Wnk1 (WNK lysine deficient protein kinase 1) - Rat Genome Database

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Gene: Wnk1 (WNK lysine deficient protein kinase 1) Rattus norvegicus
Analyze
Symbol: Wnk1
Name: WNK lysine deficient protein kinase 1
RGD ID: 621141
Description: Enables several functions, including ion binding activity; molecular condensate scaffold activity; and potassium channel inhibitor activity. Involved in several processes, including cell volume homeostasis; cellular hyperosmotic response; and negative regulation of protein localization to plasma membrane. Located in cytosol and membrane. Is active in GABA-ergic synapse and intracellular non-membrane-bounded organelle. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1); PARTICIPATES IN Erk5 MAPK signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hereditary sensory neuropathy, type II; Hsn2; Prkwnk1; protein kinase lysine-deficient 1; protein kinase with no lysine 1; protein kinase, lysine deficient 1; protein kinase, lysine-deficient 1; serine/threonine-protein kinase WNK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp116
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,800,590 - 154,926,147 (-)NCBIGRCr8
mRatBN7.24153,128,334 - 153,253,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,404,297 - 159,529,850 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04155,188,022 - 155,313,566 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,811,367 - 153,936,916 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,452,211 - 152,578,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,452,848 - 152,578,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,537,467 - 219,662,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,297,841 - 156,421,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,542,681 - 156,666,661 (-)NCBI
Celera4141,980,237 - 142,105,859 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium cyanide  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sulfadimethoxine  (EXP)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell volume homeostasis  (IDA,IEA,ISO)
cellular hyperosmotic response  (IDA,IEA,ISO,ISS)
cellular response to calcium ion  (IDA)
cellular response to chemokine  (ISO)
chemokine (C-C motif) ligand 21 signaling pathway  (IEA,ISO)
heart development  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
intracellular signal transduction  (IBA,IDA,IEA,ISO)
lymphocyte migration into lymph node  (IEA,ISO)
modulation of chemical synaptic transmission  (EXP,IDA,IMP)
monoatomic cation homeostasis  (ISO,ISS)
monoatomic ion homeostasis  (IBA,IEA)
monoatomic ion transport  (ISO,ISS)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of cell-cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of heterotypic cell-cell adhesion  (IEA,ISO)
negative regulation of kinase activity  (IDA)
negative regulation of leukocyte cell-cell adhesion  (IEA,ISO)
negative regulation of pancreatic juice secretion  (IEA,ISO)
negative regulation of protein localization to plasma membrane  (IDA)
negative regulation of protein ubiquitination  (IEA,ISO,ISS)
negative regulation of sodium ion transport  (IBA,IDA,IEA)
non-membrane-bounded organelle assembly  (IEA,ISO,ISS)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of mitotic cytokinesis  (IEA,ISO,ISS)
positive regulation of potassium ion import across plasma membrane  (IBA,IEA)
positive regulation of systemic arterial blood pressure  (IEA,ISO)
positive regulation of T cell chemotaxis  (IEA,ISO)
positive regulation of termination of RNA polymerase II transcription  (IEA,ISO,ISS)
potassium ion homeostasis  (IEA,ISO)
protein autophosphorylation  (IDA)
protein insertion into ER membrane by stop-transfer membrane-anchor sequence  (IEA,ISO,ISS)
protein phosphorylation  (IDA)
regulation of blood pressure  (ISO)
regulation of monoatomic cation transmembrane transport  (ISO)
regulation of mRNA export from nucleus  (IEA,ISO,ISS)
regulation of sodium ion transmembrane transport  (IEA,ISO)
regulation of sodium ion transport  (IDA)
signal transduction  (ISO)
sodium ion transmembrane transport  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (IBA,IDA,IEA,ISO)
GABA-ergic synapse  (EXP,IDA,IMP)
intracellular non-membrane-bounded organelle  (IDA,ISO)
membrane  (IDA)
mitotic spindle  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Boyd-Shiwarski CR, etal., Cell. 2022 Nov 23;185(24):4488-4506.e20. doi: 10.1016/j.cell.2022.09.042. Epub 2022 Oct 31.
3. WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. Cope G, etal., J Am Soc Nephrol. 2006 Jul;17(7):1867-74. Epub 2006 Jun 14.
4. SLC26A9 is a Cl(-) channel regulated by the WNK kinases. Dorwart MR, etal., J Physiol. 2007 Oct 1;584(Pt 1):333-45. doi: 10.1113/jphysiol.2007.135855. Epub 2007 Aug 2.
5. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Friedel P, etal., Sci Signal. 2015 Jun 30;8(383):ra65. doi: 10.1126/scisignal.aaa0354.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. Inoue K, etal., J Biol Chem. 2012 Jun 15;287(25):20839-50. doi: 10.1074/jbc.M111.319418. Epub 2012 Apr 27.
8. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Lee BH, etal., Mol Cell. 2004 Sep 10;15(5):741-51.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Piala AT, etal., Sci Signal. 2014 May 6;7(324):ra41. doi: 10.1126/scisignal.2005050.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. WNK Kinases, Renal Ion Transport and Hypertension. San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870.
17. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Subramanya AR, etal., Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.
18. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Tobin MD, etal., Circulation. 2005 Nov 29;112(22):3423-9. Epub 2005 Nov 21.
19. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24.
20. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, etal., Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.
21. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
22. Comparison of WNK4 and WNK1 kinase and inhibiting activities. Wang Z, etal., Biochem Biophys Res Commun. 2004 May 7;317(3):939-44.
23. Human hypertension caused by mutations in WNK kinases. Wilson FH, etal., Science. 2001 Aug 10;293(5532):1107-12.
24. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. Xu B, etal., J Biol Chem 2000 Jun 2;275(22):16795-801.
25. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. Yang CL, etal., J Clin Invest 2003 Apr;111(7):1039-45.
Additional References at PubMed
PMID:10660600   PMID:12374799   PMID:14610273   PMID:15057822   PMID:15060842   PMID:15242606   PMID:15583131   PMID:16428287   PMID:16669787   PMID:17194447   PMID:18521183   PMID:19389623  
PMID:19644017   PMID:20525693   PMID:21317537   PMID:23376100   PMID:23797875   PMID:25749374   PMID:27400149   PMID:27782176   PMID:31085334   PMID:31561038   PMID:32314908   PMID:33689398  


Genomics

Comparative Map Data
Wnk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,800,590 - 154,926,147 (-)NCBIGRCr8
mRatBN7.24153,128,334 - 153,253,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,404,297 - 159,529,850 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04155,188,022 - 155,313,566 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,811,367 - 153,936,916 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,452,211 - 152,578,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,452,848 - 152,578,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,537,467 - 219,662,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,297,841 - 156,421,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,542,681 - 156,666,661 (-)NCBI
Celera4141,980,237 - 142,105,859 (-)NCBICelera
Cytogenetic Map4q42NCBI
WNK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812752,579 - 911,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12752,579 - 911,452 (+)EnsemblGRCh38hg38GRCh38
GRCh3712861,745 - 1,020,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612732,486 - 890,879 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412732,992 - 888,219NCBI
Celera122,468,382 - 2,626,915 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef12714,669 - 871,790 (+)NCBIHuRef
CHM1_112861,230 - 1,019,755 (+)NCBICHM1_1
T2T-CHM13v2.012748,443 - 907,208 (+)NCBIT2T-CHM13v2.0
Wnk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,900,930 - 120,015,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,900,930 - 120,015,633 (-)EnsemblGRCm39 Ensembl
GRCm386119,923,969 - 120,038,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,923,969 - 120,038,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,873,987 - 119,988,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,889,957 - 120,003,398 (-)NCBIMGSCv36mm8
Celera6121,760,900 - 121,876,945 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.86NCBI
Wnk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554546,228,492 - 6,358,637 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554546,228,492 - 6,358,690 (-)NCBIChiLan1.0ChiLan1.0
