Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | schizophrenia | | ISO | RTN4R (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | schizophrenia | | ISO | RTN4R (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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# | Reference Title | Reference Citation |
1. | AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury. | Ahmed Z, etal., PLoS One. 2013 Apr 16;8(4):e61878. doi: 10.1371/journal.pone.0061878. Print 2013. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Nogo-66 receptor antagonist peptide promotes axonal regeneration. | GrandPre T, etal., Nature 2002 May 30;417(6888):547-51. |
4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
5. | LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. | Mi S, etal., Nat Neurosci. 2004 Mar;7(3):221-8. doi: 10.1038/nn1188. Epub 2004 Feb 15. |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. | Oertle T, etal., J Neurosci 2003 Jul 2;23(13):5393-406. |
8. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
9. | GOA pipeline | RGD automated data pipeline |
10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
11. | Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. | Robak LA, etal., J Neurosci. 2009 May 6;29(18):5768-83. doi: 10.1523/JNEUROSCI.4935-08.2009. |
12. | The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. | Venkatesh K, etal., J Neurosci. 2005 Jan 26;25(4):808-22. |
13. | The nogo receptor family restricts synapse number in the developing hippocampus. | Wills ZP, etal., Neuron. 2012 Feb 9;73(3):466-81. doi: 10.1016/j.neuron.2011.11.029. |
14. | Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo. | Zemmar A, etal., J Neurosci. 2014 Jun 25;34(26):8685-98. doi: 10.1523/JNEUROSCI.3817-13.2014. |
PMID:11201742 | PMID:11891768 | PMID:15297463 | PMID:15504325 | PMID:15548200 | PMID:15548666 | PMID:15694322 | PMID:15737741 | PMID:16088223 | PMID:16321384 | PMID:16603920 | PMID:16712417 |
PMID:17294731 | PMID:17329206 | PMID:17428512 | PMID:17640868 | PMID:18182498 | PMID:18337405 | PMID:18365011 | PMID:18411262 | PMID:18625710 | PMID:19063867 | PMID:19524873 | PMID:19575706 |
PMID:19901030 | PMID:20075346 | PMID:20337950 | PMID:20463223 | PMID:20473744 | PMID:20828545 | PMID:20844138 | PMID:21418929 | PMID:21817055 | PMID:22139298 | PMID:22406547 | PMID:22923615 |
PMID:23158614 | PMID:23533145 | PMID:23829864 | PMID:24244357 | PMID:26472924 | PMID:26945033 | PMID:26987715 | PMID:27033267 | PMID:27288754 | PMID:27339102 | PMID:28489665 | PMID:31948754 |
PMID:32598099 | PMID:33495810 | PMID:35263202 |
Rtn4r (Rattus norvegicus - Norway rat) |
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RTN4R (Homo sapiens - human) |
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Rtn4r (Mus musculus - house mouse) |
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Rtn4r (Chinchilla lanigera - long-tailed chinchilla) |
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RTN4R (Pan paniscus - bonobo/pygmy chimpanzee) |
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RTN4R (Canis lupus familiaris - dog) |
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Rtn4r (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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RTN4R (Sus scrofa - pig) |
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RTN4R (Chlorocebus sabaeus - green monkey) |
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Rtn4r (Heterocephalus glaber - naked mole-rat) |
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Variants in Rtn4r
72 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D11Rat50 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 64 | 17 | |||||||||||
Low | 3 | 36 | 23 | 10 | 13 | 10 | 1 | 10 | 35 | 22 | 10 | ||
Below cutoff | 7 | 29 | 26 | 6 | 26 | 7 | 9 | 2 | 1 | 7 |
RefSeq Transcripts | NM_053613 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | AF462390 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AY028438 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473999 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000011 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000051037 ⟹ ENSRNOP00000041517 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_053613 ⟹ NP_446065 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_446065 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAK20166 | (Get FASTA) | NCBI Sequence Viewer |
AAM46772 | (Get FASTA) | NCBI Sequence Viewer | |
EDL77921 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000041517 | ||
ENSRNOP00000041517.5 | |||
ENSRNOP00055004208 | |||
ENSRNOP00060017200 | |||
ENSRNOP00065009833 | |||
GenBank Protein | Q99M75 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_446065 ⟸ NM_053613 |
- Peptide Label: | precursor |
- UniProtKB: | Q99M75 (UniProtKB/Swiss-Prot), A6JSI6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000041517 ⟸ ENSRNOT00000051037 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q99M75-F1-model_v2 | AlphaFold | Q99M75 | 1-473 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:620810 | AgrOrtholog |
BioCyc Gene | G2FUF-20635 | BioCyc |
Ensembl Genes | ENSRNOG00000030920 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOG00055003604 | UniProtKB/Swiss-Prot | |
ENSRNOG00060012784 | UniProtKB/Swiss-Prot | |
ENSRNOG00065008377 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000051037 | ENTREZGENE |
ENSRNOT00000051037.6 | UniProtKB/Swiss-Prot | |
ENSRNOT00055005627 | UniProtKB/Swiss-Prot | |
ENSRNOT00060021733 | UniProtKB/Swiss-Prot | |
ENSRNOT00065013282 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 3.80.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Cys-rich_flank_reg_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Leu-rich_rpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Leu-rich_rpt_typical-subtyp | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:113912 | UniProtKB/Swiss-Prot |
NCBI Gene | 113912 | ENTREZGENE |
PANTHER | ANTIGEN BSP, PUTATIVE-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RETICULON-4 RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | LRR_8 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Rtn4r | PhenoGen |
PROSITE | LRR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000030920 | RatGTEx |
ENSRNOG00055003604 | RatGTEx | |
ENSRNOG00060012784 | RatGTEx | |
ENSRNOG00065008377 | RatGTEx | |
SMART | LRR_TYP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LRRCT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | L domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A6JSI6 | ENTREZGENE, UniProtKB/TrEMBL |
Q99M75 | ENTREZGENE, UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2004-09-10 | Rtn4r | reticulon 4 receptor | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Rtn4r | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_disease | inhibition of receptor activity by antagonist NEP1-40 may improve axonal regeneration after CNS injury | 727379 |