Txnip (thioredoxin interacting protein) - Rat Genome Database

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Gene: Txnip (thioredoxin interacting protein) Rattus norvegicus
Analyze
Symbol: Txnip
Name: thioredoxin interacting protein
RGD ID: 620886
Description: Predicted to enable enzyme inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to estradiol; response to hydrogen peroxide; and response to progesterone. Predicted to be active in cytoplasm. Used to study renal cell carcinoma. Biomarker of colorectal cancer; glaucoma; and stomach cancer. Orthologous to human TXNIP (thioredoxin interacting protein); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94673; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; Vdup1; vitamin D3 up-regulated protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
Aflatoxin G2  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
allose  (ISO)
alpha-D-galactose  (ISO)
AM-251  (ISO)
amphotericin B  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
aucubin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
baicalin  (ISO)
barium sulfate  (EXP)
beauvericin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
difenoconazole  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
fipronil  (EXP)
fluoranthene  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP)
furan  (EXP)
galactose  (ISO)
Ganoderic acid A  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lutein  (EXP)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
NMN zwitterion  (EXP,ISO)
nobiletin  (EXP,ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP,ISO)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
tricalcium bis(phosphate)  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Chen J, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):1067-74. Epub 2006 Jun 13.
2. Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Dutta KK, etal., Lab Invest. 2005 Jun;85(6):798-807.
3. Identification of novel differentially expressed genes by the effect of a high-fat n-6 diet in experimental breast cancer. Escrich E, etal., Mol Carcinog. 2004 Jun;40(2):73-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. Hirota T, etal., J Biol Chem 2002 Nov 15;277(46):44244-51.
6. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. Hui TY, etal., J Biol Chem. 2004 Jun 4;279(23):24387-93. Epub 2004 Mar 26.
7. Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease. Ikarashi M, etal., Anticancer Res. 2002 Nov-Dec;22(6C):4045-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study. Mohamed IN, etal., Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.
10. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1. Qi W, etal., Am J Pathol. 2007 Sep;171(3):744-54. Epub 2007 Aug 3.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis. Saitoh T, etal., J Neurochem. 2001 Sep;78(6):1267-76.
18. Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control. Simmons DG and Kennedy TG, Reproduction. 2004 Apr;127(4):475-82.
19. Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. van Greevenbroek MM, etal., Diabet Med. 2007 May;24(5):498-504. Epub 2007 Mar 22.
20. Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. Wang Y, etal., J Biol Chem 2002 Jul 19;277(29):26496-500.
21. Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia. Xiang G, etal., J Biol Chem. 2005 Nov 25;280(47):39394-402. Epub 2005 Sep 19.
22. Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea. Young LH, etal., Mol Carcinog 1996 Apr;15(4):251-60.
Additional References at PubMed
PMID:10843682   PMID:12477932   PMID:14632196   PMID:15123525   PMID:15128745   PMID:15489334   PMID:15520447   PMID:16938273   PMID:16983998   PMID:17023680   PMID:17143286   PMID:18541147  
PMID:18555775   PMID:19337063   PMID:19562690   PMID:19808645   PMID:19824090   PMID:19875615   PMID:19959470   PMID:20068034   PMID:20709139   PMID:20953987   PMID:21098642   PMID:21364670  
PMID:21434880   PMID:22194917   PMID:22474421   PMID:22871113   PMID:23305039   PMID:23353834   PMID:23647015   PMID:23803610   PMID:24201577   PMID:24925443   PMID:25054130   PMID:25391656  
PMID:25602171   PMID:25639671   PMID:25996168   PMID:26133299   PMID:26154105   PMID:26196303   PMID:26796253   PMID:26858253   PMID:26881256   PMID:27345365   PMID:27381856   PMID:27989964  
PMID:28420192   PMID:28490373   PMID:28492550   PMID:29110407   PMID:29792552   PMID:29905889   PMID:31017263   PMID:31173172   PMID:31344482   PMID:31505737   PMID:31652453   PMID:31763668  
PMID:31982825   PMID:31998437   PMID:32476292   PMID:32950473   PMID:32980492   PMID:33412212   PMID:33638792   PMID:34162834   PMID:34517790   PMID:35562171   PMID:36642539   PMID:37749991  
PMID:37814350  


