Pde5a (phosphodiesterase 5A) - Rat Genome Database

Name: Pde5a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pde5a (phosphodiesterase 5A) Rattus norvegicus

Analyze

Symbol:

Pde5a

Name:

phosphodiesterase 5A

RGD ID:

620995

Description:

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5A2; phosphodiesterase 5A, cGMP-specific; phosphodiesterase type 5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE5A (phosphodiesterase 5A)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pde5a (phosphodiesterase 5A, cGMP-specific)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PDE5A (phosphodiesterase 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pde5a (phosphodiesterase 5A, cGMP-specific)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pde5ab (phosphodiesterase 5A, cGMP-specific, b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PDE2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Pde11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pde6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pde5a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Genetic Models:

F344-Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI		GRCr8
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	218,537,423 - 218,677,334 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	216,445,209 - 216,585,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	211,291,504 - 211,431,374 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	219,373,455 - 219,513,972 (+)	NCBI
Celera	2	203,287,460 - 203,425,472 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

Experimental Diabetes Mellitus (IMP)

genetic disease (ISO)

Hearing Loss (IMP)

Hypertriglyceridemia (IMP)

IgA glomerulonephritis (ISO)

impotence (IMP)

Inflammation (IMP)

myocardial infarction (IMP)

Neoplasm Metastasis (ISO)

Neurodevelopmental Disorders (ISO)

pre-eclampsia (IMP)

primary biliary cholangitis (IMP)

pulmonary hypertension (IMP)

Reperfusion Injury (IMP)

Right Ventricular Hypertrophy (IMP,ISO)

Stroke (IMP)

vasculogenic impotence (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3,5-trinitro-1,3,5-triazinane (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic GMP (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-bromo-3',5'-cyclic GMP (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

anthocyanin (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromacil (ISO)

butanal (ISO)

caffeine (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

carmustine (ISO)

carnosic acid (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cyanazine (ISO)

cyclosporin A (ISO)

cyproterone acetate (EXP)

decabromodiphenyl ether (ISO)

deisopropylatrazine (ISO)

diazinon (EXP)

diethyl phthalate (EXP)

dioxygen (ISO)

dipyridamole (ISO)

disulfiram (ISO)

dizocilpine maleate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

flavonoids (EXP)

furan (EXP)

hemin (EXP)

icariin (EXP,ISO)

Indeno[1,2,3-cd]pyrene (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

malvidin (ISO)

malvidin 3-O-beta-D-glucoside (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP,ISO)

Monobutylphthalate (EXP)

morin (EXP)

N(gamma)-nitro-L-arginine methyl ester (EXP)

N-tosyl-L-phenylalanyl chloromethyl ketone (EXP)

naringin (EXP)

nickel atom (ISO)

nitric oxide (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (ISO)

pentanal (ISO)

phenobarbital (EXP)

phenylephrine (EXP)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

prometon (ISO)

propazine (ISO)

raloxifene (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sildenafil citrate (EXP,ISO)

simazine (ISO)

sodium arsenite (ISO)

streptozocin (EXP)

sulforaphane (ISO)

sulindac sulfone (ISO)

tadalafil (ISO)

temozolomide (ISO)

Terbacil (ISO)

testosterone (EXP)

testosterone enanthate (EXP)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

trans-piceid (ISO)

trichloroethene (EXP)

triptonide (ISO)

triptorelin (EXP)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cAMP-mediated signaling (IBA,IEA)

cGMP catabolic process (IEA,ISO)

cGMP metabolic process (ISO)

negative regulation of cardiac muscle contraction (IEA,ISO)

negative regulation of T cell proliferation (IEA,ISO)

nervous system development (IEP)

oocyte development (IEA,ISO)

positive regulation of apoptotic process (IMP)

positive regulation of cardiac muscle hypertrophy (IEA,ISO)

positive regulation of chronic inflammatory response (IMP)

positive regulation of oocyte development (IEA,ISO)

positive regulation of vasoconstriction (IMP)

regulation of nitric oxide mediated signal transduction (IEA,ISO)

regulation of the force of heart contraction (IMP)

relaxation of cardiac muscle (IEA,ISO)

response to hypoxia (IEP)

response to lipopolysaccharide (IEP)

response to testosterone (IEP)

short-term memory (IMP)

signal transduction (IEA)

T cell proliferation (IEA,ISO)

vasodilation (IEP)

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity (IBA,IEA)

3',5'-cyclic-GMP phosphodiesterase activity (IBA,IDA,IEA,ISO,TAS)

