Prkcq (protein kinase C, theta) - Rat Genome Database

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Gene: Prkcq (protein kinase C, theta) Rattus norvegicus
Analyze
Symbol: Prkcq
Name: protein kinase C, theta
RGD ID: 620968
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein transport; and response to insulin. Located in neuromuscular junction and sarcolemma. Biomarker of hyperinsulinism and prostate adenocarcinoma. Orthologous to human PRKCQ (protein kinase C theta); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nPKC-theta; Pkcq; protein kinase C theta type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81772,156,215 - 72,288,508 (-)NCBIGRCr8
mRatBN7.21767,246,394 - 67,379,049 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1767,246,394 - 67,378,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,722,219 - 70,854,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,551,031 - 74,683,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,594,018 - 68,726,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,971,915 - 71,105,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,971,915 - 71,105,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,669,688 - 72,800,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,486,998 - 78,566,741 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,497,951 - 78,520,090 (-)NCBI
Celera1766,745,895 - 66,876,546 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pomalidomide  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rottlerin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
cell chemotaxis  (IEA,ISO)
inflammatory response  (IEA)
intracellular signal transduction  (IBA,IDA,IEA,ISO)
membrane protein ectodomain proteolysis  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of T cell apoptotic process  (IEA,ISO,ISS)
neuron differentiation  (IEP)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
positive regulation of filopodium assembly  (IMP)
positive regulation of interleukin-17 production  (IEA,ISO,ISS)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-4 production  (IEA,ISO,ISS)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein secretion  (IDA)
positive regulation of stress fiber assembly  (IMP)
positive regulation of T cell activation  (ISO,ISS)
positive regulation of T-helper 17 type immune response  (IEA,ISO,ISS)
positive regulation of T-helper 2 cell activation  (IEA,ISO,ISS)
positive regulation of telomere capping  (IEA,ISO)
positive regulation of telomere maintenance via telomerase  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of G2/M transition of mitotic cell cycle  (IMP)
regulation of platelet aggregation  (IEA,ISO,ISS)
regulation of vasoconstriction  (IEP)
respiratory burst  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to organic cyclic compound  (IEP)
T cell activation  (ISO)
tissue regeneration  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle. Avignon A, etal., Biochem J. 1995 May 15;308 ( Pt 1):181-7.
2. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Avignon A, etal., Diabetes. 1996 Oct;45(10):1396-404.
3. Heat shock pretreatment influences the expression of PKC isoforms during sepsis. Chen HW, etal., J Surg Res. 2001 Dec;101(2):202-9.
4. Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C. Dartt DA, etal., Exp Eye Res. 2000 Dec;71(6):619-28.
5. Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells. Dennehy KM, etal., Int Immunol 2003 May;15(5):655-63.
6. Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle. Facchinetti MM and de Boland AR, Cell Signal. 1999 Jan;11(1):39-44.
7. Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation. Fleegal MA, etal., Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2012-9. Epub 2005 Jul 1.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture. Giordano G, etal., J Neurochem. 2005 Jan;92(1):143-57.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction. Hilgenberg L and Miles K, J Cell Sci. 1995 Jan;108 ( Pt 1):51-61.
12. Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle. Houdali B, etal., Diabetologia. 2002 Mar;45(3):356-68.
13. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Itani SI, etal., Diabetes. 2000 Aug;49(8):1353-8.
14. Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Lin Y, etal., Am J Physiol Endocrinol Metab. 2001 Jul;281(1):E8-E15.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Differential changes in protein kinase C associated with regeneration of rat extensor digitorum longus and soleus muscles. Moraczewski J, etal., Int J Biochem Cell Biol. 2002 Aug;34(8):938-49.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Differential expression of protein kinase C isozyme messenger RNAs in dunning R-3327 rat prostatic tumors. Powell CT, etal., Cell Growth Differ. 1994 Feb;5(2):143-9.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. p32 (gC1qBP) is a general protein kinase C (PKC)-binding protein; interaction and cellular localization of P32-PKC complexes in ray hepatocytes. Robles-Flores M, etal., J Biol Chem. 2002 Feb 15;277(7):5247-55. Epub 2001 Nov 6.
26. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Schmitz-Peiffer C, etal., Diabetes. 1997 Feb;46(2):169-78.
27. Neuronal differentiation of PC12 cells involves changes in protein kinase C-theta distribution and molecular properties. Sparatore B, etal., Biochem Biophys Res Commun. 2000 Aug 18;275(1):149-53.
28. Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells. Tang S, etal., J Biol Chem. 1997 Nov 7;272(45):28704-11.
29. Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca2+ and protein kinase C activity. Wang JP, etal., Free Radic Biol Med. 1999 Mar;26(5-6):580-8.
30. Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction. Wang YX, etal., Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H348-59. Epub 2006 Sep 1.
31. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:9857183   PMID:11220785   PMID:11342610   PMID:11728336   PMID:12618484   PMID:12782715   PMID:12867038   PMID:15057822   PMID:15117976   PMID:15128768   PMID:15263025   PMID:15364919  
PMID:16356855   PMID:16356856   PMID:16419034   PMID:16493044   PMID:16709830   PMID:17112897   PMID:18248621   PMID:18992015   PMID:19433059   PMID:19929130   PMID:20691763   PMID:21531765  
PMID:21683791   PMID:22881371   PMID:23295188   PMID:23712979   PMID:23793062   PMID:24008408   PMID:26019328   PMID:34418453  


Genomics

Comparative Map Data
Prkcq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81772,156,215 - 72,288,508 (-)NCBIGRCr8
mRatBN7.21767,246,394 - 67,379,049 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1767,246,394 - 67,378,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,722,219 - 70,854,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,551,031 - 74,683,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,594,018 - 68,726,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,971,915 - 71,105,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,971,915 - 71,105,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,669,688 - 72,800,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,486,998 - 78,566,741 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,497,951 - 78,520,090 (-)NCBI
Celera1766,745,895 - 66,876,546 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
PRKCQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,394,097 - 6,580,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl106,427,143 - 6,580,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37106,436,059 - 6,622,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,509,111 - 6,662,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34106,509,110 - 6,662,244NCBI
Celera106,391,714 - 6,479,754 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef106,388,053 - 6,541,112 (-)NCBIHuRef
CHM1_1106,468,923 - 6,622,208 (-)NCBICHM1_1
T2T-CHM13v2.0106,394,273 - 6,580,768 (-)NCBIT2T-CHM13v2.0
Prkcq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,176,922 - 11,306,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,176,919 - 11,306,033 (+)EnsemblGRCm39 Ensembl
GRCm38211,171,905 - 11,301,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,172,108 - 11,301,222 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,094,009 - 11,222,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36211,090,235 - 11,219,079 (+)NCBIMGSCv36mm8
Celera211,093,754 - 11,222,740 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.42NCBI
Prkcq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542123,070,955 - 23,175,699 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542123,072,607 - 23,151,591 (-)NCBIChiLan1.0ChiLan1.0
PRKCQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,971,178 - 19,127,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,976,501 - 19,132,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0106,458,138 - 6,610,781 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1106,440,316 - 6,528,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl106,440,316 - 6,593,900 (-)Ensemblpanpan1.1panPan2
PRKCQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,319,123 - 29,505,338 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,318,870 - 29,505,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,357,031 - 26,536,629 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0229,699,579 - 29,881,298 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl229,699,661 - 29,881,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1226,803,522 - 26,983,171 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0227,646,081 - 27,819,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,365,332 - 28,538,905 (+)NCBIUU_Cfam_GSD_1.0
