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Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. |
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2. |
Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. |
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3. |
Tumor necrosis factor receptor expression and signaling in renal cell carcinoma. |
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4. |
The thalidomide analgesic effect is associated with differential TNF-alpha receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. |
Andrade P, etal., Brain Res. 2012 Apr 23;1450:24-32. doi: 10.1016/j.brainres.2012.02.033. Epub 2012 Feb 22.
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5. |
Tumor necrosis factor-alpha modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells. |
Bader T and Nettesheim P, J Immunol 1996 Oct 1;157(7):3089-96.
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6. |
Anti-tumor necrosis factor alpha treatment of interferon-alpha-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation. |
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7. |
Fatigue and proinflammatory cytokine activity in breast cancer survivors. |
Bower JE, etal., Psychosom Med. 2002 Jul-Aug;64(4):604-11.
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8. |
TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. |
Bruggeman LA, etal., Lab Invest. 2011 Mar;91(3):413-25. doi: 10.1038/labinvest.2010.199. Epub 2011 Jan 10.
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9. |
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. |
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10. |
Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis. |
Chen B, etal., Eur Respir J. 2005 Jun;25(6):1039-43.
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11. |
The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. |
Chen H, etal., Rheumatol Int. 2013 May;33(5):1223-7. doi: 10.1007/s00296-012-2529-7. Epub 2012 Oct 2.
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12. |
Tumor Necrosis Factor-Alpha Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury. |
Chen KB, etal., Spine (Phila Pa 1976). 2011 Jan 8.
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13. |
Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. |
Cheng X, etal., J Alzheimers Dis. 2010;19(2):621-30. doi: 10.3233/JAD-2010-1253.
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14. |
Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. |
Cho HY, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L537-46.
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15. |
Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. |
Constantin CE, etal., J Neurosci. 2008 May 7;28(19):5072-81.
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16. |
Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. |
Dobrzycka B, etal., Eur Cytokine Netw. 2009 Sep;20(3):131-4.
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17. |
Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. |
Dorr AD, etal., J Appl Physiol. 2011 Apr 21.
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18. |
Efficacy of etanercept on rheumatic signs and pulmonary function tests in advanced ankylosing spondylitis: results of a randomised double-blind placebo-controlled study (SPINE). |
Dougados M, etal., Ann Rheum Dis. 2011 May;70(5):799-804. Epub 2011 Feb 13.
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19. |
Bronchospasm associated with anti-TNF treatment. |
Dubey S, etal., Clin Rheumatol. 2009 Aug;28(8):989-92. Epub 2009 Apr 2.
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20. |
Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. |
Fernandez R, etal., Respir Physiol Neurobiol. 2011 Mar 15;175(3):336-48. Epub 2010 Dec 30.
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21. |
TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice. |
Fujita M, etal., Cytokine. 2008 Nov;44(2):298-303. Epub 2008 Oct 5.
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22. |
Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. |
Gadducci A, etal., Anticancer Res. 1996 Sep-Oct;16(5B):3125-8.
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23. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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24. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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25. |
Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. |
Gohda T, etal., J Am Soc Nephrol. 2012 Mar;23(3):516-24. doi: 10.1681/ASN.2011060628. Epub 2012 Jan 19.
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26. |
Circulating TNF-alpha and its soluble receptors during experimental acute pancreatitis. |
Granell S, etal., Cytokine. 2004 Feb 21;25(4):187-91.
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27. |
Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. |
Guo G, etal., Am J Physiol. 1999 Nov;277(5 Pt 2):F766-72.
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28. |
Early subcutaneous administration of etanercept (Enbrel) prevents from hyperoxia-induced lung injury. |
Guthmann F, etal., Exp Lung Res. 2009 Nov;35(9):770-80.
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29. |
Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: effect of tumor necrosis factor blockade. |
Gutkowska J, etal., J Hypertens. 2011 Apr 17.
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30. |
Methamphetamine-induced dopamine transporter complex formation and dopaminergic deficits: the role of D2 receptor activation. |
Hadlock GC, etal., J Pharmacol Exp Ther. 2010 Oct;335(1):207-12. Epub 2010 Jul 9.
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31. |
The role of TNFalpha in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. |
Hao S, etal., Neuropsychopharmacology. 2011 Feb;36(3):664-76. Epub 2010 Nov 10.
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32. |
Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis. |
Hasegawa M, etal., Nephron Clin Pract. 2009;113(3):c222-33. doi: 10.1159/000235242. Epub 2009 Aug 18.