3',5'-cyclic-nucleotide phosphodiesterase activity (IEA,ISO)

cGMP binding (IEA,ISO)

cyclic-nucleotide phosphodiesterase activity (ISO)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity.	Abboud K, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H836-45. Epub 2009 Jun 19.
2.	The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats.	Ahn GJ, etal., Int J Impot Res. 2005 Mar-Apr;17(2):134-41.
3.	DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats.	Ahn GJ, etal., Urology. 2005 Jan;65(1):202-7.
4.	Impact of a long-term sildenafil treatment on pressor response in conscious rats with insulin resistance and hypertriglyceridemia.	Behr-Roussel D, etal., Am J Hypertens. 2008 Nov;21(11):1258-63. Epub 2008 Sep 11.
5.	The presence and function of phosphodiesterase type 5 in the rat myometrium.	Buhimschi CS, etal., Am J Obstet Gynecol. 2004 Jan;190(1):268-74.
6.	Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.	Choi DE, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F362-70. Epub 2009 May 27.
7.	Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat.	Ferrini MG, etal., Biol Reprod. 2007 May;76(5):915-23. Epub 2007 Feb 7.
8.	Characterization and functional role of androgen-dependent PDE5 activity in the bladder.	Filippi S, etal., Endocrinology. 2007 Mar;148(3):1019-29. Epub 2006 Nov 30.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat.	Ghali-Ghoul R, etal., Eur J Pharmacol. 2007 Oct 15;572(1):49-56. Epub 2007 Jun 13.
11.	Phosphodiesterase-5 gene (PDE5A) polymorphisms are associated with progression of childhood IgA nephropathy.	Hahn WH, etal., Pediatr Nephrol. 2010 Sep;25(9):1663-71. doi: 10.1007/s00467-010-1579-x. Epub 2010 Jun 20.
12.	cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.	Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
13.	The effect of DA-8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction.	Kang KK, etal., Int J Impot Res. 2005 Sep-Oct;17(5):409-16.
14.	Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling.	Kim D, etal., J Mol Cell Cardiol. 2005 Jan;38(1):175-84. Epub 2004 Dec 8.
15.	Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development.	Kotera J, etal., Eur J Biochem 1997 Oct 15;249(2):434-42.
16.	Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.	Kotera J, etal., Eur J Biochem. 1999 Jun;262(3):866-73.
17.	Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers.	Loureiro-Silva MR, etal., J Hepatol. 2006 May;44(5):886-93. Epub 2006 Feb 28.
18.	PDE5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism.	Menniti FS, etal., J Pharmacol Exp Ther. 2009 Sep 3.
19.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
20.	Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension.	Murray F, etal., Br J Pharmacol. 2002 Dec;137(8):1187-94.
21.	Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.	Nagendran J, etal., Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.
22.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
23.	Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat.	Ni XP, etal., J Am Soc Nephrol. 2004 May;15(5):1254-60.
24.	Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction.	Perez NG, etal., Hypertension. 2007 May;49(5):1095-103. Epub 2007 Mar 5.
25.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
26.	GOA pipeline	RGD automated data pipeline
27.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
28.	Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats.	Sawamura F, etal., J Pharmacol Sci. 2009 Oct 31.
29.	Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.	Takimoto E, etal., Nat Med. 2005 Feb;11(2):214-22. Epub 2005 Jan 23.
30.	The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.	Turgut NH, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):180-7. Epub 2008 Jun 4.
31.	Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats.	Wang T, etal., Eur Respir J. 2009 May;33(5):1122-32. Epub 2009 Jan 7.
32.	Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages.	Witwicka H, etal., Biochim Biophys Acta. 2007 Feb;1773(2):209-18. Epub 2006 Oct 24.

Additional References at PubMed

PMID:12554648	PMID:14687666	PMID:15075333	PMID:16150726	PMID:16651469	PMID:17101732	PMID:17690141	PMID:18534985	PMID:18723505	PMID:18790048	PMID:19127022	PMID:19338748
PMID:19474061	PMID:19961855	PMID:20039971	PMID:20177073	PMID:20511540	PMID:21063091	PMID:24068049	PMID:26657792	PMID:27923787	PMID:32311453	PMID:33009887

Genomics

Comparative Map Data

Pde5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI		GRCr8
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	218,537,423 - 218,677,334 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	216,445,209 - 216,585,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	211,291,504 - 211,431,374 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	219,373,455 - 219,513,972 (+)	NCBI
Celera	2	203,287,460 - 203,425,472 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

PDE5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	119,494,403 - 119,628,804 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	119,494,397 - 119,628,804 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	120,415,558 - 120,549,959 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	120,634,998 - 120,769,429 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	120,777,035 - 120,907,578	NCBI
Celera	4	117,795,077 - 117,929,505 (-)	NCBI		Celera
Cytogenetic Map	4	q26	NCBI
HuRef	4	116,136,584 - 116,271,133 (-)	NCBI		HuRef
CHM1_1	4	120,392,140 - 120,526,523 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	122,799,522 - 122,933,950 (-)	NCBI		T2T-CHM13v2.0

