Slc27a1 (solute carrier family 27 member 1) - Rat Genome Database

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Gene: Slc27a1 (solute carrier family 27 member 1) Rattus norvegicus
Analyze
Symbol: Slc27a1
Name: solute carrier family 27 member 1
RGD ID: 620927
Description: Predicted to enable several functions, including fatty acid ligase activity; monocarboxylic acid transmembrane transporter activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including glycerophospholipid biosynthetic process; monocarboxylic acid transport; and regulation of lipid biosynthetic process. Predicted to act upstream of or within several processes, including adiponectin-activated signaling pathway; carboxylic acid transport; and response to insulin. Located in caveola. Colocalizes with mitochondrial inner membrane. Biomarker of familial hyperlipidemia; glucose intolerance; hyperinsulinism; myocardial infarction; and obesity. Orthologous to human SLC27A1 (solute carrier family 27 member 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2-Ethylhexanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arachidonate--CoA ligase; FATP; FATP-1; fatty acid transport protein; fatty acid transport protein 1; long-chain fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 1; solute carrier family 27, member 1; very long-chain acyl-CoA synthetase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,311,859 - 18,337,024 (+)NCBIGRCr8
mRatBN7.21618,278,984 - 18,300,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,329,890 - 18,346,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,461,772 - 19,478,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,382,827 - 18,399,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,997,823 - 20,016,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,859,540 - 19,880,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,769,909 - 18,786,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,769,906 - 18,786,985 (+)NCBI
Celera1618,482,929 - 18,499,970 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Ethylhexanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Iodothyronamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
9-cis-retinoic acid  (EXP,ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
rebaudioside A  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium dodecyl sulfate  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sulfluramid  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. Chabowski A, etal., FEBS Lett. 2005 Apr 25;579(11):2428-32.
2. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats. Deng JY, etal., Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H978-87. Epub 2007 Mar 30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Heather LC, etal., Cardiovasc Res. 2006 Dec 1;72(3):430-7. Epub 2006 Sep 1.
5. Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. Marotta M, etal., Metabolism. 2004 Aug;53(8):1032-6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions. Ortegren U, etal., FEBS J. 2006 Jul;273(14):3381-92. Epub 2006 Jun 26.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Molecular cloning of fatty acid-transport protein cDNA from rat. Schaap FG, etal., Biochim Biophys Acta 1997 Oct 9;1354(1):29-34.
14. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. Sebastian D, etal., J Lipid Res. 2009 May 9.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Wu Q, etal., Mol Cell Biol. 2006 May;26(9):3455-67.
Additional References at PubMed
PMID:7954810   PMID:9671728   PMID:10593920   PMID:12235169   PMID:12533547   PMID:12566451   PMID:14991074   PMID:15496455   PMID:17130465   PMID:18258213   PMID:19523918   PMID:19560442  
PMID:19946888   PMID:20667975   PMID:21395585   PMID:21442160   PMID:28035674   PMID:28178239   PMID:30053369   PMID:31091338  