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33. |
Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. |
Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
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34. |
Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection. |
Hoffmann U, etal., Am J Transplant. 2009 Apr;9(4):675-86. doi: 10.1111/j.1600-6143.2008.02536.x. Epub 2008 Mar 2.
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35. |
Direct application of the tumor necrosis factor-alpha inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons. |
Horii M, etal., Spine (Phila Pa 1976). 2011 Jan 15;36(2):E80-5.
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36. |
Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. |
Hwang DY, etal., J Neurochem. 2009 Dec;111(5):1202-12. Epub 2009 Sep 24.
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37. |
Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. |
Iglesias J, etal., Am J Kidney Dis. 2003 Jan;41(1):62-75.
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38. |
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus. |
Ingaramo PI, etal., Mol Immunol. 2011 Apr 8.
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39. |
Differences between tumor necrosis factor-alpha receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. |
Ishikawa T, etal., Spine (Phila Pa 1976). 2013 Jan 1;38(1):11-6. doi: 10.1097/BRS.0b013e3182610fa9.
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40. |
Regression of endometrial autografts in a rat model of endometriosis treated with etanercept. |
Islimye M, etal., Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):184-9. doi: 10.1016/j.ejogrb.2011.06.029. Epub 2011 Jul 7.
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41. |
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. |
Jiang H, etal., Mol Neurodegener. 2011 Oct 6;6:69. doi: 10.1186/1750-1326-6-69.
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42. |
TNF-alpha in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters. |
Kang YM, etal., Tohoku J Exp Med. 2010;222(4):251-63.
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43. |
Serum cytokine profile in patients with active lupus nephritis. |
Koenig KF, etal., Cytokine. 2012 Nov;60(2):410-6. doi: 10.1016/j.cyto.2012.07.004. Epub 2012 Jul 28.
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44. |
Roles of TNF-alpha and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. |
Kong SS, etal., Clin Exp Pharmacol Physiol. 2011 Mar 1. doi: 10.1111/j.1440-1681.2011.05505.x.
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45. |
The association of serum lipids and inflammatory biomarkers with renal function in men with type II diabetes mellitus. |
Lin J, etal., Kidney Int. 2006 Jan;69(2):336-42.
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46. |
Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. |
Liu KD, etal., Crit Care Med. 2007 Dec;35(12):2755-61.
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47. |
Inflammatory profile and response to anti-TNF therapy in patients with chronic pulmonary sarcoidosis. |
Loza MJ, etal., Clin Vaccine Immunol. 2011 Apr 20.
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48. |
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate. |
Lu Y, etal., Arthritis Res Ther. 2011 Apr 4;13(2):R56.
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49. |
Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-alpha in rat primary astrocytes. |
Lung HL, etal., Life Sci. 2001 Mar 23;68(18):2081-91.
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50. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
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51. |
Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. |
Misaki T, etal., Am J Pathol. 2009 Jul;175(1):74-83. doi: 10.2353/ajpath.2009.080884. Epub 2009 Jun 18.
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52. |
A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. |
Moller M, etal., Am J Respir Crit Care Med. 2010 Feb 15;181(4):388-93. Epub 2009 Dec 10.
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53. |
Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. |
Nakazawa T, etal., Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1384-91. Print 2011 Mar.
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54. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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55. |
Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis. |
Nemec A, etal., Exp Lung Res. 2009 Sep;35(7):605-20.
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56. |
Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. |
Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
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57. |
Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. |
Niewczas MA, etal., J Am Soc Nephrol. 2012 Mar;23(3):507-15. doi: 10.1681/ASN.2011060627. Epub 2012 Jan 19.
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58. |
Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat. |
Osburg B, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E899-908.
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59. |
Mechanisms of immune complex-mediated experimental glomerulonephritis: possible role of the balance between endogenous TNF and soluble TNF receptor type 2. |
Pfeifer E, etal., Eur Cytokine Netw. 2012 Mar 1;23(1):15-20. doi: 10.1684/ecn.2012.0299.
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60. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
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61. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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62. |
MicroRNA Expression in Induced Sputum of Smokers and Patients with Chronic Obstructive Pulmonary Disease. |
Pottelberge GR, etal., Am J Respir Crit Care Med. 2011 Apr 1;183(7):898-906. Epub 2010 Oct 29.
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63. |
TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. |
Ramesh G and Reeves WB, Am J Physiol Renal Physiol. 2003 Oct;285(4):F610-8. Epub 2003 Jul 15.