Pde5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	122,522,822 - 122,653,023 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	122,522,596 - 122,653,023 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	122,729,158 - 122,859,374 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	122,728,947 - 122,859,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	122,432,076 - 122,562,292 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	122,721,209 - 122,848,174 (+)	NCBI		MGSCv36	mm8
Celera	3	129,135,905 - 129,269,158 (+)	NCBI		Celera
Cytogenetic Map	3	G1	NCBI
cM Map	3	53.69	NCBI

Pde5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	20,785,423 - 20,904,717 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	20,785,497 - 20,904,717 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	117,271,752 - 117,406,487 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	117,568,528 - 117,702,985 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	111,682,772 - 111,817,234 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	122,832,175 - 122,966,636 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	122,832,175 - 122,966,636 (-)	Ensembl	panpan1.1		panPan2

PDE5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	38,272,573 - 38,407,517 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	38,244,338 - 38,407,522 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	3,669,951 - 3,799,959 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	38,496,474 - 38,627,836 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	38,493,466 - 38,627,842 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	38,518,841 - 38,648,697 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	38,242,041 - 38,371,891 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	1,427,303 - 1,557,236 (+)	NCBI		UU_Cfam_GSD_1.0

Pde5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	67,158,923 - 67,251,772 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936869	39,122 - 117,127 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936869	24,265 - 117,120 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	104,270,881 - 104,420,953 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	104,270,858 - 104,420,955 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	111,948,578 - 112,077,533 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	66,826,316 - 66,955,220 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	66,826,315 - 66,955,036 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	45,686,701 - 45,815,681 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pde5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624964	14,216 - 126,553 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624964	11,085 - 126,027 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pde5a
1375 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	134
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000019638
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	185876309	219753474	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	185876309	219753474	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	189599258	218414891	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
2299161	Iddm33	Insulin dependent diabetes mellitus QTL 33	2.98		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	206312063	220876787	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	206665645	219003804	Rat

Genetic Models

This gene Pde5a is modified in the following models/strains:

F344-Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	6	16	10	5	10			53	23	30	11
Low	1	36	40	30	14	30	8	11	21	12	9		8
Below cutoff		1	1	1		1					2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB017580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB017582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY155460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY155461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D89093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U76032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000019638 ⟹ ENSRNOP00000019637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,859,419 - 210,999,701 (+)	Ensembl
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101437 ⟹ ENSRNOP00000082778

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,883,601 - 210,999,701 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119258 ⟹ ENSRNOP00000095374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl

RefSeq Acc Id:

NM_133584 ⟹ NP_598268

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	213,544,026 - 213,684,298 (+)	NCBI
mRatBN7.2	2	210,859,419 - 210,999,701 (+)	NCBI
Rnor_6.0	2	226,900,619 - 227,041,576 (+)	NCBI
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	RGD
Celera	2	203,287,460 - 203,425,472 (+)	RGD

Sequence:

