Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | KIF6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | KIF6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. | Bare LA, etal., PLoS One. 2010 Sep 29;5(9):e13081. doi: 10.1371/journal.pone.0013081. |
2. | Association between rs20456 and rs6930913 of Kinesin-Like Family 6 and Hypertension in a Chinese Cohort. | Chen YL, etal., Int J Hypertens. 2021 Dec 18;2021:1061800. doi: 10.1155/2021/1061800. eCollection 2021. |
3. | The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction. | Davani S, etal., Atherosclerosis. 2010 May;210(1):48-50. doi: 10.1016/j.atherosclerosis.2009.11.041. Epub 2009 Nov 29. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran. | Hamidizadeh L, etal., Arch Iran Med. 2015 Oct;18(10):683-7. doi: 0151810/AIM.008. |
6. | Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study. | Hoffmann MM, etal., Atherosclerosis. 2011 Dec;219(2):659-62. doi: 10.1016/j.atherosclerosis.2011.07.126. Epub 2011 Aug 5. |
7. | No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study. | Hopewell JC, etal., J Am Coll Cardiol. 2011 May 17;57(20):2000-7. doi: 10.1016/j.jacc.2011.02.015. Epub 2011 Mar 31. |
8. | KIF6 719Arg Genetic Variant and Risk for Thoracic Aortic Dissection. | Iakoubova OA, etal., Aorta (Stamford). 2016 Jun 1;4(3):83-90. doi: 10.12945/j.aorta.2016.16.003. eCollection 2016 Jun. |
9. | Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. | Luke MM, etal., Cerebrovasc Dis. 2009;28(5):499-504. Epub 2009 Sep 12. |
10. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
11. | GOA pipeline | RGD automated data pipeline |
12. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
13. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
14. | Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial. | Shiffman D, etal., Am J Cardiol. 2010 May 1;105(9):1300-5. doi: 10.1016/j.amjcard.2009.12.049. Epub 2010 Mar 20. |
15. | A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. | Shiffman D, etal., J Am Coll Cardiol. 2008 Jan 29;51(4):444-8. doi: 10.1016/j.jacc.2007.09.044. |
16. | Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. | Sperry AO and Zhao LP, Mol Biol Cell 1996 Feb;7(2):289-305. |
17. | Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study. | Stewart AF, etal., J Am Coll Cardiol. 2009 Apr 21;53(16):1471-2. doi: 10.1016/j.jacc.2008.12.051. |
18. | Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia. | Vatte C, etal., Ann Saudi Med. 2016 Mar-Apr;36(2):105-11. doi: 10.5144/0256-4947.2016.21.3.1140. Epub 2016 Mar 21. |
19. | Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men. | Wu G, etal., J Diabetes Res. 2014;2014:871439. doi: 10.1155/2014/871439. Epub 2014 Dec 31. |
20. | KRP3A and KRP3B: candidate motors in spermatid maturation in the seminiferous epithelium. | Zou Y, etal., Biol Reprod 2002 Mar;66(3):843-55. |
Kif6 (Rattus norvegicus - Norway rat) |
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KIF6 (Homo sapiens - human) |
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Kif6 (Mus musculus - house mouse) |
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Kif6 (Chinchilla lanigera - long-tailed chinchilla) |
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KIF6 (Pan paniscus - bonobo/pygmy chimpanzee) |
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KIF6 (Canis lupus familiaris - dog) |
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Kif6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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KIF6 (Sus scrofa - pig) |
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KIF6 (Chlorocebus sabaeus - green monkey) |
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Kif6 (Heterocephalus glaber - naked mole-rat) |
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Variants in Kif6
2446 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D9Rat82 |
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D9Rat88 |
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D9Got13 |
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RH130619 |
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AU046623 |
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AU049286 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | ||||||||||||
Low | 12 | 16 | 15 | 15 | 74 | 24 | 32 | 11 | |||||
Below cutoff | 3 | 13 | 30 | 25 | 8 | 25 | 3 | 3 | 11 | 6 | 3 |
RefSeq Acc Id: | ENSRNOT00000015584 ⟹ ENSRNOP00000015584 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_006244480 ⟹ XP_006244542 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XP_006244542 ⟸ XM_006244480 |
- UniProtKB: | E9PSL8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000015584 ⟸ ENSRNOT00000015584 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-E9PSL8-F1-model_v2 | AlphaFold | E9PSL8 | 1-746 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13696489 | ||||||||
Promoter ID: | EPDNEW_R7007 | ||||||||
Type: | single initiation site | ||||||||
Name: | Kif6_1 | ||||||||
Description: | kinesin family member 6 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621070 | AgrOrtholog |
BioCyc Gene | G2FUF-28343 | BioCyc |
Ensembl Genes | ENSRNOG00000011453 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000015584.8 | UniProtKB/TrEMBL |
Gene3D-CATH | 3.40.850.10 | UniProtKB/TrEMBL |
InterPro | Kinesin-like_fam | UniProtKB/TrEMBL |
Kinesin_motor_CS | UniProtKB/TrEMBL | |
Kinesin_motor_dom | UniProtKB/TrEMBL | |
Kinesin_motor_dom_sf | UniProtKB/TrEMBL | |
P-loop_NTPase | UniProtKB/TrEMBL | |
KEGG Report | rno:171291 | UniProtKB/TrEMBL |
NCBI Gene | 171291 | ENTREZGENE |
PANTHER | CENTROMERE PROTEIN E | UniProtKB/TrEMBL |
KINESIN-LIKE PROTEIN TEA2 | UniProtKB/TrEMBL | |
Pfam | Kinesin | UniProtKB/TrEMBL |
PhenoGen | Kif6 | PhenoGen |
PRINTS | KINESINHEAVY | UniProtKB/TrEMBL |
PROSITE | KINESIN_MOTOR_DOMAIN1 | UniProtKB/TrEMBL |
KINESIN_MOTOR_DOMAIN2 | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000011453 | RatGTEx |
SMART | KISc | UniProtKB/TrEMBL |
Superfamily-SCOP | SSF52540 | UniProtKB/TrEMBL |
UniProt | A6JIC2_RAT | UniProtKB/TrEMBL |
A6JIC3_RAT | UniProtKB/TrEMBL | |
A6JIC4_RAT | UniProtKB/TrEMBL | |
E9PSL8 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2004-09-10 | Kif6 | kinesin family member 6 | Krp3 | kinesin-related protein 3 | Symbol and Name updated | 1299863 | APPROVED |
2002-08-07 | Krp3 | kinesin-related protein 3 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_domains | has a conserved motor domain that can form a limited coiled-coil secondary structure, and a globular tail domain | 633049 |
gene_expression | cDNA isolated from the rat testis | 633049 |
gene_product | member of the kinesin superfamily | 633049 |
gene_transcript | present in two isoforms | 633049 |