Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NPLOC4 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Nploc4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NPLOC4 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Nploc4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of NPLOC4 mRNA | CTD | PMID:22206623 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Metribolone results in increased expression of NPLOC4 protein | CTD | PMID:17152098 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NPLOC4 mRNA | CTD | PMID:33387578 | 2-hydroxypropanoic acid | decreases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of NPLOC4 mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of NPLOC4 mRNA | CTD | PMID:21179406 | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of NPLOC4 protein | CTD | PMID:26597043 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of NPLOC4 protein | CTD | PMID:34915118 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | NPLOC4 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of NPLOC4 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of NPLOC4 protein | CTD | PMID:34186270 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of NPLOC4 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of NPLOC4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | acrylamide | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of NPLOC4 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | NPLOC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of NPLOC4 intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of NPLOC4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of and results in increased oxidation of NPLOC4 mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NPLOC4 mRNA | CTD | PMID:16483693 | arsane | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | NPLOC4 protein affects the reaction [Arsenic results in increased degradation of PML protein] | CTD | PMID:36880596 | arsenic atom | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | NPLOC4 protein affects the reaction [Arsenic results in increased degradation of PML protein] | CTD | PMID:36880596 | arsenous acid | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPLOC4 protein] | CTD | PMID:26598702 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NPLOC4 mRNA | CTD | PMID:25181051 more ... | bisphenol A | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NPLOC4 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of NPLOC4 gene | CTD | PMID:28505145 | bisphenol A | increases methylation | ISO | Nploc4 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of NPLOC4 promoter | CTD | PMID:27312807 | bisphenol F | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of NPLOC4 protein | CTD | PMID:34186270 | butan-1-ol | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of NPLOC4 mRNA | CTD | PMID:29432896 | CGP 52608 | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NPLOC4 gene] | CTD | PMID:28238834 | clozapine | decreases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Clozapine results in decreased expression of NPLOC4 protein | CTD | PMID:34122009 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of NPLOC4 mRNA | CTD | PMID:24386269 | cobalt dichloride | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of NPLOC4 mRNA | CTD | PMID:19320972 | copper(II) sulfate | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of NPLOC4 mRNA | CTD | PMID:19549813 | cyproconazole | increases expression | EXP | | 6480464 | cyproconazole results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | cyproconazole | multiple interactions | EXP | | 6480464 | [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of NPLOC4 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | diarsenic trioxide | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPLOC4 protein] | CTD | PMID:26598702 | dibutyl phthalate | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NPLOC4 protein | CTD | PMID:30218697 | doxorubicin | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of NPLOC4 mRNA | CTD | PMID:29803840 | endosulfan | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Endosulfan results in increased expression of NPLOC4 mRNA | CTD | PMID:26615145 | endosulfan | affects expression | EXP | | 6480464 | Endosulfan affects the expression of NPLOC4 mRNA | CTD | PMID:31464424 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | epoxiconazole | multiple interactions | EXP | | 6480464 | [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of NPLOC4 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | ethanol | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of NPLOC4 mRNA | CTD | PMID:29432896 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Nploc4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of NPLOC4 mRNA | CTD | PMID:22206623 | fulvestrant | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NPLOC4 gene | CTD | PMID:31601247 | gold atom | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA | CTD | PMID:28433809 | gold(0) | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA | CTD | PMID:28433809 | ivermectin | decreases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NPLOC4 protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Lead affects the expression of NPLOC4 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | mercury dichloride | increases expression | EXP | | 6480464 | Mercuric Chloride results in increased expression of NPL4 mRNA | CTD | PMID:16507785 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of NPLOC4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of NPLOC4 protein | CTD | PMID:33146391 | paracetamol | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of NPLOC4 mRNA | CTD | PMID:22230336 | pentachlorophenol | increases expression | ISO | Nploc4 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of NPLOC4 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Nploc4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NPLOC4 mRNA | CTD | PMID:36331819 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | NPLOC4 (Homo sapiens) | 6480464 | [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NPLOC4 protein | CTD | PMID:30218697 | prochloraz | multiple interactions | EXP | | 6480464 | [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | prochloraz | increases expression | EXP | | 6480464 | prochloraz results in increased expression of NPLOC4 mRNA | CTD | PMID:29038839 | rac-lactic acid | decreases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of NPLOC4 mRNA | CTD | PMID:30851411 | sodium arsenite | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of NPLOC4 mRNA | CTD | PMID:34032870 | temozolomide | increases expression | ISO | NPLOC4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of NPLOC4 mRNA | CTD | PMID:31758290 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NPLOC4 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Nploc4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of NPLOC4 mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of NPLOC4 mRNA | CTD | PMID:31150632 | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of NPLOC4 protein | CTD | PMID:35544339 | tolcapone | increases expression | EXP | | 6480464 | tolcapone results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of NPLOC4 mRNA | CTD | PMID:24136188 | |