Genomics

Comparative Map Data
Txnip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
TXNIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,992,435 - 145,996,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,992,435 - 145,996,579 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,438,490 - 145,442,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,149,939 - 144,153,882 (+)NCBINCBI36Build 36hg18NCBI36
Build 341142,927,625 - 142,931,567NCBI
Celera1119,641,815 - 119,645,987 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,402,325 - 119,406,521 (+)NCBIHuRef
CHM1_11147,360,561 - 147,364,757 (-)NCBICHM1_1
T2T-CHM13v2.01145,109,270 - 145,113,414 (-)NCBIT2T-CHM13v2.0
Txnip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 Ensembl
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
Txnip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568103,762 - 107,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568103,801 - 107,791 (+)NCBIChiLan1.0ChiLan1.0
LOC100971374
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21105,244,606 - 105,248,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11104,844,009 - 104,850,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0190,007,878 - 90,012,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,902,839 - 113,906,239 (-)NCBIpanpan1.1PanPan1.1panPan2
TXNIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,775,588 - 58,779,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,776,871 - 58,779,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,243,550 - 58,247,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,772,252 - 59,776,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,772,252 - 59,776,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,645,076 - 58,649,209 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,706,219 - 58,710,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,432,672 - 59,436,806 (-)NCBIUU_Cfam_GSD_1.0
Txnip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,846,422 - 20,850,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867722,514 - 726,617 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867722,544 - 726,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,756,145 - 12,759,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,756,053 - 12,761,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,433,418 - 15,437,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txnip
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:135
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000028793
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
RH128016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,096,506 - 184,096,702 (+)MAPPERmRatBN7.2
Rnor_6.02198,686,596 - 198,686,791NCBIRnor6.0
Rnor_5.02218,173,530 - 218,173,725UniSTSRnor5.0
RGSC_v3.42191,360,382 - 191,360,577UniSTSRGSC3.4
Celera2176,621,729 - 176,621,924UniSTS
RH 3.4 Map21231.3UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000028793   ⟹   ENSRNOP00000028793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,092,998 - 184,096,886 (+)Ensembl
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115326   ⟹   ENSRNOP00000086202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)Ensembl
RefSeq Acc Id: NM_001008767   ⟹   NP_001008767
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,781,933 - 186,785,736 (+)NCBI
mRatBN7.22184,093,079 - 184,096,882 (+)NCBI
Rnor_6.02198,683,168 - 198,686,971 (+)NCBI
Rnor_5.02218,170,102 - 218,173,905 (+)NCBI
RGSC_v3.42191,356,954 - 191,360,757 (+)RGD
Celera2176,618,301 - 176,622,104 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88411 (Get FASTA)   NCBI Sequence Viewer  
  EDL85625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028793
  ENSRNOP00000028793.5
  ENSRNOP00000086202.1
  ENSRNOP00055046247
  ENSRNOP00060016720
  ENSRNOP00065045322
GenBank Protein Q5M7W1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008767   ⟸   NM_001008767
- UniProtKB: Q5M7W1 (UniProtKB/Swiss-Prot),   A6K374 (UniProtKB/TrEMBL),   A0A8I6A352 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028793   ⟸   ENSRNOT00000028793
RefSeq Acc Id: ENSRNOP00000086202   ⟸   ENSRNOT00000115326
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7W1-F1-model_v2 AlphaFold Q5M7W1 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691582
Promoter ID:EPDNEW_R2107
Type:single initiation site
Name:Txnip_1
Description:thioredoxin interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,683,087 - 198,683,147EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620886 AgrOrtholog
BioCyc Gene G2FUF-51980 BioCyc
Ensembl Genes ENSRNOG00000021201 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032474 UniProtKB/Swiss-Prot
  ENSRNOG00060012506 UniProtKB/Swiss-Prot
  ENSRNOG00065032017 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028793 ENTREZGENE
  ENSRNOT00000028793.7 UniProtKB/Swiss-Prot
  ENSRNOT00000115326.1 UniProtKB/TrEMBL
  ENSRNOT00055056093 UniProtKB/Swiss-Prot
  ENSRNOT00060021196 UniProtKB/Swiss-Prot
  ENSRNOT00065055127 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192327 IMAGE-MGC_LOAD
InterPro Arrestin-like_C UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94673 IMAGE-MGC_LOAD
NCBI Gene 117514 ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN-INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txnip PhenoGen
RatGTEx ENSRNOG00000021201 RatGTEx
  ENSRNOG00055032474 RatGTEx
  ENSRNOG00060012506 RatGTEx
  ENSRNOG00065032017 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A352 ENTREZGENE, UniProtKB/TrEMBL
  A6K374 ENTREZGENE, UniProtKB/TrEMBL
  Q5M7W1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-08-25   thioredoxin interacting protein  Txnip  upregulated by 1,25-dihydroxyvitamin D-3  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Txnip  upregulated by 1,25-dihydroxyvitamin D-3  Vdup1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Vdup1  upregulated by 1,25-dihydroxyvitamin D-3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is suppressed by biomechanical strain or hydrogen peroxide 727213