Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2) - Rat Genome Database

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Gene: Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2) Rattus norvegicus
Analyze
Symbol: Prkab2
Name: protein kinase AMP-activated non-catalytic subunit beta 2
RGD ID: 620905
Description: Enables protein kinase binding activity. Predicted to be involved in cellular response to nutrient levels; positive regulation of cold-induced thermogenesis; and signal transduction. Located in apical plasma membrane and cytoplasm. Part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5'-AMP-activated protein kinase subunit beta-2; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta-2 chain; AMPK subunit beta-2; MGC93432; protein kinase, AMP-activated, beta 2 non-catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp365  
Candidate Gene For: Bp365
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,946,008 - 187,961,615 (+)NCBIGRCr8
mRatBN7.22185,257,218 - 185,272,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,905,393 - 192,917,612 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,713,236 - 190,725,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,538,007 - 185,550,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,831,990 - 199,847,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,831,990 - 199,847,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,309,807 - 219,325,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,498,430 - 192,510,624 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12192,461,183 - 192,473,369 (+)NCBI
Celera2177,749,772 - 177,761,966 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
graphite  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Cammisotto PG, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. doi: 10.1152/ajprenal.00373.2007. Epub 2008 Feb 6.
2. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. Chen Z, etal., FEBS Lett 1999 Oct 29;460(2):343-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
6. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
7. AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). Iseli TJ, etal., J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.
8. Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. Klaus A, etal., PLoS One. 2013 May 31;8(5):e62497. doi: 10.1371/journal.pone.0062497. Print 2013.
9. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Mottillo EP, etal., Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11724780   PMID:14614828   PMID:17709097   PMID:17851531   PMID:20562859   PMID:21399626   PMID:21988832   PMID:27099349   PMID:31189568  