WNK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2106,247,188 - 6,409,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,248,370 - 6,405,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012825,659 - 985,016 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112791,153 - 945,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12791,153 - 944,602 (+)Ensemblpanpan1.1panPan2
WNK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,764,184 - 42,914,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,765,181 - 42,912,806 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,768,749 - 3,918,144 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02743,125,909 - 43,275,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2743,125,048 - 43,275,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,064,974 - 43,214,364 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,036,519 - 43,186,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,127,998 - 3,277,800 (-)NCBIUU_Cfam_GSD_1.0
Wnk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,114,216 - 108,250,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936606934,337 - 1,067,275 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936606933,637 - 1,069,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,000,905 - 68,140,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,000,792 - 68,142,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,264,470 - 70,408,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111736,668 - 893,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11737,590 - 890,762 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660637,446,465 - 7,603,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247358,987,469 - 9,124,516 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247358,987,390 - 9,122,277 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnk1
255 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:825
Count of miRNA genes:260
Interacting mature miRNAs:338
Transcripts:ENSRNOT00000013355, ENSRNOT00000013621
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat

Markers in Region
D4Rat64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,173,847 - 153,173,999 (+)MAPPERmRatBN7.2
Rnor_6.04152,498,361 - 152,498,510NCBIRnor6.0
Rnor_5.04219,582,980 - 219,583,129UniSTSRnor5.0
RGSC_v3.44156,341,724 - 156,341,874RGDRGSC3.4
RGSC_v3.44156,341,725 - 156,341,874UniSTSRGSC3.4
RGSC_v3.14156,586,566 - 156,586,715RGD
Celera4142,025,745 - 142,025,894UniSTS
RH 3.4 Map4983.1RGD
RH 3.4 Map4983.1UniSTS
RH 2.0 Map4974.6RGD
SHRSP x BN Map477.0299RGD
Cytogenetic Map4q42UniSTS
RH143180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,164,435 - 153,164,536 (+)MAPPERmRatBN7.2
Rnor_6.04152,488,949 - 152,489,049NCBIRnor6.0
Rnor_5.04219,573,568 - 219,573,668UniSTSRnor5.0
RGSC_v3.44156,332,313 - 156,332,413UniSTSRGSC3.4
Celera4142,016,333 - 142,016,433UniSTS
RH 3.4 Map4983.2UniSTS
Cytogenetic Map4q42UniSTS
AU047215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,134,671 - 153,134,880 (+)MAPPERmRatBN7.2
Rnor_6.04152,459,186 - 152,459,394NCBIRnor6.0
Rnor_5.04219,543,805 - 219,544,013UniSTSRnor5.0
RGSC_v3.44156,302,549 - 156,302,757UniSTSRGSC3.4
Celera4141,986,566 - 141,986,774UniSTS
Cytogenetic Map4q42UniSTS
RH135198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,137,553 - 153,137,755 (+)MAPPERmRatBN7.2
Rnor_6.04152,462,068 - 152,462,269NCBIRnor6.0
Rnor_5.04219,546,687 - 219,546,888UniSTSRnor5.0
RGSC_v3.44156,305,431 - 156,305,632UniSTSRGSC3.4
Celera4141,989,448 - 141,989,649UniSTS
RH 3.4 Map4987.3UniSTS
Cytogenetic Map4q42UniSTS
RH140646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,253,583 - 153,253,788 (+)MAPPERmRatBN7.2
Rnor_6.04152,578,082 - 152,578,286NCBIRnor6.0
Rnor_5.04219,662,660 - 219,662,864UniSTSRnor5.0
RGSC_v3.44156,421,499 - 156,421,703UniSTSRGSC3.4
Celera4142,105,538 - 142,105,742UniSTS
RH 3.4 Map4981.9UniSTS
Cytogenetic Map4q42UniSTS
D8S281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,541,510 - 45,542,217 (+)MAPPERmRatBN7.2
mRatBN7.24153,162,583 - 153,162,986 (+)MAPPERmRatBN7.2
Rnor_6.04152,487,097 - 152,487,499NCBIRnor6.0
Rnor_6.01047,115,891 - 47,116,597NCBIRnor6.0
Rnor_5.01046,889,367 - 46,890,073UniSTSRnor5.0
Rnor_5.04219,571,716 - 219,572,118UniSTSRnor5.0
RGSC_v3.44156,330,460 - 156,330,863UniSTSRGSC3.4
RGSC_v3.41047,008,921 - 47,009,627UniSTSRGSC3.4
Celera1044,796,451 - 44,797,157UniSTS
Celera4142,014,481 - 142,014,883UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001002823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF227741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK004106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ177457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013355   ⟹   ENSRNOP00000013355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
