Eif2b1 (eukaryotic translation initiation factor 2B subunit alpha) - Rat Genome Database

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Gene: Eif2b1 (eukaryotic translation initiation factor 2B subunit alpha) Rattus norvegicus
Analyze
Symbol: Eif2b1
Name: eukaryotic translation initiation factor 2B subunit alpha
RGD ID: 620819
Description: Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including response to amino acid starvation; response to glucose; and translational initiation. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eIF-2a; eIF-2B GDP-GTP exchange factor subunit alpha; eIF-2Balpha; eIF2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B subunit 1; eukaryotic translation initiation factor 2B subunit 1 alpha; eukaryotic translation initiation factor 2B, subunit 1 alpha; GTP-exchange protein; translation initiation factor eIF-2B alpha-subunit; translation initiation factor eIF-2B subunit alpha; translation initiation factor eIF2B subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,686,149 - 37,694,830 (+)NCBIGRCr8
mRatBN7.21232,025,593 - 32,033,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,025,557 - 32,046,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1233,203,928 - 33,212,772 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,815,249 - 33,824,093 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,867,116 - 32,875,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,444,136 - 37,452,391 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,444,072 - 37,465,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01239,315,146 - 39,323,401 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,138,323 - 33,146,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,715,011 - 33,723,266 (+)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. Anthony TG, etal., Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E430-9.
2. Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. Fabian JR, etal., J Biol Chem. 1997 May 9;272(19):12359-65.
3. Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells. Fabian JR, etal., Protein Expr Purif. 1998 Jun;13(1):16-22.
4. Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B. Flowers KM, etal., Proc Natl Acad Sci U S A 1995 May 9;92(10):4274-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. Gilligan M, etal., J Biol Chem. 1996 Jan 26;271(4):2121-5.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
9. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
10. Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Karinch AM, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):E101-8.
11. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, etal., J Struct Funct Genomics. 2016 Mar;17(1):33-8. doi: 10.1007/s10969-016-9203-3. Epub 2016 Mar 29.
12. Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver. Kimball SR, etal., J Biol Chem. 1987 Feb 15;262(5):2220-7.
13. Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. Kimball SR, etal., J Biol Chem. 1998 Jan 30;273(5):3039-44.
14. Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b. Kimball SR, etal., J Biol Chem. 1998 May 22;273(21):12841-5.
15. Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Martin de la Vega C, etal., Biochem J. 2001 Aug 1;357(Pt 3):819-26.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Increased activity of eukaryotic initiation factor 2B in PC12 cells in response to differentiation by nerve growth factor. Munoz F, etal., J Neurochem. 1998 Nov;71(5):1905-11.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells. Sans MD, etal., Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G267-76.
25. Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells. Scheper GC, etal., J Biol Chem. 1997 Oct 24;272(43):26850-6.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. van der Knaap MS, etal., Ann Neurol 2002 Feb;51(2):264-70.
Additional References at PubMed
PMID:7495858   PMID:8626696   PMID:9235896   PMID:11323413   PMID:15060152   PMID:15217090   PMID:15489334   PMID:16289705   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Eif2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,686,149 - 37,694,830 (+)NCBIGRCr8
mRatBN7.21232,025,593 - 32,033,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,025,557 - 32,046,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1233,203,928 - 33,212,772 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,815,249 - 33,824,093 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,867,116 - 32,875,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,444,136 - 37,452,391 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,444,072 - 37,465,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01239,315,146 - 39,323,401 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,138,323 - 33,146,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,715,011 - 33,723,266 (+)NCBICelera
Cytogenetic Map12q15NCBI
EIF2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812123,620,406 - 123,633,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12123,620,406 - 123,633,766 (-)EnsemblGRCh38hg38GRCh38
GRCh3712124,104,953 - 124,118,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612122,671,523 - 122,684,200 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412122,630,458 - 122,642,993NCBI
Celera12123,702,006 - 123,714,759 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12121,066,914 - 121,079,569 (-)NCBIHuRef
CHM1_112123,926,519 - 123,939,272 (-)NCBICHM1_1
T2T-CHM13v2.012123,619,272 - 123,632,550 (-)NCBIT2T-CHM13v2.0
Eif2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395124,708,277 - 124,717,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5124,708,276 - 124,717,194 (-)EnsemblGRCm39 Ensembl
GRCm385124,570,214 - 124,579,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5124,570,213 - 124,579,131 (-)EnsemblGRCm38mm10GRCm38
MGSCv375125,020,223 - 125,029,066 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365124,831,271 - 124,839,665 (-)NCBIMGSCv36mm8
Celera5121,646,913 - 121,655,757 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.67NCBI
Eif2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,380,121 - 5,388,588 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554825,380,121 - 5,388,588 (+)NCBIChiLan1.0ChiLan1.0
EIF2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210131,695,932 - 131,708,303 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112131,692,309 - 131,704,680 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012121,206,380 - 121,218,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112125,433,227 - 125,445,418 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12125,433,227 - 125,446,665 (-)Ensemblpanpan1.1panPan2
