Ppp2r1a (protein phosphatase 2 scaffold subunit A alpha) - Rat Genome Database

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Gene: Ppp2r1a (protein phosphatase 2 scaffold subunit A alpha) Rattus norvegicus
Analyze
Symbol: Ppp2r1a
Name: protein phosphatase 2 scaffold subunit A alpha
RGD ID: 620907
Description: Predicted to enable several functions, including protein antigen binding activity; protein heterodimerization activity; and protein phosphatase regulator activity. Predicted to be involved in T cell homeostasis; chromosome segregation; and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within several processes, including meiotic sister chromatid cohesion, centromeric; nuclear division; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including chromosome, centromeric region; lateral plasma membrane; and neuronal cell body. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; Chagas disease pathway; INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha isoform of regulatory subunit A, protein phosphatase 2; MGC95083; PR65; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; protein phosphatase 2, regulatory subunit A, alpha; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,213,198 - 69,232,441 (+)NCBIGRCr8
mRatBN7.2160,540,223 - 60,559,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,540,194 - 60,560,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,329,720 - 65,348,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0174,024,287 - 74,043,556 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,239,755 - 67,258,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0160,717,386 - 60,736,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl160,717,386 - 60,736,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,883,998 - 61,903,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4158,442,220 - 58,461,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1158,458,861 - 58,463,770 (+)NCBI
Celera156,683,597 - 56,702,854 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
atrazine  (ISO)
benzene  (EXP,ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
decabromodiphenyl ether  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
hypochlorous acid  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
methidathion  (ISO)
miconazole  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pyrazinecarboxamide  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of PP2A B regulatory subunit beta isotype in rat testis. Hatano Y, etal., FEBS Lett 1993 Jun 7;324(1):71-5.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
Additional References at PubMed
PMID:9847399   PMID:12477932   PMID:12885400   PMID:12944463   PMID:16452087   PMID:16580887   PMID:16717086   PMID:17055435   PMID:17174897   PMID:22871113   PMID:23533145   PMID:24413018  
PMID:24465463   PMID:24899574   PMID:30611118  


Genomics

Comparative Map Data
Ppp2r1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,213,198 - 69,232,441 (+)NCBIGRCr8
mRatBN7.2160,540,223 - 60,559,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,540,194 - 60,560,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,329,720 - 65,348,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0174,024,287 - 74,043,556 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,239,755 - 67,258,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0160,717,386 - 60,736,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl160,717,386 - 60,736,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,883,998 - 61,903,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4158,442,220 - 58,461,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1158,458,861 - 58,463,770 (+)NCBI
Celera156,683,597 - 56,702,854 (+)NCBICelera
Cytogenetic Map1q12NCBI
PPP2R1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381952,190,052 - 52,229,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1952,170,936 - 52,229,518 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,693,305 - 52,732,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361957,385,046 - 57,421,483 (+)NCBINCBI36Build 36hg18NCBI36
Build 341957,385,045 - 57,421,482NCBI
Celera1949,742,609 - 49,779,232 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1949,023,481 - 49,060,103 (+)NCBIHuRef
CHM1_11952,694,941 - 52,731,564 (+)NCBICHM1_1
T2T-CHM13v2.01955,277,246 - 55,316,713 (+)NCBIT2T-CHM13v2.0
Ppp2r1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391721,165,716 - 21,186,167 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1721,165,573 - 21,186,178 (+)EnsemblGRCm39 Ensembl
GRCm381720,945,454 - 20,965,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1720,945,311 - 20,965,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv371721,082,418 - 21,102,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361720,650,151 - 20,670,602 (+)NCBIMGSCv36mm8
Celera1721,977,995 - 21,998,451 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1711.4NCBI
Ppp2r1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955558381,794 - 410,485 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955558381,794 - 410,485 (+)NCBIChiLan1.0ChiLan1.0
PPP2R1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22058,232,259 - 58,268,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11960,156,718 - 60,193,105 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01949,133,295 - 49,169,447 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11958,011,383 - 58,047,577 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1958,011,383 - 58,047,577 (+)Ensemblpanpan1.1panPan2
PPP2R1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11104,974,059 - 105,013,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1104,974,072 - 105,013,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1104,546,959 - 104,586,647 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01105,482,896 - 105,522,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1105,481,754 - 105,522,572 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,155,353 - 105,195,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01104,809,802 - 104,849,707 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01105,597,164 - 105,636,892 (-)NCBIUU_Cfam_GSD_1.0
Ppp2r1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093493,866,510 - 3,896,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936901622,888 - 653,044 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936901622,893 - 653,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl657,921,329 - 57,964,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1657,929,520 - 57,964,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2652,233,180 - 52,268,640 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,990,402 - 45,026,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,990,367 - 45,026,227 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607325,047,701 - 25,083,506 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,979,320 - 3,011,715 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,979,270 - 3,009,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp2r1a
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:61
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000015019
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat

Markers in Region
BF390652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2160,548,767 - 60,549,625 (+)MAPPERmRatBN7.2
Rnor_6.0160,725,930 - 60,726,787NCBIRnor6.0
Rnor_5.0161,892,542 - 61,893,399UniSTSRnor5.0
RGSC_v3.4158,450,763 - 58,451,620UniSTSRGSC3.4
Celera156,692,156 - 56,693,013UniSTS
RH 3.4 Map15328.88UniSTS
Cytogenetic Map1q12UniSTS
Ppp2r1b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,259,139 - 84,259,515 (+)MAPPERmRatBN7.2
Rnor_6.0792,488,389 - 92,488,764NCBIRnor6.0
Rnor_5.0793,130,340 - 93,130,715UniSTSRnor5.0
RGSC_v3.4789,259,069 - 89,259,444UniSTSRGSC3.4
Celera781,099,995 - 81,100,370UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015019   ⟹   ENSRNOP00000015019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl160,540,194 - 60,560,129 (+)Ensembl
Rnor_6.0 Ensembl160,717,386 - 60,736,609 (+)Ensembl
RefSeq Acc Id: NM_057140   ⟹   NP_476481
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,213,198 - 69,232,441 (+)NCBI
mRatBN7.2160,540,223 - 60,559,467 (+)NCBI
Rnor_6.0160,717,386 - 60,736,629 (+)NCBI
Rnor_5.0161,883,998 - 61,903,241 (+)NCBI
RGSC_v3.4158,442,220 - 58,461,462 (+)RGD
Celera156,683,597 - 56,702,854 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476481 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83859 (Get FASTA)   NCBI Sequence Viewer  
  BAA21903 (Get FASTA)   NCBI Sequence Viewer  
  EDL99781 (Get FASTA)   NCBI Sequence Viewer  
  EDL99782 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015019
  ENSRNOP00000015019.4
Reference Protein Sequences
RefSeq Acc Id: NP_476481   ⟸   NM_057140
- UniProtKB: Q5XI34 (UniProtKB/TrEMBL),   F7EWM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015019   ⟸   ENSRNOT00000015019

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI34-F1-model_v2 AlphaFold Q5XI34 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689651
Promoter ID:EPDNEW_R176
Type:initiation region
Name:Ppp2r1a_1
Description:protein phosphatase 2 scaffold subunit A alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0160,717,308 - 60,717,368EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620907 AgrOrtholog
BioCyc Gene G2FUF-61200 BioCyc
Ensembl Genes ENSRNOG00000011282 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015019 ENTREZGENE
  ENSRNOT00000015019.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126254 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/TrEMBL
KEGG Report rno:117281 UniProtKB/TrEMBL
MGC_CLONE MGC:95083 IMAGE-MGC_LOAD
NCBI Gene 117281 ENTREZGENE
PANTHER PTHR10648:SF2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  HEAT_2 UniProtKB/TrEMBL
PhenoGen Ppp2r1a PhenoGen
PROSITE HEAT_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011282 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A6KB84_RAT UniProtKB/TrEMBL
  F7EWM3 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI34 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Ppp2r1a  protein phosphatase 2 scaffold subunit A alpha  Ppp2r1a  protein phosphatase 2, regulatory subunit A, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ppp2r1a  protein phosphatase 2, regulatory subunit A, alpha  Ppp2r1a  protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ppp2r1a  protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform  Ppp2r1a  protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppp2r1a  protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ppp2r1a  protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform      Symbol and Name status set to provisional 70820 PROVISIONAL