Axin1 (axin 1) - Rat Genome Database

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Gene: Axin1 (axin 1) Rattus norvegicus
Analyze
Symbol: Axin1
Name: axin 1
RGD ID: 620859
Description: Enables several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of ubiquitin-dependent protein catabolic process; and response to quercetin. Located in cytoplasmic vesicle and plasma membrane. Part of beta-catenin destruction complex. Is active in synapse. Colocalizes with Golgi apparatus. Biomarker of colon cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; N-cadherin signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 5-fluorouracil; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Axin; axin-1; axis inhibition protein 1; GSK-3beta interacting protein rAxin; rAxin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,667,894 - 15,720,092 (+)NCBIGRCr8
mRatBN7.21015,163,477 - 15,215,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,903,082 - 19,955,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,391,961 - 19,444,266 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,891,384 - 14,943,546 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
apoptotic process  (IEA)
axial mesoderm development  (ISO)
axial mesoderm formation  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell development  (IBA,IEA)
cytoplasmic microtubule organization  (IEA,ISO)
dorsal/ventral axis specification  (IEA,ISO)
dorsal/ventral pattern formation  (ISO)
embryonic skeletal joint morphogenesis  (ISO)
epigenetic programming in the zygotic pronuclei  (IEA,ISO)
erythrocyte homeostasis  (ISO)
head development  (IEA,ISO)
hemoglobin metabolic process  (ISO)
in utero embryonic development  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IDA,IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
negative regulation of Wnt signaling pathway  (ISO,TAS)
nervous system process  (ISO)
nucleocytoplasmic transport  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein kinase activity  (IDA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IDA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
protein catabolic process  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of protein phosphorylation  (ISO)
response to quercetin  (IEP)
sensory perception of sound  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer Ahmed HH, etal., Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4991-4998. doi: 10.22034/APJCP.2016.17.11.4991.
2. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. Andrade Filho PA, etal., J Dent Res. 2011 Jun;90(6):740-6. doi: 10.1177/0022034511401622. Epub 2011 Mar 10.
3. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Chen HJ, etal., Genes Dev. 2006 Jul 15;20(14):1933-45. Epub 2006 Jun 30.
4. Conditional disruption of Axin1 leads to development of liver tumors in mice. Feng GJ, etal., Gastroenterology. 2012 Dec;143(6):1650-9. doi: 10.1053/j.gastro.2012.08.047. Epub 2012 Sep 6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. Han Y, etal., Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):518-26. doi: 10.1016/j.ijrobp.2009.05.040.
8. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S, etal., Mol Cell Biol 2001 Jan;21(1):330-42.
9. Synaptic scaffolding molecule interacts with axin. Hirabayashi S, etal., J Neurochem 2004 Jul;90(2):332-9.
10. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. Ikeda S, etal., EMBO J 1998 Mar 2;17(5):1371-84.
11. Inhibition of Wnt signaling pathway by a novel axin-binding protein. Kadoya T, etal., J Biol Chem 2000 Nov 24;275(47):37030-7.
12. Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. Kim SI, etal., Biochem Biophys Res Commun 2004 Apr 30;317(2):478-83.
13. Genetic polymorphisms in the Wnt/β-catenin pathway genes as predictors of tumor development and survival in patients with hepatitis B virus-associated hepatocellular carcinoma. Kim SS, etal., Clin Biochem. 2016 Jul;49(10-11):792-801. doi: 10.1016/j.clinbiochem.2016.01.025. Epub 2016 Mar 9.
14. Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. Kishida M, etal., J Biol Chem. 2001 Aug 31;276(35):33147-55. Epub 2001 Jun 25.
15. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22.
16. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. Kitagawa M, etal., EMBO J. 1999 May 4;18(9):2401-10.
17. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
18. Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-Catenin/AXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer. Li B, etal., Biomed Res Int. 2020 Jan 16;2020:2761850. doi: 10.1155/2020/2761850. eCollection 2020.
19. Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population. Li Q, etal., Dis Markers. 2019 Apr 15;2019:3949343. doi: 10.1155/2019/3949343. eCollection 2019.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma. Nakajima M, etal., Br J Cancer. 2003 Jun 2;88(11):1734-9. doi: 10.1038/sj.bjc.6600941.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Satoh S, etal., Nat Genet 2000 Mar;24(3):245-50.
30. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Schwarz-Romond T, etal., Nat Struct Mol Biol. 2007 Jun;14(6):484-92. Epub 2007 May 27.
31. MicroRNA-1181 supports the growth of hepatocellular carcinoma by repressing AXIN1. Song Z, etal., Biomed Pharmacother. 2019 Nov;119:109397. doi: 10.1016/j.biopha.2019.109397. Epub 2019 Sep 9.
32. Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation. Tanneberger K, etal., EMBO J. 2011 Apr 20;30(8):1433-43. doi: 10.1038/emboj.2011.28. Epub 2011 Feb 8.
33. Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers. Xu HT, etal., Hum Pathol. 2011 Oct;42(10):1491-8. doi: 10.1016/j.humpath.2011.01.004. Epub 2011 Apr 14.
34. Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Yamamoto H, etal., Dev Cell. 2006 Aug;11(2):213-23.
35. Axin gene methylation status correlates with radiosensitivity of lung cancer cells. Yang LH, etal., BMC Cancer. 2013 Aug 2;13:368. doi: 10.1186/1471-2407-13-368.
36. Abnormal hypermethylation and clinicopathological significance of Axin gene in lung cancer. Yang LH, etal., Tumour Biol. 2013 Apr;34(2):749-57. doi: 10.1007/s13277-012-0604-z. Epub 2012 Nov 29.
37. Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: involvement in tumor progression and metastasis. Zhou CX and Gao Y, Oncol Rep. 2007 Jan;17(1):73-9.
Additional References at PubMed
PMID:9230313   PMID:9601641   PMID:9920888   PMID:10318824   PMID:10330403   PMID:10581160   PMID:10644691   PMID:10937998   PMID:11955436   PMID:12072559   PMID:12138115   PMID:12601169  
PMID:12717450   PMID:12817302   PMID:12878610   PMID:14734535   PMID:14981260   PMID:15526030   PMID:15579909   PMID:16169070   PMID:16188939   PMID:16601693   PMID:17554179   PMID:17569865  
PMID:17681137   PMID:18076571   PMID:18316368   PMID:18593713   PMID:18606656   PMID:18632848   PMID:19038973   PMID:19075000   PMID:19204372   PMID:19513548   PMID:19759537   PMID:21003499  
PMID:21245303   PMID:21344612   PMID:21383061   PMID:21478859   PMID:22899650   PMID:23588680   PMID:27697743   PMID:33582657   PMID:34495485   PMID:36464067  


Genomics

Comparative Map Data
Axin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,667,894 - 15,720,092 (+)NCBIGRCr8
mRatBN7.21015,163,477 - 15,215,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,903,082 - 19,955,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,391,961 - 19,444,266 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,891,384 - 14,943,546 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
AXIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816287,440 - 352,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16287,440 - 352,723 (-)EnsemblGRCh38hg38GRCh38
GRCh3716337,440 - 402,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36Build 36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
T2T-CHM13v2.016282,313 - 347,596 (-)NCBIT2T-CHM13v2.0
Axin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,350,294 - 26,414,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,357,662 - 26,414,785 (+)EnsemblGRCm39 Ensembl
GRCm381726,131,217 - 26,195,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,138,688 - 26,195,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,275,631 - 26,332,756 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,866,334 - 25,923,411 (+)NCBIMGSCv36mm8
Celera1726,676,271 - 26,729,569 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
Axin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,843,152 - 16,898,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,845,728 - 16,898,301 (+)NCBIChiLan1.0ChiLan1.0
AXIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218506,910 - 581,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,299,164 - 4,372,528 (-)NCBINHGRI_mPanPan1
PanPan1.116278,239 - 337,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensemblpanpan1.1panPan2
AXIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,155,797 - 40,218,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,158,244 - 40,218,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,419,076 - 41,481,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,497,801 - 40,560,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,500,504 - 40,560,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,186,114 - 40,248,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,146,325 - 40,210,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,625,599 - 40,688,493 (+)NCBIUU_Cfam_GSD_1.0
