,012 - 4,028,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl53,569,685 - 4,028,599 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx55,686,237 - 6,146,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.057,325,121 - 7,785,453 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.057,023,712 - 7,485,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,975,934 - 3,430,837 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.052,965,248 - 3,418,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.452,683,952 - 3,154,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.152,683,951 - 3,154,908 (-)NCBI
Celera53,165,386 - 3,621,344 (-)NCBICelera
Cytogenetic Map5q11NCBI
KCNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38872,537,225 - 72,938,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl872,537,225 - 72,938,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37873,449,460 - 73,850,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36873,612,180 - 74,013,138 (+)NCBINCBI36Build 36hg18NCBI36
Build 34873,612,179 - 74,013,136NCBI
Celera869,452,496 - 69,847,725 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef868,946,299 - 69,341,459 (+)NCBIHuRef
CHM1_1873,502,691 - 73,903,408 (+)NCBICHM1_1
T2T-CHM13v2.0872,972,288 - 73,367,350 (+)NCBIT2T-CHM13v2.0
Kcnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,357,149 - 15,793,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,357,478 - 15,793,974 (+)EnsemblGRCm39 Ensembl
GRCm38115,286,925 - 15,723,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,287,254 - 15,723,750 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,302,533 - 15,704,295 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,297,666 - 15,696,895 (+)NCBIMGSCv36mm8
MGSCv36115,858,607 - 15,860,301 (+)NCBIMGSCv36mm8
Celera115,251,474 - 15,665,920 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.5NCBI
Kcnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554447,237,011 - 7,646,399 (-)NCBIChiLan1.0ChiLan1.0
KCNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2788,278,471 - 88,685,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1863,904,517 - 64,314,700 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0869,069,427 - 69,481,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1870,756,092 - 71,123,156 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl870,756,185 - 71,122,897 (+)Ensemblpanpan1.1panPan2
KCNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12921,248,531 - 21,604,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2921,248,531 - 21,604,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2921,505,987 - 21,882,104 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02921,342,535 - 21,725,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2921,349,860 - 21,713,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12921,402,617 - 21,785,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02921,443,369 - 21,808,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02921,725,677 - 22,102,596 (+)NCBIUU_Cfam_GSD_1.0
Kcnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530357,711,390 - 58,087,221 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366481,361,422 - 1,734,672 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl462,879,266 - 63,307,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1462,877,838 - 63,306,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1868,165,879 - 68,538,285 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603972,849,081 - 73,253,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474418,240,912 - 18,659,530 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474418,240,321 - 18,687,157 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnb2
2061 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000045460
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)522822265904428Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat

Markers in Region
D5Rat119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.253,844,018 - 3,844,247 (+)MAPPERmRatBN7.2
Rnor_6.053,251,329 - 3,251,557NCBIRnor6.0
Rnor_5.053,239,567 - 3,239,795UniSTSRnor5.0
RGSC_v3.452,965,857 - 2,966,086RGDRGSC3.4
RGSC_v3.452,965,858 - 2,966,086UniSTSRGSC3.4
RGSC_v3.152,965,812 - 2,966,107RGD
Celera53,437,394 - 3,437,622UniSTS
RH 2.0 Map50.0RGD
SHRSP x BN Map51.1599RGD
Cytogenetic Map5q11UniSTS
D5Uwm56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.253,957,953 - 3,958,063 (+)MAPPERmRatBN7.2
Rnor_6.053,362,091 - 3,362,200NCBIRnor6.0
Rnor_5.053,349,446 - 3,349,555UniSTSRnor5.0
RGSC_v3.453,084,892 - 3,085,002RGDRGSC3.4
RGSC_v3.453,084,893 - 3,085,002UniSTSRGSC3.4
RGSC_v3.153,084,892 - 3,085,002RGD
Celera53,551,388 - 3,551,497UniSTS
Cytogenetic Map5q11UniSTS
RH134796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.253,802,906 - 3,803,092 (+)MAPPERmRatBN7.2
Rnor_6.053,211,798 - 3,211,983NCBIRnor6.0
Rnor_5.053,200,096 - 3,200,281UniSTSRnor5.0
RGSC_v3.452,921,417 - 2,921,602UniSTSRGSC3.4
Celera53,396,879 - 3,397,064UniSTS
Cytogenetic Map5q11UniSTS
AU048421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.254,003,645 - 4,003,852 (+)MAPPERmRatBN7.2
Rnor_6.053,407,662 - 3,407,866NCBIRnor6.0
Rnor_5.053,395,017 - 3,395,221UniSTSRnor5.0
RGSC_v3.453,130,585 - 3,130,789UniSTSRGSC3.4
Celera53,597,038 - 3,597,225UniSTS
Cytogenetic Map5q11UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000045460   ⟹   ENSRNOP00000050431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl53,569,685 - 4,028,599 (-)Ensembl
RefSeq Acc Id: NM_054000   ⟹   NP_446452
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr858,352,779 - 8,811,184 (-)NCBI
mRatBN7.253,569,550 - 4,027,981 (-)NCBI
Rnor_6.052,979,863 - 3,430,837 (-)NCBI
Rnor_5.052,965,248 - 3,418,192 (-)NCBI
RGSC_v3.452,683,952 - 3,154,913 (-)RGD
Celera53,165,386 - 3,621,344 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287085   ⟹   XP_063143155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr858,340,085 - 8,787,201 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446452 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143155 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40905 (Get FASTA)   NCBI Sequence Viewer  
  EDM11519 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050431
  ENSRNOP00000050431.3
GenBank Protein Q63099 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446452   ⟸   NM_054000
- UniProtKB: Q63099 (UniProtKB/Swiss-Prot),   F1LVV2 (UniProtKB/TrEMBL),   A6JFC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050431   ⟸   ENSRNOT00000045460
RefSeq Acc Id: XP_063143155   ⟸   XM_063287085
- Peptide Label: isoform X1
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVV2-F1-model_v2 AlphaFold F1LVV2 1-720 view protein structure
AF-Q63099-F1-model_v2 AlphaFold Q63099 1-907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621349 AgrOrtholog
BioCyc Gene G2FUF-42292 BioCyc
Ensembl Genes ENSRNOG00000028991 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045460 ENTREZGENE
  ENSRNOT00000045460.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117105 UniProtKB/TrEMBL
NCBI Gene 117105 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kv2channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnb2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV22CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028991 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JFC3 ENTREZGENE, UniProtKB/TrEMBL
  F1LVV2 ENTREZGENE, UniProtKB/TrEMBL
  KCNB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnb2  potassium voltage-gated channel subfamily B member 2  Kcnb2  potassium channel, voltage gated Shab-related subfamily B, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnb2  potassium channel, voltage gated Shab-related subfamily B, member 2  Kcnb2  potassium voltage gated channel, Shab-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kcnb2  potassium voltage gated channel, Shab-related subfamily, member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnb2  potassium voltage gated channel, Shab-related subfamily, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in granule cells of the olfactory bulb and cerebellum and circumvallate papillae of rat tongue 728916