Genomics

Comparative Map Data
Prkab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,946,008 - 187,961,615 (+)NCBIGRCr8
mRatBN7.22185,257,218 - 185,272,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,905,393 - 192,917,612 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,713,236 - 190,725,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,538,007 - 185,550,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,831,990 - 199,847,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,831,990 - 199,847,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,309,807 - 219,325,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,498,430 - 192,510,624 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12192,461,183 - 192,473,369 (+)NCBI
Celera2177,749,772 - 177,761,966 (+)NCBICelera
Cytogenetic Map2q34NCBI
PRKAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,155,106 - 147,172,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,155,106 - 147,172,550 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,626,685 - 146,644,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,093,309 - 145,110,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341143,851,502 - 143,868,945NCBI
Celera1122,340,718 - 122,358,162 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1120,039,190 - 120,056,673 (-)NCBIHuRef
CHM1_11148,523,232 - 148,540,715 (-)NCBICHM1_1
T2T-CHM13v2.01147,635,939 - 147,653,299 (+)NCBIT2T-CHM13v2.0
Prkab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,565,527 - 97,581,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl397,565,509 - 97,581,128 (+)EnsemblGRCm39 Ensembl
GRCm38397,658,211 - 97,673,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl397,658,193 - 97,673,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,462,135 - 97,477,006 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,743,617 - 97,758,488 (+)NCBIMGSCv36mm8
Celera399,057,874 - 99,072,745 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.25NCBI
Prkab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,252,736 - 1,279,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,253,331 - 1,279,761 (+)NCBIChiLan1.0ChiLan1.0
PRKAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21102,556,601 - 102,574,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11102,144,935 - 102,162,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01122,577,308 - 122,595,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,934,877 - 112,952,364 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,934,877 - 112,952,364 (+)Ensemblpanpan1.1panPan2
PRKAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11757,614,499 - 57,630,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1757,616,451 - 57,630,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,138,994 - 57,154,977 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01758,608,987 - 58,624,968 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11757,507,665 - 57,523,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01757,555,486 - 57,571,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,281,440 - 58,297,432 (-)NCBIUU_Cfam_GSD_1.0
LOC101973983
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050583,224,028 - 3,239,362 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493695377,688 - 93,374 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493695377,671 - 93,383 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,378,071 - 100,394,338 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14100,378,047 - 100,394,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,207,633 - 110,223,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603815,067,417 - 15,083,027 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,110,294 - 16,127,119 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,110,805 - 16,127,221 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkab2
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000063783
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 3 8 11 62 17 10 8
Low 3 27 57 41 16 41 12 35 24 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063783   ⟹   ENSRNOP00000062137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)Ensembl
Rnor_6.0 Ensembl2199,831,990 - 199,844,649 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086588   ⟹   ENSRNOP00000069519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2199,832,023 - 199,847,629 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099010   ⟹   ENSRNOP00000086904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,632 - 185,269,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102819   ⟹   ENSRNOP00000090150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,354 - 185,264,831 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108265   ⟹   ENSRNOP00000078691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,287 - 185,269,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113165   ⟹   ENSRNOP00000093894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,213 - 185,264,329 (+)Ensembl
RefSeq Acc Id: NM_022627   ⟹   NP_072149
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,401 - 187,958,595 (+)NCBI
mRatBN7.22185,257,632 - 185,269,826 (+)NCBI
Rnor_6.02199,832,409 - 199,844,603 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
RGSC_v3.42192,498,430 - 192,510,624 (+)RGD
Celera2177,749,772 - 177,761,966 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233011   ⟹   XP_006233073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,009 - 187,961,615 (+)NCBI
mRatBN7.22185,257,235 - 185,272,846 (+)NCBI
Rnor_6.02199,831,990 - 199,847,623 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233012   ⟹   XP_006233074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,151 - 187,961,615 (+)NCBI
mRatBN7.22185,257,382 - 185,272,846 (+)NCBI
Rnor_6.02199,832,180 - 199,847,623 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103078   ⟹   XP_038959006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,424 - 187,961,615 (+)NCBI
mRatBN7.22185,257,654 - 185,272,846 (+)NCBI
RefSeq Acc Id: XM_039103079   ⟹   XP_038959007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,008 - 187,961,615 (+)NCBI
mRatBN7.22185,257,235 - 185,272,846 (+)NCBI
RefSeq Acc Id: XM_039103080   ⟹   XP_038959008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,157 - 187,961,615 (+)NCBI
mRatBN7.22185,257,388 - 185,272,846 (+)NCBI
RefSeq Acc Id: XR_005500366
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,008 - 187,957,642 (+)NCBI
mRatBN7.22185,257,218 - 185,272,846 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072149   ⟸   NM_022627
- UniProtKB: Q9QZH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233073   ⟸   XM_006233011
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVK3 (UniProtKB/TrEMBL),   A6K3B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233074   ⟸   XM_006233012
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVK3 (UniProtKB/TrEMBL),   A6K3B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062137   ⟸   ENSRNOT00000063783
RefSeq Acc Id: ENSRNOP00000069519   ⟸   ENSRNOT00000086588
RefSeq Acc Id: XP_038959007   ⟸   XM_039103079
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959008   ⟸   XM_039103080
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959006   ⟸   XM_039103078
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086904   ⟸   ENSRNOT00000099010
RefSeq Acc Id: ENSRNOP00000078691   ⟸   ENSRNOT00000108265
RefSeq Acc Id: ENSRNOP00000090150   ⟸   ENSRNOT00000102819
RefSeq Acc Id: ENSRNOP00000093894   ⟸   ENSRNOT00000113165
Protein Domains
AMP-activated protein kinase glycogen-binding   Association with the SNF1 complex (ASC)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZH4-F1-model_v2 AlphaFold Q9QZH4 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691597
Promoter ID:EPDNEW_R2122
Type:single initiation site
Name:Prkab2_1
Description:protein kinase AMP-activated non-catalytic subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2123  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,832,116 - 199,832,176EPDNEW
RGD ID:13691598
Promoter ID:EPDNEW_R2123
Type:multiple initiation site
Name:Prkab2_2
Description:protein kinase AMP-activated non-catalytic subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2122  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,832,401 - 199,832,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620905 AgrOrtholog
BioCyc Gene G2FUF-51935 BioCyc
Ensembl Genes ENSRNOG00000018166 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063783.3 UniProtKB/TrEMBL
  ENSRNOT00000099010 ENTREZGENE
  ENSRNOT00000099010.1 UniProtKB/TrEMBL
  ENSRNOT00000102819.1 UniProtKB/TrEMBL
  ENSRNOT00000108265.1 UniProtKB/TrEMBL
  ENSRNOT00000113165.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.250.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135534 IMAGE-MGC_LOAD
InterPro AMPK1_CBM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASC_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64562 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93432 IMAGE-MGC_LOAD
NCBI Gene 64562 ENTREZGENE
PANTHER 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMPK1_CBM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPKBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkab2 PhenoGen
RatGTEx ENSRNOG00000018166 RatGTEx
SMART AMPKBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF160219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHY9_RAT UniProtKB/TrEMBL
  A0A8I6GKV5_RAT UniProtKB/TrEMBL
  A6K3B7 ENTREZGENE, UniProtKB/TrEMBL
  A6K3B8_RAT UniProtKB/TrEMBL
  AAKB2_RAT UniProtKB/Swiss-Prot
  G3V9X3_RAT UniProtKB/TrEMBL
  Q9QZH4 ENTREZGENE
UniProt Secondary Q6AYZ8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkab2  protein kinase AMP-activated non-catalytic subunit beta 2  Prkab2  protein kinase, AMP-activated, beta 2 non-catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Prkab2  protein kinase, AMP-activated, beta 2 non-catalytic subunit    AMP-activated protein kinase beta-2 regulatory subunit  Name updated 1299863 APPROVED
2002-08-07 Prkab2  AMP-activated protein kinase beta-2 regulatory subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skeletal muscle 631899
gene_product member of the AMP-activated protein kinase (AMPK) isoenzyme family  
gene_regulation Ser-182 is only partially phosphorylated in skeletal muscle