Prkcq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934431,883,098 - 32,000,850 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,048,132 - 8,167,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364848,048,239 - 8,166,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,458,180 - 64,600,339 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,442,588 - 64,596,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21070,558,968 - 70,659,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,532,438 - 6,675,708 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,532,319 - 6,621,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605111,850,149 - 11,993,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247751,419,509 - 1,502,064 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247751,419,596 - 1,543,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkcq
1130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000025901
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat

Markers in Region
D17Got86  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01772,693,842 - 72,694,003NCBIRnor5.0
Rnor_5.01772,693,842 - 72,694,005NCBIRnor5.0
RGSC_v3.41778,512,934 - 78,513,200RGDRGSC3.4
RGSC_v3.41778,512,935 - 78,513,202UniSTSRGSC3.4
RGSC_v3.11778,523,767 - 78,524,035RGD
Celera1766,769,592 - 66,769,859UniSTS
Cytogenetic Map17q12.3UniSTS
RH134411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21767,246,579 - 67,246,799 (+)MAPPERmRatBN7.2
Rnor_6.01770,972,101 - 70,972,320NCBIRnor6.0
Rnor_5.01772,669,874 - 72,670,093UniSTSRnor5.0
RGSC_v3.41778,486,122 - 78,486,341UniSTSRGSC3.4
Celera1766,746,081 - 66,746,300UniSTS
RH 3.4 Map17635.8UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 6 19 6 8 11 15 17 7 2 8
Low 1 35 28 20 20 59 18 34 9
Below cutoff 8 15 15 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025901   ⟹   ENSRNOP00000025902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1767,246,394 - 67,378,704 (-)Ensembl
Rnor_6.0 Ensembl1770,971,915 - 71,105,286 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114215   ⟹   ENSRNOP00000083951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1767,246,394 - 67,302,230 (-)Ensembl
RefSeq Acc Id: NM_001276721   ⟹   NP_001263650
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81772,156,215 - 72,288,508 (-)NCBI
mRatBN7.21767,246,394 - 67,378,704 (-)NCBI
Rnor_6.01770,971,915 - 71,105,286 (-)NCBI
Rnor_5.01772,669,688 - 72,800,895 (-)NCBI
Celera1766,745,895 - 66,876,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096127   ⟹   XP_038952055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81772,156,219 - 72,212,090 (-)NCBI
mRatBN7.21767,246,395 - 67,302,583 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001263650 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA78371 (Get FASTA)   NCBI Sequence Viewer  
  EDL78611 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025902
  ENSRNOP00000025902.4
  ENSRNOP00000083951
  ENSRNOP00000083951.1
GenBank Protein Q9WTQ0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001263650   ⟸   NM_001276721
- UniProtKB: Q9WTQ0 (UniProtKB/Swiss-Prot),   F1LM10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025902   ⟸   ENSRNOT00000025901
RefSeq Acc Id: XP_038952055   ⟸   XM_039096127
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083951   ⟸   ENSRNOT00000114215
Protein Domains
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ0-F1-model_v2 AlphaFold Q9WTQ0 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620968 AgrOrtholog
BioCyc Gene G2FUF-8789 BioCyc
Ensembl Genes ENSRNOG00000019057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025901 ENTREZGENE
  ENSRNOT00000025901.7 UniProtKB/TrEMBL
  ENSRNOT00000114215.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  nPKC_theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC_theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85420 UniProtKB/TrEMBL
NCBI Gene 85420 ENTREZGENE
PANTHER PROTEIN KINASE C THETA TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PRKCQ RGD
PhenoGen Prkcq PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kin_C_theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019057 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A0B5 ENTREZGENE, UniProtKB/TrEMBL
  A6JLT4_RAT UniProtKB/TrEMBL
  F1LM10 ENTREZGENE, UniProtKB/TrEMBL
  KPCT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-21 Prkcq    PRKCQ  protein kinase C, theta  Symbol updated 1299863 APPROVED
2004-09-10 PRKCQ  protein kinase C, theta  Pkcq    Symbol updated 1299863 APPROVED
2002-08-07 Pkcq  protein kinase C, theta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by CD28 stimulation 724661