show sequence

GCAGACTTGAGAGTGGAGCGGAGGGACGAGAGGGTGGAGCGGAGTGCGTGGCGGGCGGGTCCCC
CGAAGCTCGAGGAGTCGCCGCGAAGCCCGCGCGCGCGCTTGCCTCCGGCGCGCCGATCTGGGCT
GAACTAACAAGCTCTGCTTTGGAGAAGGGGCTGGAGCCCCGCCACCGGCGCCTTGGGGCAACGG
CCGTCGAGCAGCTGGTGCTGGCCGCCCGAGCCGGGAGGTCGACTCTCGCCGGGCGGGGATGGTG
GACGAGCCGGCGGGGACTCGCCCGCGCGCGGCCGCCACAGGGCCCGGCGCTGCCCGCCAGGGGG
CGACGCCACGCGGGGTCCGCAGCCGGCGACCCGCAGCGAAGAGGCGGCGGGGGCCATAAGGGAG
CCGGTCGGGCACCCACGGAACTCCGCGGGCCCCCAGAGTCTCCCCAGTCCACCATCCGAGGAGT
TCGGAAACGAGCGCCCCACCTCTGCTATGTTGCCCTTTGGAGACAAAACGAGAGACATGGTCAA
TGCATGGTTTTCAGAGAGAGTTCACAACATTCCTGTGTGCAAGGAAGGCATCCGGGCCCACACC
GAGTCCTGCTCTTGCTCTCTGCCTCAAAGTCCTCATGCAGATAATACCACCCCTGGAGCACCAG
CCAGAAAAATCTCTGCCTCTGAATTTGACCGACCTCTTAGACCCATTGTTGTCAAGGATTCTGA
GGGAACCGTGAGCTTTCTCTCTGACTCAGGAAAAAAGGAACAGATGCCACTAACCTCTCCAAGA
TTTGATAGTGATGAAGGGGACCAGTGCTCAAGACTCTTGGAACTAGTAAAAGATATTTCCAGTC
ATTTGGATGTCACAGCCTTGTGTCACAAAATTTTCTTGCATATCCATGGACTTATCTCTGCTGA
TCGCTATTCCCTGTTCCTTGTCTGTGAGGACAGCTCTAAAGACAAATTTCTCGTCAGTCGCCTC
TTTGATGTTGCTGAAGGTTCAACACTGGAGGAAGCTTCAAATAACTGTATCCGTTTAGAATGGA
ACAAAGGCATTGTGGGACATGTGGCAGCTTTTGGAGAGCCCTTGAACATCAAAGATGCCTATGA
GGATCCCCGGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATCCTTTGT
ATGCCAATTAAGAACCACAGGGAAGAGGTCGTTGGTGTAGCTCAGGCCATCAACAAGAAATCAG
GAAACGGTGGGACATTCACTGAAAAAGATGAAAAGGACTTTGCTGCCTATCTGGCATTTTGTGG
CATTGTTCTTCACAACGCCCAGCTCTATGAAACGTCACTGCTGGAGAACAAAAGAAATCAGGTA
TTACTTGACCTTGCTAGCTTAATTTTCGAGGAGCAGCAGTCATTGGAAGTAATTCTGAAGAAAA
TAGCCGCCACTATTATCTCCTTCATGCAGGTGCAGAAGTGCACCATCTTCATCGTGGATGAAGA
CTGCCCTGACTCGTTCTCTCGTGTGTTTCAAATGGAGTGGGAGGAAGTAGGGAAATCCTCCGAG
CCTTTGACAAGGGAGCACGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAACA
CGATGGAGCCACTTAATATCCCAGATGTCACCAAGGACAACAGATTTCCCTGGACAAATGAAAA
CATGGGCCATATAAACACGCACTGCATCAGAAGTTTGCTTTGCACGCCTATAAAAAATGGGAAG
AAGAACAAAGTCATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAAGACTGGCAAGATTA
AGGCTTTCAACCAAAACGATGAACAATTCCTGGAGGCTTTTGTCATCTTCTGTGGCTTGGGGAT
CCAGAACACACAGATGTACGAAGCGGTGGAGAGAGCCATGGCCAAGCAGATGGTGACGTTAGAG
GTCCTGTCTTATCACGCATCAGCGGCGGAGGAAGAAACAAGGGAGCTCCAGGCTCTAGCGGCTG
CTGTGGTACCGTCTGCCCAAACCCTTAAAATTACCGACTTCAGCTTCAGTGACTTCGAGCTGTC
TGATCTGGAAACAGCGCTGTGTACAATTCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTC
CAGATGAAACACGAGGTTCTTTGCCGATGGATTTTGAGTGTCAAGAAGAATTATCGGAAGAACG
TTGCCTACCACAATTGGAGGCACGCCTTTAACACGGCACAGTGCATGTTTGCTGCTCTGAAAGC
AGGCAAGATTCAGAACAAGTTGACGGATCTGGAGACGCTTGCATTGCTGATTGCCGCTTTAAGC
CATGATTTGGACCATCGTGGTGTGAACAACTCATACATACAGCGGAGCGAGCACCCCCTGGCCC
AGCTGTACTGCCACTCCACCATGGAGCACCATCACTTCGACCAGTGCTTGATGGTTCTAAACAG
CCCAGGCAACCAGATCCTCAGTGGCCTCTCCATTGAAGAATATAAGACCACATTGAAAATAATC
AAGCAAGCAATTTTAGCCACTGACCTAGCACTGTACATTAAGAGACGAGGAGAATTTTTTGAAC
TTATAAGAAAAAATGAATTCAGTTTTGAAGATCCTCTTCAAAAGGAGTTGTTTCTGGCAATGCT
GATGACTGCCTGTGATCTCTCCGCCATTACTAAGCCCTGGCCTATTCAACAACGGATAGCAGAA
CTCGTGGCAGCCGAATTCTTTGATCAAGGAGACAGAGAGAGAAAAGAACTTAACATGGAGCCCG
CTGATCTAATGAACAGGGAGAAGAAAAATAAAATCCCAAGTATGCAAGTTGGGTTCATAGACGC
CATCTGCTTGCAGCTGTATGAGGCCCTGACCCACGTCTCAGAAGACTGTTTGCCCCTGCTGGAT
GGCTGCAGGAAGAACAGGCAGAAATGGCAAGCCCTCGCAGACCAGCAGGAGAAGACGCTCCTTA
ATGGGGAGAGCGGCCAGGCCAAGCGGGACTGACCTTCTCCCCCTCCTCCCCTCCCCCACCCCCA
CCGGGTGTTCGAACTGCCCTAGGCCTGGTTTCGCCATACACTATGCAGACTCGAGTGCACTTTG
CCACTGCTGTATTTTATTTTTGCACAACTTCTGAGAGCATGAGGTGTTTCAGAGATTGCTACCT
ACTTTCCGTGCTTTTGTTTTATGCCACTGAAGTGGAGCCGTCAGTCATGCCCACTCTAACACTT
TGATAAGAGTGGTGTAAACTGCATTCCCACACGCAGCTTGGTTATGCTTGGGGAGTATGAATAA
CCGGCCTTTGTGTTTCTGAGTCACCAGTCTTTCAAACACGTTAGGAATCGTTCTCGGAAGTGGG
TTAGGGGCGAACTGAATGTGTCCTGGGACATTTAAAGCCATCCTGAAATTAACGCTGAGTGGAT
GTTAG