Axin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,502,114 - 112,535,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501599,919 - 633,873 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501599,963 - 633,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,337,071 - 41,393,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,344,908 - 41,393,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,033,961 - 41,085,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AXIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15233,520 - 295,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5234,060 - 290,575 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,878,427 - 30,943,289 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Axin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,139,165 - 1,195,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Axin1
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:123
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000027705
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat

Markers in Region
PMC134648P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01015,328,132 - 15,328,789UniSTSRnor5.0
RGSC_v3.41015,413,175 - 15,413,832UniSTSRGSC3.4
Celera1014,835,340 - 14,835,997UniSTS
Cytogenetic Map10q12UniSTS
RH144513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2879,432,715 - 79,432,861 (+)MAPPERmRatBN7.2
Rnor_6.0885,929,741 - 85,929,886NCBIRnor6.0
Rnor_5.0885,479,029 - 85,479,174UniSTSRnor5.0
Rnor_5.01015,338,242 - 15,338,627UniSTSRnor5.0
RGSC_v3.4883,554,738 - 83,554,883UniSTSRGSC3.4
RGSC_v3.41015,423,288 - 15,423,673UniSTSRGSC3.4
Celera879,178,666 - 79,178,811UniSTS
Celera1014,845,408 - 14,845,792UniSTS
RH 3.4 Map8924.2UniSTS
Cytogenetic Map10q12UniSTS
RH140789  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01015,324,875 - 15,325,092UniSTSRnor5.0
RGSC_v3.41015,409,918 - 15,410,135UniSTSRGSC3.4
Celera1014,832,083 - 14,832,300UniSTS
Cytogenetic Map10q12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000112116   ⟹   ENSRNOP00000094080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115321   ⟹   ENSRNOP00000083350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
RefSeq Acc Id: NM_024405   ⟹   NP_077381
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,667,958 - 15,720,092 (+)NCBI
mRatBN7.21015,163,477 - 15,215,615 (+)NCBI
Rnor_5.01015,324,330 - 15,376,252 (+)NCBI
RGSC_v3.41015,409,373 - 15,462,726 (+)RGD
Celera1014,831,660 - 14,883,421 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269922   ⟹   XP_063125992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,668,377 - 15,720,092 (+)NCBI
RefSeq Acc Id: XM_063269923   ⟹   XP_063125993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,667,894 - 15,720,092 (+)NCBI
RefSeq Acc Id: XM_063269924   ⟹   XP_063125994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,668,120 - 15,720,092 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_077381   ⟸   NM_024405
- UniProtKB: O70239 (UniProtKB/Swiss-Prot),   A0A8I5ZVQ9 (UniProtKB/TrEMBL),   A6HD90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000083350   ⟸   ENSRNOT00000115321
RefSeq Acc Id: ENSRNOP00000094080   ⟸   ENSRNOT00000112116
RefSeq Acc Id: XP_063125993   ⟸   XM_063269923
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ALD8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125994   ⟸   XM_063269924
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125992   ⟸   XM_063269922
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ALD8 (UniProtKB/TrEMBL)
Protein Domains
DIX   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70239-F1-model_v2 AlphaFold O70239 1-827 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620859 AgrOrtholog
BioCyc Gene G2FUF-25727 BioCyc
Ensembl Genes ENSRNOG00000062714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112116.1 UniProtKB/TrEMBL
  ENSRNOT00000115321 ENTREZGENE
  ENSRNOT00000115321.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Axin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_TNKS-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79257 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79257 ENTREZGENE
PANTHER PTHR46102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46102:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AXIN1_TNKS_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Axin1 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062714 RatGTEx
SMART DAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALD8 ENTREZGENE, UniProtKB/TrEMBL
  A6HD90 ENTREZGENE, UniProtKB/TrEMBL
  A6HD91_RAT UniProtKB/TrEMBL
  A6HD92_RAT UniProtKB/TrEMBL
  AXIN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Axin1  axin 1  Axin  GSK-3beta interacting protein rAxin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Axin  GSK-3beta interacting protein rAxin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains Regulators of G protein Signaling (RGS) and dishevelled (Dsh) homologous domains in its N- and C-terminals, respectively 632259
gene_homology amino acid level shows 94% identity to mouse Axin 632259
gene_physical_interaction forms a complex with synaptic scaffolding molecule S-SCAM and beta-catenin 1304344
gene_protein 832 amino acids 632259