Rnor_6.0 Ensembl4152,452,848 - 152,578,403 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000013621   ⟹   ENSRNOP00000013622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
Rnor_6.0 Ensembl4152,452,848 - 152,578,403 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079513   ⟹   ENSRNOP00000072554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
Rnor_6.0 Ensembl4152,455,224 - 152,578,446 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080788   ⟹   ENSRNOP00000072173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
Rnor_6.0 Ensembl4152,452,848 - 152,578,403 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109428   ⟹   ENSRNOP00000089664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111379   ⟹   ENSRNOP00000097067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113392   ⟹   ENSRNOP00000077765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120316   ⟹   ENSRNOP00000080872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
RefSeq Acc Id: NM_001002823   ⟹   NP_001002823
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,926,147 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
Rnor_6.04152,452,848 - 152,578,403 (-)NCBI
Rnor_5.04219,537,467 - 219,662,981 (-)NCBI
RGSC_v3.44156,332,543 - 156,333,847 (-)RGD
Celera4141,980,237 - 142,105,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001199095   ⟹   NP_001186024
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,926,147 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
Rnor_6.04152,452,848 - 152,578,403 (-)NCBI
Rnor_5.04219,537,467 - 219,662,981 (-)NCBI
Celera4141,980,237 - 142,105,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053794   ⟹   NP_446246
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,926,147 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
Rnor_6.04152,452,848 - 152,578,403 (-)NCBI
Rnor_5.04219,537,467 - 219,662,981 (-)NCBI
RGSC_v3.44156,297,841 - 156,421,820 (-)RGD
Celera4141,980,237 - 142,105,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763201   ⟹   XP_008761423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
Rnor_6.04152,452,848 - 152,578,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763207   ⟹   XP_008761429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,130,761 - 153,253,740 (-)NCBI
Rnor_6.04152,452,848 - 152,578,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763212   ⟹   XP_008761434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
Rnor_6.04152,452,848 - 152,578,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106921   ⟹   XP_038962849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106922   ⟹   XP_038962850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106924   ⟹   XP_038962852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106925   ⟹   XP_038962853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106926   ⟹   XP_038962854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106927   ⟹   XP_038962855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106928   ⟹   XP_038962856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106929   ⟹   XP_038962857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,803,899 - 154,925,982 (-)NCBI
mRatBN7.24153,131,645 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106930   ⟹   XP_038962858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,803,899 - 154,925,982 (-)NCBI
mRatBN7.24153,131,645 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106931   ⟹   XP_038962859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106932   ⟹   XP_038962860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106933   ⟹   XP_038962861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,803,900 - 154,925,982 (-)NCBI
mRatBN7.24153,131,645 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106935   ⟹   XP_038962863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106936   ⟹   XP_038962864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106937   ⟹   XP_038962865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106938   ⟹   XP_038962866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106939   ⟹   XP_038962867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_039106940   ⟹   XP_038962868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,843,064 (-)NCBI
mRatBN7.24153,128,334 - 153,170,808 (-)NCBI
RefSeq Acc Id: XM_039106941   ⟹   XP_038962869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
mRatBN7.24153,128,334 - 153,253,905 (-)NCBI