hide sequence

RefSeq Acc Id:

XM_006233260 ⟹ XP_006233322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI

Sequence:

show sequence

ACTGCAGGGCAAAGGGGGAGGGTCTCGAACACTGTCCTGCTCCTCTGAGAGAGGGACCCTGCCG
GGTGGAAATCCGGCATCAGCGAGCCGCAGAAACCCGCGGCAAACACCATGGAACGAGCGGGCCC
CAGCTCCGTGCAGTCGCAGCAGCAGCGGGACCAGGACTGGGTGGAAGCGTGGCTGGATGATCAC
CGGGACTTTACCTTCTCTTACTTTGTTAGAAAGGCCACCAGAGACATGGTCAATGCATGGTTTT
CAGAGAGAGTTCACAACATTCCTGTGTGCAAGGAAGGCATCCGGGCCCACACCGAGTCCTGCTC
TTGCTCTCTGCCTCAAAGTCCTCATGCAGATAATACCACCCCTGGAGCACCAGCCAGAAAAATC
TCTGCCTCTGAATTTGACCGACCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACCGTGA
GCTTTCTCTCTGACTCAGGAAAAAAGGAACAGATGCCACTAACCTCTCCAAGATTTGATAGTGA
TGAAGGGGACCAGTGCTCAAGACTCTTGGAACTAGTAAAAGATATTTCCAGTCATTTGGATGTC
ACAGCCTTGTGTCACAAAATTTTCTTGCATATCCATGGACTTATCTCTGCTGATCGCTATTCCC
TGTTCCTTGTCTGTGAGGACAGCTCTAAAGACAAATTTCTCGTCAGTCGCCTCTTTGATGTTGC
TGAAGGTTCAACACTGGAGGAAGCTTCAAATAACTGTATCCGTTTAGAATGGAACAAAGGCATT
GTGGGACATGTGGCAGCTTTTGGAGAGCCCTTGAACATCAAAGATGCCTATGAGGATCCCCGGT
TCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATCCTTTGTATGCCAATTAA
GAACCACAGGGAAGAGGTCGTTGGTGTAGCTCAGGCCATCAACAAGAAATCAGGAAACGGTGGG
ACATTCACTGAAAAAGATGAAAAGGACTTTGCTGCCTATCTGGCATTTTGTGGCATTGTTCTTC
ACAACGCCCAGCTCTATGAAACGTCACTGCTGGAGAACAAAAGAAATCAGGTATTACTTGACCT
TGCTAGCTTAATTTTCGAGGAGCAGCAGTCATTGGAAGTAATTCTGAAGAAAATAGCCGCCACT
ATTATCTCCTTCATGCAGGTGCAGAAGTGCACCATCTTCATCGTGGATGAAGACTGCCCTGACT
CGTTCTCTCGTGTGTTTCAAATGGAGTGGGAGGAAGTAGGGAAATCCTCCGAGCCTTTGACAAG
GGAGCACGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAACACGATGGAGCCA
CTTAATATCCCAGATGTCACCAAGGACAACAGATTTCCCTGGACAAATGAAAACATGGGCCATA
TAAGCACGCACTGCATCGGAAGTTTGCTTTGCACGCCTATAAAAAATGGGAAGAAGAACAAAGT
CATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAAGACTGGCAAGATTAAGGCTTTCAAC
CAAAACGATGAACAATTCCTGGAGGCTTTTGTCATCTTCTGTGGCTTGGGGATCCAGAACACAC
AGATGTACGAAGCGGTGGAGAGAGCCATGGCCAAGCAGATGGTGACGTTAGAGGTCCTGTCTTA
TCACGCATCAGCGGCGGAGGAAGAAACAAGGGAGCTCCAGGCTCTAGCGGCTGCTGTGGTACCG
TCTGCCCAAACCCTTAAAATTACCGACTTCAGCTTCAGTGACTTCGAGCTGTCTGATCTGGAAA
CAGCGCTGTGTACAATTCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTCCAGATGAAACA
CGAGGTTCTTTGCCGATGGATTTTGAGTGTCAAGAAGAATTATCGGAAGAACGTTGCCTACCAC
AATTGGAGGCACGCCTTTAACACGGCACAGTGCATGTTTGCTGCTCTGAAAGCAGGCAAGATTC
AGAACAAGTTGACGGATCTGGAGACGCTTGCATTGCTGATTGCCGCTTTAAGCCATGATTTGGA
CCATCGTGGTGTGAACAACTCATACATACAGCGGAGCGAGCACCCCCTGGCCCAGCTGTACTGC
CACTCCACCATGGAGCACCACCACTTCGACCAGTGCTTGATGGTTCTAAACAGCCCAGGCAACC
AGATCCTCAGTGGCCTCTCCATTGAAGAATATAAGACCACATTGAAAATAATCAAGCAAGCAAT
TTTAGCCACTGACCTAGCACTGTACATTAAGAGACGAGGAGAATTTTTTGAACTTATAAGAAAA