Genomics

Comparative Map Data
Slc27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,311,859 - 18,337,024 (+)NCBIGRCr8
mRatBN7.21618,278,984 - 18,300,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,329,890 - 18,346,962 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,461,772 - 19,478,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,382,827 - 18,399,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,997,823 - 20,016,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,859,540 - 19,880,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,769,909 - 18,786,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,769,906 - 18,786,985 (+)NCBI
Celera1618,482,929 - 18,499,970 (+)NCBICelera
Cytogenetic Map16p14NCBI
SLC27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,468,767 - 17,506,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,468,769 - 17,506,168 (+)EnsemblGRCh38hg38GRCh38
GRCh371917,581,333 - 17,616,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,442,300 - 17,477,977 (+)NCBINCBI36Build 36hg18NCBI36
Celera1917,482,907 - 17,518,593 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,146,725 - 17,182,058 (+)NCBIHuRef
CHM1_11917,580,668 - 17,616,359 (+)NCBICHM1_1
T2T-CHM13v2.01917,602,871 - 17,640,805 (+)NCBIT2T-CHM13v2.0
Slc27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,021,372 - 72,039,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,021,526 - 72,039,946 (+)EnsemblGRCm39 Ensembl
GRCm38871,568,728 - 71,587,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,568,882 - 71,587,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,092,826 - 74,110,607 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,497,916 - 74,515,697 (+)NCBIMGSCv36mm8
Celera874,083,284 - 74,101,015 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Slc27a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524805,014 - 821,838 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955524803,793 - 821,920 (-)NCBIChiLan1.0ChiLan1.0
SLC27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,340,328 - 22,376,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,345,812 - 21,383,151 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,956,000 - 16,993,429 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,929,785 - 17,966,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,929,785 - 17,966,171 (+)Ensemblpanpan1.1panPan2
SLC27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,309,094 - 45,341,101 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,310,088 - 45,340,230 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,223,163 - 45,255,236 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,796,156 - 45,828,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,796,156 - 45,829,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,032,656 - 45,064,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,442,740 - 45,474,725 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,718,788 - 45,750,750 (-)NCBIUU_Cfam_GSD_1.0
Slc27a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,877,674 - 203,901,327 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,427,874 - 3,449,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,426,807 - 3,451,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,203,388 - 60,235,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,203,374 - 60,235,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,752,658 - 59,771,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,967,126 - 15,995,039 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,430,291 - 3,458,931 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc27a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908531,308 - 549,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908531,313 - 549,570 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc27a1
194 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:119
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000024659
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH127318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,288,679 - 18,288,883 (+)MAPPERmRatBN7.2
Rnor_6.01620,008,807 - 20,009,010NCBIRnor6.0
Rnor_5.01619,869,235 - 19,869,438UniSTSRnor5.0
RGSC_v3.41618,779,604 - 18,779,807UniSTSRGSC3.4
Celera1618,492,586 - 18,492,789UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 16 5 6 5 64 26 40 8
Low 1 17 41 36 13 36 8 11 10 9 1 3 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024659   ⟹   ENSRNOP00000024659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)Ensembl
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095535   ⟹   ENSRNOP00000077487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,280,289 - 18,296,063 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101879   ⟹   ENSRNOP00000083160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,279,789 - 18,296,042 (+)Ensembl
RefSeq Acc Id: NM_053580   ⟹   NP_446032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,312,967 - 18,330,046 (+)NCBI
mRatBN7.21618,278,984 - 18,296,064 (+)NCBI
Rnor_6.01619,999,112 - 20,016,191 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
RGSC_v3.41618,769,909 - 18,786,988 (+)RGD
Celera1618,482,929 - 18,499,970 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252953   ⟹   XP_006253015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,182 - 18,330,046 (+)NCBI
mRatBN7.21618,280,507 - 18,296,064 (+)NCBI
Rnor_6.01620,000,567 - 20,016,193 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252954   ⟹   XP_006253016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,313,897 - 18,330,046 (+)NCBI
mRatBN7.21618,279,786 - 18,296,064 (+)NCBI
Rnor_6.01619,999,914 - 20,016,191 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771156   ⟹   XP_008769378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,337,024 (+)NCBI
mRatBN7.21618,280,393 - 18,300,173 (+)NCBI
Rnor_6.01620,000,414 - 20,016,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094877   ⟹   XP_038950805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,330,681 (+)NCBI
mRatBN7.21618,280,393 - 18,296,705 (+)NCBI
RefSeq Acc Id: XM_063275793   ⟹   XP_063131863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,246 - 18,330,046 (+)NCBI
RefSeq Acc Id: XM_063275794   ⟹   XP_063131864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,330,681 (+)NCBI
RefSeq Acc Id: XM_063275795   ⟹   XP_063131865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,313,630 - 18,330,046 (+)NCBI
RefSeq Acc Id: XM_063275796   ⟹   XP_063131866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,311,859 - 18,330,046 (+)NCBI
RefSeq Acc Id: XR_010058325
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,337,024 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446032   ⟸   NM_053580
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   Q6GMM8 (UniProtKB/TrEMBL),   F7EPC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253016   ⟸   XM_006252954
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006253015   ⟸   XM_006252953
- Peptide Label: isoform X2
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   A0A8I5YCE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769378   ⟸   XM_008771156
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000024659   ⟸   ENSRNOT00000024659
RefSeq Acc Id: XP_038950805   ⟸   XM_039094877
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000083160   ⟸   ENSRNOT00000101879
RefSeq Acc Id: ENSRNOP00000077487   ⟸   ENSRNOT00000095535
RefSeq Acc Id: XP_063131866   ⟸   XM_063275796
- Peptide Label: isoform X3
- UniProtKB: F7EPC1 (UniProtKB/TrEMBL),   Q6GMM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131865   ⟸   XM_063275795
- Peptide Label: isoform X3
- UniProtKB: F7EPC1 (UniProtKB/TrEMBL),   Q6GMM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131863   ⟸   XM_063275793
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131864   ⟸   XM_063275794
- Peptide Label: isoform X1
Protein Domains
AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97849-F1-model_v2 AlphaFold P97849 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700008
Promoter ID:EPDNEW_R10530
Type:single initiation site
Name:Slc27a1_1
Description:solute carrier family 27 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,999,142 - 19,999,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620927 AgrOrtholog
BioCyc Gene G2FUF-11838 BioCyc
Ensembl Genes ENSRNOG00000018170 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024659 ENTREZGENE
  ENSRNOT00000024659.5 UniProtKB/TrEMBL
  ENSRNOT00000095535.1 UniProtKB/TrEMBL
  ENSRNOT00000101879.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104661 IMAGE-MGC_LOAD
InterPro AMP-bd_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94172 UniProtKB/TrEMBL
MGC_CLONE MGC:91570 IMAGE-MGC_LOAD
NCBI Gene 94172 ENTREZGENE
PANTHER LONG-CHAIN FATTY ACID TRANSPORT PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43107:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-binding_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc27a1 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018170 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YCE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8J5_RAT UniProtKB/TrEMBL
  A6K9W3_RAT UniProtKB/TrEMBL
  A6K9W4_RAT UniProtKB/TrEMBL
  F7EPC1 ENTREZGENE, UniProtKB/TrEMBL
  P97849 ENTREZGENE
  Q6GMM8 ENTREZGENE, UniProtKB/TrEMBL
  S27A1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc27a1  solute carrier family 27 member 1  Slc27a1  solute carrier family 27 (fatty acid transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc27a1  solute carrier family 27 (fatty acid transporter), member 1    fatty acid transport protein  Name updated 1299863 APPROVED
2002-08-07 Slc27a1  fatty acid transport protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in myocardial fatty acid utilization 730038