Rab14 (RAB14, member RAS oncogene family) - Rat Genome Database

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Gene: Rab14 (RAB14, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab14
Name: RAB14, member RAS oncogene family
RGD ID: 620881
Description: Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in apical protein localization; body fluid secretion; and regulation of protein localization. Located in several cellular components, including Golgi stack; apical plasma membrane; and cytoplasmic vesicle. Is active in synaptic vesicle membrane. Orthologous to human RAB14 (RAB14, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTPase Rab14; ras-related protein Rab-14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,899,430 - 38,920,572 (-)NCBIGRCr8
mRatBN7.2318,501,953 - 18,523,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,501,963 - 18,523,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,579,078 - 21,589,494 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,164,112 - 30,174,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,417,981 - 28,428,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,373,270 - 14,395,357 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,373,275 - 14,395,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,691,787 - 19,714,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,245,693 - 14,255,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,142,071 - 14,152,356 (-)NCBI
Celera313,223,275 - 13,233,556 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hexaconazole  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
microcystin RR  (ISO)
N-ethyl-N-nitrosourea  (EXP)
Nonylphenol  (EXP)
paracetamol  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
poly(vinylpyrrolidone)  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tipifarnib  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function
GDP binding  (IEA,ISO,ISS)
GTP binding  (IEA,ISO,ISS)
GTPase activity  (IBA,IEA,ISO,ISS,NAS)
myosin V binding  (IEA,ISO)
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Annexin A2 interactions with Rab14 in alveolar type II cells. Gou D, etal., J Biol Chem. 2008 May 9;283(19):13156-64. Epub 2008 Mar 10.
4. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Ishikura S and Klip A, Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.
5. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Junutula JR, etal., Mol Biol Cell. 2004 May;15(5):2218-29. Epub 2004 Mar 5.
6. Rab proteins in endocytosis and Glut4 trafficking. Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
7. Rab14 regulates apical targeting in polarized epithelial cells. Kitt KN, etal., Traffic. 2008 Jul;9(7):1218-31. Epub 2008 Apr 21.
8. Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria. Kuijl C, etal., EMBO J. 2013 Mar 6;32(5):713-27. doi: 10.1038/emboj.2013.10. Epub 2013 Feb 5.
9. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
15. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
16. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:12477932   PMID:16034420   PMID:16902405   PMID:17562788   PMID:17646400   PMID:17897319   PMID:19056867   PMID:20458337   PMID:21238925   PMID:21255211   PMID:22082260   PMID:22595670  
PMID:22871113   PMID:23376485   PMID:24006491   PMID:24625528   PMID:29476059  


Genomics

Comparative Map Data
Rab14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,899,430 - 38,920,572 (-)NCBIGRCr8
mRatBN7.2318,501,953 - 18,523,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,501,963 - 18,523,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,579,078 - 21,589,494 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,164,112 - 30,174,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,417,981 - 28,428,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,373,270 - 14,395,357 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,373,275 - 14,395,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,691,787 - 19,714,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,245,693 - 14,255,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,142,071 - 14,152,356 (-)NCBI
Celera313,223,275 - 13,233,556 (-)NCBICelera
Cytogenetic Map3p11NCBI
RAB14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389121,178,133 - 121,201,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9121,178,133 - 121,223,014 (-)EnsemblGRCh38hg38GRCh38
GRCh379123,940,411 - 123,964,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,980,237 - 123,003,913 (-)NCBINCBI36Build 36hg18NCBI36
Build 349121,019,968 - 121,043,640NCBI
Celera994,588,887 - 94,612,841 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,558,160 - 93,582,112 (-)NCBIHuRef
CHM1_19124,087,307 - 124,111,257 (-)NCBICHM1_1
T2T-CHM13v2.09133,374,160 - 133,397,896 (-)NCBIT2T-CHM13v2.0
Rab14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,070,217 - 35,091,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,070,217 - 35,091,132 (-)EnsemblGRCm39 Ensembl
GRCm38235,180,205 - 35,201,120 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,180,205 - 35,201,120 (-)EnsemblGRCm38mm10GRCm38
MGSCv37235,035,725 - 35,056,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,002,214 - 35,023,129 (-)NCBIMGSCv36mm8
Celera234,874,701 - 34,895,616 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.42NCBI
Rab14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,790,707 - 6,812,870 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,790,110 - 6,812,870 (+)NCBIChiLan1.0ChiLan1.0
RAB14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,142,797 - 18,165,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,145,477 - 18,167,934 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,305,656 - 92,329,419 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19120,652,075 - 120,674,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,654,180 - 120,666,170 (-)Ensemblpanpan1.1panPan2
RAB14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11174,157,497 - 74,172,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,159,414 - 74,172,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,568,670 - 72,591,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01175,294,806 - 75,317,181 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11173,802,537 - 73,824,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,832,913 - 73,855,283 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01174,572,713 - 74,595,040 (-)NCBIUU_Cfam_GSD_1.0
Rab14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,907,256 - 189,922,208 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364879,673,487 - 9,690,654 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364879,675,517 - 9,699,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,229,535 - 261,256,791 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,228,112 - 261,256,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,477,523 - 293,506,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,382,118 - 18,406,353 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,390,806 - 18,403,185 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603524,612,516 - 24,635,362 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476014,069,387 - 14,096,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476014,069,403 - 14,096,684 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab14
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:107
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000025649
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat

