Ubr5 (ubiquitin protein ligase E3 component n-recognin 5) - Rat Genome Database

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Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5) Rattus norvegicus
Analyze
Symbol: Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
RGD ID: 621236
Description: Enables protein domain specific binding activity and ubiquitin protein ligase activity. Involved in protein ubiquitination. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 100 kDa protein; Dd5; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase UBR5-like; E3 ubiquitin-protein ligase, HECT domain-containing 1; HECT-type E3 ubiquitin transferase UBR5; hyperplastic discs protein homolog; LOC102551120; progestin induced protein; progestin-induced protein; Rat100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,000,197 - 71,109,841 (-)NCBIGRCr8
mRatBN7.2769,115,216 - 69,224,843 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,116,761 - 69,224,903 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0776,789,110 - 76,835,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0776,839,661 - 76,907,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,789,531 - 76,853,840 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,906,390 - 76,952,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,467,676 - 73,545,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,488,424 - 73,512,532 (-)NCBI
Celera766,180,320 - 66,255,438 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. UBR5 oncogene as an indicator of poor prognosis in gastric cancer. Ding F, etal., Exp Ther Med. 2020 Nov;20(5):7. doi: 10.3892/etm.2020.9135. Epub 2020 Aug 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Huibregtse JM, etal., Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2563-7.
4. UBR5 promotes cell proliferation and inhibits apoptosis in colon cancer by destablizing P21. Ji SQ, etal., Pharmazie. 2017 Jul 3;72(7):408-413. doi: 10.1691/ph.2017.7433.
5. Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo. Leboeuf D, etal., Mol Ther. 2020 Apr 8;28(4):1092-1104. doi: 10.1016/j.ymthe.2020.01.021. Epub 2020 Jan 21.
6. E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Liao L, etal., Cancer Res. 2017 Apr 15;77(8):2090-2101. doi: 10.1158/0008-5472.CAN-16-2409. Epub 2017 Mar 22.
7. Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. Lim NS, etal., J Biol Chem. 2006 May 19;281(20):14376-82. Epub 2006 Mar 22.
8. Molecular characterization of a novel rat protein structurally related to poly(A) binding proteins and the 70K protein of the U1 small nuclear ribonucleoprotein particle (snRNP) Muller D, etal., Nucleic Acids Res 1992 Apr 11;20(7):1471-5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene. Oughtred R, etal., Endocrinology 2002 Oct;143(10):3740-7.
11. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing. Qin M, etal., Biochem Biophys Res Commun. 2018 Sep 5;503(2):1027-1034. doi: 10.1016/j.bbrc.2018.06.112. Epub 2018 Jun 24.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target. Saurabh K, etal., BMC Cancer. 2020 Aug 31;20(1):824. doi: 10.1186/s12885-020-07322-1.
18. UBR5 Contributes to Colorectal Cancer Progression by Destabilizing the Tumor Suppressor ECRG4. Wang J, etal., Dig Dis Sci. 2017 Oct;62(10):2781-2789. doi: 10.1007/s10620-017-4732-6. Epub 2017 Aug 30.
19. UBR5 regulates proliferation and radiosensitivity in human laryngeal carcinoma via the p38/MAPK signaling pathway. Wang K, etal., Oncol Rep. 2020 Aug;44(2):685-697. doi: 10.3892/or.2020.7620. Epub 2020 May 21.
20. Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer. Xie Z, etal., Oncotarget. 2017 Nov 20;8(64):108079-108092. doi: 10.18632/oncotarget.22531. eCollection 2017 Dec 8.
21. The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1. Yang M, etal., Biochem Biophys Res Commun. 2016 Sep 30;478(4):1624-9. doi: 10.1016/j.bbrc.2016.08.170. Epub 2016 Aug 31.
22. Overexpression of UBR5 promotes tumor growth in gallbladder cancer via PTEN/PI3K/Akt signal pathway. Zhang Z, etal., J Cell Biochem. 2019 Feb 18. doi: 10.1002/jcb.28431.