EIF2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1266,011,280 - 6,022,562 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl266,011,301 - 6,022,518 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha266,174,138 - 6,185,441 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0266,261,358 - 6,272,647 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl266,261,376 - 6,272,698 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,194,833 - 6,206,124 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,287,198 - 6,298,495 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0266,240,405 - 6,251,707 (+)NCBIUU_Cfam_GSD_1.0
Eif2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118158,273,558 - 158,283,344 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365581,196,068 - 1,205,867 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365581,196,111 - 1,205,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1429,332,233 - 29,367,918 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11429,355,497 - 29,367,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21431,047,776 - 31,060,210 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111118,949,674 - 118,961,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11118,950,409 - 118,961,687 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037126,313,981 - 126,326,188 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,414,077 - 23,421,074 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474723,413,045 - 23,422,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2b1
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:65
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000001373
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat

Markers in Region
BI279065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,033,522 - 32,033,703 (+)MAPPERmRatBN7.2
Rnor_6.01237,452,066 - 37,452,246NCBIRnor6.0
Rnor_5.01239,323,076 - 39,323,256UniSTSRnor5.0
RGSC_v3.41233,146,272 - 33,146,452UniSTSRGSC3.4
Celera1233,722,941 - 33,723,121UniSTS
RH 3.4 Map12553.3UniSTS
Cytogenetic Map12q15UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 36 20 19 20 3 6 74 35 41 11 3
Low 11 21 21 21 5 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001373   ⟹   ENSRNOP00000001373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1237,444,136 - 37,452,389 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077380   ⟹   ENSRNOP00000069357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1232,025,557 - 32,046,601 (+)Ensembl
Rnor_6.0 Ensembl1237,444,072 - 37,465,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092416   ⟹   ENSRNOP00000075870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1232,025,561 - 32,034,059 (+)Ensembl
Rnor_6.0 Ensembl1237,444,136 - 37,452,391 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092699   ⟹   ENSRNOP00000075860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1232,025,580 - 32,041,263 (+)Ensembl
Rnor_6.0 Ensembl1237,444,123 - 37,459,983 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1237,444,103 - 37,450,113 (+)Ensembl
RefSeq Acc Id: NM_172029   ⟹   NP_742026
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,686,575 - 37,694,830 (+)NCBI
mRatBN7.21232,025,593 - 32,033,848 (+)NCBI
Rnor_6.01237,444,136 - 37,452,391 (+)NCBI
Rnor_5.01239,315,146 - 39,323,401 (+)NCBI
RGSC_v3.41233,138,323 - 33,146,596 (+)RGD
Celera1233,715,011 - 33,723,266 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271616   ⟹   XP_063127686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,686,149 - 37,694,830 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_742026   ⟸   NM_172029
- UniProtKB: Q64270 (UniProtKB/Swiss-Prot),   A6J0Y3 (UniProtKB/TrEMBL),   A0A0G2JV57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075870   ⟸   ENSRNOT00000092416
RefSeq Acc Id: ENSRNOP00000075860   ⟸   ENSRNOT00000092699
RefSeq Acc Id: ENSRNOP00000069357   ⟸   ENSRNOT00000077380
RefSeq Acc Id: ENSRNOP00000001373   ⟸   ENSRNOT00000001373
RefSeq Acc Id: XP_063127686   ⟸   XM_063271616
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RRZ2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64270-F1-model_v2 AlphaFold Q64270 1-305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698614
Promoter ID:EPDNEW_R9132
Type:initiation region
Name:Eif2b1_1
Description:eukaryotic translation initiation factor 2B subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01237,444,120 - 37,444,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620819 AgrOrtholog
BioCyc Gene G2FUF-19360 BioCyc
Ensembl Genes ENSRNOG00000001039 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077380.2 UniProtKB/TrEMBL
  ENSRNOT00000092416 ENTREZGENE
  ENSRNOT00000092416.2 UniProtKB/TrEMBL
  ENSRNOT00000092699.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135576 IMAGE-MGC_LOAD
InterPro elF-2B_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF-2B-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_2B-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93113 IMAGE-MGC_LOAD
NCBI Gene 64514 ENTREZGENE
PANTHER TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA UniProtKB/Swiss-Prot
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA UniProtKB/Swiss-Prot
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA UniProtKB/TrEMBL
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IF-2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2b1 PhenoGen
RatGTEx ENSRNOG00000001039 RatGTEx
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JV57 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RRY3_RAT UniProtKB/TrEMBL
  A0A0U1RRZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6J0Y3 ENTREZGENE, UniProtKB/TrEMBL
  EI2BA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-02 Eif2b1  eukaryotic translation initiation factor 2B subunit alpha  Eif2b1  eukaryotic translation initiation factor 2B subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-26 Eif2b1  eukaryotic translation initiation factor 2B subunit 1 alpha  Eif2b1  eukaryotic translation initiation factor 2B subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2b1  eukaryotic translation initiation factor 2B subunit 1  Eif2b1  eukaryotic translation initiation factor 2B, subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Eif2b1  eukaryotic translation initiation factor 2B, subunit 1 alpha    translation initiation factor eIF-2B alpha-subunit  Name updated 1299863 APPROVED
2002-08-07 Eif2b1  translation initiation factor eIF-2B alpha-subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology sequence and function analysis suggests eif2b1 shares homology with yeast (Saccharomyces cerevisiae) GCN3 728587
gene_pathway component of the pathway for peptide chain initiation 728587
gene_protein 1510-bp cDNA contains open reading frame of 918 bp, encodes 305 aa polypeptide with predicted mass of 33.7 kDa 728587