Markers in Region
RH136853  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,509,853 - 18,510,048 (+)MAPPERmRatBN7.2
Rnor_6.0314,381,169 - 14,381,363NCBIRnor6.0
Rnor_5.0319,699,686 - 19,699,880UniSTSRnor5.0
RGSC_v3.4314,251,624 - 14,251,818UniSTSRGSC3.4
Celera313,229,206 - 13,229,400UniSTS
RH 3.4 Map3163.0UniSTS
Cytogenetic Map3p11UniSTS
AU048931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,512,214 - 18,512,399 (+)MAPPERmRatBN7.2
Rnor_6.0314,383,530 - 14,383,714NCBIRnor6.0
Rnor_5.0319,702,047 - 19,702,231UniSTSRnor5.0
RGSC_v3.4314,253,985 - 14,254,169UniSTSRGSC3.4
Celera313,231,567 - 13,231,741UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025649   ⟹   ENSRNOP00000025649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,501,963 - 18,523,172 (-)Ensembl
Rnor_6.0 Ensembl314,373,275 - 14,386,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092787   ⟹   ENSRNOP00000075991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,382,918 - 14,395,362 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,376,688 - 14,377,762 (-)Ensembl
RefSeq Acc Id: NM_053589   ⟹   NP_446041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,901,393 - 38,911,684 (-)NCBI
mRatBN7.2318,503,923 - 18,514,214 (-)NCBI
Rnor_6.0314,375,238 - 14,385,529 (-)NCBI
Rnor_5.0319,691,787 - 19,714,201 (-)NCBI
RGSC_v3.4314,245,693 - 14,255,984 (-)RGD
Celera313,223,275 - 13,233,556 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234049   ⟹   XP_006234111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,899,430 - 38,920,572 (-)NCBI
mRatBN7.2318,501,953 - 18,523,253 (-)NCBI
Rnor_6.0314,373,270 - 14,395,357 (-)NCBI
Rnor_5.0319,691,787 - 19,714,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284794   ⟹   XP_063140864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,899,430 - 38,920,099 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446041 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234111 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140864 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41994 (Get FASTA)   NCBI Sequence Viewer  
  AAI58586 (Get FASTA)   NCBI Sequence Viewer  
  EDL93150 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025649
  ENSRNOP00000025649.3
GenBank Protein P61107 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446041   ⟸   NM_053589
- UniProtKB: B0BMW0 (UniProtKB/TrEMBL),   F7F4P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234111   ⟸   XM_006234049
- Peptide Label: isoform X1
- UniProtKB: B0BMW0 (UniProtKB/TrEMBL),   F7F4P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075991   ⟸   ENSRNOT00000092787
RefSeq Acc Id: ENSRNOP00000025649   ⟸   ENSRNOT00000025649
RefSeq Acc Id: XP_063140864   ⟸   XM_063284794
- Peptide Label: isoform X1
- UniProtKB: B0BMW0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61107-F1-model_v2 AlphaFold P61107 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692016
Promoter ID:EPDNEW_R2540
Type:initiation region
Name:Rab14_1
Description:RAB14, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,395,143 - 14,395,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620881 AgrOrtholog
BioCyc Gene G2FUF-50062 BioCyc
Ensembl Genes ENSRNOG00000018901 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025649.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446356 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187348 IMAGE-MGC_LOAD
NCBI Gene 94197 ENTREZGENE
PANTHER DRAB11-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab14 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018901 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0BMW0 ENTREZGENE, UniProtKB/TrEMBL
  F7F4P0 ENTREZGENE, UniProtKB/TrEMBL
  P61107 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P35287 UniProtKB/Swiss-Prot
  Q969L0 UniProtKB/Swiss-Prot
  Q9UI11 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab14  RAB14, member RAS oncogene family    GTPase Rab14  Name updated 1299863 APPROVED
2002-08-07 Rab14  GTPase Rab14      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of a family of low molecular weight GTP-binding proteins 633184