AATGAATTCAGTTTTGAAGATCCTCTTCAAAAGGAGTTGTTTCTGGCAATGCTGATGACTGCCT
GTGATCTCTCCGCCATTACTAAGCCCTGGCCTATTCAACAACGGATAGCAGAACTCGTGGCAGC
CGAATTCTTTGATCAAGGAGACAGAGAGAGAAAAGAACTTAACATGGAGCCCGCTGATCTAATG
AACAGGGAGAAGAAAAATAAAATCCCAAGTATGCAAGTTGGGTTCATAGACGCCATCTGCTTGC
AGCTGTATGAGGCCCTGACCCACGTCTCAGAAGACTGTTTGCCCCTGCTGGATGGCTGCAGGAA
GAACAGGCAGAAATGGCAAGCCCTCGCAGACCAGCAGGAGAAGACGCTCCTTAATGGGGAGAGC
GGCCAGGCCAAGCGGGACTGACCTTCTCCCCCTCCTCCCCTCCCCCACCCCCACCGGGTGTTCG
AACTGCCCTAGGCCTGGTTTCGCCATACACTATGCAGACTCGAGTGCACTTTGCCACTGCTGTA
TTTTATTTTTGCACAACTTCTGAGAGCATGAGGTGTTTCAGAGATTGCTACCTACTTTCCGTGC
TTTTGTTTTATGCCACTGAAGTGGAGCCGTCAGTCATGCCCACTCTAACACTTTGATAAGAGTG
GTGTAAACTGCATTCCCACACGCAGCTTGGTTATGCTTGGGGAGTATGAATAACCGGCCTTTGT
GTTTCTGAGTCACCAGTCTTTCAAACACGTTAGGAATCGTTCTCGGAAGTGGGTTAGGGGCGAA
CTGAATGTGTCCTGGGACATTTAAAGCCATCCTGAAATTAACGCTGAGTGGATGTTAGGGAGAA
ATGAATGTGTTTTAACTTGTCGGAAGTGTCTCGACCAAGTTAAAGACTTGTGAAGCAAGAAAAC
GTGGTACCTAATTGCTCTGCTCTCTCTGGGATGGAGAGAACTAGCAGTGCATCCCATCTGTGGC
CGAACAAACTTAAGCGACAGCCCATCCACGCAGTCTCCCTTCAGCATGCAGAACGCCCGGGCCA
GATGATTCCTCCCCCCACTGACTGTCCTAAGAGAGAGTGCCTGTCAGACATGGGAGGGCCCTGG
ATAGCCCTCAGCCAAGAGAAATGTTTTACTTGAAGGTCTTTCTGACAATCCACTTTTTTAAACG
CTGAAAACTTTTTAAACTCTCCTTTTTGAATTTTTCTTTTACTTCTCATCTCCTTAATTCAACA
GTTTTAAGTTTCAACAGAGAAGTGGTCACAGGAGTGCCTGCCTGAAGGTAGATAGGATGGCACA
TATGTGAGTGCAAGTATGGTCTCTATTCCTTCTGTCACCTGAAATTGACAGGAAAAAATGAATA
ATTCTATGAGTAGGGGAGGTCTGTTTCCAATTGGCAGGCCAGACAATGAATTCAAAGGAGCAGT
GTGTGAAAAAGTCTTCCTGCCCAAACAAAACAACGTTTAGTACTGGGGGAATAGAAAATGGATC
GAACCAAGCGACTGCAGTGGGGGAAGAGTATCTGCTCCACGTGTGCAGGATGGTTTGGGTCTGG
GCAGAATTAGAAGGGTATGATTTCTTAATTCCCACCCTCTCCCCCAGTTCTCCCAATGAGGGTG
AAGTACTTGGTCTGGGTTTCTAGCATTAATTTGCCTTAAAATGGTTTCTTTCCCCTTTCCTCTC
TGTTTAAAACTCACCATGGTCATTTTAATCCTGTGTATGTATATTTTATTGGGGTTTTGTTCTT
CCTCGGATATGGAAGGGCAAGGCTGGTATTGCTTTGTGCTGGTCAAGGCTAGTCCAGGGAATTG
TCACCCACTGCTAAATGTATTCTTGTTGTAATACGTGTATTTTATTTTCAGAATTTTATTTTAT
TTTTATTCCATGTCGTGTAGATGAAACCTGTAAGGTTGCTGTAATGCACTGGTGTGTAAATGAT
TAGACTTTCACTAATACTAATCATATCAGCATTGAATACGCCTACGCAGAGTGTGGACGTGCTG
CCTAGAGGATGCCCACAAGCCTGGCGTTGTACCCCACACACTGAGACTGAGCAGCTCTGCTGAA
ATACCGCCATAGACATGTGTAGCTTCTCCACACTCCTCTGACTTGAGCCACTGAGAGTATTTTT
AAAGATGACAGATCATAAGTGGAGGATTTGTCTAACATAGTAATAGGCAAGAAGTCCTATGTAG
ATTGGAAATTATCTGCTTGCTTTAGGCAATGGTTTGTTTTACTCTAGACATTAACATAGGAAAA
GCAGTGTCGTGCCTGTGACATTTTTACTGCTAGGTATTTTAGTTCAGACAGAGGAGAATGCTAT
TTAATTCAAGTAATTTTTTTTATTTTATAGGAAAACCATTCCATACGTGGATTTCTATCTGTGG
TACAAGAAAACAAGTCATAGGTTTTGTTCTTAATGTGAATATTGCCTTTTCAGTATCCACTCAA
GTTGGAATATATTTATCACATTGTAATATTATAATTCCCCTCTCATGCTGCCGCGAATCGATAG