Additional References at PubMed
PMID:10030672   PMID:12011095   PMID:16601676   PMID:18076571   PMID:19946888   PMID:21118991   PMID:22884692   PMID:25470037   PMID:26224628   PMID:26514267   PMID:28689657   PMID:31093990  


Genomics

Comparative Map Data
Ubr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,000,197 - 71,109,841 (-)NCBIGRCr8
mRatBN7.2769,115,216 - 69,224,843 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,116,761 - 69,224,903 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0776,789,110 - 76,835,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0776,839,661 - 76,907,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,789,531 - 76,853,840 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,906,390 - 76,952,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,467,676 - 73,545,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,488,424 - 73,512,532 (-)NCBI
Celera766,180,320 - 66,255,438 (-)NCBICelera
Cytogenetic Map7q22NCBI
UBR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,252,273 - 102,412,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,252,273 - 102,412,759 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,264,501 - 103,424,928 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,334,745 - 103,493,671 (-)NCBINCBI36Build 36hg18NCBI36
Celera899,450,466 - 99,609,463 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,463,202 - 98,623,328 (-)NCBIHuRef
CHM1_18103,304,790 - 103,465,221 (-)NCBICHM1_1
T2T-CHM13v2.08103,378,173 - 103,538,611 (-)NCBIT2T-CHM13v2.0
Ubr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,966,421 - 38,084,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,967,572 - 38,079,098 (-)EnsemblGRCm39 Ensembl
GRCm381537,967,328 - 38,078,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,967,328 - 38,078,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371537,897,083 - 38,008,608 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361537,911,917 - 38,023,442 (-)NCBIMGSCv36mm8
Celera1538,586,135 - 38,667,882 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.1NCBI
Ubr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,998,513 - 27,083,005 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541726,997,572 - 27,085,511 (-)NCBIChiLan1.0ChiLan1.0
UBR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27119,614,528 - 119,774,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,150,769 - 95,309,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0898,904,557 - 99,064,121 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,066,463 - 101,225,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,067,435 - 101,224,913 (-)Ensemblpanpan1.1panPan2
UBR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,887,408 - 4,023,364 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,879,220 - 4,023,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha133,889,598 - 4,025,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,047,718 - 4,183,993 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,047,714 - 4,184,536 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,890,615 - 4,026,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,003,424 - 4,139,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,020,631 - 4,156,590 (-)NCBIUU_Cfam_GSD_1.0
Ubr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,826,821 - 33,919,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,252,951 - 41,344,134 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647041,222,782 - 41,345,755 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,645,809 - 34,793,940 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,645,794 - 34,794,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,744,470 - 37,783,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,104,325 - 97,257,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,103,220 - 97,257,440 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603943,394,343 - 43,547,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,414,549 - 19,530,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,414,582 - 19,530,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ubr5
431 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:324
Count of miRNA genes:207
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000009115
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat

Markers in Region
D7Rat24  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera766,281,598 - 66,281,749UniSTS
RH 3.4 Map7638.8RGD
RH 3.4 Map7638.8UniSTS
SHRSP x BN Map744.39UniSTS
SHRSP x BN Map744.39RGD
FHH x ACI Map734.52RGD
Cytogenetic Map7q22UniSTS
AW549941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,116,875 - 69,117,006 (+)MAPPERmRatBN7.2
Rnor_6.0776,789,228 - 76,789,358NCBIRnor6.0
Rnor_5.0776,906,508 - 76,906,638UniSTSRnor5.0
RGSC_v3.4773,467,794 - 73,467,924UniSTSRGSC3.4
Celera766,180,419 - 66,180,549UniSTS
Cytogenetic Map7q22UniSTS
RH15795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,116,831 - 69,117,048 (+)MAPPERmRatBN7.2
Rnor_6.0776,789,184 - 76,789,400NCBIRnor6.0
Rnor_5.0776,906,464 - 76,906,680UniSTSRnor5.0
RGSC_v3.4773,467,750 - 73,467,966UniSTSRGSC3.4
Celera766,180,375 - 66,180,591UniSTS
Cytogenetic Map7q22UniSTS
RH126145  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,116,860 - 69,117,067 (+)MAPPERmRatBN7.2
Rnor_6.0776,789,213 - 76,789,419NCBIRnor6.0
Rnor_5.0776,906,493 - 76,906,699UniSTSRnor5.0
RGSC_v3.4773,467,779 - 73,467,985UniSTSRGSC3.4
Celera766,180,404 - 66,180,610UniSTS
Cytogenetic Map7q22UniSTS