RefSeq Acc Id: XM_063285404   ⟹   XP_063141474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285405   ⟹   XP_063141475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285406   ⟹   XP_063141476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285407   ⟹   XP_063141477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285408   ⟹   XP_063141478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285409   ⟹   XP_063141479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285410   ⟹   XP_063141480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
RefSeq Acc Id: XM_063285411   ⟹   XP_063141481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,800,590 - 154,925,982 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001002823 (Get FASTA)   NCBI Sequence Viewer  
  NP_001186024 (Get FASTA)   NCBI Sequence Viewer  
  NP_446246 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761423 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761429 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761434 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962849 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962850 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962852 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962853 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962854 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962855 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962856 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962857 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962858 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962859 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962860 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962861 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962863 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962864 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962865 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962866 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962867 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962868 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962869 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141474 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141475 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141476 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141477 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141478 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141479 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141480 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141481 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF74258 (Get FASTA)   NCBI Sequence Viewer  
  ABA02202 (Get FASTA)   NCBI Sequence Viewer  
  DAA04492 (Get FASTA)   NCBI Sequence Viewer  
  EDM02045 (Get FASTA)   NCBI Sequence Viewer  
  EDM02046 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013355
  ENSRNOP00000013355.5
  ENSRNOP00000013622
  ENSRNOP00000013622.5
  ENSRNOP00000072173.2
  ENSRNOP00000072554
  ENSRNOP00000072554.1
  ENSRNOP00000077765
  ENSRNOP00000077765.1
  ENSRNOP00000080872
  ENSRNOP00000080872.1
  ENSRNOP00000089664
  ENSRNOP00000089664.1
  ENSRNOP00000097067
  ENSRNOP00000097067.1
GenBank Protein Q9JIH7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446246   ⟸   NM_053794
- Peptide Label: isoform 3
- UniProtKB: Q3S2I2 (UniProtKB/Swiss-Prot),   Q6IFS7 (UniProtKB/Swiss-Prot),   Q9JIH7 (UniProtKB/Swiss-Prot),   A6IL94 (UniProtKB/TrEMBL),   A0A8L2UQL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001002823   ⟸   NM_001002823
- Peptide Label: isoform 1
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186024   ⟸   NM_001199095
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761434   ⟸   XM_008763212
- Peptide Label: isoform X26
- UniProtKB: A0A8I5ZQI2 (UniProtKB/TrEMBL),   A0A8I6ALH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761429   ⟸   XM_008763207
- Peptide Label: isoform X20
- UniProtKB: A0A8I6AQS9 (UniProtKB/TrEMBL),   A0A8I6ALH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761423   ⟸   XM_008763201
- Peptide Label: isoform X18
- UniProtKB: A0A8I6ALH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072173   ⟸   ENSRNOT00000080788
RefSeq Acc Id: ENSRNOP00000072554   ⟸   ENSRNOT00000079513
RefSeq Acc Id: ENSRNOP00000013622   ⟸   ENSRNOT00000013621
RefSeq Acc Id: ENSRNOP00000013355   ⟸   ENSRNOT00000013355
RefSeq Acc Id: XP_038962867   ⟸   XM_039106939
- Peptide Label: isoform X19
- UniProtKB: A0A8I6ALH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962869   ⟸   XM_039106941
- Peptide Label: isoform X27