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64. |
Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. |
Renaud SJ, etal., J Immunol. 2011 Feb 1;186(3):1799-808. Epub 2010 Dec 27.
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65. |
GOA pipeline |
RGD automated data pipeline
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66. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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67. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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68. |
Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity. |
Riezzo I, etal., J Neurosci Res. 2010 Mar;88(4):905-16.
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Quantification of the mRNA encoding Tumor Necrosis Factor alpha (TNFalpha) and its receptors in human nasal polyps. |
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70. |
Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis, and a potential target of immunoglobulin therapy? |
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71. |
Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. |
Safranow K, etal., Tissue Antigens. 2009 Nov;74(5):386-92.
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72. |
Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. |
Sama DM, etal., PLoS One. 2012;7(5):e38170. doi: 10.1371/journal.pone.0038170. Epub 2012 May 29.
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Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. |
Shen CH, etal., Anesth Analg. 2011 Feb;112(2):454-9. Epub 2010 Nov 16.
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74. |
Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. |
Shi Y, etal., Chin J Integr Med. 2011 Mar;17(3):212-7. Epub 2011 Feb 27.
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75. |
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. |
Shimizu T, etal., Clin Rheumatol. 2000;19(5):352-9.
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76. |
Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. |
Shubayev VI and Myers RR, J Neuroimmunol. 2001 Mar 1;114(1-2):48-56.
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77. |
TNF-alpha type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice. |
Singh P, etal., Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F991-9. doi: 10.1152/ajprenal.00525.2012. Epub 2013 Feb 6.
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Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. |
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[Interleukin-6, tumor necrosis factor alpha and their soluble receptors in Bence-Jones nephropathy. Possible role in pathogenesis andthe importance in the determination of prognosis in renal insufficiency]. |
Spicka I, etal., Cas Lek Cesk. 1998 May 4;137(9):267-70.
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80. |
Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. |
Stoelcker B, etal., Infect Immun. 2002 Oct;70(10):5857-9.
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81. |
Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. |
Sunil VR, etal., Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55. Epub 2010 Nov 9.
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82. |
Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. |
Tian LM, etal., Dermatology. 2010;221(3):276-84. doi: 10.1159/000319851.
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83. |
Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. |
Tsuchiya N, etal., Genes Immun. 2001 Oct;2(6):317-22.
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84. |
Segregation of the classical transmitters norepinephrine and acetylcholine and the neuropeptide Y in sympathetic neurons: modulation by ciliary neurotrophic factor or prolonged growth in culture. |
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Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. |
Vielhauer V, etal., J Clin Invest. 2005 May;115(5):1199-209. Epub 2005 Apr 1.
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86. |
Tumor necrosis factor signaling. |
Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
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87. |
Opposing actions of hippocampus TNFalpha receptors on limbic seizure susceptibility. |
Weinberg MS, etal., Exp Neurol. 2013 Jan 16. pii: S0014-4886(13)00024-1. doi: 10.1016/j.expneurol.2013.01.011.
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88. |
Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. |
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89. |
Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. |
Yan P, etal., Exp Neurol 2003 Oct;183(2):286-97.
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The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. |
Yanik GA, etal., Blood. 2008 Oct 15;112(8):3073-81. Epub 2008 Jul 29.
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91. |
Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. |
Ye Q, etal., Respir Med. 2011 Feb;105(2):292-7. Epub 2010 Dec 8.
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92. |
[Effect of intra-articular ozone injection on serum and synovial TNF-alpha, TNFR I, and TNFR II contents in rats with rheumatoid arthritis]. |
Yu B, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):1055-8.
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Tumor necrosis factor-alpha induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. |
Zhang XC, etal., Pain. 2011 Jan;152(1):140-9. Epub 2010 Oct 30.
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Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor. |
Zhou QH, etal., J Pharmacol Exp Ther. 2011 Nov;339(2):618-23. doi: 10.1124/jpet.111.185876. Epub 2011 Aug 10.
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Predictive value of conjointly examined IL-1ra, TNF-R I, TNF-R II, and RANTES in patients with primary glomerulonephritis. |
Zwiech R J Korean Med Sci. 2013 Feb;28(2):261-7. doi: 10.3346/jkms.2013.28.2.261. Epub 2013 Jan 29.
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[Prognostic values of serum concentration and urinary excretion of interleukin-1 receptor antagonist and tumor necrosis factor receptors type I and II in patients with IGA nephropathy]. |
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