TGCCCGTTATGAACAAGATGGTGCTCTGGTCCTGGACTCTTTGTTTGACAAACTGCTTGGCCGG
CTGTAGTGAAATAATACGATATCATTTCATTTTAACTTTCAGCCAGAAAAATCCTCATGGTTTG
GTGACTTGTGTGTAAAGTGTCCTGATCTTACACGTTTAGAAGAGTCGCCTTTGCCAGTCAGGAT
GCTTAACCTCTGGACCTAAGGAAGGTGTGCAGCAGTTCGGAAAGAGCTTGTGTTTGAGGGGAAT
GTCCCAGGAAGCAGCTCTTAAGCCTTCCTTATGGCCTTTGAGACCCCGTCGGAAAACGGGGTAT
TGAGGCAGAGTGACCCCAAGTACTTTTGATTCACTCCACACAGACCTGGCTCAGAGCACAGACG
CAGGATGACACTCTCACTGGTTGGCTAATGATGACAGAGCTTCTTTTAGGGACAGCATGGAGAT
GAGGGAGTATGTGAAAATGTACTGGAGATAATGGTTTCTTGGAGGAACTTGAGTCCCCGAGACT
CTTGCCTACCTGTTAAGTGCCTTTACTCTCAGAACGTTGCCGAAGTGTGAGGCTTGGCACCTGT
TACATTTCCAAACTTCCCGAGTTTCTCGCTAGGTTACACTCCTAAACCTTATCGGTGAGCGGCA
TGGCCTTTTCTTTAACTTGATTTAAGGTGAGAAGAGACGAAATGTTCCCCGCTCTCCTGGAAAC
AGCTGTCTCAAATAAGGTGGCAGAATTTAATTACTCAGCATCCACCGTGCTTCAGCCCCTTTTT
ATTAGATCCTCTCCTTACGTTAGGTACAGTGCTCAGATGCTGAAACAGCAGGGAGTCCGGGGAG
CTCATGGGCCACACAGGAAATGACTAAGAGTGCCATTCCTCGACCTGCCAACCTAACATGCAAG
GGCACAAGGCTTTGTATCGCTGTCCTCTTCGTCTGTAACACACGCTGTGCACTTTTATCCAAAA
CCTCTTAAGAAGCTGTCAGTGAACATTCTGTCTTCCTGTTGGCATGGATCATTTACCTTGCTGA
TAGCTTTAAGAACACCTTACATAAGGAGTCCCATCTTCCGTGACATAGGTCATGCAACCAGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGATCAGAGTTCTCGGACCATTCAACTGCAGATTTGG
ACTTTCTGCCCTCTCACAGAGAGCAAATAAGGAAGTATTAAAGCTTACCTCACCTCTCCACGTT
GTTATCAAAAGCCTGTGTAGACATGTCTTGAATGTCATTGAAAGTGATGTAAATAGCTGAAAAA
TAGAAATTTCTATTACAGTTTAAGAACTCTAATGAACAGTCACTCGCCACTGTTGACGATCTAT
TTGTATTCTTATGCCTTTTCAATATATCTGAACAAATATATAGTTTCTGCCACTATTTTTATAC
TAGCATCAAAGAGTTACTATGTAAATTATGTTTTGCTGTGAAGTCATCCAAAAACGACTGAAAT
GTTGGTTTCTTTCCTTTCCTCACCCCACATGATAAACCATTTCCAGTGATCCTTCTTCGAGGGT
GTCATTCTCCAGAAGCACACACCCACCTGGCCCCGGGTCCCTGTGGAGTCAGACCTGGTCAGGG
AAGGGGAGAACTCACCACTTTGCTGGTTCTCATTTTGCAGTGCTGTAAAAATAAAGGGAATGAA
CGAGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_598268	(Get FASTA)	NCBI Sequence Viewer
	XP_006233322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD09578	(Get FASTA)	NCBI Sequence Viewer
	AAN87278	(Get FASTA)	NCBI Sequence Viewer
	AAN87279	(Get FASTA)	NCBI Sequence Viewer
	BAA23672	(Get FASTA)	NCBI Sequence Viewer
	BAA84641	(Get FASTA)	NCBI Sequence Viewer
	BAA84659	(Get FASTA)	NCBI Sequence Viewer
	BAA84660	(Get FASTA)	NCBI Sequence Viewer
	EDL82105	(Get FASTA)	NCBI Sequence Viewer
	EDL82106	(Get FASTA)	NCBI Sequence Viewer
	EDL82107	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019637
	ENSRNOP00000019637.4
	ENSRNOP00000082778.1
	ENSRNOP00000095374
	ENSRNOP00000095374.1
GenBank Protein	O54735	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598268 ⟸ NM_133584