EST4E9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,146,720 - 69,146,833 (+)MAPPERmRatBN7.2
Rnor_6.0776,819,154 - 76,819,266NCBIRnor6.0
Rnor_5.0776,936,434 - 76,936,546UniSTSRnor5.0
RGSC_v3.4773,497,632 - 73,497,744UniSTSRGSC3.4
Celera766,210,252 - 66,210,364UniSTS
Cytogenetic Map7q22UniSTS
RH129947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,116,311 - 69,116,491 (+)MAPPERmRatBN7.2
Rnor_6.0776,788,664 - 76,788,843NCBIRnor6.0
Rnor_5.0776,905,944 - 76,906,123UniSTSRnor5.0
RGSC_v3.4773,467,230 - 73,467,409UniSTSRGSC3.4
Celera766,179,855 - 66,180,034UniSTS
RH 3.4 Map7638.5UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009115   ⟹   ENSRNOP00000009115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,116,761 - 69,172,304 (-)Ensembl
Rnor_6.0 Ensembl776,789,531 - 76,853,840 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115536   ⟹   ENSRNOP00000097070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,116,761 - 69,224,903 (-)Ensembl
RefSeq Acc Id: NM_001419542   ⟹   NP_001406471
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,000,197 - 71,109,813 (-)NCBI
mRatBN7.2769,115,216 - 69,224,843 (-)NCBI
RefSeq Acc Id: XM_017595225   ⟹   XP_017450714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,001,739 - 71,040,669 (-)NCBI
mRatBN7.2769,116,758 - 69,155,697 (-)NCBI
Rnor_6.0776,789,129 - 76,829,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080164   ⟹   XP_038936092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,001,739 - 71,109,841 (-)NCBI
mRatBN7.2769,116,758 - 69,224,490 (-)NCBI
RefSeq Acc Id: XM_039080165   ⟹   XP_038936093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,001,739 - 71,109,841 (-)NCBI
mRatBN7.2769,116,758 - 69,224,490 (-)NCBI
RefSeq Acc Id: XM_039080166   ⟹   XP_038936094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,001,739 - 71,109,841 (-)NCBI
mRatBN7.2769,116,758 - 69,224,490 (-)NCBI
RefSeq Acc Id: XM_063262897   ⟹   XP_063118967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,001,739 - 71,109,841 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_017450714   ⟸   XM_017595225
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000009115   ⟸   ENSRNOT00000009115
RefSeq Acc Id: XP_038936093   ⟸   XM_039080165
- Peptide Label: isoform X3
- UniProtKB: Q62671 (UniProtKB/Swiss-Prot),   F1LRS0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936094   ⟸   XM_039080166
- Peptide Label: isoform X4
- UniProtKB: Q62671 (UniProtKB/Swiss-Prot),   F1LRS0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936092   ⟸   XM_039080164
- Peptide Label: isoform X1
- UniProtKB: Q62671 (UniProtKB/Swiss-Prot),   F1LRS0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000097070   ⟸   ENSRNOT00000115536
RefSeq Acc Id: NP_001406471   ⟸   NM_001419542
- UniProtKB: A0A8I6ARZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118967   ⟸   XM_063262897
- Peptide Label: isoform X2
Protein Domains
HECT   PABC   UBR-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621236 AgrOrtholog
BioCyc Gene G2FUF-33615 BioCyc
Ensembl Genes ENSRNOG00000006816 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009115.8 UniProtKB/TrEMBL
  ENSRNOT00000115536 ENTREZGENE
  ENSRNOT00000115536.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  c-terminal domain of poly(a) binding protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro E3_UbLigase_EDD_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP_HYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBR-box_UBR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_UBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117060 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/TrEMBL
Pfam E3_UbLigase_EDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ubr5 PhenoGen
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PABC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_UBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006816 RatGTEx
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PolyA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_UBR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ARZ1 ENTREZGENE, UniProtKB/TrEMBL
  F1LRS0 ENTREZGENE
  H9KVE3_RAT UniProtKB/TrEMBL
  Q62671 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1LRS0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ubr5  ubiquitin protein ligase E3 component n-recognin 5  LOC102551120  E3 ubiquitin-protein ligase UBR5-like  Data merged from RGD:7513918 737654 PROVISIONAL
2013-12-17 LOC102551120  E3 ubiquitin-protein ligase UBR5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-07-15 Ubr5  ubiquitin protein ligase E3 component n-recognin 5  Dd5  progestin induced protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dd5  progestin induced protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 dd5  progestin induced protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed mainly in brain and testis -highly expressed in spermatocytes, moderately in round spermatids and slightly in elongating spermatids; induced postnatally during rat testis development with expression peaking at day 25 625681
gene_function ubiquitin-conjugating enzyme(Ubc4)-dependent ubiquitin protein ligase (E3) 625681
gene_homology similar to human EDD and drosophila hyperplastic genes 625681
gene_homology shows homology to eukaryotic poly(A) binding proteins and the 70K protein of the U1 small nuclear ribonucleoprotein particle 632524
gene_process activity may result in ubiquitination of specific substrates important in the development of male germ cells 625681
gene_protein 300 kDa 625681