- UniProtKB: A0A0G2K3A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962866   ⟸   XM_039106938
- Peptide Label: isoform X17
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962864   ⟸   XM_039106936
- Peptide Label: isoform X15
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962860   ⟸   XM_039106932
- Peptide Label: isoform X12
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962850   ⟸   XM_039106922
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962865   ⟸   XM_039106937
- Peptide Label: isoform X16
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962863   ⟸   XM_039106935
- Peptide Label: isoform X14
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962859   ⟸   XM_039106931
- Peptide Label: isoform X11
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962856   ⟸   XM_039106928
- Peptide Label: isoform X7
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962853   ⟸   XM_039106925
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962855   ⟸   XM_039106927
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962854   ⟸   XM_039106926
- Peptide Label: isoform X5
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962852   ⟸   XM_039106924
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962849   ⟸   XM_039106921
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962868   ⟸   XM_039106940
- Peptide Label: isoform X25
RefSeq Acc Id: XP_038962861   ⟸   XM_039106933
- Peptide Label: isoform X13
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962858   ⟸   XM_039106930
- Peptide Label: isoform X10
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962857   ⟸   XM_039106929
- Peptide Label: isoform X9
- UniProtKB: A0A8I5Y206 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097067   ⟸   ENSRNOT00000111379
RefSeq Acc Id: ENSRNOP00000080872   ⟸   ENSRNOT00000120316
RefSeq Acc Id: ENSRNOP00000089664   ⟸   ENSRNOT00000109428
RefSeq Acc Id: ENSRNOP00000077765   ⟸   ENSRNOT00000113392
RefSeq Acc Id: XP_063141480   ⟸   XM_063285410
- Peptide Label: isoform X29
RefSeq Acc Id: XP_063141479   ⟸   XM_063285409
- Peptide Label: isoform X28
RefSeq Acc Id: XP_063141477   ⟸   XM_063285407
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063141481   ⟸   XM_063285411
- Peptide Label: isoform X30
RefSeq Acc Id: XP_063141478   ⟸   XM_063285408
- Peptide Label: isoform X24
RefSeq Acc Id: XP_063141476   ⟸   XM_063285406
- Peptide Label: isoform X22
RefSeq Acc Id: XP_063141475   ⟸   XM_063285405
- Peptide Label: isoform X21
RefSeq Acc Id: XP_063141474   ⟸   XM_063285404
- Peptide Label: isoform X8
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIH7-F1-model_v2 AlphaFold Q9JIH7 1-2126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621141 AgrOrtholog
BioCyc Gene G2FUF-43208 BioCyc
Ensembl Genes ENSRNOG00000009956 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013355 ENTREZGENE
  ENSRNOT00000013355.7 UniProtKB/Swiss-Prot
  ENSRNOT00000013621 ENTREZGENE
  ENSRNOT00000013621.7 UniProtKB/Swiss-Prot
  ENSRNOT00000079513.2 UniProtKB/TrEMBL
  ENSRNOT00000080788.2 UniProtKB/TrEMBL
  ENSRNOT00000109428 ENTREZGENE
  ENSRNOT00000109428.1 UniProtKB/TrEMBL
  ENSRNOT00000111379.1 UniProtKB/TrEMBL
  ENSRNOT00000113392.1 UniProtKB/TrEMBL
  ENSRNOT00000120316.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:116477 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116477 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnk1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009956 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y206 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UQL4 ENTREZGENE, UniProtKB/TrEMBL
  A6IL94 ENTREZGENE, UniProtKB/TrEMBL
  Q3S2I2 ENTREZGENE
  Q6IFS7 ENTREZGENE
  Q9JIH7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3S2I2 UniProtKB/Swiss-Prot
  Q6IFS7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-13 Wnk1  WNK lysine deficient protein kinase 1  Hsn2  hereditary sensory neuropathy, type II  Data merged from RGD:1303088 737654 APPROVED
2008-02-19 Wnk1  WNK lysine deficient protein kinase 1  Prkwnk1  protein kinase, lysine deficient 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Hsn2  hereditary sensory neuropathy, type II      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Prkwnk1  protein kinase, lysine deficient 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Prkwnk1  protein kinase, lysine deficient 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is a cause of pseudohypoaldosteronism type II (PHAII) 1299306
gene_domains contains a small N-terminal domain followed by the kinase domain and a long C-terminal tail 633747
gene_protein 2126 amino acids and 230 kDa 633747