- UniProtKB:

O54735 (UniProtKB/Swiss-Prot), A6HVH1 (UniProtKB/TrEMBL), G3V7V8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEF
DRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCH
KIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVA
AFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEK
DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFM
QVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPD
VTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTL
KITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHA
FNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTME
HHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSF
EDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKK
NKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKR
D

hide sequence

RefSeq Acc Id:	XP_006233322 ⟸ XM_006233260
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLL2 (UniProtKB/TrEMBL), A6HVG9 (UniProtKB/TrEMBL), A6HVH0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERAGPSSVQSQQQRDQDWVEAWLDDHRDFTFSYFVRKATRDMVNAWFSERVHNIPVCKEGIRA HTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTS PRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVS RLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSI LCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRN QVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKS SEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHISTHCIGSLLCTPIKN GKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAA LSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLK IIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRI AELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPL LDGCRKNRQKWQALADQQEKTLLNGESGQAKRD hide sequence

RefSeq Acc Id:

ENSRNOP00000019637 ⟸ ENSRNOT00000019638

RefSeq Acc Id:

ENSRNOP00000082778 ⟸ ENSRNOT00000101437

RefSeq Acc Id:

ENSRNOP00000095374 ⟸ ENSRNOT00000119258

Protein Domains

GAF PDEase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54735-F1-model_v2	AlphaFold	O54735	1-833	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691727

Promoter ID:

EPDNEW_R2252

Type:

single initiation site

Name:

Pde5a_1

Description:

phosphodiesterase 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	226,900,606 - 226,900,666	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620995	AgrOrtholog
BioCyc Gene	G2FUF-51351	BioCyc
Ensembl Genes	ENSRNOG00000014443	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019638	ENTREZGENE
	ENSRNOT00000019638.5	UniProtKB/TrEMBL
	ENSRNOT00000101437.1	UniProtKB/TrEMBL
	ENSRNOT00000119258.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1300.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.450.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GAF-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HD/PDEase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_catalytic_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_catalytic_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171115	UniProtKB/Swiss-Prot
NCBI Gene	171115	ENTREZGENE
PANTHER	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A	UniProtKB/TrEMBL
	PHOSPHODIESTERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEase_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pde5a	PhenoGen
PRINTS	PDIESTERASE1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PDEASE_I_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDEASE_I_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014443	RatGTEx
SMART	GAF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HDc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	GAF domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HD-domain/PDEase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZVK4_RAT	UniProtKB/TrEMBL
	A0A8I6GLL2	ENTREZGENE, UniProtKB/TrEMBL
	A6HVG9	ENTREZGENE, UniProtKB/TrEMBL
	A6HVH0	ENTREZGENE, UniProtKB/TrEMBL
	A6HVH1	ENTREZGENE, UniProtKB/TrEMBL
	G3V7V8	ENTREZGENE, UniProtKB/TrEMBL
	O54735	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6YF34_RAT	UniProtKB/TrEMBL
	Q6YF35_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Pde5a	phosphodiesterase 5A, cGMP-specific			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Pde5a	phosphodiesterase 5A, cGMP-specific			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)